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한국인 산모에서 B형 간염 바이러스의 보유율 변화에 관한 연구
오은아 ( O Eun A ),정숙애 ( Jeong Sug Ae ),정만 ( Jeong Man ),심승식 ( Sim Seung Sig ),양인애 ( Yang In Ae ),최관수 ( Choe Gwan Su ),정남기 ( Jeong Nam Gi ) 대한내과학회 1990 대한내과학회지 Vol.38 No.6
N/A In an attempt to investigate the yearly changes of the HBsAg carrier rate by observing the HBsAg positive rate in full-term pregnant women who are definitely related to the vertical transmission of the hepatitis B virus, as well as to analyze the epidemiologic factors which influence the HBsAg positive rate in pregnant women, we tested HBsAg and checked the histories of about 20 epidemiologic factors in 10,359 prgnant women .who delivered at St. Columban`s Hospital in Mokpo City from April 1, 1985 to June 30, 1989. The results were as follows: 1) Overall HBsAg positivity in all 10,359 pregnant women was 7.9%. 2) The positive rate of HBsAg was unrelated to the frequency or degree of alcohol drinking,smoking, income, nutritional state, hygiene, education, religion, occupation, locality or, injections at home in pregnant women. 3) The positive rates of HBsAg were higher in cases who had acupuncture, venereal disease, who had more than four siblings, and who worked as an institutional worker or hospital staff. The positive rates of HBsAg increased significantly in cases who had blood transfusions(0.025<p<0.05), who had injections at hospitals(p<0.005), who had no hepatitis B vaccination(p<0.005), who had a family history of liver disease(p<0.001) and who were much older(p<0.005). 4) The positive rate of HBsAg was decreased significantly from 9.2% to 7.0% for five years(p<0.001). There were several factors which influence the HBsAg positivity every year. First, the rate of hepatitis B vaccination increased significantly(p<0.001), second, the number of pregnant women who had more than six siblings increased significantly(0.025<p<0.05) and third, the number of pregnant women who had acupuncture decreased significantly(p<0.001). But the number of pregnant women who were over 30 years old increased significantly(p<0.001). 5) The positive rate of HBsAg increased significantly from 7.2% to 13.0% as the age increased(p<0.005). There were several factors which influenced HBsAg positivity by age group. Although the rate of hepatitis B vaccination increased significantly in the older age groups(p<0.001), the positive rate of HBsAg increased more in the older age groups because the numbers of pregnant women who had acupuncture(p<0.001) and a family history of liver disease(p<0.005) increased significantly. The results suggest that the number of HBV carrier pregnant women in Korea decreased progressively every year. Although the rate of hepatitis B vaccination increased significantly, it was not so effective due to the small total number. The number of pregnant women who had acupuncture and a family history of liver disease increased significantly, especially those over 30 years old. So it is important to have a nationwide program of hepatitis B immunization and to educate people on how to interfere with the transmission route in order to eradicate hepatitis B in Korea.
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