말초신경질환의 진단검사로서 피부 생검의 유용성

오지영,Oh, Jeeyoung 대한임상신경생리학회 2007 Annals of Clinical Neurophysiology Vol.9 No.2

Analysis of intraepidermal nerve fibers using skin biopsy is a recently developed technique, providing diagnostic information on small fiber neuropathies. The specimens are obtained by 3 mm punch biopsy, which is safe and minimally invasive. Immunohistochemical staining by Protein gene product (PGP) 9.5 demonstrate not only intraepidermal nerve fibers but dermal structures, such as sweat gland and erector papillae. Up to now, many studies agree that intraepidermal nerve fiber density is dramatically reduced in various sensory neuropathies. The utility of density measure was confirmed with high sensitivity in the diagnosis of sensory neuropathy, comparable to sural nerve biopsy or quantitative sensory testing. Besides quantitative methods, morphological changes like axonal swelling and fragmentation can be used as predegenerative markers. This article reviews the technique of skin biopsy and clinical and experimental usefulness of skin biopsy in diagnosing and monitoring peripheral neuropathies.

Cadmium Induces Apoptosis Through Oxidative Stress in Human Breast Cancer MCF-7 Cells

오지영,이수정,신재호,김태성,문현주,강일현,강태석,김안근,한순영,Oh Jy Young,Lee Su Jung,Shin Jae-Ho,Kim Tae Sung,Moon Hyun Ju,Kang Il Hyun,Kang Tae Seok,Kim An Keun,Han Soon Young The Korean Society of Environmental Toxicology 2004 환경독성보건학회지 Vol.19 No.3

본 연구는 건전지나 플라스틱 등 산업물질, 식품, 흡연 그리고 공기, 물 등을 통해 인간과 생태계에 노출되고 있는 중금속 카드뮴을 인간 유방암 세포 MCF-7에 처리하였을 때 일어나는 현상을 살펴보고 나아가 카드뮴의 독성기전을 규명하기 위해 시행되었다. 카드뮴으로 인한 아폽토시스는 DNA분절 현상과 핵의 쪼개짐, 세포주기에 있어서 sub-G1의 출현 그리고 아폼토시스시에 발현되는 단백질 caspase의 발현, 특히 산화적 스트레스상태에서 마이토콘드리아가 손상을 입었을 때 발현되는 caspase-9의 발현을 통해 확인하였다. 카드뮴으로 인한 산화적 스트레스는 활성 산소종이 대조군에 비해 증가하고 이를 방어하기 위한 항산화효소 superofide dismutase, catalase, glutathion redurtase가 감소함을 통하여 확인하였다. 이 상의 결과들을 통해 카드뮴은 인간 유방암 세포 MCF-7에서 산화적 스트레스를 유발시켜 아폼토시스를 일으키는 것으로 추정할 수 있다.

자문 시 유용한 신경인지검사

오지영,Oh, Jee-Young 한국정신신체의학회 2010 정신신체의학 Vol.18 No.1

대뇌 손상이 있는 환자에 대한 임상적 접근은 임상의에게 생각보다 쉽지 않다. 방대한 신경인지기능검사는 숙련된 기술을 요할 뿐 아니라 여러가지 도구들을 필요로 한다. 임상의가 대뇌의 부위에 따른 기능에 대하여 안다면 몇몇 간단한 평가로 대뇌 손상 부위를 추론해 낼 수 있다. 본고에서는 대뇌의 기능을 평가할 수 있는 여러가지 술기를 소개하고자 한다. The clinical assessment of a patient with a cerebral lesion is not easy to physicians. Extensive neuropsycho-logical tests often need both skilled experience and some special tools. Some bedside tests equally provide valuable clues to localize cerebral lesion, when a clinician knows functional anatomy of cerebral hemisphere. In this article, several techniques used to evaluate cerebral cortical function will be introduced.

A Case of Atypical Thrombotic Microangiopathy

오지영,박세진,김기환,임범진,정현주,기정혜,김기혁,신재일,Oh, Ji Young,Park, Se Jin,Kim, Ki Hwan,Lim, Beom Jin,Jeong, Hyeon Joo,Ki, Jung Hye,Kim, Kee Hyuck,Shin, Jae Il Korean Society of Pediatric Nephrology 2013 Childhood kidney diseases Vol.17 No.2

We report the case of a 14-year-old girl, diagnosed with atypical thrombotic microangiopathy (TMA). The patient presented with persistent fever, nausea, and newly developed peripheral edema. Her laboratory findings indicated chronic anemia with no evidence of hemolysis, thrombocytopenia, or elevated serum creatinine level. A few days after hospitalization, acute renal failure and fever worsened, and proteinuria developed. On day 40 of hospitalization, she experienced a generalized tonic seizure for 5 min, accompanied by renal hypertension. Brain magnetic resonance imaging revealed posterior reversible leukoencephalopathy syndrome. After steroid pulse therapy, a renal biopsy was performed because of delayed recovery from thrombocytopenia. The biopsy findings showed features of thrombotic microangiopathic hemolysis with fibrinoid change restricted. Current diagnostic criteria for TMA have focused on thrombotic thrombocytopenic purpura and hemolytic uremic syndrome, and diagnosis is based on the clinical presentation and etiology, with the consequence that idiopathic and atypical forms of TMA can be overlooked. Developing effective tools to diagnose TMA, such as studying levels of ADAMTS13 or testing for abnormalities in the complement system, will be the first step to improving patient outcomes. 응고성 미세혈관병증은 빠른 진단이 예후에 중요한 인자이나, 현재의 진단 기준에 따라서는 thrombotic thrombocytopenic purpura, haemolytic uremic syndrome 외의 비전형적인 응고성 미세혈관병증의 진단이 늦어짐에 따라 나쁜 예후를 초래하게 되는 경우가 많다고 보고되어 있다. 본 저자들은 시행한 혈액 검사상 용혈의 증거가 없는 빈혈, 혈소판 감소증 그리고 급성 신부전을 보인 소아 환아에서 신조직 검사를 통해 비특이적 응고성 미세혈관병증을 진단받은 1증례를 보고하고자 한다. 14세 여자 환아는 3주간 지속된 발열, 구역과 전신 부종을 주소로 본원으로 전원되었다. 내원하여 시행한 혈액 검사상 빈혈과 혈소판 감소증을 보였으나, 용혈의 증거는 없었으며, 혈정 크레아티닌이 증가되어 있었다. 내원 이후 급성 신부전과 발열은 지속적으로 진행되었으며, 소변 검사상 단백뇨가 발생하였다. 환아는 내원 40일경 신고혈압과 동반된 전신 경련이 5분간 있어 뇌 자기 공명 영상을 촬영하였으며, 가역성 후백질 뇌병증 증후군의 양상을 보여 항 경련제 투여를 시작하였다. 이후 지속되는 혈소판 감소증 및 발열은 고용량 스테로이드 치료를 진행한 후 호전되었으나, 급성 신부전 및 단백뇨가 지속되어 신장 조직 검사를 진행하였으며, 검사 결과상 혈전성 미세혈관병증의 소견을 보였다. 이와 같이 조직검사상에서는 응고성 미세혈관병증을 보이나 전형적인 응고성 미세혈관병증의 혈액학적인 진단 기준이 충족되지 않는 비특이적 형태의 응고성 혈관병증의 효과적인 진단을 위하여 보체 기전이나 ADAMTS 13와 같은 유전자 범위의 보다 활발한 연구를 통한 효과적인 진단 기준의 마련이 되어야 할 것으로 보인다.

상부 대류권-하부 성층권 오존이 성층권 준 2년주기 진동과 매든-줄리안 진동 상관성에 미치는 영향: GloSea5 이용 사례

오지영,손석우,백승윤,Oh, Jiyoung,Son, Seok-Woo,Back, Seung-Yoon 한국기상학회 2022 대기 Vol.32 No.3

Recent studies have shown that Madden-Julian Oscillation (MJO) is modulated by Quasi-Biennial Oscillation (QBO) during the boreal winter; MJO becomes more active and predictable during the easterly phase of QBO (EQBO) than the westerly phase (WQBO). Despite growing evidences, climate models fail to capture the QBO-MJO connection. One of the possible reasons is a weak static stability change in the upper troposphere and lower stratosphere (UTLS) by neglecting QBO-induced ozone change in the model. Here, we investigate the possible impact of the ozone-radiative feedback in the tropical UTLS on the QBO-MJO connection by integrating the Global Seasonal Forecasting System 5 (GloSea5) model. A set of experiments is conducted by prescribing either the climatological ozone or the observed ozone at a given year for the EQBO-MJO event in January 2006. The realistic ozone improves the temperature simulation in the UTLS. However, its impacts on the MJO are not evident. The MJO phase and amplitude do not change much when the ozone is prescribed with observation. While it may suggest that the ozone-radiative feedback plays a rather minor role in the QBO-MJO connection, it could also result from model biases in UTLS temperature and not-well organized MJO in the model.

Cardiac Manifestations of Inborn Error of Metabolism in Pediatric Patients

오지영,Oh, Jiyoung The Korea Society of Inherited Metabolic Disease 2021 대한유전성대사질환학회지 Vol.21 No.1

Among the various etiologies of cardiomyopathy, inborn errors of metabolism (IEM) is one of the underlying causes, especially in the pediatric population. The accurate identification of the IEM of cardiomyopathy may lead to better prognosis through disease-specific management. Therefore, clinicians should always keep in mind the possibility that IEM may be one of the underlying etiologies of cardiomyopathy, and carry out multi-systematic clinical approach to diagnosis of IEM. This review covers the pathophysiology, clinical presentations, typical laboratory findings, diagnosis, and proper treatment of each type of IEM-induced cardiomyopathy in pediatric patients to gain a deeper understanding of this subject.

Renal Manifestations and Imaging Studies of Kawasaki Disease

오지영,박세진,김선정,장광천,김유리아,신재일,김기혁,Oh, Ji Young,Park, Se Jin,Kim, Sun Jung,Jang, Gwang-Cheon,Kim, Uria,Shin, Jae Il,Kim, Kee Hyuck Korean Society of Pediatric Nephrology 2013 Childhood kidney diseases Vol.17 No.2

목적: 본 연구는 가와사키 질환의 신장 침범에 대하여 비교적 덜 침습적이며, 특이도와 민감도가 높은 검사인 Technetium-99m dimercaptosuccinic acid scintigraphy (DMSA renal SPECT)을 통하여 밝혀보고자 한다. 방법: 2011년 3월부터 10월까지 국민건강보험 일산병원에서 가와사키로 진단된 15명의 환아들을 대상으로 진행하였다. 15명의 환아 모두 가와사키의 급성기에 DMSA renal SPECT를 시행하였다. 또한 신장 세뇨관 손상 지표인 요중 ${\beta}2$-microglobulin (${\beta}2$-MG)을 측정하여 이를 통한 가와사키 환아에서 신장 손상의 조기 진단 가능 여부를 연구해보았다. 결과: 환아 15명 모두의 신기능 검사는 정상이었다. 소변 검사상 현미경적 혈뇨와 농뇨가 각각 13%, 33%에서 관찰되었다. 요중 ${\beta}2$-MG는 46%에서 증가된 소견을 보였다. 또한 환아들을 요중 ${\beta}2$MG를 기준으로 증가되어 있는 군과 증가되지 않은 군으로 나누어 비교, 분석해 보았으며, 두군간에 임상 증상, 임상 검사, 초음파 검사 및 심초음파 검사에서 유의한 차이를 보이지 않았다. 모든 환아에서 DMSA renal SPECT는 정상 소견을 보였다. 결론: 본 연구에서 가와사키 질환의 신장 침범은 경한 소변 검사 이상 및 일부 환아에서의 요중 ${\beta}2$-MG의 상승 소견을 보였으며, DMSA renal SPECT에서 관찰될 정도의 신장 침범은 보이지 않았다. Purpose: The aim of this study was to verify renal inflammation following Kawasaki disease (KD) using single photon emission computed tomography along with Technetium-99m dimercaptosuccinic acid scintigraphy (DMSA renal SPECT). Methods: From March 2011 to October 2011, 15 patients diagnosed with KD at the National Health Insurance System Ilsan Hospital were enrolled in the study. All patients underwent DMSA renal SPECT to evaluate renal involvement during the acute phase of KD. Urine ${\beta}2$-microglobulin (${\beta}2$-MG), a marker of renal proximal tubular dysfunction, was also measured to assess renal damage. Results: All 15 patients had normal renal function test results. However, microscopic hematuria and pyuria were observed in 13% and 33% of the patients, respectively. Moreover, urine ${\beta}2$-MG was elevated in 46% of the patients. In addition, patients were divided into two groups based on ${\beta}2$-MG level: those with an increased ${\beta}2$-MG level, and those with a normal ${\beta}2$-MG level. No significant differences were found between these two groups in clinical characteristics, laboratory, sonography, and echocardiography findings. All patients' DMSA renal SPECT scans were normal. Conclusion: Our study showed that mild abnormalities in the urinalysis and elevated urine ${\beta}2$-MG were the only findings of renal involvement in KD. However, no aggressive renal manifestations were detected on DMSA renal SPECT.

아파트의 친환경적 실내마감재에 대한 인테리어 디자이너와 주부의 인식 및 선호 비교

오지영,김미희,Oh, Ji-Young,Kim, Mi-Hee 한국주거학회 2009 한국주거학회 논문집 Vol.20 No.1

As a response to the recent increase in the Interest in environment friendly interior finishing materials, the purpose of this study is to compare the awareness of environment friendly interior finishing materials between interior designers and housewives, as representatives of two different consumer groups, and to examine how the preferences between them differ. The study participant group for this research consisted of 80 interior designers working in Gwangju, and 166 housewives who were residents of a number of apartments in Gwangju. Self administered questionnaires were provided to the participants and were then collected. Unpaired t-tests and $x^2$ tests were used to compare the prevalence of epidemiological factors and the variables that revealthe awareness and the preference between the two groups. While it was expected that both groups would source information using the internet, the housewives group showed a tendency to also seek advice from others in the selection of environment friendly interior finishing materials. Interior-designers considered the high price and the lack of diverse products as the most serious problems involved in selecting environment friendly interior finishing materials. Interior-designers chose design, color and long-term use, and the method of maintenance as standards by which to choose interior materials in general, while the housewives considered 'environment friendly' as the most important standard. Both groups however favored environment friendly materials. There was no difference between the two groups in terms of their belief in the need to trust a well known brand name and in the importance of a Green-label placed on interior finishing materials such as wallpaper, paint and laminate flooring.

팔라스마 비판을 통해 본 메를로-퐁티 현상학

오지영(Oh, Ji-Yeong),이동언(Lee, Dong-Eon) 대한건축학회 2020 대한건축학회 학술발표대회 논문집 Vol.40 No.1

환자의 특성에 따른 공공병원과 민간병원 차이 분석

오지영 ( Ji Young Oh ),김상미 ( Sang Mi Kim ),황성완 ( Sung Wan Hwang ) 경희대학교 경영연구원 2015 의료경영학연구 Vol.9 No.2

This study was designed to compare of the private and public hospital sectors according to the characteristic of patients as a proxy for efficiency. We used the patient survey in 2010, Measured by average length of stay, private hospitals appear to be more efficient than public hospitals across the medical departments, disease-specific and chronic diseases-specific. In the logistic regression results, all variables in the model 1, included population and social characteristics, were statistically significant and the classification accuracy was 70%. Model 2 was included the model 1 and diseases. In the model 2 cases, some variables were statistically excluded but the model 2, the classification accuracy 80.5%, was more accurate than the model 1. We conclude that private hospitals are more efficient than public hospitals in providing the range of care provided by private hospitals. These results suggest that the characteristics of the public and private hospitals had impacts on the length of stay. Therefore LOS must be taken into account by health managers when considering hospital costs.