노인층에 발생한 피부질환의 임상적 고찰(제4보)

신봉주 ( Bong Ju Shin ),최성욱 ( Seong Wook Choe ),서성준 ( Seong Jun Seo ),홍창권 ( Chang Kwun Hong ) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.11

N/A Background : With the advance of socioeconomy and medical science, the population of the aged has been significantly increased. Therefore it needs to be studied the fundamental epidemiologic survey of dermatologic disease in the elderly. Objectives : The purpose of this study is to evaluate the prevalence of common dermatoses in the elderly and to compare these to previous studies. Method : 1,916 out-patients over 65 years old who had visited the Department of Dermatology, University Hospital and Yongsan Hospital, College of Medicine, Chung Ang University from January, 1996 to December, 2001 were analyzed retrospectively. Results 1. The incidence of aged group over 65 years old to total number of out-patients(24,723) was 7.7%(1,916 cases). 2. The ratio of male to female was 1.06 :1(986:930). 3. The frequent skin diseases were herpes zoster(12.0%), benign tumor(9.0%), pruritus(8.9%), onychomycosis/tinea pedis(7.7%), contact dermatitis(7.2%), seborrheic dermatitis(5.4%). 4. Eczema was the most common disease group which revealed 18.5%. The second most frequent group was viral infection(15.3%), followed by fungal infection(12.7%), tumor(12.0%), urticaria, drug eruption and erythema(9.4%), pruritus(8.9%), papulosquamous disease(2.8%) and bacterial infection(2.6%). 5. The most common disease in each disease group were as follows : contact dermatitis in eczema, herpes zoster in viral infection, onychomycosis and tinea pedis in fungal infection, urticaria in urticaria, drug eruption and erythema group, generalized pruritus in pruritus group, psoriasis in papulosquamous disease and folliculitis in bacterial infection, respectively. 6. Among 235 cases of skin tumor, 175 cases(74.5%) were benign and the remaining 60 cases(25.5%) were premalignant or malignant. The frequency of benign tumor was in order of seborrheic keratosis, epidermal cyst, skin tag and lipoma, respectively. In malignancy, there were basal cell carcinoma, squamous cell carcinoma and cutaneous metastatic carcinoma. Conclusion : Compared to previous studies, tumor and pruritus showed a increasing tendency but eczema a decreasing tendency.

도스토옙스키의 후기 장편에 나타난 새로운 신분의 모색 : ‘뛰어난 사람들(лучшие люди)’개념을 중심으로

신봉주(Shin, Bong Ju) 한국노어노문학회 2022 노어노문학 Vol.34 No.2

레비나스와 도스토옙스키의 ‘아버지되기’에 대하여: 『전체성과 무한』과 『미성년』을 중심으로

신봉주(Shin, Bong Ju) 한국슬라브유라시아학회 2021 슬라브학보 Vol.36 No.4

Levinas and Dostoevsky’s thoughts on infinite time are inseparable from their ethics. For Levinas, the concept of “infinite time” is the ultimate condition in which subjectivity could prove its truth and goodness. Dostoevsky steadily questioned how one could do good without belief in immortality. Previous studies comparing two authors have focused on the attribution that both preached ‘an asymmetrical relationship with other’, which could realize an infinite time in this world. Therefore, this paper argues that Levinas and Dostoevsky also elaborated on their concept of paternity while deliberating on the relation between ethics and infinity. To analyze the concept of paternity, chapter 4 “Beyond the Face” in Levinas’ “Totality and Infinity” and Dostoevsky’s novel, “The Adolescent” have been chosen. In these works, Levinas and Dostoevsky share a theme of biological family that could be interpreted as a model for conceptualizing the paternity. As Levinas summed up paternity in a sentence ‘I is its son’, this paper tries to illuminate the discourse of two authors regarding the dialectics of the self. In “Totality and Infinity”, Levinas relates the son who I will have through phenomenology of Eros and paternity with my future, which is not a future of the same(du Même). However, this paper is more fixated on finding the concrete illustration of the ‘I’ who can be still ‘I in one’s son(être moi dans son fils)’ in Dostoevsky’s novel, “The Adolescent”. In “The Adolescent”, the father Versilov and his son Arkadii stay as strangers to each other throughout the entire story, thus embodying an asymmetrical relation between I and the future of I. Nevertheless, Arkadii’s notes completed with the strange father’s story illustrates how I can reconcile with the future I, despite the discontinuity of generation.

고골의 삶과 창작에 나타난 광기담론:

신봉주(Shin, Bong Ju) 충북대학교 러시아 알타이지역 연구소 2017 러시아학 Vol.- No.15

This article attempts to reinterpret the meaning of ‘madness’ of Poprishchin, hero of Diary of Madman (1835), in light of the Gogol’s mysterious desire. Inferring the prototype of Poprishchin’s desire from Gogol’s autobiographical records, this article explains the hero’s madness as a sort of language inherent in his desire. Gogol has been an ‘unreliable narrator’ all his life, which makes it hard to grasp what he really had in mind with his calling. Correspondences with mother show how Gogol acted unexpectedly and by doing so how he brought dubious reputation upon himself. Nevertheless, for Gogol madness was an object more of an inquiry than a disgrace. Instead of refuting the charge of madness, Gogol accepts fact that there are contradictory views of him regardless of his intention. When he came back shortly after leaving for Lübeck in the Divine Will, he thought that even his hardship of approaching “the high and beautiful” was ordained by God. Consequently, in his alleged madness Gogol sees not a dreadful judgement but a clue to Providence. Gogol and Poprishchin are similar in that both are well aware of what constitutes madness. Poprishchin understands that assuming the title or assuming the someone else’s identity is an act of insanity. So his decision to declare himself as the king of Spain mirrors the reality in which no one considered him insane even though he believed himself a titular councilor. However, Poprishchin is trying to keep his desire in silence until it is realized. His ultimate goal is to demonstrate how another abnormal incident can enter the world and settle down as if nothing had happened.

Dendritic Epidermal T Cell 에서 iNOS mRNA 의 발현과 IL - 3 생산에 NO 가 미치는 영향

서성준(Seong Jun Seo),신봉주(Bong Ju Shin),홍창권(Chang Kwun Hong),노병관(Byung Kwan Ro) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.10

N/A Backgroud : Stimulation of iNOS with subsequent release of NO may play a critical role in pathophysiology or host defense reaction. NO can be produced by several cell types that reside in the skin. Increasing data indicate that NO serves as an autocrine and paracrine mediator in diverse and complex cellular processes throughout the skin. Objective : The aim of the present study was to elucidate whether dendritic epidermal T cell can express iNOS and generate NO. In addition to that, this study was to evaluate whether NO may play a certain role in IL-3 production of activated dendritic epidmal T cell. Methods : iNOS was isolated by RT-PCR at 12, 24, 48, 72 hours after stimulation and NO was measured by the Griess method. IL-3 levels were assessed with a basic cell proliferation bioassay system using supernatants from T cells cultured in 96 well plates. Units of IL-3 in the culture supernatants were measured using the cytokine-dipedent DA-1 cell-line. Results : 1. NO generation was increased by UVB l00mJ/㎠ irradiation, concanavalin-A and lipopolysaccharide stimulation in dendritic epedermal T cell. The amount of NO highest in LPS. 2. The expression of iNOS was increased by UVB 100mJ/㎠ irradiation, concanavalin-A and lipopolysaccharide stimulation in dendritic epidermal T cell. Induction of iNOS revealed peak at 72 hours after concanavalin-A and lipopolysaccharide stimulation, but in UVB irradiation that of iNOS was not observed except at 48 hours. 3. NO may play a role in IL-3 production in activated dindritic epidermal T cell. Conclusion : The results strongly suggest that the expression of iNOS and NO production in dendritic epidermal T cell are upregulated by UVB, concanavalin-A and lipopolysaccharide, and NO may play a role as mediator in IL-3 production of activated of activated dendritic epidermal T Cell as autocrine manner.

대칭적 , 다발성 기저세포암을 동반한 모반양 기저세포암 증후군 1 예

탁우정(Woo Jung Tak),신봉주(Bong Ju Shin),김명남(Myeung Nam Kim),노병인(Byeung In Ro) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.6

Nevoid basal cell carcinoma syndrome is a inherited disorder characterized by multiple cutaneous basal cell carcinoma, pits of the palms and soles, cysts of the jaws, and ectopic calcification of cranial membranes. The patient was a 66 year old female. She complained of multiple, symmetrically distributed black-colored papules on the both sides of the neck. On physical examination, multiple pits were detected in the palms and soles. The histopathologic findings of the papules showed variable shaped and sized tumor nests composed of basaloma cells. On PNS CT for search of metastasis of the cancer, odontogenic keratocyst was detected at the Lt. alveolar process of maxilla by accident. We diagnosed her nevoid basal cell carcinoma syndrome and the lesions on both sides of the neck were removed completely.

아토피 피부염에서 말초 혈액내 호산구 수, 혈청 총 IgE, eosinophil cationic protein, IL-4 및 soluble E-selectin의 변화

김명남 ( Myeung Nam Kim ),신봉주 ( Bong Ju Shin ),탁우정 ( Woo Jung Tak ),노병인 ( Byung In Ro ),박애자 ( Ae Ja Park ) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.11

N/A Background : Since the management of atopic dermatitis often needs rolonged administration of medication, the laboratory index reflecting disease severity is necessary for optimal treatment for this disease. Objectives : The purpose of this study is to evaluate peripheral eosinophil counts, serum total IgE, eosinophilic cationic protein(ECP), IL-4 and soluble E-selectin as severity indices or disease marker. Method : A total of 21 patients with atopic dermatitis and 21 normal controls were evaluated for the symptoms and signs according to SCORAD index and measured for peripheral eosinophil counts, serum total IgE, ECP, IL-4 and soluble E-selectin. Results : Peripheral eosinophil counts, serum total IgE, ECP and soluble E-selectin levels of patients with atopic dermatitis were significantly increased compared with those of normal control(p<0.05). Moreover, serum ECP and soluble E-selectin correlated with SCORAD score. Serum IL-4 levels of patients with atopic dermatitis were slightly increased compared with those of normal control but not statistically significant(p>0.05). Conclusion : ECP and soluble E-selectin were good serum marker reflecting the severity of atopic dermatitis.

당뇨병성 경화부종 - 임상 - 병리조직학적 연구 및 문헌고찰 -

황호근(Ho Geun Hwang),이승하(Seoung Ha Lee),형근영(Keun Young Hyoung),신봉주(Bong Joo Shin),김경년(Kyoung Nyeon Kim),조정구(Chung Gu Cho),김주섭(Ju Seob Kim),차승훈(Seung Hoon Cha),박석돈(Seok Don Park) 대한내과학회 1996 대한내과학회지 Vol.51 No.4

N/A Objectives: We studied clinical feature, underlying disease and histo-pathologic finding of scleredema diabeticorum that was observed as non-pitting indurated edematous skin of the nape, occiput in non-insulin dependent diabetes mellitus. Methods: We performed clinico-histopathologic study in 5 cases of scleredema diabeticorum which were diagnosed at our hospital and reviewed 6 cases in Korean literatures. Results: 1) The male to female ratio was 4:1, The overweight or obese middle-aged (mean:54.6) males were prone to develop these cutaneous changes. There was no relationship between the development of diabetic scleredema and the duration, the severity of diabetes. Hypertension and hyperlipidemia were frequent associated finding among the patients. 2) The increased level of fasting C-peptide implicated that the ability of insulin secretion was preserved. 3) Non-pitting hardening of the skin on the nape, head and surrounding parts of the body was common skin change in all patients. No evidence of systemic involvements was found. 4) Typical histopathologic findings, consisted of the thickening of dermis, the degeneration of collagen bundles in mid- to deep dermis, and the deposition of acid mucopoleysaccharides, hyaluronic acid, were noted in 4 cases of our study. 5) The therapeutic responses of cutaneous changes were generally poor. Conclusion: These results implies that scleredema diabeticorum is not a rare cutaneous manifestation among the diabetic dermadromes, and special histopathologic stainings with skin tissue sections are necessary for diagnosis. Although the exact mechanisms of this disease are not known, and no effective therapy is available, it needs to be studied exactly that the facts of hyperlipidemia, overweight, hypertension and well-preservation of fasting C-peptide observed in our cases, may be related to syndrome-X.

양성 대칭성 지방종증 1예

김명남,노병인,신봉주 대한피부과학회 2002 大韓皮膚科學會誌 Vol.40 No.9

Benign symmetric lipomatosis is a rare disease of undetermined cause characterized by massive symmetric depositions of adipose tissue, predominantly on the neck, shoulder, back, and upper extremities. A 60-year-old man with chronic alcoholism was referred to our clinic for symmetric, skin-colored, non-tender masses on the posterior neck, both clavicular areas, abdomen, and back for about 10 years. He had been managed for tingling sensation on both hands in the neurologic department. Nerve conduction velocity studies were consistent with sensorimotor polyneuropathy and histopathologic findings revealed that the reticular dermis was replaced by normal uncapsulated mature fat cells. We report a rare case of benign symmetric lipomatosis associated with polyneuropathy.