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손태윤,이종환,정병조 한국광학회 2013 Current Optics and Photonics Vol.17 No.1
Various methods have been proposed for enhancing the contrast of laser speckle contrast image (LSCI)in subcutaneous blood flow measurements. However, the LSCI still suffers from low image contrast due to tissue turbidity. Herein, a physicochemical tissue optical clearing (PCTOC) method was employed to enhance the contrast of LSCI. Ex vivo and in vivo experiments were performed with porcine skin samples and male ICR mice, respectively. The ex vivo LSCIs were obtained before and 90 min after the application of the PCTOC and in vivo LSCIs were obtained for 60 min after the application of the PCTOC. In order to obtain the skin recovery images, saline was applied for 30 min after the application of the PCTOC was completed. The visible appearance of the tubing under ex vivo samples and the in vivo vasculature gradually enhanced over time. The LSCI increased as a function of time after the application of the PCTOC in both ex vivo and in vivo experiments, and properly recovered to initial conditions after the application of saline in the in vivo experiment. The LSCI combined with the PCTOC was greatly enhanced even in deep vasculature. It is expected that similar results will be obtained in in vivo human studies.
Intense Pulsed Light의 안전성 및 성능평가를 위한 시험 항목 및 시험방법(안) 연구
강동연,손태윤,주예일,최응호,정병조,Kang, Dong-Yeon,Son, Tae-Yoon,Joo, Yea-Il,Choi, Eung-Ho,Jung, Byung-Jo 대한의용생체공학회 2010 의공학회지 Vol.31 No.2
Intense pulsed light(IPL) is a photo-therapeutic medical device using xenon lamps with optical characteristics of incoherence, defocusing, and polychromatic. IPL has been recognized as a representative medical therapeutic device with growth of domestic skin care market. However, there is no standard regulation manual and guideline to evaluate the safety and performance of IPL. International Electrotechnical Commission(IEC) is being statued "Technical Report IEC TR 60825-16" which is a guidelines for the safe use of intense light source equipment on humans and animals. In this study, a standard Korea Food & Drug Administration (KFDA) regulation for the safety and performance of IPL was suggested by developing minimal evaluation methods for optical parameters of IPL such as output energy density, pulse mode, spot size, wavelength and uniformity of output light. We expect that this study may be a step to statue a standard regulation manual and guideline for IPLs used in domestic.
생체조직 내 레이저 투과 광 밀도 개선을 위한 음압 저출력 레이저 프로브 개발
황성업,허현,손태윤,이경중 대한전기학회 2010 대한전기학회 학술대회 논문집 Vol.2010 No.10
In this paper, we propose a probe that use minus pressure. This probe enhances transmission and absorption of laser energy. This probe use a cup that use minus pressure. Minus pressure increases density of soft tissue, then path that laser modules to acupoint will be short and absorption of laser will increase. We acquired image of transmitted laser diffusion from pork skin by using CCD to confirm enhancement of laser absorption. In result, we confirmed improvement of laser absorption and possibility of laser density control.
생체조직내 레이저 광 밀도 향상을 위한 압력 인가형 저출력 레이저 프로브
여창민,박정환,손태윤,이용흠,정병조,Yeo, Chang-Min,Park, Jung-Hwan,Son, Tae-Yoon,Lee, Yong-Heum,Jung, Byung-Jo 대한의용생체공학회 2009 의공학회지 Vol.30 No.1
Laser has been widely used in various fields of medicine. Recently, noninvasive low-level laser therapeutic medical devices have been introduced in market. However, low-level laser cannot deliver enough photon density to expect positive therapeutic results in deep tissue layer due to the light scattering property in tissue. In order to overcome the limitation, this study was aimed to develop a negative pressure applied low-level laser probe to optimize laser transmission pattern and therefore, to improve photon density in soft tissue. In order to evaluate the possibility of clinical application of the developed laser probe, ex-vivo experiments were performed with porcine skin samples and laser transmissions were quantitatively measured as a function of tissue compression. The laser probe has an air suction hole to apply negative pressure to skin, a transparent plastic body to observe variations of tissue, and a small metallic optical fiber guide to support the optical fiber when negative pressure was applied. By applying negative pressure to the laser probe, the porcine skin under the metallic optical fiber guide is compressed down and, at the same time, low-level laser is emitted into the skin. Finally, the diffusion images of laser in the sample were acquired by a CCD camera and analyzed. Compared to the peak intensity without the compression, the peak intensity of laser increased about $2{\sim}2.5$ times and FWHM decreased about $1.67{\sim}2.85$ times. In addition, the laser peak intensity was positively and linearly increased as a function of compression. In conclusion, we verified that the developed low-level laser probe can control the photon density in tissue by applying compression, and therefore, its potential for clinical applications.
여창민(Changmin Yeo),손태윤(Taeyoon Son),정병조(Byungjo Jung) 대한전기학회 2008 대한전기학회 학술대회 논문집 Vol.2008 No.10
Laser has been applied in various diagnostic and therapeutic medical fields. For last few decades, medical low level laser devices have been introduced in market, but they have limitations which cannot convey enough energy to deep layer of tissues for diagnostic or therapeutic purposes. To address the issue, there have been many studies of using physical and chemical methods; it is one of ways to apply negative or positive pressure to tissue. However, it is hard to apply desired pressure on tissues continuously when practical laser devices are used. In this study, we introduce a low-level laser probe which allows maintain pressure on skin tissue. Consequently, we arc confident that the pressure probe for low-level laser treatment should be a useful tool in order to deliver sufficient energy for practical uses.
생체조직 내 레이저 투과 광 밀도 개선을 위한 음압 저출력 레이저 프로브 개발
황성업(Seong up Hwang),허현(Hyun Heo),손태윤(Tae yoon Son),이경중(Kyoung joung Lee) 대한전기학회 2010 정보 및 제어 심포지엄 논문집 Vol.2010 No.10
In this paper, we propose a probe that use minus pressure. This probe enhances transmission and absorption of laser energy. This probe use a cup that use minus pressure. Minus pressure increases density of soft tissue, then path that laser module to acupoint will be short and absorption of laser will increase. We acquired image of transmitted laser diffusion from pork skin by using CCD to confirm enhancement of laser absorption. In result, we confirmed improvement of laser absorption and possibility of laser density control.