유두 갑상샘암종의 체모양-오디모양 변형 -2예 보고-

심영란,배영경,최준혁,김미진,최원희 대한병리학회 2005 Journal of Pathology and Translational Medicine Vol.39 No.1

Cribriform-morular variant of papillary thyroid carcinoma is an unusual and peculiar subtype of papillary thyroid carcinomas. It occurs both sporadically and in association with familial adenomatous polyposis. We report here on two cases of cribriform-morular variant of papillary thyroid carcinoma in a 33-year-old woman and in a 21-year-old woman. On gross examination, both cases were multicentric. The first case showed two well-encapsulated yellow solid masses in the right (2.0 cm) and the left lobes of the thyroid gland (0.5 cm). The second case showed four well-encapsulated gray-white solid lobulating masses and nodules in the right (4.5 and 1.2 cm) and the left lobes (1.1 and 0.8 cm) of the thyroid gland. Microscopically, both cases exhibited an intricate blending of papillary, cribriform, trabecular, spindle, and solid patterns of growth with morular areas. Typical nuclear features of papillary carcinomas were focally seen. Immunohistochemically, the tumor cells were positive for thyroglobulin, thyroid transcription factor-1 (TTF-1), and -catenin, but were negative for calcitonin.

꽈리연부육종의 세침흡인 세포소견 -1예 보고-

심영란,신덕섭,조길호,최준혁,Shim, Young-Ran,Shin, Duk-Seop,Cho, Kil-Ho,Choi, Joon-Hyuk The Korean Society for Cytopathology 2006 대한세포병리학회지 Vol.17 No.1

Alveolar soft part sarcoma (ASPS) is a rare soft tissue sarcoma, which occurs predominantly in adolescents and young adults. The cytological characteristics of this condition have been described only rarely in the literature. Here, we report a case of alveolar soft part sarcoma. A 28-year-old man presented with a mass in his right buttock, which had persisted for three years. The mass was subjected to a fine needle aspiration cytology (FNAC). The smears were cellular. The observed tumor cells were round or polygonal, and exhibited vesicular nuclei with prominent nucleoli and finely granular cytoplasm. Naked nuclei were frequently detected. Tumor cells were arranged singularly, but occasionally in a pseudoalveolar pattern.

따로 또 같이-"나자로야, 나오너라!"-'파트너십을 향한 여정'을 경험하고

심영란 우리신학연구소 2005 갈라진 시대의 기쁜소식 Vol.- No.675

결장암종 및 직장암종에서 p53 유전자 돌연변이의 염기서열

심영란,최준혁,최원희 대한병리학회 1999 Journal of Pathology and Translational Medicine Vol.33 No.6

겨울의 길목에서

심영란 한국외국어대학교 여학생회 1975 엔담 Vol.3 No.-

회장을 침범한 아니사키스증-2예 보고-

심영란,김동석,이태숙 대한병리학회 1995 Journal of Pathology and Translational Medicine Vol.29 No.1

정색을 침범한 거대 림프양 증식증 1례

신현철,박동춘,김영수,심영란 영남대학교 의과대학 1992 Yeungnam University Journal of Medicine Vol.9 No.1

저자들은 multicenteric form의 거대 림프양 증식증 1례를 치험하였기에 그 희귀성에 비추어 문헌 고찰과 함께 보고하는 바이다. Giant lymph node hyperplasia (Castleman's disease) is a rare disease, which represents a peculiar form of lymph node hyperplasia. Generally, it has been considered as benign and localized disease but recently, revealed malignant transformation in some cases of multicenteric form. It usually occurs on the mediastinum and occasionally neck, lung, axilla, mesentery, broad ligament, retroperitoneum or soft tissue of extremities. Histopathologically, it is divided into hyaline vascular or plasma cell type and the former is characterized with prominent vascular proliferation and hyalinization in the central portion and tight concenteric layering of lymphocytes at the periphery of the fillicles (mantle zone) and the latter is characterized by a diffuse plasma cell proliferation in the interfollicular area. Form the point of view of clinical presentation, it has been divided into solitary form, which presents as a localized mass located most commonly in the mediastinum, and multicenteric form, which occurs multiple location and has systemic manifestation and transformation into malignancy. Herein we report a case of Giant lymph node hyperplasia occurring in the left spermatic cord in a 58-year old male with brief review of literatures.

뇌 혈관계를 침범한 전신성 홍반성 루푸스 2례

김봉준,이은영,홍영훈,박기도,송영두,이충기,심영란 영남대학교의과대학 1998 Yeungnam University Journal of Medicine Vol.15 No.2

저자들은 최근 루푸스가 뇌 혈관계를 침범하여 신경·정신과적 이상 증상을 보였으며 면역검사, 뇌파검사 및 뇌 자기공명사진에서 중추 신경 루푸스의 소견에 부합되는 양상을 보였고 고용량의 부신피질 호르몬 충격요법에 반응이 좋았던 2례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Systemic lupus erythematosus(SLE) is an autoimmune disease which may affect many different organs and disclose various clinical manifestations. Recently central nervous system(CNS) involvement has been recognized as an increasingly significant contributor to morbidity and mortality of SLE. The clinical manifestations of CNS-lupus are highly variable and range from mild cognitive dysfunction, movement disorder, headache, psychosis to life-threatening stroke and coma. Among the neuropsychiatric disorders encountered in patients with SLE, cerebrovascular disease has been a relatively rare complication. The diagnosis and management of CNS-lupus is difficult because of the lack of useful diagnostic methods. If cerebrovascular involvement is suspected, aggressive treatment such as high dose steroid, immunosuppressive therapy, plasma exchange may be required to reduce high mortality rate. We experienced 2 cases cerebrovascular dis eases occurring in SLE patients which presented with various neuropsychiatric manifestations. They were diagnosed as CNS-lupus by neuropsychiatric symptoms, brain MRI, and EEG, and showed good response to high dose steroid pulse therapy.

괴사성 림프절염의 병리조직학적 소견

심영란,남혜주 영남대학교 의과대학 1993 Yeungnam University Journal of Medicine Vol.10 No.2

저자들은 최근 약 6년간 영남대학교 의과대학 부속병원에서 림프절 조직생검을 통해 진단된 괴사성 림프절염의 임상적, 병리학적 소견을 조사하여 다음과 같은 결과를 얻었다. 1) 발생 연령은 20대에 가장 많았으며 평균 27세였고 남녀비는 1 : 2였다. 2) 증상은 단순 림프절 종대가 가장 많았고 동통과 발열이 동반된 예도 있었다. 3) 림프절 종대는 대부분 측부 경부에 국한되어 있었다. 4) 조직학적으로 괴사성 병변이 나타났는데 그중 8예에서 국소적 혹은 융합성으로 완전한 조직 괴사가 나타났다. 여기에 핵 붕괴물질이 풍부하게 산재하였고 괴사 주변부에 조직구성, 림프구성의 다양한 종류의 큰 단핵구들이 소림프구와 같이 증식하여 정상 림프절 구조가 부분적으로 소실되었으며 흔히 빈번한 유사분열을 보였고 형질세포나 중성 백혈구는 관찰되지 않았다. 이상의 소견으로 괴사성 림프절염은 특징적인 조직학적 소견을 보이는 특이한 종류의 림프절염으로 그 원인은 불확실하지만 여러가지 원인에 의해 생기는 과면역성 림프절염으로 생각된다. 이에 대해서는 이 후 광범위한 임상적 검사와 자세한 면역조직학적 검사가 필요할 것으로 사료된다. Necrotizing lymphadenitis was first recognised as a self-limiting lymphadenitis by Japanese workers in 1972. It is distinct clinicopathologic entity, but can be mistaken as malignant lymphoma. We have studied clinicopathologic features in 15 cases of necrotizing lymphadenitis. This disease occurs predominantly in young adult. Male-female ratio is 2 : 1. The commonest presentation is lateral cervical lymphadenopathy. Pain, tenderness, and fever can be seen. Biopsy of the lymph nodes from all patients demonstrates the characteristic histologic features : multifocal, relatively circumscribed nodules in the cortex and/or paracortex, consisting of a mixture of activated large lymphoid cells, histiocytes and small lymphocytes. Numerous karyorrhetic debris are present. Neutrophils and plasma cells are strikingly absent.

치위생과 강의식 수업에서 효과적인 교수행동

정영란 ( Young Ran Jung ),황선희 ( Sun Hee Hwang ),안세연 ( Se Youn Ahn ),심수현 ( Soo Hyun Sim ),한화진 ( Hwa Jin Han ),최혜숙 ( Hye Sook Choi ) 한국치위생학회 2012 한국치위생학회지 Vol.12 No.1

Objectives : The purpose of this study was to examine what teaching behavior would have a good effect on learners in lecture-style instruction in the department of dental hygiene. Methods : The subjects in this study were 650 students who were in the three-year department of dental hygiene at four colleges in Gyeonggi Province and Chungcheong Province. After a survey was conducted, frequency analysis and ANOVA were utilized to analyze the collected data. The findings of the study were as follows. Results : The students put the highest value on knowledge among the factors of teaching behavior irrespective of their academic year, academic standing and learning style, followed by skills and attitude. Out of every subfactor, they set the highest value on a sense of humor regardless of their academic year, academic standing and learning style, and put the lowest value on the attitude factor such as enthusiasm. There were differences among the students in evaluation of the factors of teaching behavior according to academic year, and the students whose academic year was higher set a higher value on the factors of teaching behavior. There were no differences according to their academic standing and learning style. Conclusions : The dental hygiene students viewed the knowledge factor as the effective factor of teaching behavior, and regarded a sense of humor as the best subfactor. Although the attitude factor like enthusiasm is important, it seemed that the students hoped for the kind of instruction that would be delightful, intriguing and clearly convey what to learn.(J Korean Soc Dent Hygiene 2012;12(1):189-200)