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조갑진균증 진단에서 중합효소 연쇄반응 방법의 의의 : 진균배양 및 KONCPA 검사와의 비교
권오찬(Oh Chan Kwon),백승철(Seung Churl Paik),조백기(Baik Kee Cho) 대한피부과학회 1999 대한피부과학회지 Vol.37 No.10
N/A Background : It has been known that the polymerase chain reaction(PCR) test of clinical specimens including blood, sputum, urine, and cerebrospinal fluid collected from patients with systemic fungal infection is a highly sensitive diagnostic method. Recently, the PCR test was applied to the diagnosis of onychomycosis. Objective : This study was aimed to explore whether the PCR test would be a more sensitive diagnostic tool than the KOH smear, fungus culture and KONCPA(KOH±Nail Clipping+PAS(periodic acid-Schiff) stain) test in diagnosing the onychomycosis. Methods : Using 50 nail sample from 50 patients with onychomycosis, the result of the PCR test was compared with those of the KOH smear, fungus culture and KONCPA test. Results : The results were as follows : 1. The positive rates for detecting the causative fungi from the KOH smear, fungus culture, KONCPA test and PCR test were 64.0%, 46.0%, 90.0%, and 100.0% respectively. 2. The fungus culture identified the causative fungi from 23 samples, of which 21(91.2%) were T. rubrum, 1(4.4%) Candida sp. and 1(4.4%) C. albicans. KONCPA test yielded higher positivity by detecting the pathogenic fungi in 45 samples : dermatophytes 2(4.4%). The PCR test yielded the highest positivity by detecting the pathogenic fungi in all samples ; T. rubrum 44(88.0%) and unclassified 6(12.0%). 3. Compared with the results of fungus culture and KONCPA test, that of PCR test showed some differences. The case of Candida sp. in fungus culture was identified as T. rubrum in PCR ; the case of C. albicans in fungus culture as unclassified in the PCR. Five cases of mixed infection and 2 cases of mold infection in the KONPCA test were diagnosed as T. rubrum infection in the PCR test. Conclusion : The PCR test is useful in dianosing the onychomycosis because of its highest positive rate in detecting the causative fungi compared with fungus culture and the KONCPA test. Furthermore, a more accurate diagnostic method such as the PCR test will be necessary in case (Korean J Dermatol 1999 : 37(10): 1457∼1465)
권오찬 ( Oh Chan Kwon ),김조용 ( Jo Yong Kim ),박철종 ( Chul Jong Park ),오정 ( Jung Oh ),김형옥 ( Hyung Ok Kim ),김정원 ( Chung Won Kim ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.1
Sporotrichosis is a chronic infection that follows accidental implantation of the fungus Sporothrix schenckii into the skin. The infection begins with skin trauma under conditions when conidia may be present. A 48-year-old woman presented with a 5-year history of an 8X 12 cm sized, centrally depressed, erythematous plaque on the left wrist. She had been treated with antifungal agents at an other hospital for about 6 months but there was no improvement. The histopathological findings showed an infiltration of mononuclear cells and tuberculoid structures on the whole dermis and subcutis. According to the histopathological findings and clinical manifestations, she was diagnosed as having lupus vulgaris. There was much improvement of the lesion after antituberculous therapy. However, 2 months later she developed asymptomatic multiple erythematous papules around the lesion of lupus vulgaris and along the lymphatic drainage of the left arm. The histopathological findings of the newly developed lesion showed a granulomatous reaction and an infiltrate of acute and chronic inflammatory cells. Moist and creamy colonies were changed into brown-to-black ones with a leathery appearance with age. This appearance and clinical manifestations confirmed the diagnosis of lymphocutaneous sporotrichosis. This clinical appearance reflects that the sporotrichosis developed on the ulcerative lesion or biopsy site of lupus vulgaris. (Korean J Dermatol 1998;36(1): 181-185)
권오찬 ( Oh Chan Kwon ),양종규 ( Jong Kyu Yang ),윤두희 ( Dou Hee Yoon ),김태윤 ( Tae Yoon Kim ),김형옥 ( Hyung Ok Kim ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.3
Progressive zosteriform macular pigmented lesion(PZMPL) is a chronic pigmentary dermatosis similar to progressive cribriform and zosteriform hyperpigmentation(PCZH). This dermatosis described by Simoes in 1980 is characterized by a uniformly tanned macular pigmented lesion in a zosteriform distribution preceded by multiple pruritic macular pigmentation in a part of the dermatome for a period. PZMPL is not a fully understood disease entity but it is thought to be a variant of PCZH. It is differentiated from PCZH by accompanying pruritus as a prodromal symptom, a characteristic clinical course, and histological findings such as pigmentary incontinence. We report herein a case of PZMPL in a 17 year-old girl with the pigmentary skin lesion extending from the left forearm to the left chest along the Blaschkos line. The histological findings revealed increased melanin pigments in the basal layer and focal pigmentary incontinence in the upper dermis. To our knowledge, this case is the first report of PZMPL in korea thought to be the same case reported by Simoes. (Korean J Dermatol 1998;36(3): 456-459)
피어의 안정성과 지연을 동시에 고려한 P2P 오버레이 멀티캐스트 트리 구성 알고리즘
권오찬(Oh Chan Kwon),윤장우(Changwoo Yoon),송황준(Hwangjun Song) 한국통신학회 2011 韓國通信學會論文誌 Vol.34 No.6
본 논문은 인터넷상에서 안정적인 멀티미디어 서비스를 제공하기 위한 P2P (Peer-to-Peer) 오버레이 멀티캐스트트리 구성 알고리즘을 제안한다. 제안하는 알고리즘은 멀티캐스트 트리를 구성 할 때 링크의 지연뿐만 아니라 피어의 안정성 (Peer Stability)까지 고려한다. 실제로 피어는 매우 동적이고 불안정한 행동을 하기 때문에 안정적인 서비스를 제공하기 위해서 피어의 안정성은 필수적으로 고려해야한다. 그리고 제안하는 알고리즘에서는 멀티캐스트 트리의 상태에 따라서 링크의 지연과 피어의 안정성 사이의 가중치를 적응적으로 조절한다. 기본적으로 낮은 계산 복잡도로 근사해를 구하기 위해서 유전자 알고리즘 (Genetic Algorithm)을 이용한다. 마지막으로 실험 결과에서는 제안하는 알고리즘의 성능을 보인다. This paper presents a P2P (Peer-to-Peer) overlay multicast tree construction algorithm to support stable multimedia service over the Internet. While constructing a multicast tree, it takes into account not only the link delay, but also peer stability. Since peers actually show dynamic and unstable behavior over P2P-based network, it is essential to consider peer stability. Furthermore, the weighting factor between link delay and peer stability is adaptively controlled according to the characteristics of the multicast tree. Basically, Genetic algorithm is employed to obtain a near optimal solution with low computational complexity. Finally, simulation results are provided to show the performance of the proposed algorithm.