비중격에 발생한 혼합종양 2례

예미경,장형욱,한기원,김정수 대한이비인후과학회 1996 대한이비인후과학회지 두경부외과학 Vol.39 No.2

의인성 미각 장애

예미경 대한비과학회 2010 Journal of rhinology Vol.17 No.2

Taste is a critical component of a person’s overall sense of well-being and quality of life. Loss of taste interferes with pleasure derived from food and food-related activities. Clinically, taste disorders are less common than smell disorders and therefore the work-up and understanding of taste disorders are limited. Taste is typically ignored by otolaryngologists, even though some otolaryngologic operative procedures compromise the functioning of this sense. Long-lasting postoperative dysgeusia is less frequent but has significant consequences on patients’ quality of life, with some cases leading to medicolegal issues. Many drugs can affect the patient’s sense of taste and contribute significantly to the morbidity of the associated illness. This report provides a brief overview of iatrogenic taste disorders and emphasizes the need for increased awareness among clinicians regarding these problems.

한국인 후각장애환자에서 후각훈련과 비강내 스테로이드스프레이의 효과

예미경,정영도,김덕수,강병준,신승헌 대한비과학회 2019 Journal of rhinology Vol.26 No.2

Background and Objectives: Olfactory training is an alternative treatment based on modulation of the regeneration processof the olfactory system via repeated exposure to odors. Our study aimed to investigate the impact of olfactory training with intranasalcorticosteroid in Korean patients with various causes of olfactory dysfunction. Subjects and Method: Our study population comprised 134 adults with olfactory dysfunction of different etiologies (postviralinfection n=85; post-traumatic n=18; and idiopathic n=31). For training, patients exposed themselves to four different odorstwice a day. All patients used fluticasone nasal spray (two sprays in each nostril once daily). Olfactory function was evaluated atbaseline and again at three months, and results were quantified as patient TDI (threshold, discrimination, and identification) score. Results: Olfactory function improved in 74 of 134 patients (55.2%). Etiology of olfactory disorder, sex, and age had statisticallysignificant influence on the improvement rate of olfactory function, among which etiology of olfactory loss was the most important. However, initial severity and duration of olfactory loss had no statistically significant influence on the improvement rate. The TDI score at three months of olfactory training showed remarkable improvement, primarily because of improvements in thediscrimination and identification components. Conclusion: The present study showed that olfactory training with intranasal corticosteroid was beneficial to improve olfactoryfunction in patients with olfactory dysfunction, particularly in postviral infection patients.

미맹의 표현형과 유전자형의 관계

예미경,신태현 대한이비인후과학회 2008 대한이비인후과학회지 두경부외과학 Vol.51 No.12

The ability to taste the bitter compounds phenylthiocarbamide is a classic inherited trait in humans. This trait has also been shown to correlate with a number of dietary preferences and thus may have important implications for human health. Recently, the PTC gene that underlies the phenotype was identified. Three single nucleotide polymorphisms in the PTC gene that result in three aminoacid substitutions (A49P, V262A, I296V) demonstrated a strong association with taster status in several studies. The aim of this study was to investigate the relationship between PTC genotype and taster status in normal volunteers. Subjects and Method:Seventy-three healthy normal volunteers were included. Phenylthiocarbamide detection threshold test was performed with successive solutions, which was comprised of a total of 15 grades. PTC gene haplotypes were defined by havingsingle nucleotide polymorphisms at the base pairs, 145,785 and 886, on the PTC gene. Results:Taste sensitivity to phenylthiocarbamide had a bimodal distribution, which givesrise to the practice of dichotomizing subjects into ‘tasters’ and ‘non-tasters’. The percentages of taster and non-taster were 80.8% and 19.2%, respectively. Haplotype analyses of the three single nucleotide polymorphisms inside the PTC gene allowed to identify only two haplotypes that were associated with the non-taster phenotype (100% AVI homozygous) and the taster phenotype (49% PAV homozygous and 51% PAV/AVI heterozygous). Conclusion:There was strong concordance between non-tasters defined by phenylthiocarbamide threshold and AVI homozygous by genotype in normal volunteers. (Korean J Otorhinolaryngol-Head Neck Surg 2008;51:1124-8)

전자선 단층 촬영기를 이용한 코골이 환자의 역동적 상기도 측정

예미경,신승헌,김창균,이상흔,이종민,최재갑 대한이비인후과학회 2003 대한이비인후과학회지 두경부외과학 Vol.46 No.2

Background and Objectives:The upper airway caliber shows rhythmic changes according to the respiratory cycle. The dyna-mic imaging technique is needed to demonstrate nonfixed oropharyngeal obstruction in patients with snoring and/or obstructive from the dynamic view of the oropharynx and to estimate the usefulnes of electron beam tomography (EBT) in the snoring and/or obstructive sleep apnea patients. Materials and Method:The upper airway was scanned in 18 patients with snoring by using EBT while awake, asleep, pre and post UPPP (six patients), and pre and post oral appliance (seven patients) during at least two full respiratory cycles. Results:The oropharyngeal stenosis and collapsibility were increased during slep, especialy in the minimum cross sectional area level. In most cases, the sites of stenosis of wakefulness and slep did not coincide. The degre of stenosis as well as collapsibility of the oropharynx were reduced after UPPP and oral appliance. Conclusion:The dynamic study during sleep is needed to evaluate slep induced airway disease. EBT has the potential to provide information quickly and non-invasively on upper airway dynamics and has certain definite advantages over conventional studies. (Korean J Otolaryngol 2003 ;46 :120-5)

후각신경로의 발생부전과 연관된 선천성 무후각증 2예

예미경,임근혜,김호균 대한이비인후과학회 2009 대한이비인후과학회지 두경부외과학 Vol.52 No.8

Congenital anosmia is usually described as a familial disorder in association with various sexual and other developmental abnormalities. Congenital anosmia occurring as an isolated defect in a single family member is extremely rare. That is said to exist when a patient has no recall of smell sensation dating from early childhood. We report two cases of isolated agenesis of the olfactory bulbs and tracts unrelated to pathological, syndromic diseases. We outline the investigations which should be undertaken in such cases.

후각 및 미각 수용체 세포의 생리

예미경 대한이비인후과학회 부산,울산,경남 지부회 2020 임상이비인후과 Vol.31 No.2

The function of the olfactory and gustatory receptors is to monitor the air breathed and the food intake. Although humans are less dependent on chemosensory input than other mammals, olfactory and gustatory function still plays a critical role in health and behavior. The olfactory and gustatory system have historically received less attention than other special senses, perhaps due to challenges related to its study in humans. In this article, we review the olfactory and gustatory epithelial anatomy, epithelial recognition of stimulants and related signal transduction.

정상인의 수면 단계에 따른 상기도의 변화

예미경,신동원,신승헌,장형욱,이종민,박성파 대한이비인후과학회 2003 대한이비인후과학회지 두경부외과학 Vol.46 No.6

Background and Objectives:Sleep has five diferent periods manifested by changes in the EEG activity and certain behavioral corelates. It has been proposed that the upper airway mechanics would be influenced by slep stage. Although several methods have been used to evaluate the regions over which the upper airway collapses during slep, there were seldom reports about the changes of upper airway according to the slep stage. The present study was conducted to determine the Materials and Method:Using electron beam, we studied ten normal subjects who did not have any slep-disordered breathing. Each patient being monitored with EEG was scanned while sleping naturally. The images were acquired during light slep, deep slep and REM slep during at least two full respiratory cycles. Results:Upper airway collapse was increased with the progresion of sleep, but the level of stenosis was relatively constant throughout the slep. Sleep stage had differential effects on the upper airway size depending on the investigated site. Conclusion:study of either point of slep or either site of airway in isolation may not allow a proper insight on the overall upper airway pathophysiology. (Korean J Otolaryngol 2003 ;46 :491-5)

부비동 내시경 수술 후 후각변화에 대한 예측 인자

예미경 대한비과학회 2018 Journal of rhinology Vol.25 No.2

Olfactory dysfunction is one of the most common complaints of patients with chronic rhinosinusitis. Patients who suffer fromolfactory dysfunction report a negative effect on their overall quality of life. Chronic rhinosinusitis-related olfactory impairmentis the most treatable form of olfactory disorder; however, outcomes after endoscopic sinus surgery (ESS) are challenging to predict. Previous studies have documented a wide range in overall improvement after ESS. The purpose of this study is to reviewthe factors that predict changes in olfaction after ESS.

미각 신경의 코딩

예미경 대한이비인후과학회 2005 대한이비인후과학회지 두경부외과학 Vol.48 No.9