한국인 산모에서 B형 간염 바이러스의 보유율 변화에 관한 연구

오은아 ( O Eun A ),정숙애 ( Jeong Sug Ae ),정만 ( Jeong Man ),심승식 ( Sim Seung Sig ),양인애 ( Yang In Ae ),최관수 ( Choe Gwan Su ),정남기 ( Jeong Nam Gi ) 대한내과학회 1990 대한내과학회지 Vol.38 No.6

N/A In an attempt to investigate the yearly changes of the HBsAg carrier rate by observing the HBsAg positive rate in full-term pregnant women who are definitely related to the vertical transmission of the hepatitis B virus, as well as to analyze the epidemiologic factors which influence the HBsAg positive rate in pregnant women, we tested HBsAg and checked the histories of about 20 epidemiologic factors in 10,359 prgnant women .who delivered at St. Columban`s Hospital in Mokpo City from April 1, 1985 to June 30, 1989. The results were as follows: 1) Overall HBsAg positivity in all 10,359 pregnant women was 7.9%. 2) The positive rate of HBsAg was unrelated to the frequency or degree of alcohol drinking,smoking, income, nutritional state, hygiene, education, religion, occupation, locality or, injections at home in pregnant women. 3) The positive rates of HBsAg were higher in cases who had acupuncture, venereal disease, who had more than four siblings, and who worked as an institutional worker or hospital staff. The positive rates of HBsAg increased significantly in cases who had blood transfusions(0.025<p<0.05), who had injections at hospitals(p<0.005), who had no hepatitis B vaccination(p<0.005), who had a family history of liver disease(p<0.001) and who were much older(p<0.005). 4) The positive rate of HBsAg was decreased significantly from 9.2% to 7.0% for five years(p<0.001). There were several factors which influence the HBsAg positivity every year. First, the rate of hepatitis B vaccination increased significantly(p<0.001), second, the number of pregnant women who had more than six siblings increased significantly(0.025<p<0.05) and third, the number of pregnant women who had acupuncture decreased significantly(p<0.001). But the number of pregnant women who were over 30 years old increased significantly(p<0.001). 5) The positive rate of HBsAg increased significantly from 7.2% to 13.0% as the age increased(p<0.005). There were several factors which influenced HBsAg positivity by age group. Although the rate of hepatitis B vaccination increased significantly in the older age groups(p<0.001), the positive rate of HBsAg increased more in the older age groups because the numbers of pregnant women who had acupuncture(p<0.001) and a family history of liver disease(p<0.005) increased significantly. The results suggest that the number of HBV carrier pregnant women in Korea decreased progressively every year. Although the rate of hepatitis B vaccination increased significantly, it was not so effective due to the small total number. The number of pregnant women who had acupuncture and a family history of liver disease increased significantly, especially those over 30 years old. So it is important to have a nationwide program of hepatitis B immunization and to educate people on how to interfere with the transmission route in order to eradicate hepatitis B in Korea.

과학적 증거와 설명에 대한 초등학교 6학년 학생의 이해

정혜선 ( Jeong Hye Seon ),오은아 ( O Eun A ) 한국과학교육학회 2003 한국과학교육학회지 Vol.23 No.6

The aim of this paper was to diagnose Korean sixth graders` understanding for scientific evidence and explanation. The instrument constructed by Jeong, Songer, and Lee (2002) was used to assets students` understanding for priority of scientific evidence, objectivity of data, relevance of evidence, data interpretation, coordination of theory and evidence, and repeated observation. Results showed that although many students recognized certain features of scientific inquiry such as objectivity of data, few of them understood why such features are valued and how to collect and use such data. In particular, students experienced difficulty in formulating explanation from evidence, not knowing, for example, that repeated observations are needed before making a general statement. The results of this study suggest that efforts to foster students` inquiry abilities need to be based on careful analyses of students existing inquiry skills and understanding.

한국인 산모와 신생아에서 NANB 간염과 B 형 간염에 관한 연구

최관수(Gwan Su Choi),김지운(Ji Woon Kim),장영호(Yung Ho Chang),오은아(Eun A O),양인애(In Ae Yang),유영근(Young Geun Ryoo),이봉섭(Bong Seob Lee),정남기(Nam Ki Jong),오영종(Young Zong Oh),남명숙(Myoung Soog Nam),임순선(Soon Seon Lim),김 대한소화기학회 1988 대한소화기학회지 Vol.20 No.2

N/A To assess the frequency of hepatitis in pregnant women, we examined the findings of the physical examination, medical history, liver function tests and viral markers in 7,580 pregnant women who delivered at St. Columbans Hospital in Mokpo City from April 1st, 1985 to June 30th, 1988. We compared the characteristics of hepatitis B in 28 mothers and 17 newborn infants, and of non-A, non-B hepatitis in 17 mothers and 61 newborn infants, The results were as follows; 1) Among 7,580 pregnant women, there were 629 cases (8.30%) of HBV carriers. Abnormal elevation of transaminase at delivery was noted in cases of hepatitis A (2, 0.03%), hepatitis B (25, 0. 33%), NANB hepatitis (57, 0.75%) toxemia (9, 0.12%) and drug induced hepatitis (1, 0,01%). 2) The earliest elevation of transaminase was noted at 3 months in 9 hepatitis B infants (6, 66.7%) and 61 NANB hepatitis infants (57, 93.4%). The highest elevation of transaminase was noted at 3 months in 61 NANB hepatitis infants (41, 67. 2%) and seemed to be delayed in 9 hepatitis B infants due to the effect of vaccine. 3) Abnormal transaminase was normal within 6 months in 17 cases (60.7%) of 28 mothers with hepatitis B, and 14 cases (82.4%) of 17 mothers with NANB hepatitis. If we test and observe for )onger time the cases of chronic hepatitis with intermittent elevation of transaminase may increase more. Twenty-seven of 28 hepatitis B mothers were positive for HBsAg for more than 1 year. Duration of abnormal transaminase in hepatitis B infants was much different by the vaccination, but total number of cases was very small. Among 61 NANB hepatitis infants, continuous elevation of transaminase was noted in 5(62.5%) of 8 infants who had no imrnunoprophylaxis, 19(55.9%) of 34 infants who received HBIG & Hepavax, 5(26.3%) of 19 infants who received gamma-globulin. There was slight but not significant inhibition of persistence of abnormal transaminase in group of gamma-globulin injection (0.05<p<0.1). The mean level of maximal ALT was higher in hepatitis B (148.32+162.47 IU) than in NANB hepatitis mothers (76.53<53.14 IU). It was similar in infants of both hepatitis B & NANB, and lower in infants who received Hepavax, gamma-globulin but it was not statistically significant. 4) Among the factors which may influence the elevation of ALT in hepatitis infants the level of ALT in hepatitis mothers had no influence. The immunoprophylaxis with HBIG & hepavax for hepatitis B infants, gamma-globulin for NANB hepatitis seemed to inhibit the elevation of ALT in infants, but not signficantly. ALT was normal in 5 infants (23.8%) of 21 HBeAg positive hepatitis B mothers and in 6 infants (85.7%) of 7 HBeAg negative hepatitis B mothers. There was significant elevation of ALT in infants of HBeAg positive hepatitis B mothers (p<0.0001). The results suggest that the prevalence of NANB hepatitis was higher than hepatitis B in Korean pregnant women at the time of delivery. Duration of abnormal transaminase was similar in mothers with hepatitis B and NANB. The time of the earliest and highest elevation of ALT, the mean level of maximal elevation of ALT were similar in infants with hepatitis B and NANB. Duration of abnormal transaminase and maximal elevation of ALT seemed to be decreased by the immunoprophylaxis with HBIG and Hepavax for hepatitis B infants, gamma-globulin for NANB hepatitis infants, but there was a significant difference in hepatitis B infants whose mothers had HBeAg positivity.

B 형 간염 백신의 효과 - 산모의 HBeAg 양성 유무에 따라 -

김세종(Sei Jong Kim),윤종만(Chong Mann Yoon),최관수(Gwan Su Choi),김지운(Ji Woon Kim),정남기(nam Ki Joung),장영호(Yung Ho Chang),오은아(Eun A O),양인애(In Ae Yang),유영근(Young Geun Ryoo),이봉섭(Bong Seob Lee) 대한소화기학회 1988 대한소화기학회지 Vol.20 No.1

N/A The preventive efficacy for HBV infection and chronic HBV carrier rate by active and passive immunoprophylaxis was observed in 49 newborn infants whose mothers were healthy HBV carriers with normal ALT activity at delivery. All infants were divided into 3 groups; Group A received HBIG at birth and HB Vaccine (Hepavax- B) at month 0, 1 and 6. Group B received first or second vaccine only. Group C received no vaccine. ALT activity, HBsAg and anti-HBs were tested every 3 months for 18 rnonths after delivery, and the results were analyzed in 3 groups according to the mothers HBeAg positivity. 1) The anti-HBs response was57.1% (16/28) in Group A and 76.9% (10/13) in the control group whose mothers vere normal. The anti-HBs response was 64.3% (9.14) and 57.1% (8/14) according to the mothers HBeAg positivity and negativity. The anti-HBs response was 56.3% (9/16) in male and 66.7% (8/12) in female infants. The anti-HBs response svas higher in female infants and infants a hose mothers were normal or HBeAg positive carriers. 2) Chronic HBV carrier rate in infants of HBeAg positive mothers was 14.3% (2/l4) in Ciroup A, 72.7% (8/11 ) in Group 8, 100% (6/6) in Group c and was statistically significant (p=0.037) (c=0.816). There was no significant difference hetween group A, B, and C in infants of HBeAg negative mothers. 3) The positive rate of HBsAg showed significant difference between Groups A and B, A and C, A and (B+C), (A+B) and C in all 3 monthly follow-up tests in infants of HBeAg positive mothers. But there was no significant difference between (groups A, B, and C in infants of HBeAg negative mothers. The results suggest that the anti-HBs response was lower in infants of HBsAg carrier mothers. The preventive efficacy of vaccine for HBV infection and chronic HBV carrier rate was excellent in infants of HBeAg positive mothers but not significant in infants of HBeAg negative mothers by the active and passive immunoprophylaxis.