결장뉴 전기활동도에 대한 Ouabain과 Vanadate의 작용

박종규,김기환,서인석,Park, Jong-Kyou,Kim, Ki-Whan,So, In-Suk 대한생리학회 1988 대한생리학회지 Vol.22 No.2

The effects of ouabain on the contractile and electrical activities were investigated in the isolated preparations of guinea-pig taenia coli, and compared with those of vanadate. Spontaneous contractions were recorded with force transducer, and electrical activites were measured by use of suction electrode, or single sucrose-gap technique. The contractions were induced by the electrical stimulation for 5 seconds every 1 minute with alternating current (60 Hz, 3.0 V/cm) through the platinum electrodes located in parallel with the long axis of the preparation. All experiments were performed in tris-buffered Tyrode solution which was aerated with $100%{\;}O_2$ and kept at $35^{\circ}C$. The results obtained were as follows: 1) Responses of spontaneous contractions to ouabain were concentration-dependent; $10^{-7}M$ ouabain caused a rise of basal tone. Above the concentration of $10^{-6}M$ ouabain, an initial increase followed by a decrease in tension was observed. 2) A continuous spike discharge was induced by the administration of $10^{-7}M$ ouabain. Above $10^{-6}M$ ouabain, a transient initial increase followed by a decrease in spike frequency and amplitude was produced, and finally membrane potential was sustained at a certain level without a spike discharge. 3) The characteristic response to $10^{-7}M$ ouabain was not blocked by the pretreatment with $10^{-7}M$ atropine. 4) The electrically induced contractions were completely suppressed at the concentration of $2{\times}10^{-7}M$ ouabain. These contractions were blocked more rapidly in paralled with the increase in ouabain concentration. 5) Effects of vanadate on the spontaneous activities were quite different from those of ouabain; $10^{-6}M$ vanadate increased the amplitude of contractions and $10^{-5}M$ vanadate increased slightly both amplitude and frequency of spontaneous contractions. $10^{-4}M$ vanadate showed irregular phasic contractions superimposed on the increased basal tone. 6) $10^{-5}M$ vanadate depolarized the membrane potential and shortened the interval between the bursts of spike discharge, whereas $10^{-4}M$ vanadate induced continuous spike discharge with membrane depolarization. 7) Vanadate caused a characteristic inhibitory response to the contractions induced by electrical stimulation; An initial rapid inhibition of tension development and then gradual recovery to a certain level. From the above results, the following conclusions could be made: 1) The rise of basal tone at $10^{-7}M$ ouabain is due to continuous spike discharge without a silent period. The continuous spike discharge is likely to be associated with a slight membrane depolarization caused by the blockage of Na pump. 2) The biphasic response induced by above $10^{-6}M$ ouabain seems to occur by the different mechanisms. The initial increase in tension is associated with depolarization along with an increase in spike frquency, whereas the subsequent relaxation occurs through a non-electrical mechanism. 3) The characteristic response to $10^{-7}M$ ouabain is resulted not from the action on intrinsic nerve terminal, but from its direct action on the membrane of smooth muscle cells. 4) The phasic contractions superimposed on the increased basal tone at the concentration of $10^{-4}M$ vanadate is resulted from the continuous spike discharge with membrane depolarization, of which mechanism remains unknown. 5) The inhibitory action of ouabain on the electrically induced contractions suggests that the increasein intracellular Na in some way inhibits the electrically induced $Ca^{2+}$ influx. The mechanism of vanadate action on the induced contractions remains unknown.

임신전 신체질량지수와 임신체중 증가에 관한 연구

한윤종 ( Yun Jong Han ),나혜영 ( Hai Young La ),임재희 ( Jae Hi Ihm ),강창성 ( Chang Seong Kang ),박성철 ( Sung Chul Park ),김영제 ( Young Jae Kim ),박종규 ( Jong Kyou Park ) 대한주산의학회 2001 Perinatology Vol.12 No.4

임상 ; 비합병 초,경산부의 임신중 체중증가에 관한 연구

박현미 ( Hyun Mi Park ),유영욱 ( Yung Wook Yoo ),강창성 ( Chang Seong Kang ),박성철 ( Sung Chul Park ),박종규 ( Jong Kyou Park ) 대한주산의학회 2007 Perinatology Vol.18 No.3

목적: 초·경산부를 대상으로 임신 매 2주별 체중증가에 관한 기준을 마련하고, 임신전 신체질량지수에 의한 영향을 평가한다. 방법: 만삭 분만한 건강한 단태 초산부 536명과 경산부 114명의 임신 매 2주별 체중 자료를 임신 전 신체질량지수를 기준으로 3개군별로 나누어 비교하였다. 결과: 임신 매 2주별 체중증가는 임신 15주 이후 임신전 신체질량지수 군별로 통계적으로 유의한 차이가 있었지만, 초산부군과 경산부군간 유의한 차이는 없었다. 결론: 비정상적인 임신중 체중 증가와 관련된 여러 가지 합병증을 예방하기 위해, 초·경산부도 임신전 신체질량지수 군별로 보다 세심한 산전관리가 요망된다. 또한 한국인 임산부의 임신중 체중 증가에 관한 지표를 구하기 위해 전국적인 다기관 공동연구가 필요할 것으로 사료된다. Objective: To establish the biweekly standard values of pregnancy weight gains for primiparas and multiparas, and to investigate the influence of prepregnancy body mass index on biweekly weight gain during pregnancy. Methods: We analyzed the biweekly weight gain data from 536 primiparas and 114 multiparas who had noncomplicated singleton term pregnancy. Data was categorized according to parity and body mass index (BMI). Results: Biweekly weight gain was significantly different among prepregnancy BMI groups from the 15th week but was not different between primiparas and multiparas. Conclusion: To prevent a lot of complications which may be associated with abnormal weight gain during pregnancy, more careful prenatal care according to the prepregnancy BMI groups is needed. To establish the Korean standard value for antenatal weight gain, a nationwide multicenter study is needed.

흔적 자궁각 임신 파열 1 예와 그 임상적 고찰

나혜영(Hai Young La),한윤종(Yoon Jong Han),임재희(Jae Hee Yim),강창성(Chang Seong Kang),박성철(Sung Chul Park),김영제(Young Jae Kim),박종규(Jong Kyou Park) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.12

N/A The incidence of pregnancy in a rudimentary uterine horn is very rare. We experienced a case of ruptured rudimentary uterine horn pregnancy in the second trimester. The patient was treated by resection of the ruptured horn. Some articles concerned to this subject are reviewed briefly.

난관복원술 후 발생한 병합임신

김진호(Jin Ho Kim),홍선희(Sun Hee Hong),한윤종(Yun Jong Han),나혜영(Hai Young La),강창성(Chang Seong Kang),안기범(Ki Bum An),왕영미(Young Mee Wang),박종규(Jong Kyou Park) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.7

Heterotopic pregnancy is the coexistence of intrauterine and extrauterine pregnancy. It is a rare obstetrical phenomenon with an incidence rate about 0.003%. The risk factors of heterotopic pregnancy are IUD, PID, endometriosis, tubal surgery, etc resulting in functional and anatomical injury to tubes. Recently, the wide use of ovulation induction and in vitro fertilization has increased the incidence rate. The clinical manifestation are low abdominal pain, adnexal mass, peritoneal irritation signs, vaginal bleeding, etc. Early detecion of heterotopic pregnancy is very difficult. However, recently, due to development of pelviscopy, ultrasonogram and other diagnostic procedures, the diagnostic rate has increased.Because of the high maternal morbidity and mortality resulted from intraabdominal bleeding after rupture of ectopic pregnacy, immediate termination of ectopic pregnancy is required usually by operative methods. We experienced a case of heterotopic pregnancy after tubal reanastomosis and report this case with a brief review of literatures.

임신 2주별 정상 임산부의 체중증가에 관한 연구

장윤주 ( Youn Ju Jang ),유창준 ( Chang Jun Yoo ),박현미 ( Hyun Mi Park ),강창성 ( Chang Seong Kang ),박성철 ( Sung Chul Park ),박종규 ( Jong Kyou Park ) 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.10

목적: 산전 관리시 적절한 체중증가에 관한 지침을 마련하기 위해 임신 매 2주별 체중증가의 평균, 표준 편차 및 백분위수를 구하고, 임신전 신체질량지수 및 출산력에 의한 영향을 평가한다. 연구 방법: 만삭 분만한 건강한 단태임산부 910명의 임신 매 2주별 체중 자료를 임신전 신체질량지수를 기준으로 3개군 및 출산력 별로 나누어 비교하였다. 결과: 임신 매 2주별 체중증가의 평균, 표준 편차 및 백분위수를 각각 구했으며, 임신 매 2주별 체중증가는 Sigmoid(S)형 곡선을 나타냈다. 임신 25주 이후 초·경산모군에서 미산모군 보다 체중증가가 적었고, 임신 13주 이후 임신전 신체질량지수 군별로 통계적으로 유의한 차이가 있었다. 결론: 임신 매 2주별 체중 증가 자료를 바탕으로 보다 주의 깊은 산전관리를 통해 적정한 임신체중 증가를 유도하여 비정상적인 임신체중 증가와 관련된 여러 가지 합병증을 예방할 수 있는 자료로 활용할 수 있을 것이고, 또한 한국인 임산부의 임신중 체중 증가에 관한 지표를 구하기 위해 전국적인 다기관 공동연구가 필요할 것으로 사료된다. Objective: To establish the standard values for proper antenatal weight gain, biweekly mean weight gains, standard deviations were calculated from the 5th to the 42nd gestational week and their percentiles were determined. And the influence of prepregnancy body mass index and/or parity on biweekly weight gain was investigated. Methods: We analyzed the biweekly weight gain data from 910 women who had noncomplicated singleton term pregnancy. Data was categorized in three groups according to body mass index (BMI). Results: The biweekly weight gain table has been determined and `Sigmoid(S) shaped` weight gain curves were presented. Primipara and multipara have significantly less weight gain than nullipara beyond the 25th weeks. Biweekly weight gain was significantly different among prepregnancy BMI groups from the 13th week. Conclusion: More careful prenatal care according to the biweekly weight gain-gestational week tables is needed to prevent a lot of complications which may be associated with abnormal weight gain during pregnancy. To establish Korean standard value for antenatal weight gain, a nationwide multicenter study is needed.

비위도관을 통한 위내영양공급으로 치유된 임신오조증 2 예

안기범(Ki Bum Ahn),왕영미(Young Mee Wang),박종규(Jong Kyou Park),신옥철(Ok Cherl Shin),조정철(Jung Cherl Cho),김진호(Jin Ho Kim),홍선희(Sun Hi Hong),강창성(Chang Seong Kang) 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.12

Traditionally, total parenteral nutrition(TPN) has been used when patients with hypaemesis gravidarum failed to respond to conservative management, but now many physicians attempt to enteral feeding via nasogastric tube because TPN is expensive and has many complications. Recently, we experienced 2 cases of hyperemesis gravidarum successfully managed by enteral feeding via nasogastric tube, therefore we think that this method may be carefully considered to the patients with hyperemesis gravidarum failed to respond to conservative management. So we report them with brief review of the literatures.

20대, 30대 초반, 30대 후반 정상 임산부의 임신 개월별 체중증가

유창준 ( Chang Jun Yoo ),장윤주 ( Youn Ju Jang ),박현미 ( Hyun Mi Park ),강창성 ( Chang Seong Kang ),박성철 ( Sung Chul Park ),박종규 ( Jong Kyou Park ) 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.11

목적 : 임신개월별 체중증가의 평균, 표준 편차 및 백분위수를 20대, 30대 초반, 30대 후반 산모군별로 구하고, 각 군별로 차이가 있는지를 평가한다. 연구 방법 : 만삭 분만한 건강한 단태임산부 892명을 대상으로 임신개월별 체중 자료를 20대, 30대 초반, 30대 후반 산모군별로 나누어 비교하였다. 결과 : 산모 나이군별로 임신 개월별 체중증가의 평균, 표준 편차 및 백분위수는 Table 2, Table 3, Table 4와 같았고, 각 군별로 임신 개월별 체중증가는 통계적으로 유의한 차이는 없었다. 결론 : 나이군별로 임신 개월별 체중증가표를 통해 적정한 임신체중 증가를 유도하여 비정상적인 임신체중 증가와 관련된 합병증을 예방할 수 있는 자료로 활용할 수 있을 것이다. Objective: To calculate monthly weight gains during pregnancy among 20s, early and late 30s, and to investigate the influence of age groups on monthly weight gains. Methods: We analyzed the monthly weight gain data from 892 women who had visited before 20 weeks of gestation and had healthy singleton term pregnancy. Data was categorized in three groups according to age (20s, early and late 30s). Results: The monthly weight gain tables among 20s, early and late 30s have been determined. Monthly weight gain was not significantly different among three age groups. Conclusion: Although statistically insignificant among three age groups, more cautious prenatal care according to the monthly weight gain- gestational month tables for each age group is needed to prevent complications which may be associated with abnormal weight gain during pregnancy.

임신 중 체중증가 양상과 연관된 요인에 관한 연구

유영욱 ( Yung Wook Yoo ),하정이 ( Jeong Yi Ha ),강창성 ( Chang Seong Kang ),박성철 ( Sung Chul Park ),박종규 ( Jong Kyou Park ) 대한산부인과학회 2010 Obstetrics & Gynecology Science Vol.53 No.1

목적: 산모의 특성과 임신결과 자료를 이용하여 임신 중 체중증가 양상을 조사한다. 연구 방법: 2002년 1월부터 2009년 8월까지 비합병 단태임산부 1,825명의 임신 중 체중 자료를 이용하여 각 삼분기별로 임신 중 체중증가율을 구하고, 산모의 특성과 임신결과에 따른 임신 중 체중증가 양상과 이들 상호간의 연관성을 분석하였다. 결과: 각 삼분기별 평균 체중증가율 (kg/week)은 제1 삼분기가 가장 낮았으며 (0.06±0.30), 제2 삼분기가 최고였으며 (0.52±0.23), 제3 삼분기에서 다소 감소되는 양상을 보였으며 (0.47±0.23), 중회귀분석에 사용된 일곱 변수 중에서 신생아 성별을 제외한 모든 변수 (출산력, 나이, 키, 신체질량지수, 임신중독증, 임신성 당뇨)가 적어도 한 개 이상의 삼분기에서 임신 중 체중증가와 유의한 연관성이 있었다. 임신 중 체중증가의 중요한 예측인자로는 제1 삼분기에는 신체질량지수, 산모의 키, 나이, 제2 삼분기에는 신체질량지수, 출산력, 키, 제3 삼분기에는 키, 나이, 출산력 순이었다. 결론: 임신 중 체중증가 양상은 산모의 신체적 특성과 임신 결과와 연관이 있었으며, 임신 중 체중증가에 영향을 끼치는 중요한 예측인자는 각 삼분기 별로 서로 달랐다. Objective: To examine the pattern of gestational weight gain using maternal characteristics and pregnancy outcomes. Methods: We used maternal weight data from 1,825 women who had noncomplicated pregnancy between Jan. 2002 and Aug. 2009. The rate of maternal weight gain in each trimester, the associations between gestational weight gain per trimester and maternal characteristics and pregnancy outcomes, and the relationship between maternal characteristics and trimester weight gain were analyzed. Results: The average rate of weight gain (kg/week) was lowest during the first trimester (0.06±0.30), peaked during the second trimester (0.52±0.23), and slowed slightly in the third trimester (0.47±0.23). With the exception of infant sex, all six maternal characteristics and pregnancy outcomes included in the multivariate analyses (parity, maternal age, height, BMI, preeclampsia, gestational DM) were associated significantly with maternal weight gain in at least one trimester. The important maternal predictors of weight gain per trimester were prepregnancy BMI, height and age in the first trimester; prepregnacy BMI, parity and height in the second; and height, age and parity in the third. Conclusion: The pattern of gestational weight gain is associated with a number of maternal characteristics and pregnancy outcomes, and these relationships vary according to which trimester is being examined.

제왕절개술 후 복벽반흔에 발생한 자궁내막증 3예

이정경 ( Chung Kyung Lee ),유재형 ( Jae Hyung Yu ),전석경 ( Seok Kyeng Chun ),정은진 ( Eun Jin Jung ),김은경 ( Eun Kyong Kim ),강창성 ( Chang Seong Kang ),박성철 ( Sung Chul Park ),박종규 ( Jong Kyou Park ),조영규 ( Young Gyu C 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.8

Endometriosis in the abdominal scar following cesarean section is very rare condition among the extrapelvic endometriosis. Abdominal wall endometriosis secondary to cesarean section is being reported in less than 0.5% of patients undergoing cesarean secti