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조치흠(Chi Heum Cho),차순도(Soon Do Cha),백원기(Won Ki Baek),권건영(Kun Young Kwon),배인수(In Soo Bae) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.5
N/A Objective : Apoptosis or programmed cell death is a normally physiological cell suicide program that is highly conserved among all animals. We previously evaluated overexpression of c-IAP1(Inhibitor of Apoptosis Protein) in ovarian carcinomas compared with normal ovaries. In this study, we demonstrate evidence for the involvement of c-IAP2 in ovarian carcinomas. Methods : Fresh 9 normal ovaries, 5 benign ovarian cysts and 13 ovarian carcinomas were obtained from routine gynecologic surgeries carried out for benign and malignant ovarian tumors. They were examined for the presence of c-IAP2 by RT-PCR(Reverse Transcriptase Polymerase Chain Reaction), Western blot analysis and immunohistochemical stains. Results : Nine of 14 normal and benign ovarian tumors were negative and 11 of 13 ova rian carcinomas were positive for c-IAP2 by RT-PCR. Positive RT-PCR for c-IAP2 was seen in 11/13 of ovarian carcinomas, a significantly higher percentage than in normal and benign ovarian tumors(5/14). All of these tumors showed strong positive for c-IAP2 by western blot and immunohistochemical staining. Whereas negative RT-PCR for c-IAP2 was seen in 9/14 of normal and benign ovarian tumors, a significantly higher percentage than ovarian carcinomas(2/13). Of these 9 negative samples, 6 had positive Western blot and immunohistochemical stains. There was weak concordance of the result. But expression of c-IAP2 in normal ovarian tissue was localized exclusively in the corpus luteum. Therefore, c-IAP2 may play important role in determining the fate of the follicular destiny. There was no expression in normal ovarian stroma cells for c-IAP2. Conclusions : These findings suggest that c-IAP2 is expressed in ovarian carcinomas and emerging role in cancer. The c-IAP2 expression has been investigated in the normal ovary, where apoptosis is thought to play an important role in ovulation.
하이브리드 스토리지에서 가변적인 I/O크기를 이용한 매핑 방법
배인수(In-Soo Bae),이윤수(Yun-Su Lee),정승국(Seung-Kook Cheong),송석일(Seokil Song) 한국정보기술학회 2014 Proceedings of KIIT Conference Vol.2014 No.5
이 논문에서는SSD와 하나 이상의 HDD를 조합하여 저가격에 고성능의 저장장치를 구현하는 하이브리드 스토리지의 새로운 매핑 방법을 제안한다. 기존에 제안된 일부 방법은 대용량의 스토리지를 효율적으로 관리 하기 위해 다수의 블록으로 구성되는 익스텐트 단위를 사용하였다. 이 방법은 경우에 따라서 익스텐트 단편화 문제를 발생킨다 단편화 문제는 SSD의 공간활용률을 저하시키게 되고 이로인해 하이브리드 스토리지의 성능 저하를 발생시킨다 이 논문에서는 위 문제점들을 해결하기 위해 하이브리드 스토리지를 구성하는 매체에 따라 기본 IO단위를 다르게 하는 새로운 매핑방법을 제안한다 또하 제안하는 방법을 시뮬레이션을 통해 기존의 방법과 비교하여 검증한다. In this paper, we propose a new mapping table for a hibrid storage which consists of a SSD and a few HDDs to achieve low cost and high performance storages. Some existing hybrid storages use extents to manage a large storage efficiently. However, this method causes an extent fragmentation problem. The extent fragmentation reduces the SSD utilization and the overall performance of the hibrid storage. In this paper, to solve the problem we propose a new mapping method that uses different size of IO unit for SSD and HDDs. Also, we perform simulations to verify our proposed method.