Key Technology Enablers in Logistics

신우용 한국경영과학회 2017 한국경영과학회 학술대회논문집 Vol.2017 No.10

격동기에 애국 충정으로 일관했던 최영 장군의 생애

신우용 사회발전연구소 1994 한국인 Vol.13 No.1

요통과 견비통 환자에서 사상체질별 특성 연구

신우용,고호연,정수현,신미란 사상체질의학회 2017 사상체질의학회지 Vol.29 No.4

Objectives The purpose of this study is to investigate the characteristics of low back pain and shoulder arm pain patients according to the Sasang Constitution. Method We classified Seventy-nine participants by their Sasang Constitution. We investigated various aspects of the participant‘s pain such as the location of pain, diseases and Syndrome Differentiation etc. then intended to confirm relationship the Sasang Constitution and these research items through the statistics analysis. Results The numbers of lower back pain patients was statistically higher in Soyangin group than any other groups and the number of shoulder arm pain patients was statistically higher in Taeeumin group or Eumin group (Taeeumin group and Soeumin group) than Soyangin group. The number of diabetes patients and obesity patients was statistically higher in Taeeumin lower back pain patients, and that of obesity patients was statistically higher in Taeeumin shoulder arm pain patients than any other groups. The numbers of shoulder arm pain patients due to blood stasis and lower back pain patients due to kidney deficiency were statistically higher in Soyangin group than any other groups. The numbers of shoulder arm pain patients due to phlegm fluid retention and lower back pain patients due to phlegm fluid retention were statistically higher in Taeeumin group than any other groups. Conculsions The characteristics of lower back pain and shoulder arm pain could be different according to Sasang constitution.

중풍 환자에서 QSCC2와 변증(辨證)검사설문지 검사 비교

신우용,최인호,유준상,최선미,박은아,배나영,신미란,Shin, Woo-Young,Choi, In-Ho,Yoo, Jun-Sang,Choi, Sun-Mi,Park, Un-A,Bae, Na-Young,Shin, Mi-Ran 사상체질의학회 2007 사상체질의학회지 Vol.19 No.2

1. Objectives This study was to investigate correlation between the diagnosis of Sasang Constitutional Medicine(SCM) and the differentiation of syndromes according to the state of Qi, Blood, Body Fluid, Phlegm retention and the five viscera in storke inpatients. 2. Methods Stroke inpatients were investigated through questionaire of differentiation of syndromes and QSCC2. The results were analyzed statistically by one-way ANOVA on SPSS 12. 3. Results and Conclusions 1) Soeumin had a high grade on Qi-insufficiency than other consititutions. 2) Soyangin had a low grade on Qi-insufficiency, spleen disease than other consititutions. 3) There were not significant results in the investigation item of the sweating, constipation, diarrhea, anorexia, abdominal pain among the constitutions.

수혈적응증 입력 프로그램 개발 및 혈액제제 신청 사유 분석

신우용,이정재,정하란,신정원 대한수혈학회 2019 大韓輸血學會誌 Vol.30 No.2

Background: Transfusion guidelines are not only essential for the optimal use of blood products, but also help reduce transfusion-related adverse reactions and improve patients’ outcomes. In this hospital, a transfusion-indication data-entry program based on the national transfusion guidelines was developed and applied to the electronic medical record system in 2016. All transfusion orders, except for emergencies, have been performed using this program since then. This study analyzed the reasons for the transfusion to monitor the blood product usage and provide feedback to clinicians. Methods: The transfusion-indications were classified by the blood product and a pop-up window listing these indications was produced. The indications were as follows: red blood cells (RBCs) - acute blood loss, chronic anemia, surgery/procedure, transplantation and ‘other’; platelets (PLTs) - active bleeding, bleeding prophylaxis, surgery/procedure, massive transfusion, and ‘other’; fresh frozen plasma (FFP) - bleeding in coagulopathy, bleeding prophylaxis in coagulopathy, massive transfusion, plasma exchange, and ‘other’. The indications entered into the data-entry program from Sep 2016 to Feb 2018 were analyzed. Results: The most common indications for transfusion were chronic anemia for RBCs (7977/16138, 49.4%), bleeding prophylaxis for PLTs (5726/11158, 51.3%), and ‘other’ for FFP (2180/6024, 36.2%). Many clinicians entered the transfusion indication as ‘other’, but the free-text supplied by the clinician when ‘other’ was selected, often corresponded to an indication already categorized in the transfusion-indication data-entry program. Conclusion: Feedback and training on the data of transfusion indications are needed for clinicians to properly use blood products by operating the transfusion-indication data-entry program more efficiently. (Korean J Blood Transfus 2019;30:138-147)

IgM-κ 및 IgA-λ 이중클론감마병증을 가진 림프형질세포림프종/발덴스트롬마크로글로불린혈증 1례

신우용,방해인,김지은,박노진,신정원,최태윤 대한진단검사의학회 2019 Laboratory Medicine Online Vol.9 No.4

Lymphoplasmacytic lymphoma (LPL) is a low-grade B-cell neoplasm, composed of small B lymphocytes, plasmacytoid lymphocytes, and plasma cells, usually involving bone marrow and sometimes lymph nodes or spleen. LPL with bone marrow involvement and an IgM monoclonal gammopathy of any concentration is designated as Waldenström macroglobulinemia (WM). LPL associated with non-IgM monoclonal gammopathy or biclonal gammopathy is rarely observed. LPL diagnosis was based on clinical, morphological, and immunophenotypic findings. Recently, the test for L265P mutation of the myeloid differentiation factor 88 (MYD88) gene has been helpful in the diagnosis of LPL. Here, we reported the first case of LPL/WM with IgM-κ/IgA-λ biclonal gammopathy in Korea. 림프형질세포림프종은 소림프구, 형질세포양림프구, 형질세포로 이루어진 저등급 B-세포림프종으로서 골수, 림프절, 비장을 침범하는 질환이다. 림프형질세포림프종은 대개 골수를 침범하는데 IgM 단클론감마병증이 동반되는 경우 발덴스트롬마크로글로불린혈증이라고 일컫는다. IgM이 아닌 단클론감마병증 또는 이중클론감마병증을 동반하는 림프형질세포림프종은 매우 드물다. 통상적으로 골수 및 유세포검사를 통해 그 형태학적 소견과 세포의 면역표현형으로 진단을 하였는데, 최근에는 myeloid differentiation factor 88 (MYD88) 유전자의 L265P 돌연변이 검사가 림프형질세포림프종을 진단하는 데 많은 도움이 되고 있다. 저자들은 아직 국내에서 보고되지 않은 IgM-κ/IgA-λ 이중클론감마병증을 동반한 림프형질세포림프종 1예를 경험하였기에 문헌고찰과 함께 보고하고자 한다.

통증과 스트레스

신우용,유범희,Sihn, Woo-Yong,Yu, Bum-Hee 한국정신신체의학회 2007 정신신체의학 Vol.15 No.1

통증은 주관적인 증상이며 이전의 경험에 의해 많이 영향을 받지만, 환자가 없는 증상을 만들어내는 것이 아니라 실재하는 것이다. 객관적인 병리가 뒷받침되는 통증은 쉽게 설명되고 치료할 수 있지만 그렇지 않은 통증은 많은 혼란과 좌절을 초래한다. 통증의 종류는 1) 해부학적인 특징과 객관적인 소견이 있는 경우 2) 해부학적인 특징이 있고 객관적인 소견이 없는 경우 3) 해부학적인 특징이 없고 스트레스, 신체화 증상과 연관된 경우 4) 해부학적인 특징이 없고 신체적인 손상과 연관이 있는 경우로 나눌 수 있다. 만성 통증의 경우 감정적, 신체적 또는 성적인 학대를 당한 병력이 있는 경우가 많다. 심리적으로 신체화 증상은 고통스런 기억을 억압하고 관심을 구하는 과정에서 나타난다. 또한 학대의 병력이 생리학적인 변화를 유발하거나 발달과정 중에서 통증에 대한 감수성을 높이고 유기적인 변화를 일으키는 것으로 생각된다. 스트레스와 연관된 통증의 치료에는 운동, 명상, 인지치료, 약물치료, 바이오피드백 치료 등의 다각적인 방법이 필요하다. 인지치료는 통증에 대한 환자의 인식과 대처방식을 바꿈으로써 통증을 경감시키는 방법으로 스트레스로 인해 발생하는 통증치료에 효과적이다. 약물치료로는 주로 항우울제 계열의 약물이 효과적인데, 항우울제는 기분증상의 호전과 무관하게 통증을 경감시키는 효과를 갖고 있다. 긴장이완 훈련과 병행하는 바이오피드백 치료 역시 통증치료에 효과적일 수 있으며, 그밖에 적절한 운동과 명상요법 같은 방법 역시 통증치료에 도움이 될 수 있다. Pain is subjective and greatly influenced by prior experiences, but it is real. Pain associated with an organic(objective) pathology is more easily explained and treated. However, atypical or unexplainable pain is usually a source of greater confusion and frustration. Pain may be divided into four general diagnostic categories. 1) pain with anatomic features and objective findings 2) pain with anatomic features and without objective findings 3) pain with non-anatomic features associated with stress and somatization 4) pain with non-anatomic features associated with perceived physical injury. There is a well-established relationship between emotional, physical and/or sexual abuse history and development of chronic pain. It has been suggested that the link between somatization and abuse involves a paradoxical pattern of hiding feelings and reality, while seeking acknowledgment of suffering. History of abuse may physiologically and developmentally increase a person's susceptability to pain and organic changes can be associated with psychogenic disease. Patients with chronic pain should be treated with multidisciplinary approaches including exercise, meditation, cognitive therapy, medications, and biofeedback. Cognitive therapy alters patient's cognition and management of pain and alleviates pain, especially associated with stress. Antidepressants are the most commonly used medications and pain control effects have no relation with mood changes. Biofeedback with relaxation training, exercise and meditation may also be effective in pain control.

급성전골수성백혈병 치료를 위한 동종말초혈액조혈모세포 이식 후에 발생한 공여세포백혈병 1예

신우용,방해인,김지은,김경하,원종호,박노진 대한진단검사의학회 2020 Laboratory Medicine Online Vol.10 No.1

Donor cell leukemia (DCL), a rare but fatal complication arising from allogenic stem cell transplantation, is a complex disease associated with multiple pathophysiological processes. Specific diagnosis of DCL distinct from relapsed leukemia is important owing to its implications in setting up therapeutic approaches. Fluorescence in situ hybridization (FISH), short tandem repeat (STR), variable number tandem repeat (VNTR) tests, or informative single nucleotide polymorphism (SNP) analysis can be used to confirm the origin of leukemic cells from donor cells. Here, we report a case of DCL in a female patient after allogeneic peripheral stem cell transplantation from a male donor for the treatment of acute promyelocytic leukemia (APL) with PML-RARA . DCL developed 6 years after stem cell transplantation and leukemic cells of donor origin were confirmed by the presence of Y chromosome on the X/Y FISH analysis of bone marrow aspirate specimen. This is the first case of DCL reported in an APL patient in Korea 공여세포백혈병은 드물지만 동종조혈모세포 이식의 치명적인 합병증으로 다양한 기전이 복합적으로 작용하여 발생하는 것으로 알려져 있다. 재발한 백혈병과 공여세포백혈병의 감별진단은 치료 전략을 세우는데 영향을 주기 때문에 매우 중요하다. 백혈병세포 의 공여세포 기원을 확인하기 위해 형광동소보합법(fluorescence in situ hybridization, FISH), 단편직렬반복(short tandem repeats, STR), 직렬반복변수(variable number of tandem repeats, VNTR), 단일염기다형성(informative SNP) 분석 등의 검사가 이용된다. 급 성전골수세포백혈병 치료를 위해 남성공유자의 말초조혈모세포 이식 후 여성환자에서 발생한 공여세포백혈병은 국내에서 보고된 바가 없기에 문헌고찰과 함께 이 증례를 보고하는 바이다. 환자는 조혈모세포를 이식하고 6년 후에 공여세포백혈병이 발병하였으며 백혈병세포의 공여세포 기원은 골수흡인조직의 백혈병세포에서 Y 염색체에 대한 FISH 검사로 확인하였다.

제17대 대통령선거와 지방행정 ; 대통령선거의 공정관리 방안 -지방자치단체 공무원의 선거중립을 중심으로-

신우용 대한지방행정공제회 2007 地方行政 Vol.56 No.647

방문 과에 따른 국내 비예기항체 빈도 비교: 산과와 난임센터를 중심으로

신우용,김희정,백진영,신정원 대한수혈학회 2023 大韓輸血學會誌 Vol.34 No.3

Background: Alloantibodies against red blood cells (RBC) found in pregnant women can cause hemolytic disease in the fetus and newborn (HDFN). Therefore, checking and carefully observing the mother’s unexpected alloantibodies is essential during pregnancy. This study examined the frequency of unexpected antibodies according to the department. Methods: For patients who visited the authors’ hospital from December 31, 2020 to May 1, 2023 the results of RBC antibody screening and unexpected antibody identification tests were collected and classified according to the department. The antibody screening test was detected with Qwalys-3 DIAGAST, Loos Cedex, France) equipment using ABS HEMASCREEN (DIAGAST), and the antibody identification test was performed using the Resolve panel (Ortho-Clinical Diagnostics, San Diego, USA). The difference in frequency of each antibody according to the patient group was tested using Pearson’s chi-square test and Fisher’s exact test according to the relative frequency. Results: Among 46,193 patients who underwent unexpected antibody screening, 9,531 were obstetrics, and 18,313 were infertility centers. One hundred and seventy-seven patients underwent the unexpected antibody identification test: 57 obstetrics patients, 42 infertility center patients, and 78 positive patients who visited other departments. One hundred and ninety-three antibodies were identified, and there was no significant difference in the positive rate of unexpected antibodies by department. The antibody identified with the highest frequency was anti-M (18.1%) followed by anti-E (13.5%). Conclusion: In the East Asian population, anti-M is frequently reported, causing clinical problems. Anti-M was also commonly observed in this study; so, the clinical features should be carefully observed if anti-M is identified. (Korean J Blood Transfus 2023;34:182-188)