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메티실린 내성 황색 포도상 구균에서 mecA, femA 유전자의 임상적 의의
박정은,김택선,박수성,김은령,김일수,안일영,김영진,김재종,강성옥,박한오,Park, Jung-Eun,Kim, Taek-Sun,Park, Su-Sung,Kim, Eun-Ryoung,Kim, Il-Su,Ann, Il-Young,Kim, Young-Jin,Kim, Jae-Jong,Kang, Sung-Ok,Park, Han-Ho 대한소아감염학회 1996 Pediatric Infection and Vaccine Vol.3 No.2
Purpose : In the treatment of MRSA infection, rapid detection of MRSA is extremely important. The mecA gene codes the new drug resistant polypeptides called PBP2' which mediates the clinically relevant resistance to all beta-lactam antibiotics. The identical mecA gene has been found in coagulase-negative staphylococcus with the methicillin-resistant phenotype. On the other hand, the femA gene was absent from coagulase negative staphylococcus strains with the methicillin resistant phenotype. This study is aimed at early detection and definite diagnosis of MRSA. Methods : A total of 24 MRSA strains were studied. All strains were tested for antimicrobial susceptibility and purified DNA. We amplified both mecA and femA genes by PCR in 24 strains. Results : In MRSA all the 16 strains (100%) carried femA gene and 11 strains (68.7%) carried mecA gene. In contrast, in methicillin sensitive staphylococcus all the 8 strains (100%) carried femA and only 3 strains (37.5%) were detected mecA. Conclusions : As results, there are difference in the phenotype and genotype of methicillin resistance by PCR of mecA and femA. Such disparities between methicillin resistance and the presence of mecA gene suggest the presence of control gene of the mecA.
세치제에 함유된 비효소계 항산화제의 경시변화에 따른 잔류량
박정은 ( Jung-eun Park ),박용덕 ( Yong-duk Park ),홍태기 ( Tae-gi Hong ),장종화 ( Jong-hwa Jang ) 한국치위생학회(구 한국치위생교육학회) 2016 한국치위생학회지 Vol.16 No.5
Objectives: The purpose of this study is to evaluate the non-enzymatic antioxidants stabilities in dentifrices by ascorbic acid and tocopherol according to the chemical condition. Methods: For the analysis of two antioxidants, HPLC UV detector system was used. HPLC was performed using sodium sulfate, acetonitrile(ACN), methanol(MeOH) and measuring absorbance at 240-295 nm. To confirm general pH reaction of two compounds, buffer solution was prepared for the analysis. The dentifrice was titrated by pH so as to examine the change of elapsed time in dentifrice. Linearity of calibration curve of two antioxidants was measured. Results: Each compound showed good linearity at optimized wavelength as well as showing good precision. General pH reaction of two antioxidants was examined. Ascorbic acid showed the highest residue(63.23%) at pH 10 and the lowest residue(2.77%) at pH 4. Tocopherol showed the highest residue(55.70%) at pH 7 and the lowest residue(3.31%) at pH 4. As a result of changing elapsed time of antioxidants in dentifrice by pH, components were remained stably at low temperature(39.2℉) and pH 7. Conclusions: It is necessary to keep dentifrice including ascorbic acid and tocopherol, and non-enzymatic antioxidants at pH 7 and low temperature for improving chemical stability.
자당 및 탄산음료 섭취 후 생성되는 구강 내 치아우식 유발성 유기산의 농도 차이
박정은 ( Jung-eun Park ),장종화 ( Jong-hwa Jang ) 한국치위생학회 2017 한국치위생학회지 Vol.17 No.3
Objectives: This study aims to evaluate carbonated drinks induced dental caries with qualitative analysis and to compare with oral organic acids including lactate, acetate, propionate, formate, butyrate, pyruvate and valerate which cause caries when taking either 10% sucrose drinks or carbonated drinks. Methods: Saliva was collected from six study subjects before and after (start, 5, 10, 30 minutes) taking water intake upon (A) 10% sucrose intake, (B) 10% sucrose intake, and (C) carbonated drink intake, then they were centrifuged at 1,200 rpm followed by removing bacteria and enzymes with syringe filtering, performing a qualitative analysis with HPLC conductivity detection (GP50 gradient pump, ED 50 detector) after saliva pre-treatment under isocratic 100 mM NaOH mobile phase. Results: Higher risk of dental caries was evaluated in order of C>B>A, with the results of total oral organic acids` concentration, lactates of organic acids and organic acids produced after 5 minutes from the 3 types of drinks intake. Conclusions: Carbonated beverages were estimated to develop higher dental caries induction than beverages containing 10% sucrose because of the high organic acid concentration in the mouth after its intake.
크론병 환자에서 메살라진 투여 중 발생한 호산구 폐렴 1예
박정은 ( Jeung Eun Park ),황보영 ( Bo Young Hwang ),장린 ( Rin Chang ),장영운 ( Young Woon Chang ),장재영 ( Jae Young Jang ),김병호 ( Byung Ho Kim ),동석호 ( Seok Ho Dong ),김효종 ( Hyo Jong Kim ) 대한소화기학회 2009 대한소화기학회지 Vol.53 No.2
Mesalazine (5-aminosalicylic acid) and sulfasalazine are widely used in the treatment of inflammatory bowel disease. The pulmonary toxicity related to sulfasalazine was well-recognized complication and it was caused by sulfapyridine moiety in sulfasalazine. However, the lung injury related to mesalazine has rarely been reported. A thirty five-year-old man with Crohn`s disease who was treated with mesalazine complained fever and dry cough. The finding of bilateral wandering pulmonary infiltration, peripheral eosinophilia and increased eosinophils in bronchoalvolar lavage were consistent with eosinophilic pneumonia. His symptoms and laboratory findings were markedly improved after the discontinuation of mesalazine. The mesalazine-induced eosinophilic pneumonia was diagnosed according to his clinical course. This report shows that the eosinophilic pneumonia should be considered in patients who develope pulmonary involvement with inflammatory bowel disease receiving mesalazine therapy. (Korean J Gastroenterol 2009;53:116-120)
Imatinib 치료 후 수술로 제거된 바터씨 팽대부의 악성 위장관간질종양
박정은 ( Jeung Eun Park ),동석호 ( Seok Ho Dong ),조근형 ( Kun Hyung Cho ),장재영 ( Jae Young Jang ),김효종 ( Hyo Jong Kim ),김병호 ( Byung Ho Kim ),장영운 ( Young Woon Chang ),장린 ( Rin Chang ) 대한소화기학회 2010 대한소화기학회지 Vol.56 No.1
Gastrointestinal stromal tumor (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract arising from Cajal`s cells, expressing CD 117. The standard treatment for primary GIST is complete surgical resection. Imatinib mesylate, a specific tyrosine kinase inhibitor, is effective against locally advanced and metastatic GIST. There are several reports of the effect of preoperative imatinib in patients with unresectable and locally advanced primary GIST. We report a case of unresectable primary GIST of the ampulla of Vater, which we were able to completely resect after treatment with a dosage of imatinib 400 mg daily for 5 months. Twelve months later, the patient was treated with imatinib and doing well with no evidence of recurrence. (Korean J Gastroenterol 2010;56:39-44)
커뮤니티케어 기반의 방문노인구강관리 중재 프로그램 개발을 위한 기초연구
장종화 ( Jong-hwa Jang ),조자원 ( Ja-won Cho ),김여주 ( Yeo-ju Kim ),기지윤 ( Ji-yun Ki ),조경숙 ( Kyung-sook Jo ),김지량 ( Ji-ryang Kim ),박정은 ( Jung-eun Park ),김다희 ( Da-hui Kim ) 대한예방치과·구강보건학회 2020 大韓口腔保健學會誌 Vol.44 No.3
Objectives: We evaluated the level of oral health status and oral health behavior in the elderly prior to their participation in a visiting oral health care intervention program as part of a community healthcare project in Cheonan city, South Korea. Methods: The oral hygiene conditions, oral health behaviors, and oral senility of 64 elderly people subject to community care were measured during the period January 1 to February 15, 2020 using dental health surveys and questionnaire-based interviews conducted in line with World Health Organization standard criteria. Results: The systematic disease retention rate of the elderly in this study was 90.6%, followed by hypertention (70.7%), and diabetes (51.7%). Scores were 1.69 out of 5 for subjective health evaluation, 1.8 out of 5 for subjective awareness of oral health, and the number of natural teeth was 14.9 per person (average mean for elderly people 18.38-19.34). During the day, 94.9% practiced brushing, after dinner 58.9%, and before bedtime 26.8%, which shows a diminished rate of practice. The percentage of participants dissatisfied with dental treatment was high at 67.2%, and the six measures of oral sensitivity, masticatory discomfort, pronunciation discomfort, and tongue pressure, presented less than average scores. Conclusions: The level of oral health and oral health behavior of the elderly prior to the visiting oral health care community intervention program, was very poor. Therefore, the results of this study suggest that there is a need to develop a more systematic and thorough strategy to activate visiting community oral health care intervention programs.
강화학습과 감정모델 기반의 지능적인 가상 캐릭터의 구현
우종하(Woo Jong Ha),박정은(Jung-Eun Park),오경환(Kyung-Whan Oh) 한국지능시스템학회 2006 한국지능시스템학회논문지 Vol.16 No.3
학습과 감정은 지능형 시스템을 구현하는데 있어 가장 중요한 요소이다. 본 논문에서는 강화학습을 이용하여 사용자와 상호작용을 하면서 학습을 수행하고 내부적인 감정모델을 가지고 있는 지능적인 가상 캐릭터를 구현하였다. 가상 캐릭터는 여려 가지 사물들로 이루어진 3D의 가상 환경 내에서 내부상태에 의해 자율적으로 동작하며, 또한 사용자는 가상 캐릭터에게 반복적인 명령을 통해 원하는 행동을 학습시킬 수 있다. 이러한 명령은 인공신경망을 사용하여 마우스의 제스처를 인식하여 수행할 수 있고 감정의 표현을 위해 Emotion-Mood-Personality 모델을 새로 제안하였다. 그리고 실험을 통해 사용자와 상호작용을 통한 감정의 변화를 살펴보았고 가상 캐릭터의 훈련에 따른 학습이 올바르게 수행되는 것을 확인하였다. Learning and emotions are very important parts to implement intelligent robots. In this paper, we implement intelligent virtual character based on reinforcement learning which interacts with user and have internal emotion model. Virtual character acts autonomously in 3D virtual environment by internal state. And user can learn virtual character specific behaviors by repeated directions. Mouse gesture is used to perceive such directions based on artificial neural network. Emotion-Mood-Personality model is proposed to express emotions. And we examine the change of emotion and learning behaviors when virtual character interact with user.
강화학습과 감정모델 기반의 지능적인 가상 캐릭터의 구현
우종하(Woo Jong Ha),박정은(Jung-Eun Park),오경환(Kyung-Whan Oh) 한국지능시스템학회 2005 한국지능시스템학회 학술발표 논문집 Vol.15 No.2
학습과 감정은 지능형 시스템을 구현하는데 있어 가장 중요한 요소이다. 본 논문에서는 강화학습을 이용하여 사용자와 상호작용을 하면서 학습을 수행하고 내부적인 감정모델을 가지고 있는 지능적인 가상 캐릭터를 구현하였다. 가상 캐릭터는 여러 가지 사물들로 이루어진 3D의 가상 환경 내에서 내부상태에 의해 자율적으로 동작하며, 또한 사용자는 가상 캐릭터에게 반복적인 명령을 통해 원하는 행동을 학습시킬 수 있다. 이러한 명령은 인공신경망을 사용하여 마우스의 제스처를 인식하여 수행할 수 있고 감정의 표현을 위해 Emotion-Mood-Personality 모델을 새로 제안하였다. 그리고 실험을 통해 사용자와 상호작용을 통한 감정의 변화를 살펴보았고 가상 캐릭터의 훈련에 따른 학습이 올바르게 수행되는 것을 확인하였다.