국소 진행성 유방암 환자에서 선행 항암화학요법의 치료결과

배선현(Sun Hyun Bae) · 박 원(Won Park) · 허승재(Seung Jae Huh) · 최두호(Doo-Ho Choi) · 남희림(Heerim Nam) · 양정현(Jung-Hyun Yang) · 남석진(Seok-Jin Nam) · 이정언(Jeong Eon Lee) · 임영혁(Young-Hyuck Im) · 안진석(Jin-Seok Ahn) · 박 대한방사선종양학회 2010 Radiation Oncology Journal Vol.28 No.2

목 적: 국소 진행성 유방암으로 선행 항암화학요법 후 수술과 방사선치료를 시행한 환자를 대상으로 치료 결과와 예후에 영향을 미치는 인자를 알아보고자 하였다.대상 및 방법: 1995년 4월부터 2006년 11월까지 삼성서울병원에서 유방암으로 선행 항암화학요법을 받은 환자는총 159명이었다. 이중에서 진단 당시 종양의 크기가 5.0 cm를 초과하거나 액와림프절 전이가 의심된 유방암 환자로 항암화학요법 후 근치적 수술을 시행하고 방사선치료가 시행된 105명을 대상으로 하였다. 선행 항암화학요법은2명을 제외한 모든 환자에서 anthracycline을 기반으로 하는 복합항암요법을 사용하였다. 치료 전 임상적 병기는 T13명(3%), T2 26명(25%), T3 39명(37%), T4 37명(35%)이었고 액와림프절 전이가 의심되는 사람이 98명(93%)이었다. 선행 항암화학요법을 시작한 날을 기준으로 추적 조사하였고 중앙추적조사기간은 41개월(7∼142개월)이었다.결 과: 전체 환자의 5년 국소제어율은 82.1%, 원격전이제어율은 69.9%, 무병생존율은 66.1%, 전체생존율은 77.1%이었다. 무병생존율과 전체생존율에 영향을 미치는 인자를 알아보기 위해 단변량분석을 시행하였을 때 임상적 원발병소 병기, 병리학적 원발병소 병기, 병리학적 림프절 병기 그리고 병리학적 TNM 병기가 공통적으로 통계적으로 유의한 인자들이었다. 다변량 분석을 시행하였을 때 호르몬치료 유무만 생존율과 연관된 의미 있는 인자였다.결 론: 본 연구를 통하여 삼성서울병원에서 국소 진행성 유방암으로 선행 항암화학요법이 시행된 환자의 치료 성적이 지금까지 보고된 다른 선행 항암화학요법 치료 결과와 비교할 때 비슷하거나 나은 결과를 보여주었다. 또한, 호르몬치료를 시행한 경우에만 생존율이 의미 있게 좋았고 임상적 병기나 병리학적 병기가 낮은 경우 생존율이 좋은경향을 보였다. Purpose: To evaluate the result of neoadjuvant chemotherapy, surgery, and radiation therapy in locally advanced breast cancer as well as analyze the prognostic factors affecting survival. Materials and Methods: One hundred fifty-nine patients with breast cancer were treated by neoadjuvant chemotherapy between April 1995 and November 2006 at the Samsung Medical Center. Among these patients, we retrospectively reviewed 105 patients treated with neoadjuvant chemotherapy followed by surgery and radiation therapy for a cure with an initial tumor size >5 cm or clinically positive lymph nodes. All patients received anthracycline based chemotherapy except for 2 patients. According to clinical tumor stage, 3 patients (3%) were cT1, 26 (25%) were cT2, 39 (37%) were T3 and 37 (35%) were T4. Initially, 98 patients (93%) showed axillary lymph node metastasis. The follow-up periods ranged from 7∼142 months (median, 41 months) after the beginning of neoadjuvant chemotherapy. Results: Locoregional failure free survival rate and distant metastasis free survival rate at 5 years were 82.1% and 69.9%, respectively. Disease free survival rate and overall survival rate at 5 years were 66.1% and 77.1%, respectively. The results of a univariate analysis indicate that clinical tumor stage, pathologic tumor stage, pathologic nodal stage and pathologic TNM stage were statistically significant factors for disease free survival rate and overall survival rate. Whereas, a multivariate analysis indicated that only hormone therapy was a statistically significant factor for survival. Conclusion: The current study results were comparable to other published studies for neoadjuvant chemotherapy for breast cancer. Hormone therapy was a statistically significant prognostic factor. The patients with early clinical or pathologic stage had a tendency to improve their survival rate.

사회 네트워크 분석의 활용을 통한 조직진단 분석에 관한 연구

박치성(Park Chisung),원구환(Won Gu-Hwan) 한국조직학회 2009 한국조직학회보 Vol.6 No.2

단일 의료기관에서 진단된 아나필락시스 환자의 임상적 특성

박향미 ( Hyang Mi Park ),노진철 ( Jin Chul Noh ),박종현 ( Jong Hyun Park ),원연경 ( Youn Kyoung Won ),황세희 ( Se Hee Hwang ),김재윤 ( Jae Yoon Kim ),김유영 ( You Young Kim ),노의정 ( Eui Jung Roh ),정은희 ( Eun Hee Chung ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2012 소아알레르기 및 호흡기학회지 Vol.22 No.3

Purpose: The studies concerning the clinical features of patients with anaphylaxis, who meet the newly established diagnostic criteria, are reported in Korea, but comparative studies regarding the clinical features of children and adult patients with anaphylaxis are lacking. The purpose of this study is to compare the clinical features of the children and adults with anaphylaxis, who meet the new diagnostic criteria at a single hospital. Methods: We reviewed the medical records of patients who were diagnosed with anaphylaxis, anaphylactic shock, urticaria, and angioedema, including inpatients, outpatients and emergency room visited patients, at the National Medical Center from July, 2005 to August, 2011. The clinical characteristics of children and adults, who met the new diagnostic criteria for anaphylaxis, were analyzed. Results: We identified 91 patients with anaphylaxis. Sixteen were children and 75 were adults. The sex ratio (male:female) and the mean age were 1:1.7 and 9.6 years among children, respectively, and 1:2.3 and 42.3 years, respectively, among adults. The most common cause of anaphylaxis based on clinical history was foods in 15 children (93.7%) and 35 adults (46.7%). Twelve children (75%) and 36 adults (48%) were rediagnosed with anaphylaxis. Patients with cardiovascular symptoms and severe severity were 1 (6.3%) and 1 (6.3%), respectively, among children, and 28 (37.3%) and 23 (30.3%), respectively, among adults. Conclusion: We rediagnosed some cases of anaphylaxis, using the new diagnostic criteria and most of the cases were diagnosed initially as urticaria or angioedema. The adults had more severe and more cardiovascular symptoms than children. In the future, a nationwide, multiinstitutional research will be necessary for the prevalence and the clinical features of anaphylaxis by the new diagnostic criteria in Korea.

교양체육참여 대학생들이 인식하는 헬스케어 여가인지와 양생실천정도의 관계에서 여가태도의 매개효과

박휴경(Park, Hyu-Kyoung),원영신(Won, Young-Shin),김희진(Kim, Hee-Jin) 한국사회체육학회 2020 한국사회체육학회지 Vol.0 No.80

Purpose: This study is to find out the mediating effects of leisure aittutde in healthcare leisure perception and YangSaeng behavior. Method: The data were obtained from 320 questionnaires collected by uivnersity students from three universities. They were analyzed by structural models using SPSS. 21.0 and AMOS 21.0. Results: As a result, health care leisure perception had affected the leisure attitude of university students, leisure attitude had affected the YangSaeng behavior, and leisurea ttitude had a medial effect on the relationship between health care leisure and YangSaeng behavior. Conclusion: In summary, it is important for university students to raise their leisure awareness and attitude so that leisure activities can be an important tool to promote a ehalthy lifestyle. Accordingly, measures should be devised to motivate and sustain the participation of college students in leisure activities. Most of all, they should be done through liberal physical activity education and club activities.

기본심폐소생술 교육에 대한 보건계열 대학생의 지식과 태도에 관한 연구

원복연(Bok-Yeon Won),장계원(Gye-Won Jang),황미영(Mi-Yeong Hwang),박성숙( Sung-Suk Park),성정희(Jung-Hee Sung) 대구과학대학교 국방안보연구소 2020 사회융합연구 Vol.4 No.3

본 연구는 2019년 9월부터 10월까지 심폐소생술 교육경험이 있는 전국의 보건계열 학생 529명을 대상으로 일반적인 특성과 심폐소생술의 지식 정도, 인지도, 술기, 태도 등을 조사하기 위하여 자기입식 설문지를 조사하여 다음과 같은 결론을 얻었다. 심폐소생술의 인지도는 학년별로 3학년이 18.09±2.30으로 가장 높고, 1학년이 17.84±2.25로 가장 낮게 조사되었다. 심폐소생술의 술기는 학년별로는 응급구조과 학생이 10.39±4.56으로 가장 높게 나타났고 다음으로 임상병리과, 치위생과 순으로 나타났다. 성별, 학년, 학과별로 분석한 심폐소생술의 지식과 태도와의 관련성을 분석한 결과 심폐소생술 인지와 심폐소생술의 태도에는 통계적으로 유의미한 양의 관련성으로 나타내고 있었다(p〈0.001). 앞으로 보건계열대학에서는 학교마다 다르게 운영되고 있는 심폐소생술교육의 표준화된 교육을 제시하고 교육할 필요가 있다고 판단된다. In this study, a self-administered questionnaire survey had been conducted from Sep. to Oct. 2019 with 529 health related students in the nation who experienced cardiopulmonary resuscitation (CPR) education, in order to find their general characteristics, and their knowledge, perception, performance and attitude of CPR. Method: Frequency and t-test, ANOVA was performed using IBM SPSS, and were conducted according to the need for health-related in order to determine the determinants of the students. Result: Regarding their perception of cardiopulmonary resuscitation, third-year students had the highest score, or 18.09±2.30, and first-year students had the lowest, or 17.84±2.25. Regarding their performance of cardiopulmonary resuscitation, students majoring in emergency rescue had the highest score, or 10.39±4.56, followed by students majoring in clinical pathology and students majoring in dental hygienics. The relation between their knowledge of CPR and their attitude toward CPR was analyzed according to their sex, school year, and department. As a result, there was a statistically significant positive relation between their perception and attitude (p〈0.001). Conclusions: It is judged that universities with health related need to suggest and provide standardized education of CPR which is educated differently in each school at present.

직장여성의 바디-컨디셔닝 프로그램 참여 경험

박휴경 ( Hyu Kyoung Park ),원영신 ( Young Shin Won ),조은영 ( Eun Young Cho ) 대한무용학회 2013 대한무용학회논문집 Vol.71 No.4

This study identified the meanings and changes of experiences of working women in participating Body-Conditioning program, with consisted of elastic bands, ball massages and Ballet barre exercises. To reach this aim, the researcher observed Five working women participants for 6-month from March to August, 2011 at an H department store culture center in Seoul. The data collection included video recording, experience description, literature reviews and in depth interviews with participants. The result through phenomenological analysis, First, usage of tools and the composition of three programs yielded different experience. Second, changed experience occurred in body concept and living habits.

GPS 안테나 위상중심변동 보정모델 비교

박관동(Park, Kwan-Dong),원지혜(Won, Jihye) 한국측량학회 2006 한국측량학회지 Vol.24 No.4

국토지리정보원 GPS 상시관측소 관측환경 분석

박관동(Park, Kwan Dong),김혜인(Kim, Hye In),원지혜(Won, Ji Hye) 한국측량학회 2007 한국측량학회지 Vol.25 No.4

모야모야질환을 동반한 산모 9예의 임상적 고찰

박선경 ( Sun Kyung Park ),현민경 ( Min Kyung Hyun ),차경희 ( Kyung Hee Cha ),심재윤 ( Jae Yoon Shim ),원혜성 ( Hye Sung Won ),이필량 ( Pil Ryang Lee ),김암 ( Ahm Kim ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.11

To describe the clinical manifestations and to establish the management of pregnancy and delivery in pregnant patients with Moyamoya disease. We identified nine women with Moyamoya disease. Six of these patients underwent cesarean section. General anesthesia was administered to only one patient, while epidural or combined spinal-epidural anesthesia was used for the others. The patient diagnosed during pregnancy was epidural anesthesia used for vaginal delivery and two patients diagnosed during post-delivery were delivered vaginally without anesthesia. Three patients showed pregnancy-related complications: intracranial hemorrhage, severe pre-eclampsia, and stroke. Five patients had term delivery, and four had pre-term delivery. The babies were healthy and had no complications. As blood pressure control is the most important factor for the pregnant women with Moyamoya disease, we recommend a spinal or epidural anesthesia in order to reduce the potential complications. Management of the patient`s underlying disease is also crucial.

주관적인 가상 실감화 측정 방법에 대한 시각적 요소 평가 연구

원명주 ( Myeung Ju Won ),박상인 ( Sang In Park ),김치중 ( Chi Jung Kim ),이의철 ( Eui Chul Lee ),황민철 ( Min Cheol Whang ) 한국감성과학회 2012 감성과학 Vol.15 No.3

최근 가상-현실 융합의 VnR(Virtual and Real worlds)은 가상 환경 속에서 경험할 수 있는 실재감을 추구하고 있다. 이러한 가상 세계의 실감화 평가는 다수의 독립적 요인으로 구성된 주관평가에 근거하여 평가 되고 있다. 그러나 기존 대부분의 연구에서는 가상 실감화를 측정하는 문항 및 요인 규명에 대하여 논리적 근거가 제시되지 않고 있으며, 측정 방법에 대한 타당성 검증이 미비한 실정이다. 또한 일부 연구는 가상 환경에 의한 실재감을 시각적 요소 측면에서 진행 하였다. 따라서 본 연구에서는 가상 실감화의 구성요소인 실재감의 시각적 요소를 중점으로, 더욱 합리적이고 타당하게 주관적 가상 실감화 측정 방법을 제안하고자 한다. 이를 위해, 가상 실감화를 연구한 문헌과 전문가를 대상으로 21개의 문항을 수집하였다. 200명의 피험자를 대상으로 극사실주의 인물이미지를 제시하여 상기 문항으로 구성된 설문지를 통하여 5점 척도로 보고하게 하였다. 측정된 데이터에 대해탐색적 요인분석을 수행하여, 요인 적재량 값이 적은 문항은 제거하였으며, 도출된 요인 모형이 적합한지에 대해서 확인적 요인분석을 통하여 통계적으로 타당함을 검증하였다. 요인 분석 결과 가상 실감화의 실재감을 측정하기 위한 주요 세 가지 요인이 결정되었다. 이는 시각적 실재감(3 문항), 시각적 몰입감(7 문항), 시각적 상호작용(4 문항)으로 구성 되었다. 또한 실재감의 시각적 요소를 기반으로 3차원 가상 안구 모델을 표현함에 따라 제안하는 가상 실감화 측정 결과에 영향을 끼침을 확인하였다. 이 결과는 논리적 근거를 통하여 수집된 문항에 대해서 합리적이고 타당하게 가상 실감화의 실재감(시각적 요소) 정도를 평가할 수 있는 측정 방법을 제안하였으며, 제안된 측정 방법의 타당도 검증을 통하여 합리적으로 실감화 정도를 평가함을 검증 하였다. Virtual worlds have pursued reality as if they actually exist. In order to evaluate the sense of reality in the computer-simulated worlds, several subjective questionnaires, which include specific independent variables, have been proposed in the literature. However, the questionnaires lack reliability and validity necessary for defining and measuring the virtual realization. Few studies have been conducted to investigate the effect of visual factors on the sense of reality experienced by exposing to a virtual environment. Therefore, this study was aimed at reinvestigating the variables and proposing a more reliable and advisable questionnaire for evaluating the virtual realization, focusing on visual factors. Twenty-one questions were gleaned from the literature and subjective interviews with focused groups. Exploratory factor analysis with oblique rotation was performed on the data obtained from 200 participants(females: 100) after exposing to a virtual character image described in an extreme way. After removing poorly loading items, remained subsets were subjected to confirmatory factor analysis on the data obtained from the same participants. As a result, 3 significant factors were determined to efficiently measure the virtual realization. The determined factors included visual presence(3 subset items), visual immersion(7 subset items), and visual interactivity(4 subset items). The proposed factors were verified by conducting a subjective evaluation in which participants were asked to evaluate a 3D virtual eyeball model based on the visual presence. The results implicated that the measurement method was suitable for evaluating the degree of the virtual realization. The proposed method is expected to reasonably measure the degree of the virtual realization.