Rifampin 과 Isoniazid 에 의한 약진 1 예

탁우정(Woo Jung Tak),장대성(Dae Sung Chang),서성준(Seong Jun Seo),홍창권(Chang Kwun Hong) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.5

Drug cruption is a cutancous reaction caused by various drugs, which include antibiotics, antipyreties, anti-inflammatory analhesics, antidepressants, antitubereulosis drugs, etc. Drug cruptions caused by antitubercrlosis drugs are relatively uncommon and there have been no previous reports in Korea which caused simultaneously by isoniazid and rifampin. A 57-year-old female patient, who treated with antituberculosis drugs, was seen with generalized crythematous maculopapular eruption. We performed patch test and prick test with the antitubereulosis drugs and could confirm a drug cruption caused by isoniazid and rifampin. And we performed descensitization to isoniazid for an optimal antituberculosis regimen and completed the treatment with isoniazid, successfully.

대칭적 , 다발성 기저세포암을 동반한 모반양 기저세포암 증후군 1 예

탁우정(Woo Jung Tak),신봉주(Bong Ju Shin),김명남(Myeung Nam Kim),노병인(Byeung In Ro) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.6

Nevoid basal cell carcinoma syndrome is a inherited disorder characterized by multiple cutaneous basal cell carcinoma, pits of the palms and soles, cysts of the jaws, and ectopic calcification of cranial membranes. The patient was a 66 year old female. She complained of multiple, symmetrically distributed black-colored papules on the both sides of the neck. On physical examination, multiple pits were detected in the palms and soles. The histopathologic findings of the papules showed variable shaped and sized tumor nests composed of basaloma cells. On PNS CT for search of metastasis of the cancer, odontogenic keratocyst was detected at the Lt. alveolar process of maxilla by accident. We diagnosed her nevoid basal cell carcinoma syndrome and the lesions on both sides of the neck were removed completely.

원형 탈모증의 임상적 고찰 ( 1996 - 2000 ) ( 제 4 보 )

탁우정(Woo Jung Tak),정유선(You Sun Chung),노병인(Byung In Ro) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.7

N/A Background : Alopecia areata patients has recently increased in number. The clinical features and therapeutic results of alopecia areata are diverse and unpredictable. Objective : We, the authors, performed a study on alopecia areata in order to evaluate the clinical manifestations and compare the efficacies of treatment with intralesional injection of triamcinolone acetonide suspension, immunotherapy with diphenylcyclopropenone(DPCP), and photochemotherapy with psoralen plus UVA(PUVA). Methods : A clinical study of 732 patients with alopecia areata including 33 cases of alopecia totalis and 46 cases of alopecia universalis was performed for 5 years, since March, 1996 to February, 2001 who visited to Alopecia Clinic at the Department of Dermatology, Collage of Medicine, Chung-Ang University. Results 1) The age distribution showed a peak incidence in the third decade(29.1%) and the mean age was 26.8 years and 136 cases(18.6%) showed alopecia areata in patients below 10 years old. 2) Previous episodes of alopecia were observed in 173 cases(23.6%) and 58 cases(7,9%) had family history of alopecia areata. 3) The most common site was the occipital region in both male and female patients, which were 251 cases(38.4%) and 218 cases(33.4%) respectively. 4) Associated diseases with alopecia areata included seborrheic dermatitis(97 cases), allergic contact dermatitis(25 cases), liver disease(22 cases), hypertension(18 cases), diabetes mellitus(16 cases), urticaria(16 cases), atopic dermatitis(l4 cases) and thyroid disease(8 cases). 5) The efficacies of treatment modality had no statistical differences in DPCP immunotherapy, intralesional triamcinolone injection or photochemothrapy. Conclusion : There was no noticeable differences compared to previous studies on alopecia areata, except that increasing tendency of severe, recurrent, and refractory alopecia areata and number of chilclhood patients.

안드로겐성 탈모증의 임상적 고찰 ( 제 4 보 )

정유선(You Son Chong),탁우정(Woo Jung Tak),노병인(Byung In Ro) 대한피부과학회 2002 大韓皮膚科學會誌 Vol.40 No.7

N/A Background : Androgenetic alopecia is considered to be a genetically determind disorder influenced by age and androgen. The proportion of patients with androgenetic alopecia among the total number of patients with alopecia seems to be gradually increasing. Objective : The purpose of this study was to find the family history, clinical and endocrine status of the patients with androgenetic alopecia. Method : 736 patients with androgenetic alopecia who had visited the Department of Dermatology, Yongsan and Pil-dong Hospital, College of Medicine, Chung-Ang University during the last 2 years(1999.1-2000.12) were examined. Results : 1) Incidence of androgenetic alopecia among the total number of alopecia patients was 75.8%. 2) There were 571 male and 165 female patients being most prevalent in the 3rd decade in male patients and in the 4th decade in female patients. 3) In male androgenetic alopecia, Norwood-Hamilton`s type Ⅱ was the most common and following Ⅲv, Ⅱ, Ⅳ, Ⅲa, and in female patients, Ludwig`s type Ⅰ was most common. 4) There was a family history of baldness in 59.5% of first degree relatives in male patients and 30.9% in female patients. 5) The most common associated disorder is seborrheic dermatitis. 6) Serum testosterone levels were increased in 78 males(13.7%) and 23 females(13.9%). Conclusion : Based on these results, the number of young patients who visit dermatologists tends to be increasing and genetic factor, ages and abnormal androgen metabolism in scalp are affecting the development of androgenetic alopecia.

아토피 피부염에서 말초 혈액내 호산구 수, 혈청 총 IgE, eosinophil cationic protein, IL-4 및 soluble E-selectin의 변화

김명남 ( Myeung Nam Kim ),신봉주 ( Bong Ju Shin ),탁우정 ( Woo Jung Tak ),노병인 ( Byung In Ro ),박애자 ( Ae Ja Park ) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.11

N/A Background : Since the management of atopic dermatitis often needs rolonged administration of medication, the laboratory index reflecting disease severity is necessary for optimal treatment for this disease. Objectives : The purpose of this study is to evaluate peripheral eosinophil counts, serum total IgE, eosinophilic cationic protein(ECP), IL-4 and soluble E-selectin as severity indices or disease marker. Method : A total of 21 patients with atopic dermatitis and 21 normal controls were evaluated for the symptoms and signs according to SCORAD index and measured for peripheral eosinophil counts, serum total IgE, ECP, IL-4 and soluble E-selectin. Results : Peripheral eosinophil counts, serum total IgE, ECP and soluble E-selectin levels of patients with atopic dermatitis were significantly increased compared with those of normal control(p<0.05). Moreover, serum ECP and soluble E-selectin correlated with SCORAD score. Serum IL-4 levels of patients with atopic dermatitis were slightly increased compared with those of normal control but not statistically significant(p>0.05). Conclusion : ECP and soluble E-selectin were good serum marker reflecting the severity of atopic dermatitis.

레이저 치료 후 포도주색 모반에서 발생한 다발성 화농성 육아종

탁우정,김명남,노병인,최병익 대한피부과학회 2003 대한피부과학회지 Vol.41 No.4

Pyogenic granuloma (PG) and port-wine stain (PWS) are vascular lesions that rarely occur in association. While PWSs are congenital capillary vascular malformations, PGs are acquired benign vascular proliferations. Although the pathogenesis of PG is unknown, many authors feel that they represent reactive hyperplasias, especially as they are often seen in response to trauma. We report the multiple pyogenic granulomas developed in a port-wine stain following Nd-YAG laser therapy. (Korean J Dermatol 2003;41(4) 535~537)

성인에서 발생한 피부 비만세포증 1예

김범준,탁우정,김명남,노병인,송계용 대한피부과학회 2002 대한피부과학회지 Vol.40 No.12

Urticaria pigmentosa is a form of urticaria characterized by abnormality of cutaneous mast cells. No prediction for either gender has been reported but it usually occurs in children. When it develops in an adult cutaneous manifestations often follows recalcitrant and persistent course. Though tendency of genetic inheritance with an autosomal dominant pattern has been suggested most patients have no family history of mastocytosis, We report a case of adult-onset urticaria pigmentosa with references. (Korean J Dermatol 2002;40(12) 1587∼1590)

대상포진에 의해 발생한 운동신경 마비 1예

서성준,홍창권,탁우정,정유선 대한피부과학회 2002 대한피부과학회지 Vol.40 No.9

Motor loss caused by herpes zoster is less well known but occurs in a significant number of cases, probably far more frequent than is recognized because the weakness is readily obscured by pain. The incidence of herpetic motor involvement was reported to be between 0.5% and 31%. A 65-year-old male patient with herpes zoster on the right lower limb had complained with progressive weakness of the limb, during treatment. We examined the limb using electromyographic(EMG) and motor nerve conduction velocity(MNCV) studies. Thereafter we concluded he had motor paralysis caused by herpes zoster. The weakness progressed to the complete motor loss of the right limb. Presenty, he still suffers from the paralysis of the right limb.