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실험연구 : 백서 피질 신경원 혼합배양 모델에서 α-amino-5-methyl-4-isoxazolepropionate로 유도된 뇌독성에 대한 Propofol의 효과
서명신 ( Myoung Sin Seo ),박성용 ( Sung Yong Park ),김계숙 ( Kye Sook Kim ),문봉기 ( Bong Ki Moon ),김진수 ( Jin Soo Kim ),이숙영 ( Sook Young Lee ) 대한마취과학회 2008 Korean Journal of Anesthesiology Vol.55 No.5
Background: The pattern of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-mediated neurotoxicity (necrosis vs apoptosis) and the neuroprotective effect of propofol on AMPA-mediated neurotoxicity are still unclear. Methods: Thirteen-day-old primary rat mixed cortical cultures were used. To measure the neuroprotective effect of propofol, AMPA (50 μM), AMPA (50 μM) plus propofol (0.1, 1, 25, 50 μM), AMPA (50 μM) plus DMSO, propofol (50 μM) and DMSO were administered (n=45). Seventy-two h later, surviving cells were counted using trypan blue staining and were converted to cell death rate (CDR). To measure the effect of propofol (50 μM) on AMPA (50 μM)-induced apoptosis, a triple stain was done. In a fixed field (×400), the number of neuronal cells stained by neuronal nuclei (NeuN) and Hoechst staining and apoptotic cells stained by terminal deoxynucleotidyl transferase mediated dUTP nick-end-labeling (TUNEL) assays were counted. Apoptotic cell rates (ACR) were also calculated. Statistical analyses were performed using one way-analysis of variance followed by Bonferroni`s test. P<0.05 was considered statistically significant. Results: AMPA (50 μM) stimulation demonstrated 49.3% CDR, and adding propofol 50 μM decreased CDR to 29.4% (P<0.05). In the TUNEL assay, cells with no drug treatment demonstrated 12.3% ACR and 50 μM AMPA increased ACR to28% (P<0.05). Adding 50 μM propofol to AMPA decreased the ACR to 20.1% (P<0.05). Conclusions: Propofol (50 μM) had neuroprotective effects against AMPA (50 μM)-induced cell death by reducing apoptosis. (Korean J Anesthesiol 2008;55:607~12)
작물모형의 생물계절 및 잠재수량 예측력 개선 방법 탐색: I. 유전 모수 정보 향상으로 콩의 개화시기 및 잠재수량 예측력 향상이 가능한가?
정유란,신 평,서명철 한국농림기상학회 2017 한국농림기상학회지 Vol.19 No.4
There are two references of genetic information in Korean soybean cultivar. This study suggested that the new seven genetic information to supplement the uncertainty on prediction of potential yield of two references in soybean, and assessed the availability of two references and seven genetic information for future research. We carried out evaluate the prediction on flowering time and potential yield of the two references of genetic parameters and the new seven genetic parameters(New1∼New7); the new seven genetic parameters were calibrated in Jinju, Suwon, Chuncheon during 2003-2006. As a result, in the individual and regional combination genetic parameters, the statistical indicators of the genetic parameters of the each site or the genetic parameters of the participating stations showed improved results, but did not significant. In Daegu, Miryang, and Jeonju, the predictability on flowering time of genetic parameters of New7 was not improved than that of two references. However, the genetic parameters of New7 showed improvement of predictability on potential yield. No predictability on flowering time of genetic parameters of two references as having the coefficient of determination (R2) on flowering time respectively, at 0.00 and 0.01, but the predictability of genetic parameter of New7 was improved as R2 on flowering time of New7 was 0.31 in Miryang. On the other hand, R2 on potential yield of genetic parameters of two references were respectively 0.66 and 0.41, but no predictability on potential yield of genetic parameter of New7 as R2 of New7 showed 0.00 in Jeonju. However, it is expected that the regional combination genetic parameters with the good evaluation can be utilized to predict the flowering timing and potential yields of other regions. Although it is necessary to analyze further whether or not the input data is uncertain. 본 연구에서는 진주, 수원, 춘천의 정보로만 추정한 유전 모수(New1∼New3)와 지역 조합으로 추정한 유전 모수(New4∼New7), NICS (2010)와 Kim et al.(2004)의 유전 모수의 개화시기 및 잠재수량의 예측력을 평가하여 기존의 유전 정보와 새로운 유전 정보에 대한 불확실 정도를 알고 다음 후속 연구에 활용 가능성을 알아보고자 수행했다. 결과적으로, 개별 및 지역 조합 유전 모수에서 모수 추정 지점 혹은 참여한 지점의 유전 모수의 평가 지표들은 비교적 좋은 결과를 보여 주었지만 뚜렷하게 나타나지 않았다. 대구, 밀양, 전주에서 New7 유전 모수의 개화시기의 예측력은 NICS (2010)나 Kim et al. (2004)의 유전 모수의 개화시기 예측력보다 개선되지 않았다. 그러나 New7 유전 모수의 잠재수량의 예측력은 큰 차이는 아니지만 NICS (2010)나 Kim et al. (2004)의 유전 모수의 잠재수량 예측력보다 개선되는 현상을 보였다. 예를 들면, 밀양에서 NICS (2010)와 Kim et al. (2004)의 유전 모수의 잠재수량 결정계수가 0.00과 0.01로 전혀 예측력이 없는 것으로 평가하였지만 New7 유전 모수의 잠재수량 결정계수는 0.31로 나타났다. 반면, 전주에서 NICS (2010)과 Kim et al. (2004)의 유전 모수의 잠재수량 결정계수는 0.66과 0.41로 평가되었는데, New7 유전 모수의 잠재수량 결정계수는 0.00으로 예측력이 없는 것으로 평가되었다. 새로운 유전 모수의 예측력(New1∼New7)이 기존의 유전 모수(NICS(2010)과 Kim et al. (2004))의 예측력보다 크게 개선 되지는 않았지만, 평가 결과가 좋은 지역 조합 유전 모수를 지역별 개화시기 및 잠재수량을 예측하는 데에는 활용할 수 있을 것으로 판단된다.
ABO 혈액형이 적합하나 불일치하는 환자에서의 간이식술 경험 2 예
이숙영,서명신 대한마취과학회 2000 Korean Journal of Anesthesiology Vol.39 No.1
Due to the limited supply of livers for transplantation and acute situations in which an orthotopic liver transplantation (OLT) is needed, nonidentical ABO blood group OLTs are performed. One of the risks of transplantiag an 0 liver into an A/B/AB recipient is the development of hemolysis. We managed 2 cases of ABOompatible but nonidentical OLTs. Both recipients suffered from Wilsons disease (blood group B^+) and received a blood group 0^+ donor liver. One of them was,a 39.5 kg, 12 year-old-girl and the other was an 81 kg, 21 year-old-woman. The average duration of anesthesia was about 12 hr 30 min and the anhepatic times were 51 min and 57 min, respectively. During and after the operation, we used the recipients type packed red cells and fresh frozen plasma. Hemodynamic values, serum electrolytes and blood coagulation were relatively well maintained throughout the operntion. A mild decrease in hematocrit was observed 10 and 7 days after operation, respectively. However, there was no evidence of hemolysis, clinically. (Korean J Anesthesiol 2000; 39: 129~133)
다발성 관절통 환자에서 전신성 홍반성 루푸스 진단 증례 보고
박지현,이평복,서명신,오용석 대한통증학회 2004 The Korean Journal of Pain Vol.17 No.01
The systemic lupus erythematosus (SLE) is a multisystemic disease which primarily affects young females and is caused by tissue damage due to antibody and complement-fixing immune complex deposition. It has a wide spectrum of clinical presentations. The most common initial symptoms of SLE show cutaneous, musculoskeletal, renal, and hematological involvement. Despite advances in the diagnostic and serologic testing for SLE, the interval between symptom onset and diagnosis is protracted. Arthritis and/or arthralgia are the most common initial symptoms in SLE patients, but the diagnosis of patients with these symptoms is no more rapid than in patients without. The cause of this may be that joint involvement is relatively mild and deformity is rare in SLE. Therefore, patients presenting with symptoms of arthritis and/or arthralgia should be evaluated for SLE carefully, so that SLE can be diagnosed earlier, and morbidity and mortality can be reduced. We describe the case of a patients eventually diagnosed as SLE after several visits of our pain clinic, who showed the initial symptoms of SLE with polyarticular joint pain.