방풍통성산의 비만에 대한 약리학적 고찰 - 일본의 연구를 중심으로 -

박상아,방극수,장영남,이정호,이종현,진종식,Park, Sang-Ah,Bang, Keuk-Soo,Chang, Young-Nam,Lee, Jeong-Ho,Lee, Jong-Hyun,Jin, Jong-Sik 대한한의학방제학회 2014 大韓韓醫學方劑學會誌 Vol.22 No.2

Objectives : Excessive nutrition intake and lack of physical activity induce obesity through accumulation of fat in human body. The obesity have been categorized as a disease and known to cause several chronic diseases and cancers. In Japan, Bangpungtongsung-san has been applied as one of the therapies of the obesity and it's pharmacological uses have been studied for a long time. The purpose of this study is reviewing researches of Bangpungtongsung-san related to the obesity. Methods : By searching with the keyword of "Bangpungtongsung-san" or related words such as "Bofutsushosan" and 'TJ-62" from PubMed and off-line libraries, many reports were gathered and reviewed from the perspective of the obesity. Results and Conclusions : It has become evident by reviewing the reports that Bangpungtongsung-san is useful as a therapy of the obesity though some case reports showed side effects. Also, the mechanisms of Bangpungtongsung-san on obesity were reviewed and suggested.

논 문 : 토양 및 퇴적물 시료 중 다이옥신(PCDD/DFs)의 전처리방법 개선에 관한 연구

박상아 ( Sang Ah Park ),이혜리 ( Hye Ri Lee ),김지인 ( Ji In Kim ),최종우 ( Jong Woo Choi ),이원석 ( Won Seok Lee ) 한국환경분석학회 2015 환경분석과 독성보건 Vol.18 No.4

This study was carried out to improve pretreatment methods for analyzing polychlorinated dibenzo-p-dioxinsdibenzofurans (PCDD/DFs) in environmental samples such as soils and sediments. The official method of using clean-up standard substances and the method of pre-packed column system analysis were applied to the environmental samples. The recovery rates of these two methods were low. In addition, wide ranges of relative standard deviations (RSD) were observed in highly-chlorinated congeners of sediment samples. In the soil samples, similar PCDD/DFs concentrations were observed for each pretreatment method. The sediment samples, however, showed larger RSDs due to complex matrices and low concentrations. An automated preparation system was also applied as a pretreatment method for analyzing PCDD/DFs in environmental samples. This system was found less affected by the proficiency of analysts than the other pretreatment methods. Besides, the automated preparation system was useful for simple/rapid clean-up, and can reduce the consumption of analysis apparatus as well as organic solvents. The automated preparation system can also be applied to monitoring and screening PCDD/DFs in environmental samples.

실내 바닥먼지 중 폴리브롬화디페닐에테르(PBDEs)의 잔류수준 및 이성질체 분포특성

박상아 ( Sang Ah Park ),와타나베이사오 ( Isao Watanabe ),이원석 ( Won Seok Lee ),이두희 ( Doo Hee Lee ),민병윤 ( Byung Yoon Min ),혼다카츠히사 ( Katsuhisa Honda ) 한국환경분석학회 2015 환경분석과 독성보건 Vol.18 No.2

We investigated the concentrations, congener distributions, and characteristics of polybrominated diphenyl ethers (PBDEs) in house dust samples collected from general houses of an industrial area in Korea. The mean concentration of ΣPBDEs in indoor dust samples from 20 houses was 1900 ng/g, while deca-BDE (BDE-#209) was the predominant congener accounting for 85% of ΣPBDEs. The concentration of PBDEs increased with the presence of electrical/electronic products in the indoor environment, except for the dust samples collected from the inside of TV. The congener distribution patterns were similar in nearly all samples. However, BDE- #99, BDE-#100 and BDE-#47, which belonged to Σlower-BDEs (38%), were dominant in the samples from the inside of TV, displaying a slightly different distribution from the other indoor environment conditions. Meanwhile, there was no relationship between the particle size of house dust and the PBDE concentration. The distribution patterns of congeners were also similar to those prior to re-classification (>150 μm). In this study, we concluded that the electrical/electronic products were an important factor for the concentration of PBDEs in the indoor environment, and deca-BDE was a major contaminant. Therefore, analytical methods for deca- BDE should be established for further regulatory monitoring of PBDEs from electrical/electronic products.

청주 도심 내 현존 건축물의 신축 시기별 유형분류 및 분포특성

박상아(Park, Sang-Ah),정진주(Jung, Jin-Ju),김태영(Kim, Tai-Young) 대한건축학회 2023 대한건축학회 학술발표대회 논문집 Vol.43 No.1

This study examines the classification and distribution characteristics of existing buildings by period around Seongan-dong and Jungang-dong, downtown Cheongju. First, the existing 4,644 buildings account for 1,295 buildings (27.89%) built before 1969, 972 buildings (20.93%) in the 1970s, 895 buildings (19.27%) in the 1980s, 696 buildings (14.99%) in the 1990s, and 786 buildings (16.92%) since 2000. Second, residential buildings (2,293 buildings, 49.3%) and neighborhood living facilities (2,023 buildings, 43.5%) account for 92.8% of the total. Apartment houses were newly built in the 70s and multi-family houses in the 80s, and 529 houses with commercial functions and 369 neighborhood living facilities with residential functions are distributed. Third, there are 967 wooden buildings (20.8%), 1,439 building structures (30.9%), and 1,359 reinforced concrete structures (29.3%). More than 90% of the wooden structures on the first and second floors were constructed before 69 years, and the building structure has rapidly decreased since 2000, and the reinforced concrete structure is mainly built after the 1970s.

컨텍스트를 고려한 옛 주거지의 유휴지 개발 프로세스에 관한 연구

박상아(Park, Sang-Ah),정진주(Jung, Jin-Ju),김태영(Kim, Tai-Young) 대한건축학회 2023 대한건축학회 학술발표대회 논문집 Vol.43 No.2

This study was to explore context-based development plans for idle land in old residential areas located outside the southern gate of Cheongju, and a five-step process was conducted. In the first step, referring to the restoration map of the old residence, the road, direction, and the previous layout of houses suitable for each lot shape were reflected, in the second step, a plan was carried out through a review of the current laws, structures, and modules, and in the third step, a cross-sectional plan was carried out through a review of the size of buildings and internal and external spaces. Step 4 is a parking lot plan based on a combination reflecting the architectural agreement system, and step 5 is a feedback from steps 1 to 4. At each stage, it was intended to reflect the contents of the physical space that the existing old residence had continuously, but it should be supplemented through more in-depth research on historical, place, and architectural values in the future.

환경의식, 사회책임적 의류소비태도와 패스트 패션 결과지각의 관계

박상아 ( Sang Ah Park ),박재옥 ( Jae Ok Park ),이지연 ( Ji Yeon Lee ) 복식문화학회 2014 服飾文化硏究 Vol.22 No.2

This study examines how environmental consciousness and socially responsible clothing consumption attitude influence people’s perceptions of the consequences of fast fashion· Data were collected through a questionnaire survey administered to females in their 20s to 40s, and a total of 430 surveys were used in the final analysis· The research results are as follows· First, environmental consciousness-which was conceptualized as interest in consumer effectiveness and the environment-had a positive influence on attitudes toward socially responsible clothing consumption attitude, i·e·, clothing recycling and resource conservation· As the perception of consumer effectiveness was high, respondents had a tendency not to follow trends· Second, consumers with a high level of interest in the environment perceived the effect of fast fashion on the environment as serious, and they felt negatively toward personal use of fast fashion· Third, consumers with strong resource conservation behavior perceived the effect of fast fashion on the environment as serious, but those with positive attitudes toward secondhand clothing did not appear to have that perception· Finally, consumers who followed trends and those with weakly held attitudes about resource conservation felt positively toward personal use of fast fashion· The results of this research indicate that environmental consciousness is an important factor for socially responsible clothing consumption behavior· In addition, consumers with strong attitudes regarding resource conservation were more perceptive of the negative effect of fast fashion on the environment·

콘크리트에 매립된 평판의 부착강도에 대한 실험적 연구

박상아(Park, Sang-Ah),황환명(Hwang, Hwan-Myung),이용택(Lee, Yong-Taeg),김승훈(Kim, Seung-Hun) 대한건축학회 2022 대한건축학회 학술발표대회 논문집 Vol.42 No.2

십자형 스티프너가 보강된 H형 전단패널 댐퍼에 관한 해석적 연구

박영상(Park, Yeong-Sang),최진철(Choi, Jin-Chul),이도경(Lee, Do-Gyeong),박상아(Park, Sang-Ah),김승훈(Kim, Seung-Hun),박해용(Park, Hae-Yong) 대한건축학회 2023 대한건축학회 학술발표대회 논문집 Vol.43 No.2

초산부, 경산부 초유 중 PCDDs, PCDFs, dioxin-like PCBs의 축적수준 및 상관성 평가

Sung-Ug We(위성욱),Ki-Ho Kim(김기호),Yu-Jin Cho(조유진),Bong-Hui Cho(조봉희),Sang-Ah Park(박상아),In-Cheon Baek(백인천),Seong-Hoon Kang(강성훈),Cho-Hee Yoon(윤조희),Byung-Yoon Min(민병윤) 한국생명과학회 2010 생명과학회지 Vol.20 No.7

PCDDs, PCDFs, dl-PCBs는 많은 역학 연구에서 독성오염물질이라고 간주되고 있는 생물축적 화학물질이다. 본 연구는 산모 초유 중에 이들 오염물질을 조사 분석하여 산모특성에 따른 축적성 및 상관성을 평가한 것으로, 실험대상 산모는 2007년에 평균연령 31.5세(표준편차=3.6세)의 건강한 초산부와 경산부이다. PCDDs 7개 이성질체, PCDFs 10개 이성질체, non-ortho PCBs 4개와 mono-ortho PCBs 8개 이성질체가 HRGC/HRMS로 분석되었다. 총 WHO-TEQs 평균값은 9.41 pg TEQ/g lipid로 다른 나라 농도에 비하여 낮은 수준이었다. 백분율의 증가와 함께 총 WHO-TEQs의 주요 기여자는 2,3,4,7,8-PeCDF, 1,2,3,7,8-PeCDD 및 3,3´,4,4´,5-PCB (#126)이며, 총 WHO-TEQs의 60% 이상으로 나타났다. PCDFs 농도와 총 WHO-TEQs는 출산경험에 대해서는 음의 상관관계를 나타내었으며(p<0.05) 산모의 연령은 총 WHO-TEQs에 대해서 양의 상관관계를 나타내었다(p<0.01). 그러나, 임신 전 체질량지수와 어류섭취의 상관관계는 유의성이 없었다. 이들 결과로부터 출산경력과 산모 연령은 모유 내의 PCDD/DFs 및 dl-PCBs의 농도에 영향을 미치는 중요한 인자로 판단된다. Polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and dioxin-like polychlorinated biphenyls (dl-PCBs) are bioaccumulative chemicals that are considered to be toxic contaminants based on several epidemiological studies. These chemicals in colostrum were investigated and estimated for their residual consistencies by maternal characteristics like parity and maternal ages. Test subjects were healthy primipara and multipara mothers with a mean age of 31.5 (S.D=3.6) in 2007. Seven isomers of PCDDs, 10 of PCDFs, 4 of non-orthopolychlorinated biphenyls(non-ortho PCBs) and 8 of mono-orthochlorinated polychlorinated biphenyls (mono-ortho PCBs) were analyzed by HRGC/HRMS. From the analyzed data, the mean level of total WHO-TEQs was 9.41 pg TEQ/g lipid, which is significantly lower than the level found in individuals from other countries. The main contributors to the total WHO-TEQs with increasing percentages were 2,3,4,7,8-PeCDF, 1,2,3,7,8-PeCDD and 3,3',4,4',5-PCB (#126), and they accounted for more than 60% of the total WHO-TEQs. PCDFs concentrations and total WHO-TEQs were negatively associated with parity (p<0.05), and maternal age was positively associated with total WHO-TEQs (p<0.01). However, the associations with body mass index (BMI) and fish intake during pregnancy were not significant. These results were suggested that parity and maternal age are an important factor affecting the concentrations of PCDD/DFs and dl-PCBs in these specimens.

춘천지역 모유 중 폴리브롬화디페닐에테르(PBDEs)의 이성체별 분포특성과 노출경로

Sung-Ug We(위성욱),In-Cheon Baek(백인천),Sang-Ah Park(박상아),Seong-Hoon Kang(강성훈),Yu-Jin Cho(조유진),Bong-Hui Cho(조봉회),Cho-Hee Yoon(윤조희),Ki-Ho Kim(김기호),Byung-Yoon Min(민병윤) 한국생명과학회 2010 생명과학회지 Vol.20 No.3

본 연구는 비교적 청정한 지역인 춘천시에 거주하는 일반인 모유 중 PBDEs의 노출 경로를 확인하기 위해 처음으로 시도된 연구이다. 본 연구지역의 모유 중 ∑PBDEs의 수준은 북아메리카지역에 비하여 낮은 수준이었으나 일부 아시아, 유럽국가와 유사하였다. 모유 내 PBDEs의 축적은 산모의 특성과 상관관계가 나타나지 않았으나, 상업용 PBDEs 제품을 포함하여 여러 복합적 인자에 의하여 노출되고 있었으며, 식품 섭취와 같은 식이노출은 한국인에 있어 중요한 노출 경로의 하나로 판단되었다. 따라서 본 연구 결과는 한국인의 PBDEs 노출 경로 파악에 중요한 정보를 제공하여, 장차 PBDEs 및 관련 브롬계 난연제의 노출에 따른 인체 위해성 평가를 수행함에 있어 중요한 참고자료가 될 것이다. 또한, 한국 내의 PBDEs에 대한 인체노출 경로를 명확하게 하기 위한 연구는 계속적으로 이루어져야 할 것이다. This study was carried out to investigate the exposure pathway of PBDEs in human breast milk collected from new mothers residing in Chuncheon, a comparatively clean area in Korea. The congeners of PBDE in 22 human breast milk samples were analyzed using a high resolution gas chromatography with a high resolution mass detector. The residue level of ΣPBDEs was higher in primipara subjects than in multipara subjects (p<0.05). The levels in this study were similar to those of people in some Asian and European countries, but were lower than those of people in north America. In the congener profiles, BDE-47 (mean contribution=36.1%) was predominant, followed by BDE-153 (27%), BDE-99 (11.7%), BDE-100 (11.1%), BDE-28 (7.9%) and BDE-183 (3.5%). The sum of BDE-47 and BDE-153 accounted for more than 50% of ΣPBDEs in most samples. BDE-47 was highly correlated with ΣPBDEs (r=0.94, p<0.001). No strong trend was observed between PBDE levels and a number of key biological factors (women’s age, weight, height and body mass index) examined in this study, however, weak correlations were observed in PBDE levels measured against dietary habits, particularly in fish consumption frequency. It seems that Korean people might be exposed to multiple sources including products of PBDEs, and particularly food resources.