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성연은,조의주,이교영 대한병리학회 2020 Journal of Pathology and Translational Medicine Vol.54 No.4
Background: Squamous cell carcinomas (SqCCs) of the lung are known to arise more often in a central area but reports of peripheral SqCCs have increased, with a pathogenesis that is obscured. In this study, the clinicopathologic characteristics of peripheral lung SqCCs were studied and compared with those of the central type. Methods: This study included 63 peripheral lung SqCCs and 48 randomly selected central cases; hematoxylin and eosin-stained slides of surgically resected specimens were reviewed in conjunction with radiologic images and clinical history. Cytokeratin-7 immunohistochemical staining of key slides and epidermal growth factor receptor (EGFR)/KRAS mutations tested by DNA sequencing were also included. Results: Stages of peripheral SqCCs were significantly lower than central SqCCs (p = .016). Cystic change of the mass (p = .007), presence of interstitial fibrosis (p = 0.007), and anthracosis (p = .049) in the background lung were significantly associated with the peripheral type. Cytokeratin-7 positivity was also higher in peripheral SqCCs with cutoffs of both 10% and 50% (p = .011). Pathogenic mutations in EGFR and KRAS were observed in only one case out of the 72 evaluated. The Cox proportional hazard model indicated a significantly better disease-free survival (p = .009) and the tendency of better overall survival (p = .106) in the peripheral type. Conclusions: In peripheral type, lower stage is a favorable factor for survival but more frequent interstitial fibrosis and older age are unfavorable factors. Multivariate Cox analysis revealed that peripheral type is associated with better disease-free survival. The pathogenesis of peripheral lung SqCCs needs further investigation, together with consideration of the background lung conditions.
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성연은,이교영,이진국 대한병리학회 2017 Journal of Pathology and Translational Medicine Vol.51 No.1
Angioleiomyoma is a rare disease that is histologically characterized by smooth muscle cells arranged around vascular spaces. Although angioleiomyomas occur rarely in the head and neck region, they can cause various symptoms according the site involved. Here, we present a 44-year-old male patient with a 15-year history of asthma, who presented with recent onset of chest discomfort,globus sensation and throat pain. Medication was not effective in relieving his symptoms, and further evaluation revealed a polypoid ovoid mass, almost obstructing the airway at the border of the larynx and upper trachea on chest computed tomography. The mass was completely resected via a rigid bronchoscopy procedure. Histopathologic examination revealed that the excised mass was angioleiomyoma, which was immunohistochemically positive for smooth muscle actin and negative for desmin.
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성연은,기은영,이연수,허수영,이아원,박종섭 대한부인종양학회 2016 Journal of Gynecologic Oncology Vol.27 No.6
Objective: Infection with high-risk genotypes of human papillomavirus (HR-HPV) is themajor cause of invasive cervical cancers. HPV-16 and HPV-18 are known to be responsiblefor two-thirds of all invasive cervical carcinomas, followed by HPV-45, -31, and -33. Current guidelines only differentiate HPV-16/18 (+) by recommending direct colposcopy fortreatment. We tried to evaluate whether there are differences in risk among 12 non-16/18 HRHPVgenotypes in this study. Methods: The pathology archive database records of 1,102 consecutive gynecologic patients,who had results for cervical cytology and histology and for HPV testing, as determined byHPV 9G DNA chip, were reviewed. Results: Among the 1,102 patients, 346 were non-16/18 HR-HPV (+) and 231 were HPV-16/18(+). We calculated the odds ratios for ≥cervical intraepithelial neoplasia 2 (CIN 2) of 14groups of each HR-HPV genotype compared with a group of HR-HPV (−) patients. Based onthe odds ratio of each genotype, we divided patients with non-16/18 HR-HPV genotypes (+)into two groups: HPV-31/33/35/45/52/58 (+) and HPV-39/51/56/59/66/68 (+). The age-adjustedodds ratios for ≥CIN 2 of the HPV-31/33/35/45/52/58 (+) and HPV-39/51/56/59/66/68 (+) groupscompared with a HR-HPV (−) group were 11.9 (95% CI, 7.6 to 18.8; p<0.001) and 2.4 (95% CI,1.4 to 4.3; p<0.001), respectively, while that of the HPV-16/18 (+) group was 18.1 (95% CI, 11.6to 28.3; p=0.003). Conclusion: The 12 non-16/18 HR-HPV genotypes can be further categorized (HPV-31/33/35/45/52/58 vs. HPV-39/51/56/59/66/68) by risk stratification. The HPV-31/33/35/45/52/58genotypes might need more aggressive action. Large scale clinical trials or cohort studies arenecessary to confirm our suggestion.
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췌장소도세포에서 인지질분해산물에 의한 Guanine Nucleotide 결합단백질 활성의 조절
성연아(Yeon Ah Sung),경난호(Nan Ho Kyung) 대한내과학회 1995 대한내과학회지 Vol.49 No.1
N/A Objectives: Physiologic secretagogues of insulin, such as glucose, work via the generation of soluble mediators. One group of such mediators consists of phospholipid hydrolytic products generated by phospholipases A2 and D endogenous to pancreatic islets. Experimental data also suggest that some of these lipid second messengers may regulate the function of certain G-protein in different cell types, such as brain cells and neutrophils. Based on the available in- formation on the potential regulator properties of G-protein function by these lipids and their purported role in insulin secretion, we undertook the present investigation to determine whether the functional properties of G-proteins, are regulated by these lipids in normal pancreatic islets. Methods: After isolation and subcellular fractionation of normal rat pancreatic islets, we measured the effects of phospholilpid hydrolytic products (arachidonic acid, lysophospholipids, phosphatidic acid) on GTP binding, GTPase activity, and GDP/GTP exchange activity in each subcellular fractions Results: 1) Arachidonic acid and lysophospholipids(lysophosphatidylcholine or lysophosphatidylinositol) inhibited GTPase activity in all of the subcellular fractions of normal rat pancreatic islets, but phosphatidic acid inhibited GTPase activity in plasma membrane and cytosol. 2) Arachidonic acid, lysophosphatidylcholine and phosphatidic acid increased the GTP binding and GDP/GTP exchange activity in normal rat pancreatic islets. Conclusion: Insulinotropic lipids regulate the activity of G-protein in a manner that would pro- mote the maintenance of G-proteins in their active (GTP bound) configuration.
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양성 단일 갑상선결절의 L - Thyroxine 억제요법
성연아(Yeon Ah Sung),경난호(Nan Ho Kyung) 대한내과학회 1991 대한내과학회지 Vol.41 No.6
N/A Clinically apparent thyroid nodule is a very common disease in adults and patients with benign solitary thyroid nodules on aspiration biopsy often treated nonsurgically. We investigated the efficacy of thyroxine sup pressive therapy and the hormonal characteristics during thyroxine therapy to findout whether such measurements could be used to determine the effectiveness of this therapy in patients with benign solitary thyroid nodule proved by aspiration biopsy. Fifty-two patients were randomized to receive the L-thyroxine treatment (group I, n=28) or a placebo (group II, n=24). High resolution ultrasonography was used to measure the size of the nodules before and after treatment. The dose of thyroxine was adjusted until the TRH test was negative. Patients were followed at 3- month intervals. The results were as follows: 1) Twelve (42.9%) out of 28 Group I patients after adequate TSH suppression and 6 (25.0%) out of 24 Group II patients after 3 months had a reduction of nodule size, and before-to after nodule volume ratios were not significantly different between the Group I and Group II patients. 2) In 15-month follow-up periods, the nodule volume decrement was larger in Group I than Group II, but there was no statistical significance. 3) In the responders among Group I patients, the before-to-after therapy ratio of thyroglobulin was significantly higher than in the nonresponder. 4) In the responders among the Group I patients, the before-to-after therapy ratio of the nodule volume was not related to the pretreatment nodule size or thyroid hormone and thyroglobulin levels. Thus we concluded that an adequate suppressive dose of L-thyroxin did not alter the natural course of the benign solitrry thyroid nodules, and serum thyroglobulin measurements may prove a useful indicator of the efficacy of thyroxine therapy.
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성연아 대한내분비학회 2011 Endocrinology and metabolism Vol.26 No.3
Polycystic ovary syndrome (PCOS) is a common disorder of premenopausal women, affecting 4 to 8% of this population. Diagnosis of PCOS lays on a combination of clinical, biological and ultrasound criteria that has been used variably worldwide. The phenotype of women with PCOS is variable depending on ethnic background and diagnostic criteria may rely on it. Fewer studies have extensively examined reproductive and metabolic characteristics and hyperandrogenism in Korean women. Despite the paucity of these studies, they are critical for the ascertainment of criteria for the diagnosis of PCOS. This review address the issues pertaining to diagnostic issues of PCOS in Korean women, specifically: reproductive and metabolic derangements and criteria for hyperandrogenism based on hirsutism and serum androgen concentrations. The prevalence (estimated) of PCOS in Korean women was 5.8%. To diagnose PCOS, the cut off value for hirsutism needs to be differently adjusted in Korean women. Regarding phenotypic characteristics of PCOS in Korean women, the various phenotypes of PCOS have the different overall morbidity (e.g. insulin resistance and hyperinsulinism,abnormal glucose metabolism and metabolic syndrome). Especially patients with oligomenorrhea/polycystic ovary and hyperandrogenism/polycystic ovary did not seem to have metabolic derangements. Thus these subgroups need to be determined if they can be classified as PCOS.
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