탐슐로신 복용 환자에서 경험한 홍채이완증후군 1예

신광훈,손희진,이대영,남동흔 대한안과학회 2009 대한안과학회지 Vol.50 No.10

Purpose: To report a case of Intraoperative Floppy Iris Syndrome (IFIS) experienced during pars plana vitrectomy and phacoemulsification in a patient using tamsulosin, which is a selective alpha 1 adrenergic antagonist. Case summary: A 77-year-old male who had used tamsulosin for the previous month for prostate cancer visited our clinic with left visual disturbance, that had developed a week earlier. The best-corrected visual acuity of the left eye was 0.02 and both pupils showed incomplete mydriasis. Pars plana vitrectomy and phacoemulsification with PCL implantation were performed on his left eye to correct a left cataract and retinal vein occlusion with vitreous hemorrhage. Phacoemulsification idenfied a billowing iris and progressive pupillary constriction. Therefore, we administered an intracameral epinephrine injection and applied an iris hook. The procedure was completed successfully without any complications. The best-corrected visual acuity of the left eye was good as at 0.9, and iris depigmentation and atrophy were checked two months postoperatively in the right eye, which had not had any previous surgical history. Conclusions: A detailed medical history taking is essential because IFIS may raise the risk of intraoperative complications, such as posterior capsule rupture, especially when the small pupil is small. Safe procedures must be planned with cessation of tamsulosin at least a week preoperatively. 목적: 선택적 Alpha 1 교감신경 길항제인 Tamsulosin을 복용 중인 환자에서 유리체절제술과 백내장 동시 수술 중 경험한 Intraoperative Floppy Iris Syndrome (IFIS) 1예를 보고하고자 한다. 증례요약: 전립선암으로 1달 전부터 Tamsulosin을 복용 중인 77세 남자 환자가 1주 전부터 발생한 좌안 시력저하를 주소로 내원하였다. 양안 모두 산동이 불충분하였고 좌안 최대교정시력은 0.02였다. 좌안에 백내장, 망막정맥폐쇄 및 유리체출혈을 보여 좌안 유리체 절제 술과 백내장 수술을 시행하였다. 좌안 백내장 수술 중 물결치는 홍채, 진행성 동공 수축 소견을 보여 안내 Epinephrine을 주입하고 홍채 훅을 사용하여 합병증 없이 성공적으로 수술을 시행하였다. 술 후 2개월 째 경과 관찰에서 좌안 최대교정시력은 0.9로 양호하였고, 양안 모두에서 홍채 탈색소 및 위축 소견을 확인하였다. 결론: IFIS는 백내장 수술 시 합병증의 위험을 높일 수 있으므로 수술 전 자세한 병력 청취가 필요하며, 특히 술 전 산동이 불충분한 환자에서는 Tamsulosin을 복용 여부를 꼭 확인하고 적절한 조치를 통해 안전한 수술을 도모해야 할 것이다.

우리나라 一部地域의 接待婦에 對한 梅毒檢査 成績

辛光勳 서울大學校保健大學院 1973 公衆保健雜誌 Vol.10 No.2

A serological test for syphilis among prostitutes were made to find the degree of treponemal infection. For this study sera were collected from 1, 206 prostitutes of Seoul, Incheon, Euijeongbu and Yangjoo from November 27 to December 7, 1972 and were examined through VDRL slide qualitative test and quantitative test. As the results of this study the following conclusions were obtained. 1. The reactive sera were 7.9 per cent out of 254 prostitutes in Seoul, 8.2 per cent out of 317 in Euijeongbu and 7.2 per cent out of 254 prostitutes in Seoul, 8.2 per cent out of 317 in Euijeongbu and 7.2 per cent out of 328 in Yangjoo with average reactive value of 7.2 per cent out of 1,206. 2. The prozone phenomenon was not appeared in weakly reactive sera. 3. The hightest reagin tier was 1:32 serum dilution in one case.

性因傳播疾患 病原體에 대한 免疫學的 硏究 : 淋菌株의 抗原性및 藥劑耐性 遺傳子에 關한 硏究 Studies on the Antigenicity and Drug resistance gene of N. gonorrhoeae

辛光勳,金鎬薰,李馥權,金順南,申永鶴,姜鍊浩,張泳美,宋淇俊,廉? 국립보건연구원 1989 국립보건원보 Vol.26 No.

2007년 한국 굴절수술학회 회원 설문조사 - 한국에서의 굴절수술의 최근 경향 -

신광훈,신경환 대한안과학회 2009 대한안과학회지 Vol.50 No.10

목적: 설문 조사 결과를 분석하여 국내 굴절수술의 현 추세를 파악하고 미래를 예측하는데 도움이 되고자 하였다. 대상과 방법: 한국 백내장굴절수술학회 회원 336명을 대상으로 총 66문항의 제13차 설문조사를 2008년 8월 실시하여 14.9%의 응답률 을 얻었고, 이전의 설문조사 및 2007년 미국 설문조사와 비교하였다. 결과: 응답자의 연령은 40대가 38%로 가장 많았다. 굴절수술 장비로 VISX S4가 32%로 가장 많이 사용되고 있었으며, 미세각막절개도 구로 IntraLase Femtosecond laser (AMO, USA) 사용이 증가하였다. 가장 많이 시행하는 굴절수술로 LASIK이 48%로 여전히 높은 지지를 얻었다. -8D 미만의 근시에서는 LASIK이, -8D 이상의 근시에서는 유수정체용 인공수정체 삽입술을 가장 선호하였다. 가장 촉망 받는 굴절수술로 유수정체용 인공수정체삽입술이 지목되었고, LASIK이라고 답한 경우는 감소하였다. 결론: LASIK이 여전히 가장 선호되는 굴절수술 방법이나 유수정체용 인공수정체 삽입술을 비롯하여 다른 수술법에 대한 관심이 크게 증가하였음을 알 수 있었다. 국내 굴절수술의 경향이 선진국 수준에 근접하여, 굴절수술 법에 대한 선호도 및 합병증의 빈도 변화 양상이 미국의 추세와 비슷하였다. Purpose: To investigate the current situation and future trends in the field of refractive surgery in Korea. Methods: Since 1995, the members of the Korean Society of Cataract and Refractive Surgery (KSCRS) have been annually surveyed on cataract and refractive surgery. The 2007 annual survey, consisting of 66 multiple-choice questions, was mailed in August 2008 to 336 KSCRS members. Fifty (14.9%) members answered. Current data were compared with those of previous annual survey and with those of the USA. Results: The respondents in their forties accounted for the highest percentage (38%) of the subjects, and VISX S4 was the most popularly used (32%). The use of IntraLase femtosecond laser (AMO, USA) had increased. LASIK still accounted for the highest percentage (48%) of refractive surgeries. LASIK was preferred for myopia less than -8D, and phakic IOL was preferred for myopia more than -8D. Almost all the respondents answered that most promising refractive surgery is phakic IOL and the respondents who preferred LASIK decreased. Conclusions: This survey summarized current trends and changes in cataract and refractive surgery in Korea.

당뇨 환자의 안저 검사 수진율과 이에 영향을 미치는 보건학적 요인

신광훈,지미정 대한안과학회 2009 대한안과학회지 Vol.50 No.9

Purpose: To investigate the fundus examination rate in diabetic patients and the public health factors associated with the fundus examination rate. Methods: We analyzed the results of the third Korean National Health and Nutrition Examination Survey. We investigated the fundus examination rate in patients who had diabetes mellitus for more than 3 months during the previous year and determined the relationship of public health factors with the fundus examination rate. Results: In all 547 patients (38.1%) received the fundus examination out of 1,437 total patients with diabetes mellitus. We found that many public health factors influenced the higher fundus examination rate, including patients who were residents in urban areas, women, office workers, university graduates, patients with a higher family income or more than 5 years duration of diabetes mellitus, patients with current insulin treatment, treatment of diabetes mellitus, education about diabetes mellitus, subjective visual problems or subjective health problems. However, age, marital status, health insurance and residential district did not influence the fundus examination rate. Conclusions: The Korean National Health and Nutrition Examination Survey is the largest health survey in Korea. This study is meaningful as a population-based study, not a clinic-based cross-sectional study and it suggests the basic data for improving the fundus examination rate in diabetes mellitus patients. 목적: 당뇨환자에서 안저검사 수진율과 이에 영향을 미치는 보건학적 요인에 대하여 조사하고자 하였다. 대상과 방법: 국민건강영양조사 3기의 조사결과를 분석하였다. 당뇨환자 1437명을 대상으로 지난 1년간 안저검사 수진율과 보건학적 요인들과의 관계를 분석하였다. 결과: 당뇨환자 1,437명 중 지난 1년간 안저검사를 받은 자는 547명(38.1%)이었다. 동지역 거주자, 여성, 직업의 경우 사무직 종사자, 대졸 이상 학력, 높은 월 가구소득, 당뇨 유병기간이 5년 이상, 인슐린 치료를 받고 있는 경우, 현재 당뇨치료를 받고 있는 경우, 당뇨교육을 받은 적이 있는 경우, 시력 이상이 있는 경우, 주관적으로 건강상태가 나쁘다고 생각하는 경우에 그렇지 않은 경우에 비해 유의하게 높은 안저검사 수진율을 보였다. 연령, 결혼상태, 의료보장종류, 16개 시도 지역에 따른 수진율의 유의한 차이는 없었다. 결론: 국민건강영양조사는 우리나라에서 가장 규모가 큰 건강조사로서, 본 연구는 당뇨 환자의 안저검사 수진율에 대하여 병원에 내원 한 환자들이 아닌 지역사회 주민을 대상으로 하였다는데 의의가 있으며 향후 안저검사 수진율을 높이기 위한 방안을 수립하는데 기초 자료가 될 것으로 기대한다.

국내의 새로운 백신의 개발에 따른 제조 허가조건에 대하여

신광훈 대한감염학회 1995 감염 Vol.27 No.3

국내 연근해 및 환자로부터 분리된 vibrio vulnificus의 세균학적 특징

신광훈,신영학,이종삼 한국미생물학회 1992 미생물학회지 Vol.30 No.1

국내 연안의 어패류, 해구 및 환자 등으로부터 Vibrio vulnificus를 분리동정하여 생화학적 성상, 생장조건, 혈천형, 약제 감수성 시험 등 세균학적 특성을 밝혔다. V. vulnificus 균의 생화학적 성상은 유당을 발효(95%)하고 서당은 발효 (4%)않은 균주가 대부분이었으며, ornithine 발효능, gelatine 액화능, mannitol 분해능 등이 다른 연구자들과 동일한 결롸를 나타내지 않았다. 따라서 이들 성상이 V. vulnivicus 동정에 그리 유용하지 않다. o 혈청형은 자연계 분리균주의 경우 o2 혈청형이 제일 많았고 (24%) 환자 분리균주의 경우 04 균(42%)이 제일 많았다. V. vulnificus 의 최적 생상조건은 염농도는 306%였고, 온도는 25-35.deg.C, pH는 8로 나타났다. V. vulnificus균은 chloramphenicol, erythromycin, tetracycline, ampicilin 에 높은 감수성을 지니고 있었고 gentamycin 에 대하여는 내성을 가진 것으로 나타났으며, 자연계 분리균주가 환자 분리균주보다 이들 항생제에 더 높은 감수성을 지니고 있었다. chelating agent EDTA가 V. vulnificus에 대하여 생장억제효과가 있음이 밝혀졌으나 치사적으로 작용치는 않았다. Vibrio vuln$cus has been recognized as a pathogen of septicemia and wound infection, when the organism attacks high-risk persons with a history of hepatic disease. alcohol abuse. diabetes or any debilitative disease. Forty six strains of K vulnzjicus. isolated from 1025 marine specimens from May to Novemver for three years. from 1985 to 1987. were studied for their biochemical properties. growth requirements, serotype and drug susceptibilities. The isolates were different in their various biochemical reactions. Ninety-five percent of isolated strains were able to ferment lactose, while most strains didn't utilize sucrose in their biochemical test, for example ornithine, gelatin and mannitol were quite dit'ferent composition than those described in other reports. It was found that the biochemical test wasn't useful for identifying strain. The type of somatic 0 antiserum was determined in isolates from marine sources and in patients with Vibrio septicemia. In patient isolates. 1-2 group were 24% and 1-4 group were 42%. However. 02 group(33%) were more abundant in isolates from marine sources. Minimal inhibitory concentrations(M1Cs) of chloramphenicol, tetracycline. erythromycin and ampicillin were determinef for V vuln~ficus by broth dilution method. MIC90 was I , 0.25, :! and 4,ug/ml in patient isolates. 1, 0.25, 2 and 2 ,ug/ml in marine isolates. The divalent chelating agent, IDTA. inhibited the growth of V. vuln!'ficus at 6.25 mMlml of MIC90.

간헐 외사시에 대한 양안 외직근 후전술 후 발생한 속발 내사시 치료를 위한 외직근 전진술의 장기 효과

신광훈,위재민,백혜정,Kwang Hoon Shin,Jae Min Wi,Hae Jung Paik 대한안과학회 2014 대한안과학회지 Vol.55 No.8

Purpose: To investigate the long-term outcome of lateral rectus (LR) advancement for consecutive esotropia following bilateral LR recession for intermittent exotropia. Methods: Medical records of 25 patients who underwent LR advancement for consecutive esotropia after bilateral LR recession and who were followed up for more than 24 months postoperatively were reviewed. Patients were divided into two groups: bilateral lateral rectus recession (BLR) group included 16 patients with consecutive esotropia greater than or the same magnitude as the initial exotropia and who underwent bilateral LR advancement; Unilateral lateral rectus recession (ULR) group included nine patients with consecutive esotropia less than the initial exotropia and who underwent unilateral LR advancement. Main outcome measurements were motor and sensory outcomes and the dose-effect relationship calculated from observed overall and group changes in the angle of deviation per millimeter. Motor success was defined as alignment from orthotropia to exodeviation less than 10 PD at distance. Sensory outcome was described by comparing the Titmus stereoacuity test before and after LR advancement. Sensory successvwas defined at 100 seconds of arc. Results: Eighteen patients (72.0%) showed satisfactory long-term motor and sensory outcomes. Seventeen (77.3%) of 22 patients showed favorable stereopsis of 100 seconds of arc or more at final observation. The long-term motor success rate of the ULR group was better than that of the BLR group (<em>p</em> = 0.025). The average observed change in the angle of deviation was 3.6 PD/mm at the final visit in all patients. A greater dose-effect relationship was observed in the ULR group than in the BLR group at the final visit (<em>p</em> = 0.043). Conclusions: LR advancement showed favorable motor and sensory outcomes in the majority of patients. The surgical outcome was not favorable in patients in the BLR group with consecutive esotropia of the same magnitude as the initial exotropia. These results require further investigation for verification. J Korean Ophthalmol Soc 2014;55(8):1180-1186

적대적 훈련 기반의 시계열 데이터 증강 기법

신광훈,김도국 한국정보과학회 2023 정보과학회논문지 Vol.50 No.8

Recently, time series data are being generated in various industries with advancement of the Internet of Things (IoT). Accordingly, demands for time series forecasting in various industries are increasing. With acquisition of a large amount of time-series data, studies on traditional statistical method based time-series forecasting and deep learning-based forecasting methods have become active and the need for data augmentation techniques has emerged. In this paper, we proposed a novel data augmentation method for time series forecasting based on adversarial training. Unlike conventional adversarial training, the proposed method could fix the hyperparameter about the number of adversarial training iterations and utilize blockwise clipping of perturbations. We carried out various experiments to verify the performance of the proposed method. As a result, we were able to confirm that the proposed method had consistent performance improvement effect on various datasets. In addition, unlike conventional adversarial training, the necessity of blockwise clipping and the hyperparameter value fixing proposed in this paper were also verified through comparative experiments.

The Effect of Preoperative Occlusion Therapy on Long-term Outcome after Surgery for Early-onset Exotropia

신광훈,Iris Naheah Kim,백혜정 대한안과학회 2017 Korean Journal of Ophthalmology Vol.31 No.3

Purpose: To investigate the effect of preoperative part-time occlusion therapy on long-term surgical successin early-onset exotropia. Methods: The medical records of patients who underwent surgery for exotropia with onset before the firstyear of age and who were followed for ≥3 years were reviewed. Patients were divided into two groups accordingto the degree of compliance with part-time occlusion therapy: the good compliance group (>50%adherence rate) and the poor compliance group (≤50% adherence rate). Surgical success was defined asorthophoria to exodeviation less than 10 prism diopters both at distance and near. The level of postoperativestereopsis was compared between the two study groups among total enrolled patients and among thosewith constant exotropia. Results: Of the 51 patients, 26 were assigned to the good compliance group and the remaining 25 patients tothe poor compliance group. The surgical success rate was significantly higher in the good compliance groupthan in the poor compliance group (80.8% vs. 52.0%, p = 0.040). Among 24 constant exotropia patients (12patients for each group), the success rate was insignificantly higher in the good compliance group than in thepoor compliance group (75.0% vs. 58.3%, p = 0.448). The good compliance group had a better level of stereopsisthan the poor compliance group (p = 0.045 for all 44 patients, p = 0.020 for 19 patients with constantexotropia). Conclusions: Preoperative part-time occlusion therapy was useful for improving the surgical outcome of early-onset exotropia and postoperative stereopsis.