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기관지확장제 반응 검사에서 속효성 기관지확장제 투여 용량의 차이가 소기도 반응도에 영향을 줄까?
백지현 ( Ji Hyeon Baek ),장호민 ( Homin Jang ),전유훈 ( You Hoon Jeon ),서보선 ( Bo Seon Seo ),이승진 ( Seung Jin Lee ),지혜미 ( Hye Mi Jee ),이경석 ( Kyung Suk Lee ),정영호 ( Young-ho Jung ),신윤호 ( Youn Ho Sheen ),한만용 ( Man 대한천식알레르기학회(구 대한알레르기학회) 2016 Allergy Asthma & Respiratory Disease Vol.4 No.4
Purpose: It is recommended to use 200 (2 puffs) or 400 (4 puffs) μg of salbutamol in the bronchodilator response (BDR) test. We aimed to compare the difference between these 2 doses with regard to small airway dysfunction.Methods: One hundred sixteen subjects who visited the hospital for diagnosis or follow-up of asthma were consecutively enrolled between June 1 and November 31, 2013. The subjects were randomly assigned to the BDR test at the 2 doses (200 or 400 μg of salbutamol), with physicians blinded to the group each subject was assigned to and undertook the BDR test using the spirometry and impulse oscillometry system (IOS).Results: A total of 116 subjects participated in this study; the mean age was 7.8±3.6 years. The number of participants who were assigned to 2 and 4 puffs groups was 59 and 57, respectively. The mean age was older in the 4 puffs group than in the 2 puffs group (P=0.008). There were no significant difference in spirometric and oscillometric parameters between the 2 and 4 puffs groups. However, in subgroup analysis of asthmatic patients on maintenance therapy (n=21), there was a significant difference in relative changes in Rrs5 between the 2 and 4 puffs groups (16.4%±9.6% vs. 28.7%±8.8%, P=0.035). The forced expiratory volume of 1 second showed a significant correlation with resistance in the 2 puffs group and with reactance in the 4 puffs group.Conclusion: There was a significant relationship between the amounts of bronchodilators administered and the small airway dysfunction in children with asthma on maintenance therapy. Further research is warranted to delineate changes in spirometric and IOS measures in accordance with the different amounts of bronchodilators administered. (Allergy Asthma Respir Dis 2016:4:284-289)
주파수 선택적 페이딩 채널에서 안치 무선 통신을 위한 Alamouti 코딩 기반 협력 전송 기법
강승구,김준환,백지현,윤석호,Kang, Seung-Goo,Kim, Jun-Hwan,Baek, Jee-Hyeon,Yoon, Seok-Ho 한국통신학회 2011 韓國通信學會論文誌 Vol.36 No.6C
본 논문에서는 주파수 선택적 페이딩 채널에서 (frequency selective fading channels) 인지 무선 통신을 위한 Alamouti 코딩 기반 협력 전송 기법을 제안한다. 제안한 기법은 시간 반전 연산과 (time-reversal operation) 공액 복소 연산을 (conjugate operation) 사용하는 기존 기법과 다르게 소스 노드에서의 간단한 심볼 조합을 통해 목적지 노드에서 Alamouti 부호 구조를 획득한다. 모의실험 결과를 통하여 제안한 기법의 다이버시티 이득 차수가 기존 기법의 다이버시티 이득 차수보다 높은 것을 확인한다. This paper addresses a cooperative transmission scheme based on Alamouti coding for cognitive radio networks over frequency selective fading channels. In the proposed scheme, the Alamouti coded form at the destination node is constructed through a simple combination of symbols at the source node, instead of the time-reversal operation and the conjugate operation at the relay nodes used in the conventional scheme. Numerical results show that the proposed scheme achieves a higher order cooperative diversity than that of the conventional scheme.
소아 천식 환자에서 비염과 천식과의 관계: 알레르기비염과 비알레르기비염 비교
권은별 ( Eun Byul Kwon ),백지현 ( Ji Hyeon Baek ),김형윤 ( Hyeong Yun Kim ),윤정원 ( Jung Won Yoon ),신윤호 ( Youn Ho Shin ),지혜미 ( Hye Mi Jee ),최선희 ( Sun Hee Choi ),한만용 ( Man Yong Han ) 대한천식알레르기학회 2013 Allergy Asthma & Respiratory Disease Vol.1 No.3
Purpose: We aimed to determine the prevalence of allergic rhinitis and nonallergic rhinitis, difference in symptoms between allergic rhinitis and nonallergic rhinitis, and the association between lung function and the degree of asthma control in children with asthma. Methods: One hundred seventy patients who were followed-up for asthma treatment at the department of pediatrics of CHA Bundang Medical Center were enrolled in this study. We conducted the questionnaire regarding coexistence of rhinitis, childhood asthma control test (C-ACT), and the basic lung function test. The patients were classified as allergic rhinitis group and nonallergic rhinitis group according to the response to 11 common inhalation and food allergens, and assessed the degree of asthma control and the severity of rhinitis. Results: One hundred thirty patients (73%) were found to have rhinitis. Of these, 79 patients (53%) had allergic rhinitis and 34 patients (20%) had nonallergic rhinitis. The allergic rhinitis group was older than the nonallergic rhinitis group or the nonrhinitis group (7.73±2.85 vs. 5.97±2.48 vs. 6.12±2.70, P<0.001). Nasal itching sense was more prevalent in the allergic-rhinitis group than in the nonallergic rhinitis group (3.23±1.90 vs. 2.44±1.56, P=0.036). There was an inverse correlation between the rhinitis and C-ACT (r= -0.329, P<0.05). Of note, nasal obstruction symptom was highly correlated with C-ACT (r=-0.334, P<0.001). Conclusion: Allergic rhinitis and nonallergic rhinitis were highly prevalent in the pediatric patients with asthma and both of them had a significantly adverse impact on asthma control by rhinitis-itself. Therefore, regardless of atopic status, clinicians should focus on relieving rhinitis symptoms. (Allergy Asthma Respir Dis 2013;1:241-247)
소아 천식 환자에서 비염과 천식과의 관계: 알레르기비염과 비알레르기비염 비교
권은별 ( Eun Byul Kwon ),백지현 ( Ji Hyeon Baek ),김형윤 ( Hyeong Yun Kim ),윤정원 ( Jung Won Yoon ),신윤호 ( Youn Ho Shin ),지혜미 ( Hye Mi Jee ),최선희 ( Sun Hee Choi ),한만용 ( Man Yong Han ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 1991 소아알레르기 및 호흡기학회지 Vol.1 No.3
Purpose: We aimed to determine the prevalence of allergic rhinitis and nonallergic rhinitis, difference in symptoms between allergic rhinitis and nonallergic rhinitis, and the association between lung function and the degree of asthma control in children with asthma. Methods: One hundred seventy patients who were followed-up for asthma treatment at the department of pediatrics of CHA Bundang Medical Center were enrolled in this study. We conducted the questionnaire regarding coexistence of rhinitis, childhood asthma control test (C-ACT), and the basic lung function test. The patients were classified as allergic rhinitis group and nonallergic rhinitis group according to the response to 11 common inhalation and food allergens, and assessed the degree of asthma control and the severity of rhinitis. Results: One hundred thirty patients (73%) were found to have rhinitis. Of these, 79 patients (53%) had allergic rhinitis and 34 patients (20%) had nonallergic rhinitis. The allergic rhinitis group was older than the nonallergic rhinitis group or the nonrhinitis group (7.73±2.85 vs. 5.97±2.48 vs. 6.12±2.70, P<0.001). Nasal itching sense was more prevalent in the allergic-rhinitis group than in the nonallergic rhinitis group (3.23±1.90 vs. 2.44±1.56, P=0.036). There was an inverse correlation between the rhinitis and C-ACT (r= .0.329, P<0.05). Of note, nasal obstruction symptom was highly correlated with C-ACT (r=.0.334, P<0.001). Conclusion: Allergic rhinitis and nonallergic rhinitis were highly prevalent in the pediatric patients with asthma and both of them had a significantly adverse impact on asthma control by rhinitis-itself. Therefore, regardless of atopic status, clinicians should focus on relieving rhinitis symptoms. (Allergy Asthma Respir Dis 2013;1:241-247)
윤광석 ( Gwang Seok Yoon ),박원 ( Won Park ),백지현 ( Ji Hyeon Baek ),한지영 ( Jee Young Han ),정경희 ( Kyong Hee Jung ),임미진 ( Mei Jin Lim ),주고운 ( Ko Woon Joo ),권성렬 ( Seong Ryul Kwon ) 대한류마티스학회 2013 대한류마티스학회지 Vol.20 No.6
Adult-onset Still`s disease (AOSD) is a rare systemic inflammatory disease characterized by spiking fever, arthralgia, salmon pink rash, neutrophilic leukocytosis, and multi-organ involvement. Although renal involvement may appear in some cases of adult Still`s disease, onset over 70 years of age with renal involvement has not been described. We report a 73-years-old woman whose illness manifested with fever of unknown origin, massive proteinuria, and multiple lymph nodes enlargement. With proteinuria of 2,650 mg/day, a renal biopsy was performed, and histopathological evaluation yielded the diagnosis of chronic glomerulonephritis (CGN). After excluding infectious disease, malignancy, and other rheumatic disease, AOSD was diagnosed with symptoms including fever over 39.0oC for more than a week, leukocytosis, generalized lymphadenopathy, and negative autoantibodies. Proteinuria and fever were improved markedly by high dose glucocorticoids and methotrexate therapy.
소아천식 환자에서 충격진동법과 폐활량기로 측정한 소기도 장애와 호기산화질소와의 관계
서보선 ( Bo Seon Seo ),이정민 ( Jeong Min Lee ),조은혜 ( Eunhae Cho ),백지현 ( Ji Hyeon Baek ),이경석 ( Geong Suk Lee ),신윤호 ( Youn Ho Shin ),지혜미 ( Hye Mi Jee ),정영호 ( Yong Ho Jung ),한만용 ( Man Yong Han ) 대한천식알레르기학회 2015 Allergy Asthma & Respiratory Disease Vol.3 No.4
Purpose: Fractional exhaled nitric oxide (FeNO) is a maker of airway inflammation, and impedance of low frequency in the impulse oscillometry system (IOS) reflects small-airway obstruction. We investigated the association of the FeNO level with IOS parameters and spirometry results in asthma patients. Methods: Fifty-eight children with asthma (60.3%, male), mean age 8.3 years (range, 4.5.16.0 years), were enrolled in the study. Reactance and resistance at 5 Hz with IOS, forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and forced expiratory flow 25%.75% of the vital capacity (FEF25%-75%) with spirometry and FeNO were measured in all patients. The Z-score of spirometry and IOS parameters and the mean level of FeNO were used for correlation and regression analysis. Results: FeNO was not significantly associated with height, age, or other demographic parameters. There was a statistically significant correlation between spirometry results and IOS measurements. The FeNO level was not significantly correlated with IOS variables. After adjusting for height, sex, atopic status, and the use of inhaled corticosteroid, the FeNO level showed significant correlations with Z-score of FEV1/FVC (P=0.037, adjusted R2=0.234). Conclusion: FeNO was significantly correlated with Z-scores of FEV1/FVC, but not with IOS variables. Therefore, FeNO may be used to detect whole airway obstruction, but not small-airway obstruction. (Allergy Asthma Respir Dis 2015;3:267-271)
전형적인 알레르기 증상으로 내원한 6세 미만 소아 환자에서 항원 감작 패턴: 단일 기관 연구
윤정원 ( Jung Won Yoon ),이상민 ( Sang Min Lee ),김준환 ( Joon Hwan Kim ),김나연 ( Na Yeon Kim ),백지현 ( Ji Hyeon Baek ),백혜성 ( Hey Sung Baek ),지혜미 ( Hye Mi Jee ),김형윤 ( Hyeung Yoon Kim ),최선희 ( Sun Hee Choi ),김기은 ( K 대한천식알레르기학회 2014 Allergy Asthma & Respiratory Disease Vol.2 No.4
Purpose: Population studies have reported that sensitization to inhalant allergens is rare in young children; however, most subjects in those studies had little or no symptoms or signs highly suggestive of allergic diseases. The aim of the present study was to assess the prevalence of sensitization to inhalant allergens in young children with symptoms and/or signs of allergic disease. Methods: We analyzed the results of all specific IgE tests performed at our hospital laboratory in children younger than 6 years presenting with symptoms and/or signs highly suggestive of allergic diseases between 2008 and 2013. Specific IgE tests for Dermatophagoides pteronyssinus, Dermatophagoides farinae, Alternaria alternata, German cockroach, cat dander, egg white or egg yolk, milk, peanut, and soybean were performed on 295 children; a specific IgE concentration ≥0.35 or ≥0.2 IU/mL was considered positive. We also compared allergen sensitization rates using the two cutoff values. Results: One hundred eighty-one children (61.4%) were positive to at least 1 allergen tested and 53 children (18.9%) were positive to at least 1 inhalant allergen when a specific IgE concentration ≥0.35 IU/mL was considered positive. The children were more likely to have asthma or allergic rhinitis when they were sensitized to any inhalant allergen, particularly house dust mites. The prevalence of sensitization to inhalant allergens increased with age (P<0.001). There was no significant difference in the prevalence of polysensitization among different age groups, but sensitization to both inhalant and food allergens significantly increased with age. Conclusion: Our results suggest that specific IgE tests to common inhalant allergens, particularly the house dust mites, may be considered when performing blood screening tests for young children presenting with symptoms and/or signs of allergic diseases