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흉막 결핵에서 연령과 흉수 Adenosine Deaminase 활성도와의 연관성
문진욱 ( Jin Wook Moon ),한창훈 ( Chang Hoon Han ),강신명 ( Shin Myung Kang ),박무석 ( Moo Suk Park ),황상연 ( Sang Yeon Hwang ),변민광 ( Min Kwang Byun ),정우영 ( Wou Young Chung ),황혜진 ( Hye Jin Hwang ),김영삼 ( Young Sam K 대한결핵 및 호흡기학회 2005 Tuberculosis and Respiratory Diseases Vol.58 No.5
흉막 결핵의 진단에 있어서 흉수 검체양에 따른 중합효소연쇄반응 검사의 민감도
문진욱 ( Jin Wook Moon ) 대한결핵 및 호흡기학회 2007 Tuberculosis and Respiratory Diseases Vol.62 No.3
연구배경: 결핵성 흉막염의 진단에 있어서 흉수에 대한 중합효소연쇄반응 검사는 매우 낮은 민감도를 보였으며, 이는 흉수 내의 결핵균의 수가 적은 데에 기인하는 것으로 추정된다. 이번 연구에서는 흉수의 검체양을 증가시켰을 때 결핵성 흉수에 대한 중합효소연쇄반응 검사의 민감도가 향상되는지를 알아보고자 하였다. 방법: 결핵성 흉막염에 대한 감별 진단이 필요하였던 53명의 환자에 대하여 전향적인 연구를 시행하였다. 각각의 환자로부터 얻은 흉수를 10 ml, 25 ml, 50 ml로 양을 달리 하여 결핵균에 대한중합효소연쇄반응 검사를 시행하였으며, Cobas Amplicor MTB (Roche Diagnostic Systems)를 이용하였다. 결핵성 흉막염은 흉수에서 결핵균이 배양된 경우, 흉막 생검에서 결핵이 진단된 경우, 가래에서 결핵균이 배양된 경우 및 기타 원인이 배제된 상태에서 임상적으로 결핵성 흉수가 의심되며 항결핵제 투약으로 흉수가 호전된 경우를 포함하였다. 결과: 53명의 환자 중 26명이 결핵성 흉막염으로 진단되었다. 흉수에 대한 항산균 바름질, 결핵균 배양, 아데노신 디아미나아제 측정 및 흉막 생검의 민감도는 각각 3.8%, 15.4%, 88.5%, 84.6%이었다. 10 ml, 25 ml, 50 ml의 흉수를 이용한 결핵균 중합효소연쇄반응 검사는 각각 3명(11.5%), 4명(15.4%), 3명(11.5%)에서 양성이었으며, 통계적으로 유의한 차이를 보이지 않았다(p>0.05, symmetry exact 검사). 결론: 결핵균의 수가 극히 적을 것으로 예상되는 흉수 등의 검사물에 대해서는 결핵균 중합효소연쇄반응 검사의 임상적 유용성이 극히 제한적이며, 검사물의 양을 증가시키더라도 민감도는 향상되지 않는다. Background: For the diagnosis of pleural tuberculosis, polymerase chain reaction (PCR) of pleural effusion specimens has shown very low sensitivity, which might be due to the small number of bacilli in the samples. The purpose of this investigation is to determine whether the sensitivity of PCR testing can be improved when increasing the amount of pleural effusion specimens. Methods: We prospectively analyzed pleural effusion specimens obtained from 53 patients for whom the exclusion of the possibility of tuberculous pleural effusion was necessary. We performed Mycobacterium tuberculosis PCR testing using the Cobas Amplicor MTB test (Roche Diagnostic Systems) with three different amounts (10ml, 25ml, and 50ml) of pleural effusion specimen in each patient. Pleural tuberculosis was defined as having one of the following: culture-positive pleural fluid sample, histopathologic finding consistent with tuberculosis on pleural biopsy, culture-positive sputum specimen, and/or positive response to anti-tuberculous medication without other possible causes of pleural effusion. Results: Of the 53 patients, 26 received the diagnosis of pleural tuberculosis. The sensitivities of AFB smearing, Mycobacterium tuberculosis culture of pleural effusion specimen, pleural biopsy, and measurement of ADA were 3.8%, 15.4%, 84.6%, and 88.5%, respectively. The results of PCR testing were positive for 3 (11.5%), 4 (15.4%), and 3 (11.5%) of the 26 patients when using 10ml, 25ml, and 50ml of pleural effusion specimens, respectively. These results did not show a statistically significant difference in the sensitivity of PCR testing when increasing the amount of pleural effusion samples (p>0.05, symmetry exact test). Conclusion: For specimens such as pleural effusion, in which the bacillary load is very low, the clinical utility of PCR testing seems highly limited with the kits designed for the diagnosis of pulmonary tuberculosis. An increased amount of pleural effusion sample does not improve the sensitivity of PCR testing. (Tuberc Respir Dis 2007; 62: 184-191)
RF/DC 동시인가 마그네트론 스퍼터링 방법으로 증착된 ITO 박막의 열처리 특성 연구
문진욱(Jin-Wook Moon),김동원(Dong-Won Kim) 한국표면공학회 2007 한국표면공학회지 Vol.40 No.3
The ITO films were deposited on glass substrates by RF-superimposed dc reactive magnetron sputtering and were annealed in N₂ vacuum furnace with temperatures in the range of 403 K~573 K for 30 minutes. Electrical, optical and structural properties of ITO films were examined with varying annealing temperatures from 403 K to 573 K. The resistivity of as-deposited ITO films was 5.4×10?⁴Ω㎝ at the sputter conditions of applied RF/DC power of 200/200 W, O₂ flow of 0.2 sc㎝ and Ar flow of 0.2 sc㎝. As a result of annealing in the temperature range of 403 K~573 K, the crystallization occurred at 423 K that is lower than the crystallization temperature caused by a conventional sputtering method. And the resistivity decreased from 5.4×10?⁴Ω㎝ to 2.3×10?⁴Ω㎝, the carrier concentration and mobility of ITO films increased from 4.9×10 20/㎤ to 6.4×1020/ cm3, from 20.4 ㎠/Vsec to 41.0 ㎠/Vsec, respectively. The transmittance of ITO films in visible became higher than 90% when annealed in the temperature range of 423 K~573 K. High quality ITO thin films made by RF-superimposed dc reactive magnetron sputtering and annealing in N₂ vacuum furnace will be applied to transparent conductive oxides of the advanced flat panel display.
인슐린양 성장 인자 결합 단백-3 유전자-202 좌위의 다형성에 따른 비소세포폐암의 위험도
문진욱 ( Jin Wook Moon ),장윤수 ( Yoon Soo Chang ),한창훈 ( Chang Hoon Han ),강신명 ( Shin Myung Kang ),박무석 ( Moo Suk Park ),변민광 ( Min Kwang Byun ),정우영 ( Wou Young Chung ),박재준 ( Jae Jun Park ),유경남 ( Kyeong Nam Yo 대한결핵 및 호흡기학회 2005 Tuberculosis and Respiratory Diseases Vol.58 No.4
정상윤 ( Sang Youn Jung ),문진욱 ( Jin Wook Moon ),박민찬 ( Min Chan Park ),박용범 ( Yong Beom Park ),윤미진 ( Mi Jin Yun ),이수곤 ( Soo Kon Lee ) 대한류마티스학회 2003 대한류마티스학회지 Vol.10 No.3
Neuropsychiatric lupus is a complication of systemic lupus erythematosus (SLE) characterized by profound metabolic alteration including impaired blood flow, ischemia, decreased aerobic metabolism and progressive neuronal loss of central nervous system. Because of the lack of useful diagnostic methods, it`s diagnosis and management is difficult. Recently, F-18-fluoro-2-deoxy-D-glucose positron emission tomography (18FDG-PET) is considered to be a sensitive and reliable method for evaluating SLE patients with neuropsychiatric involvement as compared with brain computed tomography (CT) or magnetic resornance imaging (MRI). In SLE patient having mild or severe neuropsychiatric manifestations, 18FDG-PET shows hypo- or hypermetabolism by different glucose utilization in brain tissue. We experienced a 23-year-old woman with SLE who presented with seizure and loss of consciousness. Initially, brain MRI finding was negative, but brain 18FDG-PET revealed significant hypometabolism in the cerebral hemisphere at active stage of disease and complete resolution of metabolic abnormalities after treatment. Herein, we report a case of neuropsychiatric lupus diagnosed by brain 18FDG-PET.