임신 제 3 분기까지 진행된 비교통성 흔적자궁각 임신 1 예

황경주(Kyung Joo Hwang),양정인(Jeong In Yang),오기석(Kie Suk Oh),김행수(Haeng Soo Kim),안은주(Eun Joo Ahn),양성천(Seong Cheon Yang),이은주(Eun Ju Lee),주희재(Hee Jae Joo) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.1

The uterus with rudimentary horn occurs as a result of a lack of development during fetal life of the middle and lower parts of one of the Miillerian ducts, in which there is a failure of fusion of the two ducts, The incidence of this uterine anomaly is rare. Many cases of rudimentary uterine horn are not discovered since they do not become involved in a pregnancy, and thus remain symptomless and uncomplicated, and the diagnosis usually being made only with pregnancy with rupture. In this presentation, we describe a case of diagnosis and management of unruptured non-communicating rudimentary uterine horn pregnancy at the third trimester. The patient diagnosed by ultrasonography and MRI, was hospitalized for further evaluation and delivery under the impression of unruptured non-communicating rudimentary horn pregnancy. A living male infant weighing 1,930 gm was delivered by cesarean section at 33+l weeks due to impending preterm labor. Some articles concerned this subject were reviewed briefly to discuss relevant method of diagnosis, treatment, and clinical characteristics.

다낭성 난소 증후군 환자에서 체중과 임신이 내분비 양상 및 당 대사에 미치는 영향

황경주(Kyung Joo Hwang),오기석(Kie Suk Oh),김세광(Sei Kwang Kim),권혁찬(Hyuck Chan Kwon),박영한(Young Han Park),양정인(Jung In Yang),유희석(Hee Suk Rhyu) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.3

N/A Objective: The purpose of this study attempts to determine the endocrinologic characteristics and changes in glucose metabolism before/during pregnancy according to different body weights in women with Polycystic ovarian syndrome (PCOS). Methods: 94 women dia with PCOS were evaluated through measuring serum hormone levels and oral glucose tolerance tests preconceptionally and gestationally. Results: In patients who were of normal weight showed significantly increased serum LH levels compared to those who were overweight (12.8+-0.9 Vs. 7.1+-0.8 mIU/ml, p= 0.000), and the serum levels of insulin was increased significantly in the overweight group (7.1+-0.7 Vs. 15.2+-2.8 ulU/ml, p= 0.000). the IGFBP-I (32.8+-10.6 Vs. 8.3+-2.5 ng/ml, p=0.034) and SHBG (55.8+-4.2 Vs. 37.1+-3.1 nmol/ml, p= 0.001) were significantly lower in the ovnweight group. The oral glucose tolerance test before/after pregnancy showed increased frequency of abnormal glucose metabolism, in both of the non-obese group (38.8%, 26,9%) and the obese group (64.2%, 53.9%) compared with normal population. Conclusion: It is thought that in the normal weight group with polycystic ovarian syndrome androgen production is stimulated in the theca cells by abnormally high LH secretion, while in the overweight group the hyperinsulinemia state which decreases the SHBG and IGFBP-I, lead to increase biologically active hee androgens and IGF-I and increase insulin binding to its receptor. And during/before pregnancy, women with PCOS showed that incidence of abnormal glucose metabolism was significantly increased in both of non-obese and obese groups.

Multi Strategy 운용 체계 금융 투자 사례연구: E증권사 Prop Trading을 중심으로

이주한 ( Joo Han Lee ),박태현 ( Tae Hyun Park ),오경주 ( Kyung Joo Oh ) 한국지식경영학회 2021 지식경영연구 Vol.22 No.1

본 연구의 목적은 일반적으로 공유되어 있지 않은 Multi Strategy 관련 금융투자 지식을 사례 연구를 통해 탐색하고 이를 국내 헤지 펀드 시장에 공유하는데 있다. 현재 국내에서 본격적인 사모 헤지펀드 시대가 열리면서 많은 펀드들이 만들어지고 있지만 전략의 다양성에 있어 부족한 것이 현실이다(이준서, 2016). 초기 단순한 Equity Long/Short 전략으로 시작되어 메자닌, 대체투자 등 여러 전략들이 활용되고 있지만 Multi Strategy를 활용한 펀드는 제한적인 상황이다. 본 연구에서는 증권사 Prop Trading에서 적극적으로 활용되고 있는 Multi Strategy 기법을 이용해 Absolute Return을 달성하는 과정과 결과에 대한 사례 분석을 바탕으로 헤지펀드 운용전략에 대한 실증적인 활용 방안을 제시하고자 한다. 본 연구의 결과를 통해 헤지펀드 시장에서 Multi Strategy를 활용해 Absolutr Return을 추구하고자 하는 연구자 및 실무에서 운용하는 펀드매니저가 지식을 탐색하고 공유해서 금융 경쟁력 강화를 도모하는데 기여하고자 한다. The purpose of this study is to explore financial investment knowledge related to multi-strategy, which is not generally shared. Through case studies, we will share it with the domestic hedge fund market. Since the era of full-fledged private equity hedge funds in Korea opens, many funds are created; however, reality is that there is a lack of diversity in strategies. Initially, it started with a simple stock long/short strategy, and various strategies such as mezzanine and alternative investments are in use but funds using multi-strategy are limited. This study aims to present an empirical application plan for hedge fund management strategies using a case study. It will specifically focus on process of achieving Absolute Return using the Multi Strategy technique actively used in securities firms’ Prop Trading. With the results of this study, we intend to contribute to those fund managers and desired researchers who are utilizing multiple strategies in the hedge fund management to pursue Absolute Return and to help them strengthening their financial knowledge and competitiveness.

인간 체외수정 및 배아이식에 있어서 과배란 유도 과정에 사용한 GnRH Agonist가 배란 전 난포내 과립 세포의 세포자연사에 미치는 영향

양현원,권혁찬,황경주,박종민,오기석,윤용달,Yang, Hyun-Won,Kwon, Hyuck-Chan,Hwang, Kyung-Joo,Park, Jong-Min,Oh, Kie-Suk,Yoon, Yong-Dal 대한생식의학회 1999 Clinical and Experimental Reproductive Medicine Vol.26 No.1

There have been many reports to date regarding the role of GnRH as a local regulatory factor of ovarian function as studies of human and rat ovaries revealed GnRH and its receptor. In recent studies it has been shown that GnRH directly causes apoptosis in the granulosa cells of the rat ovary, and such results leads to the suggestion that the use of GnRH agonist for more stable long term ovarian hyperstimulation in human IVF-ET programs causes granulosa cell apoptosis which may lead to follicular atresia. Therefore this study attempts to determine if granulosa-luteal cell apoptosis occurs in patients during IVF-ET programs in which GnRH agonist is employed for ovarian hyperstimulation. The quality of oocyte-cumulus complexes obtained during ovum pickup procedures were assessed morphologically and then the fertilization rate and developmental rate was determined. Apoptotic cells among the granulosa-luteal cells obtained during the same procedure were observed after staining with Hematoxylin-eosin. The fragmentation degree of DNA extracted from granulosa-luteal cells was determined and comparatively analyzed. There was no difference in the average age of the patients, the number of oocytes retrieved, and fertilization and developmental rates between the FSH/hMG group and GnRH-long group. There was also no difference in the apoptosis rate and pyknosis rate in the granulosa-luteal cells between the two groups. However, when the oocyte-cumulus complexes were morphoogically divided into the healthy group and atretic group without regard for the method of hyperstimulation, the results showed that the number of oocytes obtained averaged $11.09{\pm}8.75\;and\;10.33{\pm}4.53$ per cycle, respectively, showing no significant difference, but the fertilization rate (77.05%, 56.99%, respectively, p<0.01) and developmental rate (65.96%, 41.51%, respectively, p<0.01) was significantly increased in the healthy group when compared to the atretic group. The degree of apoptosis in the granulosa-luteal cells showed that in the healthy group it was 2.25% which was not significantly different from the atretic group (2.77%), but the pyknosis rate in the atretic group (27.81%) was significantly higher compared to the healthy group (11.35%, p<0.01). The quantity of DNA fragmentation in the FSH/hMG group was 32.22%, while in the GnRH-long group it was 34.27%, showing no significant difference. On the other hand the degree of DNA fragmentation was 39.05% and 11.83% in the healthy group and atretic group, respectively, showing significantly higher increase in the atretic group (p<0.01). The above results suggest that death of granulosa-luteal cells according to the state of the oocyte-cumulus complex is more related to pyknosis rather than apoptosis. Also, the GnRH agonist used in ovarian hyperstimulation does not seem to directly affect the apoptosis of retrieved oocytes and granulosa-luteal cells, and which is thought to be due to the suppression of the apoptogenic effect of GnRH agonist as a result of the high doses of FSH administered.

주성분 분석과 로지스틱 회귀분석을 이용한 다국 통화포트폴리오 전략

심경식,안재준,오경주,Shim, Kyung-Sik,Ahn, Jae-Joon,Oh, Kyong-Joo 한국데이터정보과학회 2012 한국데이터정보과학회지 Vol.23 No.1

본 논문에서는 외환시장에서 주성분 분석과 로지스틱 회귀분석을 이용한 다국 통화 포트폴리오 전략을 개발하는 것을 제안한다. 과거 환율시장의 분석에 대한 많은 연구가 진행되어 왔으나 상대적으로 외환시장에서의 거래 전략을 개발하는 연구는 거의 없었다. 본 연구는 크게 두 가지 목적을 가지고 있다. 첫 번째 목적은 주성분 분석을 적용시켜 포트폴리오를 구성하는 다양한 나라의 환율에 가중치 할당 방법을 제안하는 것이다. 두 번째 목적은 로지스틱 회귀분석을 이용하여 구성된 포트폴리오의 적절한 매수시점과 매도시점을 정하는 것이다. 이 논문의 실험결과는 제안한 투자전략의 유용성을 증명할 수 있을 것이며, 또한 이를 통해 시장참여자들에게 투자 결정에 있어 도움을 줄 수 있을 것이다. This paper proposes to develop multi-currencies portfolio strategy using principal component analysis (PCA) and logistic regression (LR) in foreign exchange market. While there is a great deal of literature about the analysis of exchange market, there is relatively little work on developing trading strategies in foreign exchange markets. There are two objectives in this paper. The first objective is to suggest portfolio allocation method by applying PCA. The other objective is to determine market timing which is the strategy of making buy or sell decision using LR. The results of this study show that proposed model is useful trading strategy in foreign exchange market and can be desirable solution which gives lots of investors an important investment information.

가중증상모델과 패턴매칭을 이용한 화학공정의 이상진단

오영석(Youngseok Oh),모경주(Kyung Joo Mo),윤종한(Jong Han Yoon),윤인섭(En Sup Yoon) 제어로봇시스템학회 1997 제어·로봇·시스템학회 논문지 Vol.3 No.5

생쥐 배아의 체외배양시 저농도 산소 환경이 배아 발달에 미치는 영향

유정현(Jong Hyun Woo),황경주(Kyung Joo Hwang),양현원(Hyun Won Yang),이치형(Chi Hyeong Lee),양정인(Jeong In Yang),권혁찬(Hyuck Chan Kwan),오기석(Kie Suk Oh) 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.12

N/A Objective: It is known that mouse embryos before implantation develop in a low oxygen environment of 3- 8% concentration and with antioxidant materials such as vitamins, antioxidant enzymes, ferrous binding proteins, and albumin in follicular and tubal fluids. However, the 20% oxygen culture condition with chemically defined media might be produce an abundance of ROS, and leads to developmental delay or developmental block in vitro. In this study, we attempt to elucidate the relationship between intracellular H2O2 production and embryo development in different oxygen culture conditions of mouse embryos. Methods: Prenuclear embryos from C57BL/CBA Fl hybrid and ICR mouse were cultured in incubators which provided 5% carbon dioxide, 20% oxygen and 5% carbon dioxide, 5% oxygen. Measurement of H2O2 level in a embryo was performed with DCHFDA(2,7 -dichlorodihydroflourescein diacetate)and analyzed with Quanti-cell 700, and the number of blastomeres was counted with DAPI( 4, 6'-diamidino-2-phenylindole). Results: Oxygen concentration of the culture medias was significantly higher in the 20% oxygen environment compared to that of 5% oxygen environment. Culture of mice embryos in high oxygen condition leads to high HO concentrations at 2 cell stage and developmental delay or 2-cell block regardless of the strain. But in a 5% oxygen environment, which is similar to in-vivo conditions HO production was suppressed continuously through out culture and development of embryos was definitely improved. Conclusion: These results suggest that there is a difference in the production of ROS or protective mechanism according to the mouse strains and stage of development, and it is thought that in-vitro culture in 5% oxygen environment provides stable in vivo equilibrium but in a 20% oxygen environment there is production of ROS which overcome the protective mechanism which leads to cellular damage and embryo developmental delay.

영지버섯 생장점 단백다당체 GLB의 대식세포 활성화 효과

오정연(Jung Yeon Oh),조경주(kyung Joo Cho),정수현(Soo Hyun Chung),김진향(Jin Hyang Kim),Hyun S. Lillehoj,정경수(Kyeong Soo Chung) 대한약학회 1998 약학회지 Vol.42 No.3

In the previous study we described the antitumor activity of GLB, a protein-polysaccharide fraction of the growing tips of Ganoderma lucidum, against sarcoma 180 solid tumor in ICR mice. In this study we investigated the stimulatory activity of GLB on macrophages. When analyzed using a flow cytometer, GLB (100mcg/ml) was found to increase the phagocytic activity of the BALB/c mouse peritoneal macrophages as well as chicken macrophage BM2CL cells against FITC-labeled C.albicans by 55.2% and 21.2%, respectively. GLB also increased the spreading and the expression of MHC class II molecules of BM2CL cells as well as the mouse peritoneal macrophages. From these results, it is clear that GLB is a strong stimulator to the macrophages.

고령화 지역의 Aging in Place에 영향을 주는 조건분석을 통한 정책방향 탐색

김수영(Kim, Soo-Young),문경주(Moon, Kyung-Joo),오찬옥(Oh, Chan-Ohk) 한국지역사회학회 2015 지역사회연구 Vol.23 No.2

The rapid aging society requires welfare programs and services corresponding to complex and diverse needs of the elderly. Aging- in-place policy is known as a key strategy in dealing with and meeting the needs of the elderly. This study proposes two main purposes. Firstly, the study tries to seek out the factor which affects the elderly to continuously live in the residential area or within the community. Then, it strives to suggest policy orientations concerning the elderly living in the residential area or within the community based on the analysis. Survey was conducted by the elderly over sixty, living in the metropolitan city, the medium-sized city, and the agricultural village. Five independent and six control variables are used in analysis which affects Aging-in-place. The major findings are as follows: First regarding convenience and safety when walking or using transportations, condition for moving and social interactions with younger generation mainly affected Aging-in-place. Second, concerning control variables, owing house primarily affected Aging-in-place. Specifying in cities, medium-sized city had a positive influence on Aging in Place compared to the metropolitan city. Since Local government initiated Age-in-place policy ,or so called “government-led community building project”, can not be sustained without government support, the elderly and local residents will have to voluntary participate in Aging-in-place which will lead to community care system and social participation. and Also we searched for the alternatives for the model of Aging-in-Place, which is called NORC, Villages model.

인간 자궁내막에서 Cyclooxygenase-1과 -2의 주기적 발현 양상

박동욱,양현원,권혁찬,황경주,유정현,이치형,김세광,조동제,오기석,Park, Dong-Wook,Yang, Hyun-Won,Kwon, Hyuek-Chan,Hwang, Kyung-Joo,Yoo, Jung-Hyun,Lee, Chi-Hyeong,Kim, Sei-Kwang,Cho, Dong-Jea,Oh, Kie-Suk 대한생식의학회 1998 Clinical and Experimental Reproductive Medicine Vol.25 No.1

Cyclooxygenase (COX) is an enzyme involved in the conversion of arachidonic acid to prostaglandins (PGs), and exists in two forms, COX-1 and COX-2. COX has been reported to be involved in early implantation by secretion of PGs which causes permeability of vessels and reaction of decidual cells around the implantation site. Recently, in mice and sheep studies, COX-1 and COX-2 expression in the endometrium has been reported to be different according to implantation and stages of the estrous cycle, but expression of COX-1 and COX-2 in human endometrium during the menstrual cycle has not yet been established. The purpose of this study was to observe the variances of COX-1 and COX-2 expression by immunohistochemical staining in endometrial samples obtained from human hysterectomy specimens and biopsies of women of reproductive age according to different stages of the menstrual cycle. Also, we attempted to observe COX-1 and COX-2 expression in the epithelial and stromal cells of the endometrium obtained during the mid-secretory phase, which were cultured separately. COX-2 showed a cyclic pattern of expression according to the different stages of the menstrual cycle and was strongly expressed particularly at the mid-secretory phase which corresponds to the time of implantation. However, COX-1 tended to be increased in the early proliferative, and mid- and late secretory phases, but was also expressed in the whole menstrual cycle showing no particular pattern. In the separately cultured cells COX-1 was expressed in epithilial cells and COX-2 in the stromal cells. The above results suggest that since COX-2 is expressed at the same time as implantation and cultured cells display a specific secretory pattern, COX-2 has inductive endocrine enzyme properties and has an important effect on endometrial cells during implantation. Also, COX-2 expression in endometrial cells may be utilized as a useful marker of endometrial maturation.