Rituximab으로 치료한 불응성 특발성혈소판감소성자반증 1예

서석민,임창훈,최선욱,김희제,이종욱,민우성,김춘추 대한내과학회 2005 대한내과학회지 Vol.69 No.5S

Deoxyribonucleic Acid Copy Number Aberrations in Vasospastic Angina Patients Using an Array Comparative Genomic Hybridization

서석민,고윤석,정해억,최진수,김범준,백상홍,윤호중,이권행,승기배 대한심장학회 2011 Korean Circulation Journal Vol.41 No.7

Background and Objectives: Vasospastic angina (VA) is a specific type of coronary artery disease and develops as a result of coronary artery spasm. Recently, a few studies have revealed that VA caused by coronary artery spasm is related to genetic traits. The objective of this study was to use the recently developed technique of array comparative genomic hybridization (CGH) to screen the genetic aberrations of VA. Subjects and Methods: To identify candidate genes that might be causally involved in the pathogenesis of VA, genomic deoxyribonucleic acids were extracted from whole blood of 28 patients with VA who presented at Department of Cardiology at Seoul St. Mary’s Hospital, Seoul, Korea. The copy number profiles of these patients was then analyzed using array CGH and reverse transcriptase (RT) quantitative polymerase chain reaction (PCR). Results: Array CGH revealed gains in 31 different regions, with losses in the 4q35.2, 7q22.1, 10q26.3, 15q11.2, 16p13.11, 17p11.2 and 19q13.3 regions (more than 32% aberration in these regions). Several loci were found to be frequently including gains of 5p and 11q (50% of samples). The most common losses were found in 7q (54% of samples). Copy number aberrations in chromosomal regions were detected and corresponding genes were confirmed by RT quantitative PCR. The fold change levels were highest in the CTDP1 (18q23), HDAC10 (22q13.33), KCNQ1 (11p15.5-p15.4), NINJ2 (12p13.33), NOTCH2 (1p12-p11.2), PCSK6 (15q26.3), SDHA (5p15.33), and MUC17 (7q22.1) genes. Conclusion: Many candidate chromosomal regions that might be related to the pathogenesis of VA were detected by array CGH and should be systematically investigated to establish the causative and specific genes for VA.

데스크 서비스 문화상품 디자인 개발 연구 - 하회탈을 모티브로한 문화상품 디자인을 중심으로 -

서석민,신랑호,Seo, Seok-Min,Shin, Rang-Ho 한국가구학회 2007 한국가구학회지 Vol.18 No.3

21 Century is said the age of cultural industry. In this cultural Industry one of very important factors which guides this times is the exploitation of cultural goods, which is based on regional identity. Therefore, at this point of time when its weighty has been raised, the aim of this study is to fill the image Korean tradition and modernity culture in them, through the search on their characteristics among regions and nations, desk the cultural service goods which gets survival power of traditional and cultural identity. Nine existing Hahoe masks are changed into nine new cultural items, which are presented the nine dreams of Hahoe masks. As consumer's choice is diversified by a set of products, main concept in this study is the focus on modernity, rationality, traditionality and popularity. The main concept of this study is on rational functions and convenience, the harmony of tradition and modernity. As said above, in the process of manufacture the mass production of goods is stressed, and by getting the composition and making a set of goods, the choice of consumers will be extended. Getting ideal globalization by the coexistence of tradition and modernity on goods, is very important. Consequently, cultural goods must be recognized as a factor of its medium, and also, on domestic cultural goods people's interest must be risen all the more.

선국정치시대의 당-군 관계 연구: 핵심 엘리트의 위상 변화를 중심으로

서석민 서강대학교 사회과학연구소 2007 社會科學硏究 Vol.15 No.1

The Study of Party-military Relations in the Military-first era of North Korea Suh, Seok-Min The purpose of this study is to reexamine party-military relations in the ‘military-first era’ of North Korea with a focus on the power change of core elites. Under the contemporary policy, the power of military has been remarkably intensified. In addition, we can easily verify that the position of military elite group has been considerably promoted to a higher rank. Nevertheless, this study finds it necessary to analyze whether the reinforcement in the military group really affects a reversion in the party-military relations as had been noted by preceding studies. Therefore the analysis was focused on the following: 1) the degree of control by party organs within the military circles; 2) the status and role of KWP elites among military authorities; and equally important, 3) the degree of control by military organs within the party; and 4) the status and role of military personnels in the party. Also an important factor was the changing ratio between the two groups at on-the-spot guidance and banquets of brain trusters. Analysis on the aforementioned criteria was based on a method different from previous studies. It was conducted with a more detailed and strict classification of the categories of the party and military groups. As a result, this study found that the party still remains in a superior position compared to the military group in spite of the military-first policy which has been deemed as a unique ideology belonging to the Kim Jong il era. In order to cope with urgent adversities at home and abroad, North Korea put forward its military allowing the rise of military elites to be distinctively observed. However, in conclusion, this should not be interpreted as a power shift from the party to the military group. 이 논문의 목적은 선군정치 시대의 당-군 관계를 핵심 엘리트의 위상 변화에 비중을 두고 재조명하는 데 있다. 선군시대에서 군의 위상이 강화된 것과 같이 군의 핵심 엘리트의 위상 또한 강화된 것을 알 수 있다. 하지만 이런 핵심 엘리트의 위상 강화가 기존 연구들이 주장하는 당-군 관계의 변화를 불러올 만큼의 영향력이 큰 것인지에 대해서 문제의식을 가지고 재분석을 시도했다. 분석 대상은 군내 당 조직에 의한 군 통제와 핵심 엘리트의 존재 및 역할, 당내 군 조직에 의한 통제와 핵심 엘리트의 존재 및 역할, 그리고 현지지도와 측근연회에 나타난 당과 군의 핵심 엘리트 비율 등이다. 이에 대한 분석에서는 기존의 분석 기준과는 다르게 당과 군의 핵심 엘리트를 보다 엄격히 분류하여 그 변화를 살펴보았다. 그 결과는 기존과 다른 점을 보였는데, 당-군 관계에서 당이 여전히 우위에 있음을 보여주었다. 결국 북한이 급박한 국내외적인 상황 변화에 대응하기 위해 선군을 내세움으로써 군 핵심 엘리트의 위상이 강화되기는 했지만 그것이 당-군 관계의 변화를 가져오지는 못했음을 의미한다.

조선시대 가구 주문자와 생산자의 상호관계성

서석민(Seok Min Seo),김명태(Myeong Tae Kim) 한국가구학회 2015 한국가구학회지 Vol.26 No.3

This study is a review on the relationship between furniture purchasers and producers in the Joseon period. Understanding the relationships in our traditional spirit and the Joseon furniture that reflects a aesthetic sense is a meaningful work. Joseon was to build an ideal country which put emphasis on the order and harmony through Theory of ‘Yeak’ as the confucianism nation. Human aesthetics, which emphasis on the spiritual value by confirmity to nature and forcus on the relaxed, deficient personality rather than completeness was established as the central formative consciousness of the Joseon Dynasty. The nature of things in the confucian scholar prior to the representations of things is expressed in the form of master craftsman’s skill and soul. Formative consciousness of the confucian scholar is to realize ideals by communciation and interchange with master craftsman’s soul in the form of the Joseon furniture. The beauty of restraint and brevity in the Joseon Dynasty furniture includes meanings and procedures of art work. It implies an orderer’s purpose of production and a producer’s products. Understanding the spirit of times in the production becomes the cornerstone capable of getting closer to the furniture ultimate proper function. These problems have a very close relationship with the problems of modern people’s commnuication. We expect an even higher growth of the furniture by achieving more improved communication based on the consumer’s great insight and the producer’s passion.

풍수와 실내⋅가구 코디네이션

서석민(Seok Min Seo),김명태(Myeong Tae Kim) 한국가구학회 2012 한국가구학회지 Vol.23 No.3

Geomancy accepts with a pre-requisite that human beings adapt themselves to nature as an organism, because people and environment, bodies and space have the homogeneity which can not be divided by a dichotomy. The homogeneity as a structure alive implies a deep relationship with biorhythm and the change of space, and is regarded as a concept and role significant on the coordination. In other words, applying the element in the geomancy could be interpreted as a work giving a new meaning and spirit on a creation of space and furniture coordination. Harmony and balance shown in design concepts have a relationship with the meaning on Yin-Yang and the Five Elements theory. In addition, the characteristic in each element is suggested as an example applying the concept of geomancy through furniture coordination for each space in the chapter 4.

발전용 SOFC 열교환기 열유동 및 열전달 성능 특성 연구

서석민(Seo Sukmin),박소연(Park Soyeon),조형진(Jo Hyungjin),Mai Van Trung,Nguyen Thanh Phuong,권재일,박찬우(Chan Woo Park) 대한기계학회 2023 대한기계학회 춘추학술대회 Vol.2023 No.11

회전류 생성 난류 발생기를 적용한 진공관형 태양열 매니폴드의 성능 특성 연구

서석민(Suk Min Seo),노세현(Se Hyeon Noh),이민성(Min Sung Lee),박찬우(Chan Woo Park) 대한설비공학회 2022 대한설비공학회 학술발표대회논문집 Vol.2022 No.11

The purpose of this study is increasing the efficiency of the solar collectors heat transfer rate. By inserting the turbulence generator into manifold in the solar collector, compare the heat transfer rate of with or without the turbulence generator and analyze. The main idea is increasing heat transfer rate without changing any other variable, except pressure difference by inserting the turbulence generator.

산업제품 설계자의 안전의식 요인과 가구디자인 조형 및 제품가치의 상관관계분석

서석민(Seok min Seo) 한국가구학회 2018 한국가구학회지 Vol.29 No.2

As the economy of the furniture market grows, there are few deaths among children. Thus, awareness for eliminating the risk of design products is improved, and ergonomic aspects are required in design. In particular, product safety is the most important factor in the initial design process because it is difficult to correct and supplement in the production process. According to the Korea Occupational Safety and Health Agency, the higher the safety consciousness, the higher the safety because it can predict and prevent accidents. The safety of the product is inseparable from the practice of ergonomics in terms of safety consciousness of the designer. In this study, we surveyed the designers of industrial product design in Korea and measured the safety consciousness scale. The research hypotheses were set up to clarify the relationship between design influence and safety consciousness on product design. In order to verify the research hypothesis, the correlation between the safety consciousness of the industrial product designer and the office furniture design was analyzed. Based on the results of the correlation analysis, the safety factors related to the mutual relationship were searched and the improvement directions according to the consumer ’s connection with the design were suggested. And it can be used as a utilization data of design safety design by suggesting a complementary point of mutual consciousness.

국내산 소나무 슬라이스 기법을 통한 조명디자인 개발연구

서석민(Seok Min Seo),김정호(Chung Ho Kim) 한국가구학회 2011 한국가구학회지 Vol.22 No.4

This study aims to find new solutions to the problem of utilization of materials and techniques represented in the development of modern lighting design. LED is an important component in modern lighting design and pine tree is one of the most popular domestic wood in furniture design in Korea. In this study, design is developed into various types of furniture such as a table, a chest, and a lighting, by researching manufacturing process and examining the use of slicing pine tree. The technique of slicing pine tree is a simple linear arrangement that was traditionally used in wooden furniture in Lee dynasty, with an emphasis on repetitive rhythm. The slicing technology is used to expand the usage of domestic pine tree. The beauty of natural wood is expressed with the transmission of light by applying this technique to the lighting design. It also brings new communication in between artificial lighting and natural wood combining this traditional technique and LED lighting in design. Finally, this study suggests particular value through the convergence of analog and digital by using the traditional wooden technique that keeps natural wood prints and new digital technology by using LED lighting. More discussions and research about this subject are expected continuously through this study.