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이승호(Seung Ho Lee),유시용(Shi Yong ryu),최상운(sang Un Choi),노재성(Zaesung No),김성기(Sung Ki Kim),이정옥(Chong Ock Lee),안종웅(Jong Woong Ahn) 한국생약학회 1995 생약학회지 Vol.26 No.1
EtOAc soluble part of MeOH extract of Anemarrhena asphodedoides rhizome was evaluated for the cytotoxicity against the five kinds of human tumor cell lines (A-549, SK-OV-3, SK-MEL-2, XF498 and HCT15) in vitro. Bioassay-guided fractionation of EtOAc soluble part led to the isolation of active compound which was identified as timosaponin A-III showed potent cytotoxic activity, but its genin, sarsasapogenin, did not show cell growth inhibition.
새로운 9-(5-isoxazolemethoxyphenyl) imino-8-thia-1,6-diazabicyclo [4.3.0]nonan-7-one 유도체의 합성과 제초활성
전동주(Dong Ju Jeon),박관용(Kwaun Yong Park),정순민(Soon Min Chung),김형래(Hyoung Rae Kim),송종환(Jong Hwan Song),노재성(Zaesung No),황인택(In Taek Hwang) 한국농약과학회 2003 농약과학회지 Vol.7 No.4
New series of 9-(5-Isoxazolemethoxyphenyl)imino-8-thia-1,6-diazabicyclo[4.3.0]nonan-7-one which are the cyclic imide type compounds were designed and synthesized. The herbicidal activities of main dominant weeds to these compounds were evaluated under rice field condition. There is the possibility for a new herbicide since the most of compounds were excellent to main dominant weeds occurring in rice field without the serious rice injury.
The Structure of Kushenol M from Sophora flavescens
Ryu, Shi Yong,Lee, Seung Ho,No, Zaesung,Kim, Kye-Young,Lee, Sueng-Geun,Ahn, Jong Woong 영남대학교 약품개발연구소 1995 영남대학교 약품개발연구소 연구업적집 Vol.5 No.-
The linkage pattern of two side chains i.e., a isopentenyl and a lavandulyl group in kushenol M(I), a flavonoid form Sophora flavescns was established by the aid of 2-D NMR techniques, especially DEPT, ¹³C-¹H COSY and COLOC experiments. Thus, I was unequivocally determined and (2R, 3R)-5, 7, 2', 4'-tetrahydroxy-6-isopentenyl-8-lavandulylflavanonol.
이승호,유시용,최상운,노재성,김성기,이정옥,안종웅 영남대학교 약품개발연구소 1995 영남대학교 약품개발연구소 연구업적집 Vol.5 No.-
EtOAc soluble part of MeOH extract of Anemarrbena asphodeloides rhizome was evaluated for the cytotoxicity against the five kinds of human tumor cell lines (A-549, SK-OV-3, SK-MEL-2, XF498 and HCT15) in vitro. Bioassay-guided fractionation of EtOAc soluble part led to the isolation of active compound which was identified as timosaponin A-Ⅲ1 showed potent cytotoxic activity, but its genin, sarsasapogenin, did not show cell growth inhibition.
Lee, Seung-Ho,Ryu, Shi Yong,Choi, Sang Un,Lee, Chung Ock,No, Zaesung,Kim, Sung-Kie,Ahn, Jong-Woong 영남대학교 약품개발연구소 1995 영남대학교 약품개발연구소 연구업적집 Vol.5 No.-
The cytotoxicity-directed fractionation of MeOH extract of Terminalia chebula fruits led to the isolation of three hydrolyzed tannins and a related compound, gallic acid(1), 1, 2, 3, 4, 6-penta-O-galloyl-β-_(D)-g1ucopyranose(Ⅱ), chebulagic acid(Ⅲ) and chebulinic acid(Ⅳ), as active principles. They were shown to exhibit moderate cytotoxicity against cultured human tumor cell lines including A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15 in vitro.
Antitumor Triterpenes from Medicinal Plants
Ryu, Shi Yong,Choi, Sang Un,Lee, Seung Ho,Lee, Chung Ock,No, ZaeSung,Ahn, Jong Woong 영남대학교 약품개발연구소 1995 영남대학교 약품개발연구소 연구업적집 Vol.5 No.-
Thirteen kinds of natura11y occurring or derivatised triterpenes, reported to have an antitumoral property, were reinvestigated on the basis of their direct cytotoxicity or the inhibitory activity on cell growth against five kinds of cultured human tumor cells, i. e., A-549, SK-OV-3, SK-MEL-2, XF498 and HCT15, in vitro. Ursonic acid Ⅲ, betulinic acid Ⅷ, betulonic acid X and glycyrrhetinic acid XI were exhibited a marked inhibition on cell growth.
Antitumor activity of Trichosanthes kirilowii
Ryu, Shi Yong,Lee, Seung Ho,Choi, Sang Un,ee, Chung Ock,No, Zaesung,Ahn, Jong Woong 영남대학교 약품개발연구소 1995 영남대학교 약품개발연구소 연구업적집 Vol.5 No.-
The acitivity-directed fractionation upon the MeOH extract of the not of trichosanthes kirilowill led to the isolation of eight cucurbitane triterpenes namely cucurbitacin B(Ⅰ), isocucubitacin B(Ⅱ), cucurbitacin D (Ⅲ), isocucurbitacin D (Ⅳ, 3-epi-isocucurbitacin B(Ⅴ), dihydrocucurbitacin B(Ⅵ), dihydroisocucurbitacin B(Ⅶ) and dihydrocucurbitacin E(Ⅷ), as active principles. All isolates were shown to exhibit significant cytotoxicity against cultured human tumor cells, including A-549, SK-OV-3, 5K-MIL-2, XF-498 and HCT 15, with an exceptionally high potency.