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오성민 ( Sung-min Oh ),한민수 ( Min-su Han ),권영민 ( Yeong-min Kwon ),박원서 ( Won-seo Park ),김준현 ( Jun-hyeon Kim ),신현승 ( Hyeon-seung Shin ),하상윤 ( Sang-yun Ha ),정해도 ( Hae-do Jung ) 국군의무사령부 2018 대한군진의학학술지 Vol.49 No.1
Objectives : Aedes albopictus(Skuse) is known as the major vector of human arboviruses that can transmit approximately 22 virus belonging to Togaviridae, Flaviviridae, Bunyaviridae families. Recently, Aedes albopictus has been suggested to be involved in the transmission of Zika virus in several countries, including Southeast Asia. Methods : In this study, Among the military units stationed in Incheon, two coastal units were selected and two inland units were selected, we used BG sentinel trap to collection mosquitoes from June to September. Results : We have collected mosquitoes at intervals of 2 weeks and the total population of mosquito is 7,917. From among these 1,617 mosquitoes were Ae. albopictus, this accounted for 20.4% of the total mosquitoes which has greatly exceeded the national average of 23.8%. In addition, We have collected 5,460 Cx. pipiens(69.0%), 225 Anopheles spp.(2.8%), 497 Och. koreicus(6.3%), 92 Ar. subalbatus(1.2%), 20 Ae. vexans(0.3%), 2 Cx. bitaeniorhynchus, 2 Cx. orientalis, 2 Cx. tritaeniorhynchus. After we collected mosquitoes, we move immediately to the laboratory, classified mosquitoes and tested the pathogen in the way(1 pool contains maximum 50 mosquitoes) of a standard inspection method(Real-time PCR) by Korea centers for disease control and prevention. Although a total of 50 pools from the collected Ae. albopictus was performed. Flavivirus including Zika virus was not detected during study period. Moreover, malaria inspection of Anopheles spp. 30 pools were tested and that were all negative. Conclusions : According to the study, white-rooted mosquitoes living in military areas have not yet been contaminated with pathogens such as Zikavirus, Dengue fever and yellow fever, but the high habitat density indicates that there is a risk of rapid spread if these kind of diseases are infulx from abroad. Therefore, by establishing a system to monitor mosquitoes in the military, we can use it to prepare for the outbreak of foreign infectious diseases and to improve the health of soldiers and prevent the national infectious disease.
각질형성세포에서 레티노인산(All-trans Retinoic Acid)에 의한 IL-8 발현의 기전
정예리 ( Yae Lee Chung ),강태원 ( Tae Won Kang ),오성민 ( Sung Min Oh ),정승용 ( Seung Yong Chung ),김수찬 ( Soo Chan Kim ) 대한피부과학회 2009 大韓皮膚科學會誌 Vol.47 No.6
Background: Retinoic acid (RA) has been reported to induce the up-regulation of inflammatory cytokines such as IL-1, TNF-α and IL-8 in dermal fibroblasts and keratinocytes. There is no evidence to support a direct interaction between the RA-mediated transcriptional machinery and IL-8 gene transcription. Objective: The aim of this study is to clarify the mechanism of the up-regulation of IL-8 in keratinocytes by RA. Methods: The IL-1, IL-8, TNF-α and MCP-1 mRNA expressions in HaCaT cells stimulated by RA were measured by quantitative RT-PCR. The effects of a NF-κB inhibitor and IL-1 receptor antagonist (ra) on the IL-8 mRNA expression were measured by quantitative RT-PCR. Electrophoretic motility shift assay (EMSA) was conducted on the RA-stimulated HaCaT cells that were or were not treated with NF-κB inhibitor to measure the NF-κB binding activity in each group. The phospho-IκB activity in the HaCaT cells after stimulation with RA was also measured by Western blotting. Results: An up-regulation of the IL-8 gene expression by RA was demonstrated in the HaCaT cells. The inhibition assay revealed the involvement of the NF-κB binding site of the IL-8 gene in the RA-enhanced promoter activity. EMSA demonstrated that RA enhanced the formation of the DNA-NF-κB complex. There was no evidence to support IL-1 as an intermediate stimulus between the RA-mediated transcriptional machinery and IL-8 gene transcription. Western blot analysis revealed increased phospho-IκB activity in the HaCaT cells after stimulation with RA. Conclusion: Our result suggested that the IL-8 gene expression of HaCaT cells after RA stimulation is caused by the activation of IKK and the dissociation of IκB from NF-κB and the transcription of NF-κB in the nucleus. (Korean J Dermatol 2009;47(6):674∼682)
보호계전기 정정을 위한 Open Interface 개념의 사용자 환경 설계
吳成民,崔勉松,李承宰 明知大學校 産業技術硏究所 2004 産業技術硏究所論文集 Vol.23 No.-
KEPCO is using power system protection business developing PROSET2000 to computerize synthesis. This system is database and synthesis computing program that have correction automation program etc., for protective relaying business. PROSET2000's Human Machine Interface(HMT) that is designed by GOMS could not reflect justly user's requirement. Studied new design method of HMI for fast penumbra of user's requirement. Apply and designs Open Interface technique in view of software methodology to solve problem of performance of existent PROSET2000 system. System developer can receive optimum service by offering interface(Meta Interface) that user can exhibit on outside, and change achievement strategy etc., that must select according to circumstance among embodiment contents in case apply Open Interface technique. Could reflect requirement of PROSET2000 development time shortening and user fast by developing HMI to Open Interface concept. Can improve PROSET2000 performance by selecting Open Interface concept.