http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
박귀영,박미경,김은주,이미경,서성준 대한의학회 2011 Journal of Korean medical science Vol.26 No.7
IgE-dependent activation of mast cells and basophils through the high-affinity IgE receptor (FcεRI) is involved in the pathogenesis of allergen-induced immune responsiveness in atopic diseases like atopic dermatitis (AD). We sought to determine FcεRI gene polymorphisms are associated with AD in Korean patients, and analyzed the relevance of FcεRI gene polymorphisms and serum IgE levels. We conducted a case-control association analysis (175 patients and 56 controls) of Korean subjects. Genotyping was performed using the TaqMan fluorogenic 5´ nuclease assay, and serum levels of IgE were measured using a fluorescence enzyme immunoassay. We found that there were no significant relationships between FcεRI and AD, although there were trends towards an association between the 66T>C (rs2251746) polymorphism and total serum IgE levels in the Korean AD patients. In conclusion, while the 66T>C (rs2251746) of the FcεRIα polymorphism may be linked to AD and higher serum IgE levels, polymorphisms in the FcεRIβ gene did not confer susceptibility to AD in our patient sample.
박귀영 한국군사회복지학회 2013 한국군사회복지학 Vol.6 No.2
본연구의 목적은 군 사회복지사 자격제도와 양성방안에 대한 세부 교육과정을 통한 양성방안을 제 시하는 것이다. 이에 본 연구는 군에 적합한 군 사회복지의 실행과, 국가가 인증하는 전문적인 군 사회복지사의 양 성이시급히 이루어져야 될 것으로 사료되어 군에서의 사회복지를 재조명하고 현행 한국에서 시행되 고 있는 전문 사회복지와 미국의 군 사회복지에 대한 연구를 통해 군사회복지사 자격제도와 양성을 위한 세부교육과정을 검토하였다. 군 복무 중에 있는 개인과 가족, 군 환경이 개선됨을 통해 염려와 고충을 해결하고 전투력 손실을 사 전에 예방하여 전장에서 승리하는데 필요로 하는 강한 군대 조성을 위해서는 전문적인 군사회복지 사 자격을위한 법제화가 추진되어야 할 것이며 군사회복지사의 활동과 배치 등을 위한 계속적인 노 력이 필요하며 군사회복지를 담당하는 전문 군사회복지사의 양성이 시급히 요구되고 있다. 따라서 본 연구는 군의 목표인 전장에서 승리하는데 필요로 하는 강한 군대를 육성하는데 꼭 필요로 하는 군 사회복지사 자격제도와 양성방안을 제시였다.
An Analysis of the Filaggrin Gene Polymorphism in Korean Atopic Dermatitis Patients
박귀영,Kapsok Li,석준,서성준 대한의학회 2016 Journal of Korean medical science Vol.31 No.7
Research of the FLG mutation in various ethnic groups revealed non-overlapping mutation patterns. In addition, Japanese and Chinese atopic patients showed somewhat different mutations. These ethnic differences make the research on Korean patients mandatory; however, no systematic research on Korean atopic dermatitis (AD) patients has been performed. This study aims to investigate the genetic polymorphism of FLG in Korean atopic dermatitis patients. The study was made up of three groups including 9 Ichthyosis vulgaris (IV) patients, 50 AD patients and 55 normal controls: the ichthyosis group was incorporated due to the reported association between the FLG mutation and IV. In comparison to other sequencing methods, the overlapping long-range PCR was used. We revealed the genetic polymorphism of filaggrin in Koreans, and at the same time, we discovered nonsense mutations in p.Y1767X and p.K4022X in Korean AD patients. By using FLG sequencing techniques confirmed in this study, new mutations or genetic polymorphisms with ethnic characteristics would be detected and further larger studies of repeat number polymorphisms could be performed.
박귀영 대한의사협회 2018 대한의사협회지 Vol.61 No.11
Acne vulgaris is a very common condition affecting up of about 80% to 90% of adolescents. The patients with acne have been shown to be adversely impacted by the effect of acne on their quality of life. Four factors are believed to play a key role in the development of acne lesions: excess sebum production, disturbed keratinization within the follicle, colonization of the pilosebaceous duct by Propionibacterium acnes, and the release of inflammatory mediators into the skin. Consequently, the target for acne therapy is these well-known pathogenic factors responsible for this disease state. Topical retinoids correct abnormal keratinization, but it should be applied cautiously because of irritation. Benzoyl peroxide is an effective bactericidal agent against P. acnes. Main topical antibiotics are erythromycin and clindamycin. Fixed combination topical products with retinoids, benzoyl peroxide and antibiotics have been introduced. Use of systemic antibiotics, including tetracyclines and macrolides rapidly improves inflammatory acne lesions. Oral isotretinoin is effective against all of the main pathogenic features of acne but is contraindicated in pregnant women and has been associated with cheilitis and dry skin. Hormonal therapy has been found to improve acne in some selective patients and should be considered for appropriate candidates. This review will present the general aspects of the pharmacological treatments for acne.