수산가공 부산물을 이용한 생리기능성 소재 개발

백지영(Ji Young BEAK),강동수(Dong Soo KANG),정복미(Bok Mi JUNG),김귀식(Kui Shik KIM),박표잠(Pyo Jam PARK),안창범(Chang Bum AHN) 전남대학교 수산과학연구소 2006 수산과학연구소논문집 Vol.14 No.2

About 100 million tons of fish are annually harvested in the world, of which 30% of the total catch is transformed into fish meal or discarded. Above 50% of the fish harvested for food is processing waste including offals, fins, skin, intestines, head, bone and so on, and not used as food. In the recent, some biologically active materials were identified and applicated to the useful materials for human utilization. The potential applications of proteins, lipids, chitin and minerals in marine bioprocessing leftovers as bioactive materials have increased the value of processing byproducts. In the present study, we have focused on the utilization of marine processing byproducts to screen bioactive materials and their potential applications.

Testifying LTE Assumption for Heat Transport in GWHP Systems

Ji-Young Baek(백지영),Byeong-Hak Park(박병학),Kang-Kun Lee(이강근) 한국신재생에너지학회 2021 한국신재생에너지학회 학술대회논문집 Vol.2021 No.7

Accurate prediction of thermal plume propagation is very important in the design stage of groundwater heat pump (GWHP) systems. Generally, a single differential transport equation has been applied to interpret the propagation of thermal plume by assuming local thermal equilibrium (LTE), immediate thermal equilibrium between the solid and neighboring fluid. With the increase of flow velocity, however, the thermal equilibrium cannot be reached immediately. Despite this possibility, there is a lack of studies that enable to verification of the LTE assumption for the hydrogeological systems. In this study, laboratory experiments were performed using both heat and solute as tracers at various background flow velocities (Reynolds number, Re 〈0.37) to testify the LTE assumption. Observed responses to the tracer injection were analyzed by mathematical models and derived velocities and dispersion coefficients of solute and heat were compared using retardation factors. Consequently, it was experimentally confirmed that the LTE assumption can be violated in Darcy range (Re 〈3). Thermal dispersion coefficients derived by the heat tracer were larger than those estimated by the solute tracer due to violation of the LTE. This result suggests that the LTE assumption needs to be verified for the design of the GWHP system.

소아 천식에서 유도 객담 내 CXCL13의 의의

백지영 ( Ji Young Baek ),최봉석 ( Bong Seok Choi ),이용주 ( Yong Ju Lee ),박여훈 ( Yeo Hoon Park ),김경원 ( Kyung Won Kim ),손명현 ( Myung Hyun Sohn ),김규언 ( Kyu Earn Kim ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2009 소아알레르기 및 호흡기학회지 Vol.19 No.4

목적: CXCL13은 B 세포의 귀소 반응에 관여하는 케모카인으로 알려져 있으나 최근 T 세포 관련 염증에 관여한다는 보고가 있고, Th17 세포에서 주로 분비된다는 보고도 있다. 이에 본 연구에서는 소아 천식에서 CXCL13의 임상적인 의의와 기관지과민성, 폐기능과 기도 내 호산구성 염증과의 관련성에 대해 알아보고자 하였다. 방법: 세브란스 어린이 병원에 내원한 만 6세에서 15세 이하의 소아 160명을 대상으로 하였다. 천식 환아는 80명, 대조군은 80명이었다. 전체 대상아에서 폐기능 검사, 메타콜린 기관지 유발 검사를 시행하였고, 혈액 내 호산구 수, 혈청 총 IgE, ECP 및 유도객담 내 호산구 수, ECP 및 CXCL13을 측정하였다. 결과: 유도 객담 내 CXCL13은 천식군에서 대조군에 비해 의미 있게 높았으며(P=0.003), 객담 내 호산구 수(r=0.190, P=0.017) 및 ECP(r=0.285, P=0.002)와 양의 상관관계를 보였다. 혈액 내 호산구 수 및 ECP, 총 IgE와는 통계적 연관성을 보이지 않았고, 폐기능 및 메타콜린 기관지과민성과 도 연관성을 보이지 않았다. 결론: CXCL13은 소아 천식에서 호산구성 염증과 관련하여 기도 내 만성 염증에 역함을 담당할 것으로 사료되며, 유도 객담 CXCL13은 향후 케모카인과 천식의 연관성을 연구하는데 도움이 될 것으로 생각된다. Purpose: CXCL13 is known to be a chemokine delivering B cell to the secondary lymphatic follicles, such as spleen, lymph nodes, and Peyer`s patches. Recently, there have been some reports that CXCL13 is important for T cell inflammation and expressed by Th17 cell which produces IL-17. This study attempted to examine the clinical implication of CXCL13 in children with asthma. Methods: This study included a total of 160 children aged 6 to 15 years who visited Severance Children`s Hospital. There were 80 children with asthma and 80 children without. The pulmonary function test and the methacholine challenge test were performed. Total eosinophi1 count, eosinophil cationic protein (ECP) and total IgE in serum and eosinophils, ECP and CXCL13 in sputum were measured. Results: The mean age of the subjects was 8.3±2.3 years for the asthma group and 9.3±2.5 years for the control group. The male to female ratio was 67.5% and 55.0% respectively. The sputum CXCL13 level for the asthma group was significantly higher than that level for the control group (P=0.003). This significance persisted even after adjustment for age and sex (P=0.010). The sputum CXCL13 level showed a positive correlation with that of sputum eosinophils (r=0.190, P=0.017) and ECP (r=0.285, P=0.002). Conclusion: Our results suggest that CXCL13 may play an important role in the pathophysiology of asthma related to eosinophilic inflammation. Further studies on sputum CXCL13 could help to reveal the role of chemokines in asthma. [Pediatr Allergy Respir Dis(Korea) 2009;19:420-428]

Verifying Local Thermal Equilibrium Assumption in Hydrogeological Systems

Ji-Young Baek(백지영),Byeong-Hak Park(박병학),Kang-Kun Lee(이강근) 한국신재생에너지학회 2020 한국신재생에너지학회 학술대회논문집 Vol.2020 No.8

Experimental Investigation of Thermally Affected Zone Prediction under Local Thermal Non-Equilibrium in Groundwater Heat Pump (GWHP) Systems

Ji-young Baek(백지영),Byeong-Hak Park(박병학),Kang-Kun Lee(이강근) 한국신재생에너지학회 2019 한국신재생에너지학회 학술대회논문집 Vol.2019 No.5

여성 회음부에 생긴 지방육종 1예

백지영 ( Ji Young Baek ),박창서 ( Chang Seo Park ),주성홍 ( Sung Hong Joo ) 대한산부인과학회 2007 Obstetrics & Gynecology Science Vol.50 No.6

지방육종은 전체 암의 1% 정도를 차지할 정도로 성인에 발생하는 연조직육종 중 가장 흔하지만 회음부에서 발생하는 지방육종은 드문 질환으로 술 전 진단이 용이하지 않아서 대부분 수술 후 병리조직학적 검사로 확진된다. 저자는 약 4달전부터 서서히 커지기 시작한 양측 회음부의 무통성 종물을 주소로 내원한 33세 여자의 회음부 지방육종에 대해 완전한 수술적 절제 후 보조 방사선 치료 하지 않고 수술로 완전 절제가 이루어져 국소재발 없이 치료에 성공한 사례를 보고하는 바이다. Liposarcoma is one of the most common soft tissue sarcoma of adults and accounts for 1% in all malignant neoplasm. A liposarcoma of perineal origin is excessively rare, and preoperative diagnosis is difficult. Perineal liposarcoma was diagnosed in a 38-year-old woman. She presented with a large soft lump in the both perineal region of 4 months duration. We report a case of a liposarcoma on perineum which was treated with complete surgical resection without adjuvant radiation therapy. The patient has survived 2 years with no evidence of a recurrence.

아파트 구조 형식의 변천 및 향후 전망

윤영호(Young-Ho Yoon),백지영(Ji-Young Park),이수진(Su-Jin Lee) 한국콘크리트학회 2006 콘크리트학회지 Vol.18 No.3

Henoch-$Sch{\ddot{o}}nlein$ 자반증에서 항인지질 항체의 임상적 의의

박은정,백지영,신재일,이재승,김현숙,Park, Eun-Jung,Baek, Ji-Young,Shin, Jae-Il,Lee, Jae-Seung,Kim, Hyon-Suk 대한소아신장학회 2009 Childhood kidney diseases Vol.13 No.2

목적 : Henoch-$Sch{\ddot{o}}nlein$ 자반증에서 항인지질 항체에 대한 연구가 외국에서 몇몇 보고되고 있지만 국내에서는 소아 환자를 대상으로 한 연구가 거의 없는 실정이며 또한 항인지질 항체가 양성인 그룹과 음성인 그룹을 비교하여 연구한 논문은 아직 없는 상태이다. 따라서 한국 소아 Henoch-$Sch{\ddot{o}}nlein$ 자반증에서 항인지질 항체가 양성인 환아의 항인지질 항체의 임상적 의의를 알아보고자 본 연구를 시행하였다. 방법 : 2007년 1월부터 2009년 6월까지 신촌 세브란스 병원 소아청소년과에 내원하여 Henoch-$Sch{\ddot{o}}nlein$ 자반증으로 진단받은 62명의 환아를 대상으로 의무기록을 후향적으로 조사하여 분석하였다. 환아의 일반적인 특징으로 성별, 나이, 복통, 관절통과 자반증 등의 임상 증상을 조사하였고, 검사 소견으로는 백혈구수, 혈색소, 혈소판수, 호산구수, C-반응 단백, 혈침 속도, 단백뇨, 대변 잠혈 검사, 혈청 면역 글로불린(IgG, IgA, IgM, IgE), 혈청 보체(C3, C4), 항핵 항체(ANA), 알부민과 항인지질 항체(루프스 항응고인자, 항카디오리핀 항체, 항${\beta}$ 2GPI 항체) 등을 조사하였다. 결과 : 총 62명의 환아중 남녀 각각 31명이었고 평균 연령은 $6.0{\pm}3.1$세(범위: 1-16세)였다. 루프스 항응고인자 양성인 그룹과 음성인 그룹으로 나누어 비교한 결과 복통, 자반증, 관절통, 신염 등의 임상 증세에서는 두 그룹 간에 통계적으로 유의한 차이가 없는 걸로 나타났으나 검사 소견을 비교하였을 때 양성인 그룹에서 C-반응 단백($4.3{\pm}7.2$ mg/dL vs. $1.3{\pm}1.8$ mg/dL, P=0.035), 혈침 속도($37.5{\pm}26.2 mm/hr vs. $25.1{\pm}22.6$ mm/hr, P=0.039), IgM ($148.1{\pm}48.4$ mg/dL vs. $114.9{\pm}41.5$ mg/dL, P=0.024), C3 ($143.1{\pm}21.9$ mg/dL vs. $129.7{\pm}24.5$ mg/dL, P=0.048), C4 ($30.9{\pm}6.3$ mg/dL vs. $24.9{\pm}7.8$ mg/dL, P=0.002)가 통계학적으로 유의하게 높았다. 결론 : Henoch-$Sch{\ddot{o}}nlein$ 자반증에서 루프스 항응고인자는 29%에서 양성 소견을 보였으며 양성인 그룹에서 염증 인자인 C-반응단백, 혈침 속도 그리고 IgM, C3, C4 수치가 유의하게 높게 측정되었다. 이것은 루프스 항응고인자가 Henoch-$Sch{\ddot{o}}nlein$ 자반증에서 질병의 활성과 병인에 어떤 역할을 수행함을 암시한다고 볼 수 있다. Purpose : We performed this study to evaluate the incidence and clinical significance of antiphospholipid antibodies (aPL Ab) in Korean children with Henoch-$Sch{\ddot{o}}nlein$ purpura (HSP). Methods : The medical records of 62 patients (31 boys and 31 girls) aged $46.0{\pm}3.1$ (1-16) years with a clinical diagnosis of HSP based on the EULAR/PReS criteria were reviewed retrospectively. From the years 2007 to 2009, the sera from children with acute HSP were tested for aPL Ab such as LA, anti-cardiolipin antibody and anti-${\beta}_2$ glycoprotein I antibody. Results : LA was positive in 18 (29%) of the 62 patients with HSP and We divided the patients into the two groups LA positive group (N=18) and LA negative group (N=44). There were no significant differences between the two groups with regard to abdominal pain, arthralgia and renal involvement, but LA positive group had significantly higher C-reactive protein ($4.3{\pm}7.2$ mg/dL vs. $1.3{\pm}1.8$ mg/dL, P=0.035), erythrocyte sedimentation rate ($37.5{\pm}26.2$ mm/hr vs. $25.1{\pm}22.6$ mm/hr, P= 0.039), IgM ($148.1{\pm}48.4$ mg/dL vs. $114.9{\pm}41.5$ mg/dL, P=0.024), C3 ($143.1{\pm}21.9$ mg/dL vs. $129.7{\pm}24.5$ mg/dL, P=0.048) and C4 levels ($30.9{\pm}6.3$ mg/dL vs. $24.9{\pm}7.8$ mg/dL, P=0.002) compared with LA negative group. Conclusion : We found that the incidence of positive aPL Ab tests was relatively higher in Korean children with HSP and the presence of aPL Ab was associated with acute inflammatory process of HSP. These results suggest that the aPL Ab are involved in the pathogenesis of HSP in children.

3도 방실차단 환자에 대한 칠기탕(七氣湯)투여 증례 보고

최현주,장영우,백지영,조승모,이혜윤,김도형,박승찬,이인,홍진우,권정남,Choi, Hyun-Ju,Jang, Young-Woo,Baek, Ji-Young,Cho, Seung-Mo,Lee, Hye-Yoon,Kim, Do-Hyung,Park, Seung-Chan,Lee, In,Hong, Jin-Woo,Kwon, Jeong-Nam 대한한방내과학회 2013 大韓韓方內科學會誌 Vol.34 No.4

This clinical case reports the effect of Chilgi-tang, a kind of traditional Korean herbal medicine, on $3^{rd}$ degree AV block patients also known as complete heart block. Complete heart block caused by degeneration of electrical conduction system of heart may result in weakness, dizziness, syncope, etc. Two clinical cases reported herein are diagnosed as $3^{rd}$ degree AV block caused by psychological stress with chief complaints of syncope and dyspnea respectively. The chief complains of cases cured remarkably after Chilgi-tang medication. In one case, $3^{rd}$ degree AV block was disappeared. In conclusion, we suggest that Chilgi-tang can be a potential treatment for complete heart block due to psychological stress.

구강내에 발생한 혈관림프증식증: 증례보고

조동백,박지운,백지영,최원식,Cho, Dong-Baek,Park, Ji-Un,Baek, Ji-Young,Choi, Won-Sik 대한악안면성형재건외과학회 2010 Maxillofacial Plastic Reconstructive Surgery Vol.32 No.6

Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare benign vascular lesion that is characterized by proliferation of small to medium-sized vascular structures lined by histiocytoid or epithelioid endothelial cells and often accompanied by an inflammatory infiltrate comprising lymphocytes, plasma cells and eosinophils. A 34-year-old man without any generalized systemic conditions presented with a slowly enlarging painless swelling in the buccal area. An excisional biopsy was conducted and the diagnosis of Angiolymphoid hyperplasia with eosinophilia was confirmed. We report a case of angiolymphoid hyperplasia with eosinophilia of the buccal area in oral cavity and review the previously reported cases and literatures of angiolymphoid hyperplasia with eosinophilia.