농촌지역 주민의 건강관련 행위와 질병이환과의 관계

송주복,이부옥,신해림,정갑열,김준연,Song, Jue-Bok,Rhee, Boo-Ouk,Shin, Hai-Rim,Jung, Kap-Yeol,Kim, Joon-Youn 대한예방의학회 1997 Journal of Preventive Medicine and Public Health Vol.30 No.2

This research was carried out to determine the performance rate of health related practices, to measure the agreement between morbidity by doctor's diagnosis and morbidity by subject' self-reported and the degree of association between health related practices and morbidity rate by doctor's diagnosis, to identify their effects on morbidity among rural area populations. The data were gathered by volunteer residents (over the age of 20) of Haman Myeon, Haman Gun, Kyeongsangnam Do in Korea, from June 10, 1993 to June 12, 1993 (369 male and 516 female). Face to face interview, lab, chest P-A, EKG and physical examination were completed. Descriptive statistics, agreement analysis and multiple logistic regression procedures were employed for analyses. The results of the study were summarized as follows : 1) Age adjusted morbidity rates by doctor's diagnosis and self-reported were 38.5% (male:37.3%, female:36.5%), 26.4% (male:33.3%, female:27.5%), respectively. Kappa coefficient between morbidity by doctor's diagnosis and morbidity by self-reported was 0.21 (male:0.21, female:0.22). 2) The frequency of disease by doctor's diagnosis was as follows: hypertension(15.3%), gastritis (9.6%), diabetes mellitus (8.5%), live. disease (8.1%), and degenerative arthritis (6.2%) in the study population. 3) Order of health practice performance rate was as follows: Males-normal body weight (62.1%), non-heavy alcohol consumption (57.5%), 7-8 hours of sleeping (50.1%), non-smoking (21.7%), and exercise (19.8%). Females- non-heavy alcohol consumption (97.3%), non-smoking (84.7%), normal body weight (57.8%), 7-8 hours of sleeping (45.0%), and exercise (9.9%). 4) There was no significant relationship between health related practice and morbidity except exercise among health related practices. 5) Health related practice index which was recategorized by high, medium, and low had effects on the probability of developing morbidity.

이명 여부와 소음성 청력손실에 따른 변조 이음향 검사 연구

송주복,김정일,김병권,김준연 가톨릭대학산업의학센타 산업의학연구소 2003 韓國의 産業醫學 Vol.42 No.2

This study was performed to investigate the characteristics of distortion product otoacoustic emission (DPOAE) audiogram in noise exposed workers who were classified by hearing loss and noise-induced tinnitus (NIT). 7,204 noise exposed workers who had participated in noise-specific health examination in ship yard were surveyed to the tinnitus questionnaire and were conducted on the hearing threshold by pure tone audiometry. Of 7,204 noise exposed workers, 288 ears of 144 subjects selected by stratified random sampling according to hearing loss and NIT, and those were conducted on DPOAE audiogram. All examinee with known external or middle ear disorders were excluded. In DPOAE audiogram, distortion product and noise floor were elicited from L1=50 ㏈ SPL, L2=40 ㏈ SPL and F2/F1 ratio was set at 1.22. The averaged D/N ratio gram of normal hearing group was significantly different from that of high frequency hearing loss group and sensory hearing loss group. In multiple comparison test, average D/N ratio of normal hearing group was significantly different from that of high frequency hearing loss group and sensory hearing loss group at 1, 2, 4 ㎑. Significant decreases in average D/N ratio at 8000 ㎐ and averaged D/N ratio grams were observed between normal hearing group with tinnitus and normal hearing group without tinnitus(p<0.01). The data support that DPOAE audiogram of noise induced hearing loss and NIT may be useful in diagnosis and management of noise induced hearing loss and NIT noise exposed population and encourage noise exposed population to cooperate more actively in a hearing conservation program.

소음노출 근로자의 이명의 유병률과 특성

송주복,김병권,Song, Ju-Bok,Kim, Byeong-Gwon 대한산업보건협회 2002 산업보건 Vol.170 No.-

Prevalence and Characteristics of Tinnitus in Noise Exposed Workers

韓國의 財閥과 獨占問題

宋柱福 충남대학교 법경대학 경영동우회 1968 經友論集 Vol.1 No.-

부산지역 C형 간염 바이러스 genotype에 관한 역학적 연구

김인후,김정만,신해림,이명기,김준연,정갑열,김인식,서병성,신우원,양학도,허윤영,송주복 동아대학교 부설 산업의학연구소 1999 산업의학연구소 논총 Vol.- No.4

The authors investigated the distribution of Hepatitis C virus (HCV) genotype in blood donors with positive for anti-HCV (n=34), health check up examinees with positive for anti-HCV (n=29), and in patients with various chronic liver diseases positive for anti-HCV (n=63) in Pusan, Korea. HCV genotype was determined by using the molecular typing method through the reverse transcription - polymerase chain reaction (RT - PCR) with four type specific primers. Among 116 anti-HCV positive study subjects, 66.4% were positive HCV RNA by RT-PCR. The major HCV genotype was type Ⅱ (31.9%) and it was followed by type Ⅲ (27.6%). Two cases were type Ⅳ (1.7%). Double infection with two different HCV genotypes (mixed type) was found in three cases (2.6%). Three cases (2.6%) were not determined by the four type specific primers, it may have different subtype. Type Ⅱ was more prevalent than type Ⅲ in the blood donors and health check-up examinees, but the reverse was true in the chronic liver diseases patients including hepatocellular carcinoma patients, Type Ⅱ was more prevalent than type Ⅲ among the anti-HCV positive subjects with risk factors such as acupuncture history, surgical operation history, and transfusion history. In contrast type Ⅲ was more prevalent than type Ⅱ among the subjects without the above risk factors. It is supposed that the pathogenicity of different kind of HCV genotype might be different. The results of this study suggest that the type Ⅱ and type Ⅲ may be the major HCV genotype in Korea. The differences of HCV genotype distribution between the study groups support that the clinical significance according to the HCV genotype may be different.

Prevalence of Hepatitis C Virus Genotype as a Risk Factor of Hepatocellular Carcinoma in Pusan, Korea

SHIN,Hai-Rim,SONG,Jue-Bok,SHIN,Woo-Won,JUNG,Kap-Yeol 동아대학교 부설 산업의학연구소 1999 산업의학연구소 논총 Vol.- No.4

최근 노년기에 간암을 일으키는 주요원인으로 보고된 C형 간염 바이러스(Hepatitis C virus : HCV)의 각종 간질환에서의 genotype 분포와 간염의 위험요인들과의 연관성을 알아보고자 본 연구를 시행하였다. 연구대상자들은 동아대학병원 건강관리과에서 종합건강진단을 받기 위하여 내원한 검진자 중에서 anti-HCV 양성인 사람(28명), anti-HCV 양성인 헌혈자(7명) [35명, Carrier군] 및 동병원 내과에 입원하였던 만성간질환 환자들 [만성간염과 간경화증 환자 93명 (Chronic liver disease: CLD군), 간세포암 환자 78명(Hepatocellular carcinoma: HCC군)]이었다. 연구방법은 각각의 연구대상자군별로 연령 및 B형 간염 표식자, anti-HCV 양성률을 비교하였으며, 또한 간질환의 위험요인의 양성률의 차이를 비교하였다. 전제 anti-HCV 양성인 연구대상자 중에서 40명의 혈청에서 genotyping ELISA방법으로 HCV genotype을 조사하였다. CLD군과 HCC군 모두에서 anti-HCV 음성인 경우 anti-HCV 양성인 환자들에 비해 HBsAg 양성률이 높았으며, anti-HBs 양성률은 더 낮았다. HBsAg 양성인 환자들의 평균 연령은 CLD군 43.8세, HCC군에 53.4세로 anti-HCV 양성인 환자들의 평균연령보다 낮았다 (CLD군 49.6세, HCC군 62.8세). 간 질환의 위험요인이라고 알려진 과거 수술력, 수혈력, 침을 맞은 과거력들은 Carrier, CLD, HCC군 모두에서 유의한 차이가 없었다. 40명의 anti-HCV 양성인 사람들을 대상으로 HCV genotype을 조사한 결과 SG-1 type이 47.5%로 가장 많았으며, SG-2 type은 35.0%였다. SG-1/2 type은 7.5%, SG-ud는 10.0%를 차지하였다. 이들에 대해서는 polymerase chain reaction, HCV RNA sequencing 등을 통한 분석이 더 필요하다고 하겠다. 위의 결과들을 종합하면 만성간염, 간경화에서 간세포암으로의 진행에 유의한 영향을 미치는 요인은 연령이라고 할 수 있으며, 부산지역의 C형 간염 바이러스 중에서 SG-1형이 가장 많았다. 앞으로 간염 표식자들이 양성인 사람들에 있어서는 정기적인 추적조사로 간세포암으로의 진행을 조기 발견하도록 하여야 할 것이며, HCV genotype과 간세포암과의 관계에 대해서는 더 많은 연구가 있어야 할 것이다. The epidemiologic study was conducted to determine the hepatitis C virus(HCV) genotype and to evaluate the association of known risk factors and chronic liver diseases in Pusan, Korea. The blood donors(n=7) and health check-up examinees(n=28) with positive anti-HCV were recruited as carrier group(carrier, n=35). Those who took anti-HCV test(ELISA, Lucky HCD 3.0) among in patients from September, 1995 at December, 1996 at Dong-A University Hospital were divided into chronic liver disease group(CLD, n=93) and hepatocellular carcinoma group(HCC, n=78). Among anti-HCV negative subjects, the hepatitis B surface antigen(HBsAg) positive rates(73.7% in CLD, 80.0% in HCC) were higher than those of anti-HCV positive subjects(11.4% in CLD, 7.1% in HCC). The average age was younger in HBsAg positive cases(43.8 years in CLD, 53.4 years in HCC) than in anti-HCV positive cases(49.6 years in CLD, 62.8 years in HCC) The Positive rates of past histories of surgical operation, acupuncture, and transfusion among anti-HCV positive cases were higher than those of negative cases(p<0.01). Most prevalent HCV genotype tested by genotyping ELISA was SG-1(47.5%). The mean ages of each HCV genotype were not significantly different (p>0.05). Most prevalent risk factor among each HCV genotype was acupuncture history. From this study, HCV genotype SG-1 was found to predominate in Korean patients with type C hepatitis. There were no significant association between the risk factors and HCV genotype. More research to evaluate the HCV genotype and the role of liver diseases, especially of the hepatocellular carcinoma are needed.

錦江産 Zacco Platypus 에 對한 Metagonimus 吸蟲 被囊幼蟲에 關한 調査硏究

金鍾煥,宋柱福 충남대학교 자연과학연구소 1980 學術硏究誌 Vol.7 No.2

A. Zacco platypus was caught from three localities in Gum River and the metacercariae of Metagoniums yokogawai were isolated from the fish. The rate of metacercarial infection showed 70.4 per cent among 54 fish examined. The prevalence rates of the fish were 93.3~100 per cent at the both areas Jeogok-Ri and Sintanjin, otherwise the rate was only 21.1 per cent at Dae-hak-Ri. The larger fish and the female had the higher rates of the metacercarial infections than the smaller one and the male. B. The distribution rates of metacercaria in the fish was observed the following order. on the scale: 77.1%, in the muscle and fin:18.7%, the head part:2.9%, and the intestine and visceral organs. 1.3%, respectively. C. The shape of metacercaria was oval or spherical form, and 150.3μ in length, 1404μ in width and 2.0μ in the thickness of the cyst wall D. Tne adult worms which were experimentally infected to the mouse host were observed The morphological character of worms were the eccentric position of the ventral sucker, which was located about half way between the anterior and posterior ends of the body but to the right of the midline

농촌지역의 B형, C형 간염에 관한 혈청역학적 연구

신해림,김준연,송주복,서병성,김정만,이부옥,김수량,양무관,이채언,전진호,유근영,안윤옥,Shin, Hai-Rim,Kim, Joon-Youn,Song, Jue-Bok,Suh, Byung-Seong,Kim, Jung-Man,Lee, Bu-Ok,Kim, Su-Yang,Ryang, Mu-Guan,Lee, Chae-Un,Chun, Jin-Ho,Yoo, Keun-You 대한예방의학회 1997 Journal of Preventive Medicine and Public Health Vol.30 No.1

To estimate the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection and to determine associated risk factors, a population-based seroepidemiologic study was carried out. In 1993, a health examination survey of the population was carried out in rural area known to have a high incidence of liver cancer. The study population were those who volunteered to participate in a health survey over 10 years of age. Examinees were interviewed by specially trained staffs. Sera from 1,033 study subjects were tested for hepatitis B surface antigen (HBsAg) by .everse passive hemagglutinin (RPHA) estimation and for hepatitis C virus antibody (anti-HCV) by 2nd generation passive hemagglutinin (PHA) estimation. The age and sex standardized prevalence of HBsAg was 6.3% which was similar to national average, but that of anti-HCV was 5.1% which was 4 to 5 times higher than that of blood donors or other health examinees in Korea. In a multivariate analysis, transfusion history, surgical operative history, and acupuncture history were not associated with HBsAg positivity. In contrast, acupuncture history (adjusted odds ratio[OR]=2.2 : 95% Confidence interval[CI] 1.0-4.7) and surgical operative history(adjusted OR=2.0 : 95% CI 1.0-4.1) were associated with anti-HCV positivity. The present study suggest that there is an highly endemic area of HCV infection in Korea and probably this endemicity is associated with a parenteral source of HCV infection other than blood transfusion.