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Identification of Inhibitors Against BAK Pore Formation using an Improved in vitro Assay System
송승수,이원규,Sreevidya Aluvila,오경준,유연규 대한화학회 2014 Bulletin of the Korean Chemical Society Vol.35 No.2
The pro-apoptotic BCL-2 family protein BID activates BAK and/or BAX, which form oligomeric pores in the mitochondrial outer membrane. This results in the release of cytochrome c into the cytoplasm, initiating the apoptotic cascade. Here, we utilized liposomes encapsulating sulfo-rhodamine at a controlled temperature to improve upon a previously reported assay system with enhanced sensitivity and specificity for measuring membrane permeabilization by BID-dependent BAK activation. BAK activation was inhibited by BCL-XL protein but not by a mutant protein with impaired anti-apoptotic activity. With the assay system, we screened a chemical library and identified several compounds including trifluoperazine, a mitochondrial apoptosisinduced channel blocker. It inhibited BAK activation by direct binding to BAK and blocking the oligomerization of BAK.
입자크기와 열처리 분위기 변화에 따른 Y-TZP에서의 상안정성 변화
정태주,안승수,송은화,오경식,이종숙,김영식,Chung, Tai-Joo,Ahn, Seung-Su,Song, Eun-Wha,Oh, Kyung-Sik,Lee, Jong-Sook,Kim, Young-Sik 한국분말야금학회 2006 한국분말재료학회지 (KPMI) Vol.13 No.5
The phase stability of tetragonal phase in Y-TZP was investigated in terms of the distribution of grain sizes and heat-treating atmosphere. Y-TZP with various grain sizes were prepared using duration time at $1600^{\circ}C$ as experimental parameter. Accumulated grain size distributions were built from the SEM micrographs and the amount of tetragonal phase were measured using XRD. Both results were compared to determine the critical grain size before and after heat-treatment in vacuum. The critical grain size drastically decreased compared with the small increase of average grain size due to the autocatalytic effect which critically affects the tetragonal to monoclinic phase transformation. After heat-treatment in reductive atmosphere critical grain size relatively increased due to the stabilization of tetragonal phase. The formation of oxygen vacancies during heat-treatment was ascribed to the increase of stability.