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서주현,백소원,이진원,박진병 한국생물공학회 2017 Biotechnology and Bioprocess Engineering Vol.22 No.3
Acid tolerance is one of the critical factors to determine the quality of the industrial production strains. Therefore, we have investigated the introduction of the acid tolerance genes into the genome of Escherichia coli BL21 by using CRISPR-Cas9 system. The dsrA and rcsB genes of E. coli K-12, which are involved in the heptanoic acid tolerance, were inserted into the genome of E. coli BL21 without scar. The native transcription unit (TU) of dsrA and the synthetic TU of rcsB were integrated in E. coli BL21 genome. We found that the position of genomic coordinate of 1,300,270 was more efficient to integrate dsrA and rcsB than genomic coordinate of 3,876,428. Furthermore, the rcsB was successfully expressed in the resulting engineered strains (i.e., rcsB+ or dsrA+ rcsB+ strains). The engineered strains expressing dsrA and/or rcsB showed the higher survival rate and specific growth rate under n-heptanoic acid stress than wild-type E. coli BL21. These results indicate that the newly introduced acid-tolerance systems were active in the E. coli BL21 strain.
혈관내 B 대세포 림프종 환자에서 발견된 99mTc-MIBI의 미만성 골수 섭취
문승환 ( Seung Hwan Moon ),오소원 ( So Won Oh ),팽진철 ( Jin Chul Paeng ),백진호 ( Jin Ho Paik ),이동수 ( Dong Soo Lee ) 대한핵의학회 2009 핵의학 분자영상 Vol.43 No.4
Intravascular large B-cell lymphoma (IVLBCL) is a subtype of diffuse large cell lymphoma, characterized by proliferation of lymphoid cells in the intravascular space of various organs without causing a mass effect. Although 18F-FDG PET is a powerful imaging tool in lymphoma, the usefulness of 18F-FDG PET in the assessment of IVLBCL is still controversial. 99mTc-MIBI, a tumor imaging radiopharmaceutical with a different mechanism from that of 18F-FDG, has been reported to be also effective in lymphoma. However, there is nearly no report on the efficacy of 99mTc-MIBI in the assessment of IVLBCL. We present one case of IVLBCL that showed 99mTc-MIBI accumulation in the involved bone marrow as an incidental finding, which was discrepant from that of 18F-FDG PET. (Nucl Med Mol Imaging 2009;43(4):352-356)
에지 디바이스를 이용한 인공지능 기반의 마이크로 솔더링 상태 판정 연구
문주원(Ju-Won Moon),김재경(Jae-Gyeong Kim),백소원(So-Won Baek),김철호(Chul-Ho Kim),이영학(Yeungjhak Lee) 한국정보기술학회 2021 Proceedings of KIIT Conference Vol.2021 No.11
본 논문은 반도체 생산 공정 중 가장 중요한 마이크로 솔더링 상태 검사를 인공지능 기반의 에지 디바이스에 대한 연구이다. 마이크로 솔더링 상태 검사의 오류는 다른 부품에 치명적인 오류를 야기시킬 수 있으므로 전체 공정에서 가장 중요한 요소이다. 본 연구는 물체의 검출이 빠르고 에지 디바이스에 적용할 수 있는 ssd_mobilenet과 Yolov4-tiny 모델을 이용하였다. 공정 자동화를 위해 가장 문제가 되는 것이 False Positive 이며 Yolov4-tiny가 이것에 대해 가장 좋은 성능을 나타내었다. This paper is a study on the edge device based on artificial intelligence that inspects the most important micro soldering state in the semiconductor production process. An error in the micro soldering condition inspection is the most important factor in the entire process, as it can cause fatal errors in other components. In this study, we used the ssd_mobilenet and Yolov4-tiny models that are fast to detect objects and can be applied to edge devices. False Positive is the most problematic for process automation, and Yolov4-tiny showed the best performance for the False Positive.