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천자혜,김현아,곽미정,김효선,박선경,김문숙,최애리,황지인,김윤숙,Chun, Ja-Hae,Kim, Hyun-Ah,Kwak, Mi-Jeong,Kim, Hyuo-Sun,Park, Sun-Kyung,Kim, Moon-Sook,Choi, Ae-Lee,Hwang, Jee-In,Kim, Yoon-Sook 한국의료질향상학회 2018 한국의료질향상학회지 Vol.24 No.2
Purpose: Falls are one of the most frequent health events in medical institutions, however, they can be predicted and prevented. The Quality Improvement Nurse Society clinical practice guideline Steering Committee developed the Clinical Practice Guideline for the assessment and prevention of falls in adult people. The purpose of this study was to assess the risk factors for falls in adults aged 19 years and older, to present an evidence for preventing falls, formulate a recommendations, and indicators for applying the recommendations. Methods: This clinical practice guideline was developed using a 23-step adaptation method according to the Handbook for clinical practice guideline developer (version 1.0) by National Evidence-based Healthcare Collaborating Agency. Evidence levels and recommendation ratings were established in accordance to SIGN 2011 (The Scottish Intercollegiate Guidelines Network). Results: The final 15 recommendations from four domains were derived from experts' advice; 1) assessment of risk factor for falls in adult 2) preventing falls and reducing the risks of falls or falls-related injury 3) management and reassessment after a person falls 4) leadership and culture. Conclusion: This clinical practice guideline can be used as a basis for evaluation and prevention of fall risk factors for adults, to formulate recommendations for fall risk assessment and fall prevention, and to present monitoring indicators for applying the recommendations.
葛根抽出物이 Alloxan으로 誘發된 家兎의 高血糖에 미치는 影響
洪慈惠,朴平心,李明烈 조선대학교 기초과학연구소 1992 自然科學硏究 Vol.15 No.1
Effects of Puerariae radix extract on experimentally alloxan-induced hyperglycemia in rabbits and acute toxicity of mouse were investigated ; LD_50 of Puerariae radix Methanol extract (=P.M.E.) was 11.2g/kg in mice by intraperitoneal injection. P.M.E. 800mg/kg showed more excellent hypoglycemic effect after 5 days and 3 days compared to the control group. sGPT activity and total cholesterol level were significantly decreased in P.M.E. 800mg/kg and blood urea nitrogen level was not showed excellent decreasing effect within 5 days.
편입생의 대학생활 적응을 위한 요구도 조사 및 프로그램 개발
전태일,박성옥,이은화,이자혜,김희경 大田大學校 學生生活硏究所 1998 學生生活硏究 Vol.7 No.-
The first purpose of this research is to investigate the enrollee need assesement for adjustment of the college life . The second purpose of this research is to provide a basis for development and application of enrollee' s adjustment program. The conclusions from above investigation are as follows 1. Each level of the need for classwork , scholastic attainments , career guidance is very high. Thus adjustment program for enrollee needs develop and apply 2. The effectiveness of the enrollee adjustment program has been evalu ated by taking response of the participant. Participant' s response is very positive
${\apha}$-Casein의 인산화 위치 규명을 위한 티타늄 다이옥사이드($TiO_2$) 방법의 최적화
김혜정,박자혜,백문창,Kim, Hye-Jeong,Park, Ja-Hye,Baek, Moon-Chang 대한약학회 2008 약학회지 Vol.52 No.5
Phosphorylation plays the most important role in cell signaling mechanism. Various methods to identify the phosphorylation sites of proteins using tandem mass spectrometry (MS/MS) have been reported recently. Furthermore, the enrichment strategy such as Titanium dioxide ($TiO_2$) method should be combined with MS/MS analysis to effectively identify phosphorylation sites. It is necessary to optimize phosphopeptide-enrichment strategy, $TiO_2$ method in this study, due to the low amount of phosphorylated form followed by analyzing them by MS/MS. To evaluate the several conditions to enrich phosphopeptides using $TiO_2$ method, we used ${\apha}$-casein as a standard phosphoprotein and analyzed a representative phosphopeptide (VPQLEIVPNpSAEER) peak of MS spectrum. Batch is better than column method for binding and 300 g/l DHB in loading buffer is better than lower concentration of DHB. 3% TFA and pH 10.5 shows high efficiency of phosphopeptide-enrichment for washing and elution steps, respectively. Finally we identified various efficient conditions of phosphopeptide-enrichment method using $TiO_2$. This optimized method would assist in reliable identifying thousands of phosphorylation sites existed in low abundance from various complex proteins.
정태능,김동수,임자혜,박인원 ( Tae Neung Johng,Dong Soo Kim,Ja Hei Ihm,In Won Park ) 생화학분자생물학회 1992 BMB Reports Vol.25 No.1
Using fragments of appropriate sizes of 5.8S, 17S, and 25S rRNAs as probes, the arrangement of rRNA genes of cytoplasmic rDNA of Chaetomorpha moniligera has been determined, and also the restriction map of the rDNA has been analyzed. The length of the repeating unit of rDNA is approximately 17 kb long and its organization is as follows: (17S rDNA)-ITS 1-(5.8S rDNA)-ITS 2-(25S rDNA). It has been found that 5S rDNA is not present within 17 kb repeating unit. Interestingly, the presence of an intron of about 0.5 kb has been found within the region of 25S rDNA.