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인슐린 비의존형 당뇨병 환자에서 당뇨병성 신증의 지표로서 혈청과 IV형 collagen의 의의
김소연,최병진,김윤권,반금진,노영호,조민구,장태종,이권진 대한신장학회 1996 Kidney Research and Clinical Practice Vol.15 No.4
To evaluate the usefulness of serum and urinary concentrations of type IV collagen as a marker of glomerular basement membrane metabolism and the severity of diabetic nephropathy, we measured serum and urinary concentrations of type IV collagen-7S in 69 patients with non-insulin dependent diabetes and in 20 control subjects. And we compared serum and urinary concentrations of type IV collagen with the severity of diabetic nephropathy and glomerular filtration rate. The results were as follows: 1) The mean serum concentrations of type IV collagen was significantly higher in diabetic patients without nephropathy(4.50±1.48ng/ml) than in control subjects(3.55±0.47ng/ml)(p$lt;0.05). 2) The mean serum concentrations of type IV collagen was significantly higher in diabetic patients with microalbuminuria(5.86±4 1.66ng/ml) than in diabetic patients without nephropathy(p$lt;0.05). 3) The mean ratio of urinary type IV collagen/ urine creatinine was significantly higher in diabetic patients with microalbuminuria(23.04) than in diabetic patients without nephropathy(8.15±5.55) (p$lt; 0.05). 4) The serum concentrations of type IV collagen became higher as the glomerular filtration rate declined(r=-0.39, p$lt;0,01). 5) The mean ratio of urinary type IV collagen/ creatinine became higher as the glomerular filtration rate declined(r=-0.57, p$lt;0.01). These results suggest that serum and urinary concentrations of type IV collagen seem to be a useful, noninvasive and mproducible marker for assessment of glomerular basement membrane metabolism and urinary concentrations of type IV collagen may have a role as an indicator of early diabetic nephropathy in patients with non-insulin dependent diabetes.
김홍남,윤수진,한신,김소연,반금진,시석,박병익,이권전 대한내분비학회 1998 Endocrinology and metabolism Vol.13 No.2
The occurrences of thyrotoxicosis in patients with myasthenia gravis have been reported before the knowledge of the pathogenesis of the two disease. Thytotoxicosis is known to occur in 3 to 6 percent of patients with myasthenia gravis and myasthenia gravis occurs in only a fraction of 1 percent of the thyrotoxic populatian. Myasthenia gravis is currently considered as a systemic autoimmune disorder of acetylcholine receptor and often presented with other autoimmune diseases such as SLE, Rheumatoid arthritis. We experienced a 18-year-old woman who presented with graves disease and isolated ocular myasthenia gravis. Chest CT didnot reveal enlarged thymus. The usual treatement of myasthenia gravis associated with thymtoxicosis consists of medical control of the thyrotoxicosis, then thymectomy and later subtotal thyroidectomy. Her ptosis and thyrotoxicosis have improved after the medicatian of anticholinesterase and propylthiourecil. A case of ocular myasthenia gravis with Gravesdisease was experienced, so we reported the case with a brief review of literature (J Kor Soc Endocrinol 13:252-257, 1998).
종양양 위 전정부 폐쇄를 동반한 미만성 호산구성 위장관염 1 예
윤수진,노영호,조민구,김소연,이권전,반금진,한신,시석 대한소화기학회 1999 대한소화기학회지 Vol.33 No.5
Eosinophilic gastroenteritis is a rare disease characterized by tissue eosinophilia that can involve different layers of the gut wall. The pathogenesis and pathophysiology of this condition are poorly understood. Its clinical feature depends on the type of layer and location involved. The endoscopic and radiologic findings of eosinophilic gastroenteritis mimicked many other gastrointestinal diseases. We experienced a case of diffuse eosinophilic gastroenteritis in a 21-year-old male who presented severe vomiting and weight loss. After performing gastrofiberoscopy, barium study for upper gastro intestinal tract and abdominal computed tomography, we concluded that the lesion was gastric tumo with severe antral obstruction. Then, we carried out subtotal gastrectomy. We could confirm the diagnosis of eosinophilic gastroenteritis by full-thickness biopsy of the stomach wall. We report this case with a brief review of the literatures.
조민구(Min Koo Cho),김영중(Young Jung Kim),김진욱(Jin Wook Kim),서대원(Dae Won Seo),김홍남(Hong Nam Kim),장태종(Tae Jong Jang),반금진(Geum Jin Ban),김윤권(Youn Gwon Kim) 대한소화기학회 1997 대한소화기학회지 Vol.30 No.1
Since Rokitansky described the hamartoma of the spleen first in 1861, it has been a rare benign tumor composed of abnonnal rnixtures of normal splenic elements. Clinically it is asymptomatic in most patients but left upper quadrant mass, abnormal hetnatologic findings, frequent infection, fever, generalized weakness, and loss of appetite may be present in some cases. Although it can be diagnosed by roentgenologic examinations and aspiration biopsy, no one has been certain preoperatively. A case of splenic hamartoma in 35 years old male diagnosed postoperatively is presented. (Korean J Gastroenterol 1997;30:131 - 135)