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주상(酒傷)에 응용되는 성주청간탕(醒酒淸肝湯)이 알코올대사 및 간장애에 미치는 영향
박성규,윤상협,류봉하,류기원,김진성,Park Seong-Kyu,Yoon Sang-Hyub,Ryu Bong-Ha,Ryu Ki-Won,Kim Jin-Sung 대한한방내과학회 2003 大韓韓方內科學會誌 Vol.24 No.1
Objectives : The aim of this study was to investigate effects of the Sungjuchunggan-tang(Xingjiuqinggan-tang), which has been used for alcoholic diseases in Oriental medicine, on alcoholic metabolism and alcoholic liver damage. Methods : We evaluated the activities of alcohol dehydrogenase(ADH)and aldehyde dehydrogenase(ALDH), and measured the levels of AST, ALT, glucose, triglyceride, HDL-cholesterol, LDL-cholesterol and phospholipid in serum of guinea pigs. Results and Conclusions : In this experiment, Sungjuchunggan-tang, Pharbitidis Semen and Puerariae Radix significantly suppressed the activity of ADH which is a precursor enzyme of acetaldehyde. Sungjuchunggan-tang and Pharbitidis Semen significantly suppressed the activity of ALDH, which is a catabolic enzyme, and increased its level. Due to alcohol consumption, level of ALT and AST were significantly reduced. These experimental results suggest that Sungjuchunggan-tang and Pharbitidis Semen inhibit the formation of acetaldehyde in the metabolism of alcohol, and affect the recovery of weakened liver functions caused by alcohol.
Cryptand 21 합성수지를 이용한 금속 이온의 흡착 및 분리에 관한 연구
박성규,김준태 ( Seong Kyu Park,Joon Tae Kim ) 한국공업화학회 1995 공업화학 Vol.6 No.6
1%, 2%, 및 20% 다리결합도의 클로로메틸화된 1,4-디비닐벤젠에 cryptand 21 거대고리 리간드를 치환반응으로 결합시키고, 이들 수지로부터 흡착에 미치는 pH, 수지의 다리결합도 그리고 금속 이온 농도의 영향에 대하여 조사하였다. 금속 이온들은 pH 3 이하에서는 잘 흡착되지 않았으나 pH 4 이상에서는 큰 흡착률을 보였으며 금속 이온들의 흡착 평형시간은 약 2시간 이었다. 한편, 에탄올 매질에서의 흡착선택성은 UO₂^(2+)>Ni^(2+)>Ce^(3+)이었으며 1% 다리결합도의 수지를 충진시킨 컬럼에 흡착시킨 후 용리액으로 pH 2.5 HNO₃을 사용하여 개별 분리가 가능하였다. Resins with cryptand 21 macrocyclic ligand attached to chloromethylated styrene-1,4-divinylbenzene by substitution reaction were prepared and the effect of pH, metal concentration and cross-linkage of the matrix on the adsorption for UO₂^(2+), Ni^(2+) and Ce^(3+) was investigated. The metal ion was not adsorbed on the resins pH range below 3 and above pH 4, fast adsorption behavior was showed. The resin selectivity determined in ethanol matrix was in increasing order UO₂^(2+)>Ni^(2+)>Ce^(3+). In addition, these metal ion could be separated on the column packed with 1% crosslinked resin by pH 2.5 HN₃ as an eluent.
박성규,안덕균,우은란,박현미,Park, Seong-Kyu,Ahn, Duk-Kyun,Woo, Eun-Ran,Park, Hyun-Mee The Society of Korean Medicine 1997 대한한의학회지 Vol.18 No.1
Scutellariae Radix has been widely used as oriental herbal medicine for the treatment of bacterial infections in the respiratory or the gastrointestinal tract. In partition experiment for better understanding of herbal medicine with various solvents, baicalein or wogonin have more hydrophobic characteristics than baicalin or wogonoside. Unexpectedly, methylene chloride could extract more for baicalin or wogonoside over other active ingredients. New compound from baicalin is discovered casting frointier area on herbal medicine in the future. Application study with new molecule hydrolyzed from baicalin is on the way for better treatment of the patient against specific disease. The baicalin modified with reaction has been shown weak antibacterial activity against Streptococcus pyogenes 308A and Pseudomonas aeruginosa 1771. The minimum inhibitory concentration (MIC) of the baicalin modified compound against those strains were about $600\;{\mu}g/mL$, respectively. In vitro antitumor experiment, $EC_{50}$ of baicalin modified with reaction was more than $300\;{\mu}g/mL$ and $EC_{50}$ of baicalein was $100\;{\mu}g/mL$. Among these compounds, baicalin exhibited high level of antitumor activity. $EC_{50}$ of baicalin was less than $33.3\;{\mu}g/mL$.