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새로운 2-(5-Propargyloxyphenyl)-4,5,6,7-tetrahydro-2H-indazole의 합성과 제초활성
전동주(Dong Ju Jeon),박관용(Kwaun Yong Park),김영미(Young Mi Kim),김형래(Hyoung Rae Kim),송종환(Jong Hwan Song),황인택(In Taek Hwang),유응걸(Eung K Ryu) 한국농약과학회 2001 농약과학회지 Vol.5 No.4
Of the cyclic imide type compounds, S-275 was known to exhibit a potent herbicidal effects. We have designed and synthesized the compounds having diverse substituents in place of the chlorine group of bicyclic 4,5,6,7-tetrahydroindazole part of S-275. Their herbicidal activities were studied under flooded paddy conditions. The results showed that the most compounds gave relatively weak herbicidal activities, whereas the compound substituted with methylthio group showed potent herbicidal effects against paddy weeds at a rate of 0.015 ㎏/㏊ and improved tolerance on rice compared to S-275.
새로운 9-(5-isoxazolemethoxyphenyl) imino-8-thia-1,6-diazabicyclo [4.3.0]nonan-7-one 유도체의 합성과 제초활성
전동주(Dong Ju Jeon),박관용(Kwaun Yong Park),정순민(Soon Min Chung),김형래(Hyoung Rae Kim),송종환(Jong Hwan Song),노재성(Zaesung No),황인택(In Taek Hwang) 한국농약과학회 2003 농약과학회지 Vol.7 No.4
New series of 9-(5-Isoxazolemethoxyphenyl)imino-8-thia-1,6-diazabicyclo[4.3.0]nonan-7-one which are the cyclic imide type compounds were designed and synthesized. The herbicidal activities of main dominant weeds to these compounds were evaluated under rice field condition. There is the possibility for a new herbicide since the most of compounds were excellent to main dominant weeds occurring in rice field without the serious rice injury.
Dong Ju Jeon(전동주),Young Mi Kim(김영미),Kwaun Yong Park(박관용),Hyoung Rae Kim(김형래),Jong Hwan Song(송종환),Jin-Seog Kim(김진석),Eung K Ryu(유응걸) 한국농약과학회 2001 농약과학회지 Vol.5 No.3
A series of bicyclic 4,5,6,7-tetrahydroindazole derivatives 6 have been synthesized, and their herbicidal activities were studied in flooded paddy condition. The compounds 6 showed herbicidal effects to bamyardgrass and Monochoria and good tolerance against rice at a rate of 0.063 ㎏/㏊~0.25 ㎏/㏊.
살균성, Phenylthionocarbamate 유도체들의 정량적인 구조와 독성과의 관계
성낙도,양숙영,박관용 충남대학교 농업과학연구소 2001 농업과학연구 Vol.28 No.1
아직까지 시도된 바 없는 살균성 phenylthionocarbamate 유도체들의 phenyl-치환기가 변화함에 따라 TOPKAT 계산으로 예측된 다양한 급성 및 만성 독성값에 미치는 정량적인 분자구조와 독성과의 관계 (QSTRs)를 검토한 결과는 다음과 같다. (1) 기질분자의 구조변화에 따른 독성치와 그의 판별점수 (D.S.)에 기초하여 분자 중 특정부분(FRAGMENT)이 양 (+)의 값으로 독성에 기여하는 대체적인 순서는 Aro, C=C, -O-, -NH- 및 할로겐 (X) 원자의 순이었다. (2) 대부분의 화합물들은 매우 높은 돌연변이와 발암성이 예측되었으며 특히, 치환기의 위치에 관계없이 fluoro-치환체는 B₂상수에 따른 입체효과 ((B₂)_(opt)=1.54Å)에 의하여 모두 100% 돌연변이를 발현한 반면에 trifluoromethyl-치환체는 돌연변이 발현 가능성이 전혀 없었다. (3) 가장 높은 독성 발현조건은 phenyl-치환기에 대한 소정의 적정값으로 돌연변이성에는 (B₂)_(opt)=1.54Å, 발암성에는 수컷 rat와 mouse는 (R)_(opt)=0.16 및 (π)_(opt)=0.16 그리고 rat는 경구독성은 LD_(50)(εLUMO)_(opt)=-0.52e.v, chronic LOAEL; (B₃)_(opt)=1.54Å, 어독성은 LC_(50);(log P)_(opt)=4.25 및 물벼룩에 대한 독성은 EC_(50),(σ)_(opt)=0.68를 나타내는 경우이었다. (4) 돌연변이성에는 할로겐 중 fluoro-기를 위시하여 nitro 및 methyl-기 등의 순서로 기여하였고 phenyl 고리 상, 치환기의 위치와 전자수수관계에는 대체로 무관한 경향을 나타내었다. The authors attempted to derive a comprehensive quantitative structure-toxicity relationships (QSTRs) between various physicochemical parameters of phenyl substituents in fungicidal phenylthionocarbamate derivatives and toxicity evaluated using TOPKAT calculation On the basis of this approach we made preditions for toxicity values for not yet tested substances with respect to these systems The results suggested that the optimal values. (B_(2))_(opt)=l.54_(A)(Ames mutagnicity). (R)_(opt)=0.l6 (car-cinogemcity of male rat). (π)_(opt)=0.16 (carcinogenicity of male mouse). (εLUMO)_(opt)=-0.52 ev (LD of rat oral). (B_(3)opt =l54_(A)(chronic LOAEL), (logP)_(opt) =425(LC_(50) of Fathead minnow) and (σ)_(opt)=-0.68(EC_(50) of Daphnia magna) of phenyl substituents were strongly correlated with the acute and chronic toxicities