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배종석(Jong Seok Bae),김상진(Sang Jin Kim),박강민(Kang Min Park),지근하(Geun Ha Chi),황태규(Tae Gyu Hwang) 대한소아신경학회 2007 대한소아신경학회지 Vol.15 No.2
저자들은 22년 6개월의 장기생존을 보이는 물무뇌증환자를 경험하였고 임상적 방사선학적인 특징을 기술하였다. 기록을 통해서 본 증례가 전세계에서 현재까지 보고된 물무뇌증환자의 장기생존한 예들 가운데 가장 긴 생존을 보인 경우라는 것을 확인하였고 문헌고찰과 함께 보고하는 바이다. Hydranencephaly is a rare condition in which the brain's cerebral hemispheres are absent and replaced by sacs filled with cerebrospinal fluid. The prognosis for children with hydranencephaly is generally poor, so many children with this disorder die before the age of 1 year. We experienced a patient with hydranencephaly who showed prolonged survival until age of 22 years. To our limited knowledge, this case may be the longest survival of a patient with hydranencephaly in the world.
고석민(Seok-Min Go),박병선(Byoung-Sun Park),배종석(Jong-Seok Bae) 한국중독정신의학회 2006 중독정신의학 Vol.10 No.1
Wernicke encephalopathy is characterized by nystagmus, abducens and conjugate gaze palsy, gait ataxia and confusion. Persistent dysphagia in Wernicke encephalopathy was reported rarely. A 50-year-old man who was diagnosed with Wernicke encephalopathy was treated with intravenous thiamine. His clinical symptoms such as ophthalmoplegia, ataxia and confusion was improved except for severe dysphagia by thiamine replacement. We presumed that dysphagia in this patient might result from the involvement of the solitary nucleus located in the medulla oblongata around the 4 th ventricle.
유길종 ( Kil Jong Yu ),배종석 ( Jong Seok Bae ),서영진 ( Young Jin Seo ),이준엽 ( Juhn Yeob Lee ),임경진 ( Kyung Jin Lim ),조유리 ( You Lee Joh ),윤원찬 ( Wern Chan Yoon ),김채기 ( Chae Gi Kim ),송용호 ( Yong Ho Song ),최정윤 ( Ju 대한류마티스학회 2001 대한류마티스학회지 Vol.8 No.4
Adult onset Still`s disease (AOSD) is a rare, distinct clinical entity which affects predominantly young adults aged 16-35. It affects multiple organs, and at present, the etiology is still unclear. Because this disease has few diagnostic or confirmative test, the diagnosis is made by the differential diagnosis and by excluding other diseases. Several reports have suggested a viral trigger in the pathogenesis of this disease. It has some common clinical features; abrupt onset, high fever, sore throat, transient maculopapular rash, lymphadenopathy, and hepatosplenomegaly. We describe a 17-year-old man who fulfilled the proposed diagnostic criteria of AOSD and had evidence of acute Epstein-Barr virus infection. He complained of intermittent high fever and myalgia for a week. He also had maculopapular rash, sore throat, multiple right cervical lymphadenopahty, and right ankle pain and swelling. After admission, intermittent fever persisted for a month, but diffuse myalgia and migrating arthralgia fluctuated.
류마티스 관절염 환자에서 Methotrexate 사용 중 발생한 악성 림프종
김무곤 ( Moo Gon Kim ),이준엽 ( Juhn Yeob Lee ),배종석 ( Jong Seok Bae ),서영진 ( Young Jin Seo ),임경진 ( Kyung Jin Lim ),정승혜 ( Seung Hie Chung ),윤현대 ( Hyun Dae Yoon ),김은영 ( Eun Young Kim ),윤원찬 ( Wern Chan Yoon ),류 대한류마티스학회 2002 대한류마티스학회지 Vol.9 No.1
Rheumatoid arthritis (RA) is a multisystemic inflammatory disease with a prevalance of approximately 1% of the population. The use of disease modifying anti-rheumatic drug (DMARD) is an essential regimen for the treatment of RA. Among DMARDs, methotrexate (MTX) is used worldwide with confirmed effectiveness. However, cytopenia, pulmonary injury, and hepatic toxicity are a few side effects limiting its use. In addition, although the oncogenic potential of MTX is low, several cases have been reported. Recently an increased risk of developing lymphoproliferative disorders has been reported in patients with RA. The incidence is higher in elderly individuals with severe longstanding seropositive RA, those with Sjoren`s or Felty`s syndrome, and in patients with RA treated with prolonged low dose MTX. We describe a case of RA who developed non-Hodgkin`s lymphoma during low dose MTX therapy.
한국인 폐경 후 여성에서 골관절염과 비타민 D 수용체의 다형성과의 연관관계의 부족
임경진 ( Gyung Jin Lim ),김무곤 ( Moo Gon Kim ),배종석 ( Jong Seok Bae ),유길종 ( Kil Jong Yu ),조유리 ( You Lee Cho ),윤현대 ( Hyun Dae Yoon ),김은영 ( Eun Young Kim ),윤원찬 ( Wern Chan Yoon ),김채기 ( Chae Gi Kim ),송용호 ( Yon 대한류마티스학회 2002 대한류마티스학회지 Vol.9 No.1
Objective: To determine whether polymorphisms of the Vitamin D receptor (VDR) gene, known to be associated with osteoporosis and/or osteoarthritis (OA) in Caucasians, might also relate to the risk of OA and osteoporosis in Korean postmenopausal women Methods: A population of 130 postmenopausal women, including 76 healthy controls and 54 knee OA patients, were studied using anteroposterior radiographs of the knee, which were graded for OA according to the Kellgren classification system. The VDR genotype was determined by using polymerase chain reaction and by digestion with the three restriction enzymes Taq I, Bsm I, and Apa I. Femoral neck bone mineral density (BMD) was assessed in all participants by dual energy X-ray absorptiometry. Results: VDR genotype frequency distributions in Koreans were much different from Caucasian`s both in the OA group and the control group. Especially, tt, BB and AA genotype were very rare, prominently differentiating from Caucasians. But within Koreans, no significant differences in VDR genotype frequencies were observed between OA cases and controls. VDR genotype was not significantly associated with the radiographic grades of OA. And there were no significant relationships of VDR genotype with BMD scores in each group. Conclusion: In Korean postmenoposal women, the VDR gene polymorphisms do not significantly contribute to an increased prevalence of knee OA or to differences in BMD. VDR genotype analysis would not be helpful for assessing the risk of knee OA in Koreans because: (1) there is no correlation of VDR genotypes with the radiographic severity of OA; and (2) there is a more skewed distribution of VDR genotypes in Korean population compared to the Caucasian`s.
췌장의 비기능성 도세포종양의 임상적 특징 및 악성 예측인자
김현준 ( Kim Hyun Jun ),김명환 ( Kim Myung Hwan ),이성구 ( Lee Sung Koo ),이상수 ( Lee Sang Soo ),배종석 ( Bae Jong Seok ),장명국 ( Jang Myoung Kuk ),변정식 ( Byeon Jeong Sik ),민영일 ( Min Young Il ),황신 ( Hwang Shin ),박광민 ( 대한소화기학회 2003 대한소화기학회지 Vol.42 No.1
Background/Aims: It is difficult to determine preoperatively whether nonfunctioning islet cell tumors (NFICTs) are malignant or benign. The purposes of this study were to evaluate clinical characteristics and to differentiate benign from malignant behavior of NFICTs. Methods: We retrospectively analyzed 21 patients with NFICTs between 1990 and 2002. Results: Mean age was 51.4±13.2 years and female was predominant. Tumor size ranged from 0.5 to 13 cm (average 3.3±1.8 cm). Thirteen patients had variable symptoms. Histologically, 14 tumors were malignant and 7 were benign. In 9 out of 13 patients, pancreatogram showed narrowing of the main pancreatic duct, which was more frequently detected in patients with malignant NFICTs than in patients with benign ones (p<0.01). Surgical resection was performed in 20 patients. All patients with benign NFICTs are still alive after surgery, while 3 out of 14 patients with malignant NFICTs died 11, 22, 30 months after operation or diagnosis, respectively. The follow up time ranged from 1 to 111 months (mean 32.6 months) Conclusions: The presenting symptoms of patients with NFICTs were non-specific. The malignancy rate of NFICTs was high. Narrowing of the main pancreatic duct on pancreatogram suggested the malignancy. (Korean J Gastroenterol 2003;42:57-62)