In vivo Optical Coherence Tomography Imaging of the Mesothelium Using Developed Window Models

안예찬,옥철호,채유경,황상석,천봉권,정만홍,남성진,이해영,정재민,박은기 한국광학회 2015 Current Optics and Photonics Vol.19 No.1

The mesothelium is an essential lining for maintaining the normal homeostasis of the closed body cavityand a central component of pathophysiologic processes. The mesothelium has been known as the end targetfor asbestos which induces asbestos-related lung diseases. Malignant mesothelioma (MM) is a rare andfatal neoplasm predominantly due to asbestos exposure. Adaptation of an advanced and reliable technologyis necessary for early detection of MM because it is difficult to diagnose this disease in its early stages. Optical coherence tomography (OCT) provides cross-sectional images of micro-tissue structures with aresolution of 2-10 μm that can image the mesothelium with a thickness of ~100 μm and, therefore, enableinvestigation of early development of MM. The mesothelium is typically located at the pleura and tunicavaginalis of the scrotum. In this study, we developed animal window models in the above two anatomicalsites to visualize mesothelial layers within the mesothelium. OCT images at the two locations were alsoacquired

IoT 네트워크 환경에서 클라우드 기반의 사용자 인증을 통한 건물 내의 LED에너지 효율화 연구

안예찬,이근호 한국디지털정책학회 2017 디지털융복합연구 Vol.15 No.5

TOMO HDA와 Radixact 치료 계획 간 Transfer에 대한 유용성 평가 : Planning Study

안예찬,김종식,권동열,김진만,최병기,An, Ye Chan,Kim, Jong Sik,Kwon, Dong Yeol,Kim, Jin Man,Choi, Byeong Ki 대한방사선치료학회 2018 대한방사선치료학회지 Vol.30 No.1

목 적 : iDMS(Integrated Database Management System, 통합 데이터베이스 관리 시스템) 내 TOMOTHERAPY 치료 계획을 ACCURAY $Precision^{TM}$ 1.1.1.1을 이용하여 본원의 TOMO HDA와 Radixact 장비 간 Transfer하였고 선량학적 차이를 분석하였으며, 이를 통해 치료 계획 Transfer의 유용성을 평가하였다. 대상 및 방법 : 두경부암 두 부위와 전립선암 두 부위의 치료를 가정하여 4개의 서로 다른 치료 계획을 세웠다. 각 치료 계획은 95 % 처방선량(Prescription dose)이 표적 체적의 99 % 이상 조사되도록 설계하였고, 정상장기 선량은 SMC tolerance dose protocol을 기준으로 하였다. 수립된 치료 계획은 각 장비로 Transfer 시켰으며 Transfer된 치료 계획의 DVH(Dose Volume Histogram) 분석을 통해 선량학적 차이를 비교 평가하였다. 결 과 : Transfer된 치료 계획에서 CTV 및 GTV의 Mean Dose는 증가 및 감소하였으나 유의할 만한 차이는 보이지 않았다. CTV 및 GTV 처방 선량의 Target Coverage는 HDA에서 Radixact로 Trasnfer 시 전부 감소하였으며, CTV에 대한 CI 및 HI 변화도 0.1 이내였다. Normal Organ Dose는 두 치료 계획 모두 HDA에서 Radixact로 Transfer 시 대부분의 항목에서 선량이 증가하였다. 결 론 : 본 실험의 결과에 따르면 Radixact에서 HDA 장비로 치료 계획 Transfer 시 Target Coverage는 기준 이상이었으며 Normal Organ Dose 또한 대부분 같거나 감소하였다. HDA에서 Radixact로 치료 계획 Transfer 시 Target의 Coverage는 감소하는 경향을 보였고, Normal Organ Dose는 Optic Chiasm($D_{max}$ 1.38 Gy 증가), Bladder($D_{max}$ 3.07 Gy 증가), Penile Bulb($D_{max}$ 1.14 Gy 증가) 등 부작용(side effects)을 일으킬 수 있는 장기에서 선량이 증가였다. 이에 따라 치료 계획 Transfer 시 선량 변화에 주의해야 하며 장비 점검으로 인한 일회성 Transfer는 효율적인 방사선 치료를 위해 유용할 것이나, Transfer된 치료 계획으로 치료가 수회간 이어질 경우 치료 계획을 다시 세워 진행해야 할 것으로 사료된다. Purpose : To evaluate the usability of plan transfer between TOMO HD and Radixact, we compared the differences of dose in transferred plans by evaluating the dose of normal organ and target. TOMO HDA and Radixact. The completed plans were transferred each other and we compared the differences of dose by evaluating the DVH of each plans. Materials and Methods : We planned 4 different plans assuming the treatment of 2 cases in Head and Neck Cancer and 2 cases Prostate cancer. Each plan was designed so that 95 % of the prescription dose was irradiated over 99 % of the target volume, and the normal organ constraints dose was based on the SMC tolerance dose protocol. Each plan was transferred to each equipment and DVH(dose volume histogram) analysis of the transferred plans was compared and evaluated. Results : The Mean dose of CTV and GTV was increased and decreased in the transferred plans, but there was no significant differences. The target coverage of CTV and GTV was decreased in all cases of transferred plans from TOMO HAD to Radixact, and the change of CI and HI in CTV was within 0.1. Normal organ dose was increased in most cases when transferring from HAD to Radixact in both treatment plans. Conclusion : According to the results of this experiment, the target coverage was above the standard and the normal organ dose was almost same or decreased when transferring the plans from Radixact to HDA equipment. However the target coverage was reduced when transferring the plans from HDA to Radixact and there was an increase in dose in normal organs that could cause sever side effects such as Optic Chiasm ($D_{max}$1.38 Gy), Bladder ($D_{max}$3.07 Gy), Penile Bulb ($D_{max}$1.14 Gy). Therefore, it is necessary to pay attention to the dose change when transferring the plan and one-time transfer due to equipment inspection will be useful for efficient radiation therapy, but if the transferred treatment plans continue for several consecutive days, the treatment plan should be resumed.

빅데이터 플랫폼과 모니터링 시스템의 융합을 이용한 BLE기반의 ZEP시스템 공격 기법에 대한 대응방안 연구

안예찬,신영현,이근호 한국디지털정책학회 2015 디지털융복합연구 Vol.13 No.8

첨단 광 단층촬영 기법을 이용한 미세채널 내 유동 및 혼합장 가시화

안예찬 대한기계학회 2010 대한기계학회 춘추학술대회 Vol.2010 No.4

고주파 삼각파 여자법을 사용한 실시간 슬러그 유동 측정용 전자기유량계

안예찬,차재은,김무환,Ahn, Yeh-Chan,Cha, Jae-Eun,Kim, Moo-Hwan 대한기계학회 2002 大韓機械學會論文集B Vol.26 No.11

In order to investigate the characteristics of two-phase slug flow, an electromagnetic flowmeter with 240Hz triangular AC excitation was designed and manufactured. The signals and noise from the flowmeter were obtained, and analyzed in comparison with the observations with a high speed CCD camera. The uncertainty of the flowmeter under single-phase flow was $\pm$ 2.24% in real-time. For two-phase slug flow, electromagnetic flowmeter provided real-time simultaneous measurements of the mean film velocity around Taylor bubble and the relative location and the length of the bubble. Besides, it is an easier and cheaper method for measuring mean film velocity than others such as photochromic dye activation method or particle image velocimetry.

IoT환경에서의 센서 네트워크와 영상처리 기반의 융합 스마트 홈 플랫폼 개발

안예찬,이정필,이재욱,송준권,이근호,Ahn, Ye-Chan,Lee, Jeong-Pil,Lee, Jae-Wook,Song, Jun-Kwun,Lee, Keun-Ho 한국사물인터넷학회 2016 한국사물인터넷학회 논문지 Vol.2 No.3

본 논문에서는 영상처리기술과 네트워크와 연동이 가능한 센서 기술을 활용하여 발빠른 첨단기술에 맞춘 사물 인터넷을 기반으로 한 가정 및 사업 환경을 구축하고자 하였다. OpenCV 라이브러리의 분석 알고리즘을 활용한 영상 처리 기술을 사용하여 객체를 탐지 및 추적하고 그에 대한 데이터로 객체를 추적하고 다양한 센서들을 제어한다. 또한, 마스터 싱글보드와 슬레이브 싱글보드를 통하여 다양한 센서들을 통제하고 센싱 네트워크 환경을 구축 및 연계하여 데이터를 수집하고 기록하여 다양한 서비스를 제공 할 수 있는 플랫폼을 구현하고자 한다. In this thesis, we sought to build a home and business environment based on the rapid prototyping technology and network technologies that enabled rapid access to high-speed technologies and technologies. Using the analytic algorithm for image processing techniques, using the analytic algorithm for analyzing and tracking objects in the OpenCV library, trace objects and track objects and control various sensors. It also wants to implement a platform enabling various sensors to collect and record various services by controlling and connecting various sensors through the master Single board and the slave single.

의광학 및 생체유체 연구실

안예찬 한국가시화정보학회 2014 한국가시화정보학회지 Vol.12 No.1

Hypopharynx Cancer의 VMAT 치료 시 Neck 3D Bolus 적용에 대한 유용성 평가

안예찬,김진만,김찬양,김종식,박용철,An, Ye Chan,Kim, Jin Man,Kim, Chan Yang,Kim, Jong Sik,Park, Yong Chul 대한방사선치료학회 2020 대한방사선치료학회지 Vol.32 No.-

목 적: Hypopharynx Cancer의 VMAT 치료 시 Neck 부분에 Commercial Bolus(이하 CB)와 3D Printing 기술로 제작한 3D Bolus를 각각 적용한 두 치료 계획을 비교함으로써 3D Bolus 적용의 선량학적 유용성, setup 재현성 및 효율성을 알아보고 임상적 적용 가능성을 평가하고자 한다. 대상 및 방법: CB를 적용한 RANDO phantom의 CT image를 바탕으로 3D Bolus를 동일한 형태로 제작하였다. 3D Bolus는 OMG SLA 660 Printer, MaterialiseMagics software를 이용하여 SLA기법을 통해 밀도 1.2 g/㎤의 폴리우레탄 아크릴레이트 수지로 출력하였다. CB와 3D Bolus를 적용한 두 CT image를 바탕으로 Hypopharynx Cancer의 VMAT 치료를 가정하여 치료 계획을 수립하였다. 수립한 두 치료 계획을 각각 18회에 걸쳐 CBCT image를 획득하였고, 매 회 setup time을 측정하여 치료 효율성을 평가하였다. 획득한 CBCT image를 바탕으로 전산화 치료계획 시스템 Pinnacle을 통해 Adaptive Plan을 진행함으로써 Target, 정상 장기 선량 평가와 Bolus Volume의 변화를 평가하였다. 결 과: 각 치료 계획에 대한 setup time은 CB 적용 치료 계획에 비해 3D Bolus 적용 치료 계획에서 평균 28 sec 감소하였다. 치료 전 기간 내 Bolus Volume 변화는 CB Initial Plan 83.9㎤에서 86.1±2.70㎤, 3D Bolus Initial Plan 92.2㎤에서 99.8±0.46㎤로 나타났다. CTV Min Value의 변화는 CB Initial Plan 191.6cGy에서 167.4±19.38cGy, 3D Bolus Initial Plan 167.3cGy에서 149.5±18.27cGy로 나타났다. CTV Mean Value의 변화는 CB Initial Plan 227.1cGy에서 228.3±0.38cGy, 3D Bolus Initial Plan 225.9cGy에서 227.7±0.30cGy로 나타났다. PTV Min Value의 변화는 CB Initial Plan 128.5cGy에서 74.9±19.47cGy, 3D Bolus Initial Plan 139.9cGy에서 83.2±12.92cGy로 나타났다. PTV Mean Value의 변화는 CB Initial Plan 225.4cGy에서 226.2±0.83cGy, 3D Bolus Initial Plan 224.1cGy에서 225.8±0.33cGy로 나타났다. 정상 장기 Spinal Cord에 대한 Max Value는 매 회 평균 135.6cGy로 동일하게 나타났다. 결 론: 본 논문의 실험 결과를 통해 불균등한 체표면에 대한 3D Bolus의 적용이 Commercial Bolus 적용에 비해 선량학적으로 유용하고 setup 재현성 및 효율성 또한 우수함을 알 수 있었다. 추후 3D Printing 재료의 다양성에 대한 연구와 함께 추가적인 사례 연구가 진행된다면 방사선 치료 분야에서 3D Bolus의 적용이 더욱 활발하게 진행될 것으로 사료된다. Purpose: To find out the dosimetric usefulness, setup reproducibility and efficiency of applying 3D Bolus by comparing two treatment plans in which Commercial Bolus and 3D Bolus produced by 3D Printing Technology were applied to the neck during VMAT treatment of Hypopahrynx Cancer to evaluate the clinical applicability. Materials and Methods: Based on the CT image of the RANDO phantom to which CB was applied, 3D Bolus were fabricated in the same form. 3D Bolus was printed with a polyurethane acrylate resin with a density of 1.2g/㎤ through the SLA technique using OMG SLA 660 Printer and MaterializeMagics software. Based on two CT images using CB and 3D Bolus, a treatment plan was established assuming VMAT treatment of Hypopharynx Cancer. CBCT images were obtained for each of the two established treatment plans 18 times, and the treatment efficiency was evaluated by measuring the setup time each time. Based on the obtained CBCT image, the adaptive plan was performed through Pinnacle, a computerized treatment planning system, to evaluate target, normal organ dose evaluation, and changes in bolus volume. Results: The setup time for each treatment plan was reduced by an average of 28 sec in the 3D Bolus treatment plan compared to the CB treatment plan. The Bolus Volume change during the pretreatment period was 86.1±2.70㎤ in 83.9㎤ of CB Initial Plan and 99.8±0.46㎤ in 92.2㎤ of 3D Bolus Initial Plan. The change in CTV Min Value was 167.4±19.38cGy in CB Initial Plan 191.6cGy and 149.5±18.27cGy in 3D Bolus Initial Plan 167.3cGy. The change in CTV Mean Value was 228.3±0.38cGy in CB Initial Plan 227.1cGy and 227.7±0.30cGy in 3D Bolus Initial Plan 225.9cGy. The change in PTV Min Value was 74.9±19.47cGy in CB Initial Plan 128.5cGy and 83.2±12.92cGy in 3D Bolus Initial Plan 139.9cGy. The change in PTV Mean Value was 226.2±0.83cGy in CB Initial Plan 225.4cGy and 225.8±0.33cGy in 3D Bolus Initial Plan 224.1cGy. The maximum value for the normal organ spinal cord was the same as 135.6cGy on average each time. Conclusion: From the experimental results of this paper, it was found that the application of 3D Bolus to the irregular body surface is more dosimetrically useful than the application of Commercial Bolus, and the setup reproducibility and efficiency are excellent. If further case studies along with research on the diversity of 3D printing materials are conducted in the future, the application of 3D Bolus in the field of radiation therapy is expected to proceed more actively.

Ex vivo High-resolution Optical Coherence Tomography (OCT) Imaging of Pleural Reaction after Pleurodesis Using Talc

안예찬,옥철호,박정은,정민정,김제훈,이해영,김성원,박은기,정만홍 한국광학회 2016 Current Optics and Photonics Vol.20 No.5

The pleura is known as an end target organ of exposure to toxic environmental materials such as fineparticulate matter and asbestos. Moreover, long-term exposure to hazardous materials can eventually leadto fatal lung disease such as diffuse pleural fibrosis or mesothelioma. Chest computed tomography (CT)and ultrasound are gold standard imaging modalities for detection of advanced pleural disease. However,a diagnostic tool for early detection of pleural reaction has not been developed yet due to difficulties inimaging ultra-fine structure of the pleura. Optical coherence tomography (OCT), which provides cross-sectionalimages of micro tissue structures at a resolution of 2-10 μm, can image the mesothelium with a thicknessof ~100 μm and therefore enables investigation of the early pleural reaction. In this study, we inducedthe early pleural reaction according to a time sequence after pleurodesis using talc, which has been widelyused in the clinical field. The pleural reaction in talc grouped according to the time sequence (1st, 2nd,4th weeks) showed a significant thickening (average thickness: 45 ± 7.5 μm, 80 ± 10.7 μm, 90 ± 12.5μm), while the pleural reaction in sham and normal groups showed pleural change from normal to minimalthickening (average thickness: 16 ± 5.5 μm, 17 ± 4.5 μm, 15 ± 6.5 μm, and 12 ± 7.5 μm, 13 ± 2.5μm, 12 ± 3.5 μm). The measurement of pleural reaction by pathologic examinations was well-matchedwith the measurement by OCT images. This is the first study for measuring the thickness of pleuralreactions using a biophotonic modality