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안현철 ( Hyun Cheol Ahn ),황규윤 ( Kyu Yoon Hwang ),남해선 ( Hae Seon Nam ),박준수 ( Joon Soo Park ),이준혁 ( June Hyuk Lee ),박성우 ( Sung Woo Park ),김도진 ( Do Jin Kim ),박춘식 ( Choon Sik Park ) 대한천식알레르기학회 2003 천식 및 알레르기 Vol.23 No.2
Background:Obesity is related to asthma symptoms and airway hyperresponsiveness. Both asthma and obesity are becoming worldwide chronic health problems. This study was designed to evaluate the association between asthma and anthropometric indices such as
연취급 근로자들의 혈중 ZPP 농도 선별기준에 따른 정확도의 변화
김용배,안현철,황보영,리갑수,이성수,안규동,이병국,Kim, Yong-Bae,Ahn, Hyun-Cheol,HwangBo, Young,Lee, Gap-Soo,Lee, Sung-Soo,Ahn, Kyu-Dong,Lee, Byung-Kook 대한예방의학회 1997 예방의학회지 Vol.30 No.4
Measurement of blood lead (PbB) and blood zinc protoporphyrin (ZPP) are most common biological indices to identify the individual at risk for excess or the health sequences by lead exposure. Because PbB is known most important and reliable index of lead exposure, PbB is often regarded as a gold standard to detect lead exposure. But in Korea PbB is a secondary test item of detailed health check-up with positive finding of screening test in most occasion. Our lead standard requires all lead workers to take annual heath-check twice a year for investigation of their health effect due to lead exposure. Blood ZPP is one of most important index to detect high lead absorption in lead workers as a screening test. Measurement of blood ZPP is known ,well to correlate with PbB in steady state of exposure in most lead workers and is often used as a primary screening test to detect high lead absorption of lead workers with the advantage of simplicity, easiness, portability and low cost. The current cut-off criteria of blood ZPP for further detailed health check-up is $100{\mu}g/d\ell$ which is supposed to match the level of $40{\mu}g/d\ell$ of PbB according to our standard. Authors tried to investigate the validity of current criteria of cut-off level $(100{\mu}g/d\ell)$ of blood ZPP and possible another better cut-off level of it to detect the lead workers whose PbB level over $40{\mu}g/d\ell$. The subjects in our study were 212 male workers in three small scale storage battery industries. Blood ZPP, PbB and hemoglobin (Hb) were selected as the indices of lead exposure. The results were as follows. 1. The mean of blood ZPP, PbB and Hb in lead workers were $79.5{\pm}46.7{\mu}g/d\ell,\;38.7{\pm}15.1{\mu}g/d\ell,\;and\;14.8{\pm}1.2g/d\ell$, respectively. There were significant differences in blood ZPP, PbB and Hb by industry (P<0.01). 2. The percents of lead workers whose blood ZPP were above $100{\mu}g/d\ell$ in the group of work duration below 1, 1-4, 5-9 and above 10 years were 8.6%, 17.2%, 47.6%, and 50.0%, respectively. The percents of lead workers whose PbB were above $40{\mu}g/d\ell$ in those were 31.4%, 40.4%, 71.4%, and 86.4%, respectively. 3. The percents of lead workers whose PbB were below $40{\mu}g/d\ell$, $40-59{\mu}g/d\ell$ and above $60{\mu}g/d\ell$ were 54.7%, 34.9% and 10.4%, respectively. Those of lead workers whose blood ZPP were below $100{\mu}g/d\ell$, $100-149{\mu}g/d\ell$ and above $150{\mu}g/d\ell$ were 79.2%, 13.7% and 7.1%, respectively. 4. Simple linear regression of PbB on blood ZPP was statistically significant (P<0.01) and as PbB was $40{\mu}g/d\ell$, blood ZPP was $82.1{\mu}g/d\ell$. 5. While the highest sensitivity and specificity of blood ZPP test to detect lead workers with PbB eve. $40{\mu}g/d\ell$ were observed in the cut-off level of $50{\mu}g/d\ell$ and $100{\mu}g/d\ell$ of blood ZPP, respectively, the highest validity (sensitivity+specificity) of blood ZPP to detect lead workers with PbB over $40{\mu}g/d\ell$ was observed in the cut-off level of around $70{\mu}g/d\ell$ of blood ZPP. But even with optimal cut-off level of around $70{\mu}g/d\ell$ of blood ZPP, still 25.0% of false negative and 20.7% false positive lead workers were found. As the result of this study, it was suggested that reconsideration of current blood ZPP cut-off of our lead standard from $100{\mu}g/d\ell$ to somewhat lower level such as around $70{\mu}g/d\ell$ and the inclusion of PbB measurement as a primary screening test for lead workers was highly recommended for the effective prevention of lead workers.
강원 동해안 지역 돼지 폐렴에서 분리한 pasteurella multocida에 대한 조사
김광재 ( Kwang Jae Kim ),안현철 ( Hyun Cheol An ),조현웅 ( Hyun Ung Cho ),육심용 ( Sim Young Youk ),전현정 ( Hyun Jeong Jeon ),김동훈 ( Dong Hoon Kim ) 한국가축위생학회 1994 韓國家畜衛生學會誌 Vol.17 No.2
The present study was conducted to investigate the incidence of pasteurella multocida(p. muitocida) infection and some properties of the isolated organisms from the swine herds in Eastern Kangwon during the periods from March 1993 to November 1993. The results obtained were summerized as follows: 1. The lungs of 180 slaughtered pigs were sampled and p. muitocida was isolated from 38 pigs(21.1%) and cultured positive. 2. The majority of biochemical and cultural properties of the p. muitocida isolates were identical to those of the standard strains. 3. We investigated the capsular serogroup and drug susceptibility of 38 isolates of p. muitocida from pigs with pneumonic lesions 4. p. muitocida isolateds were typed for capsular serogroupes A by hyaluronidase inhibition of capsule and D by acriflavin auto agglutination. Most isolates(55.3%) were type A, 15.8% were type D, and the remaining 28.9% were untypable 5. In antimicrobial susceptibility test these isolates of p. muitocida were susceptible in order of colistin(94.7%), ampicillin(94.7%), cepalothin(92.1%), gentamicin(92.1 %), amikacin(89.5%) , but the majority of them were resistant in order of neomycin(26.3%), teracycline(23.7%), streptomycin (15.8%).
연 폭로시 성별에 따른 혈중 Zinc Protoporphyrin의 양-반응 관계
김용배,리갑수,황규윤,이성수,안규동,이병국,안현철,Kim, Yong-Bae,Lee, Gap-Soo,Hwang, Kyu-Yoon,Lee, Sung-Soo,Ahn, Kyu-Dong,Lee, Byung-Kook,Ahn, Hyun-Cheol 대한예방의학회 1999 Journal of Preventive Medicine and Public Health Vol.32 No.4
Objectives : To evaluate whether a relation between blood lead and zinc proto porphyrin(ZPP) was modified by gender in Korean lead workers. Methods : A cross-sectional study was conducted with 1,304 male and 101 female subjects in 1997. The relation between blood lead and ZPP were evaluated with linear, exponential, and quadratic models. Then, the different effect of gender on the relation was examined by adding the interaction terms in the each model. Results : $Mean{\pm}SD$ of blood lead and ZPP level was different between male$(27.7{\pm}10{\mu}g/dl\;and\;51.3{\pm}23.4{\mu}g/dl)$ and female subjects$(22.5{\pm}9.2{\mu}g/dl\;and\;78.7{\pm}38.6{\mu}g/dl)$. After adjusting for possible confounders, the effect modification by gender was significant in linear$(\beta=1.119,\;p<0.001)$, exponential$(\beta=Exp(0.008),\;p<0.05)$, and quadratic model$(\beta=1.388,\;p<0.001)$. In separate analysis, a quadratic relation between blood lead and ZPP was shown in male lead workers$(\beta=0.036,\;p<0.001)$, but an exponential relation in female lead workers$(\beta=Exp(0.029), p<0.001)$. Conclusion : Our data showed that the increasing rate of ZPP in female were always higher than in male lead workers, suggesting that females were more susceptible to occupational lead exposure than males.
강원(江原) 동해안지역(地域) 도축돈(屠畜豚)의 전염성(傳染性) 관절염(關節炎)에 관한 조사(調査)
육심용 ( Sim Yong Youk ),조현웅 ( Hyun Ung Cho ),김광제 ( Kwang Jae Kim ),안현철 ( Hyun Cheol An ),김동훈 ( Dong Hoon Kim ) 한국가축위생학회 1993 韓國家畜衛生學會誌 Vol.16 No.2
This study was conducted to investigate the infectious arthritis on pigs slaughter in eastern Kangweon. During the period of between Feb. and Nov. 1992, 469 pigs were sampled at six abattoirs. Bacterial isolation and identification were perfomed from the arthritic lesions. In addition, drug susceptibility for the major isolated microoganisms were examined. The results obtained were summarized as follows: 1. From arthritic lesions bacteria were most frequently isolated, isolation rate being 21.1%. 2. The bacteria isolated from arthritic lesion, Staphylococcus spp.(33.9%), Coli form(39.3%) were most frequently isolated, while the genera of Mycoplasma were detected less frequently. 3. Antimicrobial drug susceptibility of the major organisms showed that all the isolated bacteria were susceptible to SXT(91.0%), cephalothin(82.5%), but resisted to penicillin and streptomycin.