변형근전치술의 임상 결과

문준웅,김성준,장봉린,.Jun-Woong Moon. M.D... Sung-Jun Kim. M.D... Bong-Leen Chang. M.D.. 대한안과학회 2005 대한안과학회지 Vol.46 No.8

Purpose: To report the clinical experience and surgical results of modified transposition surgery, in which half-width tendons are isolated and sutured into the paralyzed extraocular muscle. Methods: We retrospectively reviewed the medical records of 6 patients (7 eyes), who had undergone modified transposition surgery to correct severe limitation of eye movement from January 1996 to December 2001. First, we divided the half-width tendons of two rectus muscles adjacent to the paralyzed rectus muscle and disinserted the halves from the sclera. The two half-width tendons were positioned underneath of the scleral insertion of the paralyzed muscle, sutured together and then sutured to the paralyzed muscle. In the case of contracture of the antagonizing extraocular muscle, recession of the antagonist was performed. Results: Five of the six patients showed deviation under 15 prism diopters at primary gaze at distance, while synergistic divergence recurred in the sixth patient. Conclusions: Modified transposition surgery as described in this paper is thought to be an effective and safe method for correction of paralytic strabismus.

베체트 포도막염에 대한 타크로리무스(Tacrolimus)의 단기 효과와 합병증

문준웅,송수정,구보경,조영민,유형곤,Jun Woong Moon,Su Jeong Song,Bo Kyung Koo,Young Min Cho,Hyeong Gon Yu 대한안과학회 2007 대한안과학회지 Vol.48 No.12

Purpose: To investigate the clinical effects and side effects of Tacrolimus for ocular Beh?et`s disease. Methods: Eight patients (male: 5, age: 35±7.5 (25-48) years) with Beh?et`s uveitis, refractory posterior uveitis unresponsive to combination treatment with cyclosporine, azathioprine, and oral steroid or significant cyclosporine-related adverse effects were recruited prospectively, and cyclosporine was switched to Tacrolimus. Visual acuity, degree of anterior chamber, and vitreous haze were compared before the conversion and three months after. Oral glucose tolerance, plasma insulin, cholesterol, creatinine, and aspartate (AST)/alanine aminotransferase (ALT) were measured to monitor systemic effects. Results: Visual acuity did not change significantly after conversion to Tacrolimus. Anterior chamber (seven patients) and vitreous (four patients) inflammation were found before conversion and decreased or disappeared after conversion. Overall plasma levels of glucose, insulin, creatinine, and AST/ALT were similar before and after conversion. However, cholesterol was significantly decreased after conversion (p=0.028). One patient developed diabetes mellitus. Conclusions: Tacrolimus may be effective for Beh?et`s uveitis unresponsive to or intolerable of traditional treatments. In addition, periodic monitoring for side effects, such as hyperglycemia and diabetes mellitus, may be necessary.

노인성 초기 백내장 진행의 위험인자

문준웅,이진학,Jun-Woong Moon,Jin-Hak Lee 대한안과학회 2005 대한안과학회지 Vol.46 No.5

Purpose: To investigate risk factors for the progression of age-related incipient cataract. Methods: Among patients who visited the authors’ clinic (SNUH) from Jun 2002 to Jan 2003 for age-related incipient cataract, those meeting one of the following two criteria were recruited: 1) non-progressive group: BCVA (best corrected visual acuity) decrease by two lines or less for 5 years or more according to Snellen’s chart, 2) progressive group: BCVA decrease by four lines or more in 5 years or less. Age, sex, regular exercise, smoking, drinking, anti-cataract eyedrops, duration of menopause, hormone replacement therapy, weight, height, and BMI (body mass index) were investigated by questionnaire and compared between the two groups. If both eyes met the eligibility criteria, one eye was randomly selected. Results: There were not statistically significant differences regarding age, sex, anti-cataract eyedrops application, regular exercise, duration of menopause and hormone replacement therapy, smoking, drinking, weight, and height. However, the mean BMI of the progressive group was significantly higher than that of the non-progressive group (p=0.041, Student t-test). Conclusions: In patients with age-related incipient cataract, high BMI may be related to more rapid progression of incipient cataract, thus resulting in faster visual loss.

제3형 머리얼굴틈새와 동반된 선천결막붙음증

문준웅,황정민-,Jun Woong Moon Jeong-Min Hwang- 대한안과학회 2006 대한안과학회지 Vol.47 No.1

Purpose: To report a case of congenital symblepharon associated with No. 3 craniofacial cleft. Methods: A 40-month old girl with left eyelid lesion underwent an ophthalmologic examination at the department of ophthalmology and a face examination at the department of plastic and reconstructive surgery. Results: Congenital symblepharon associated with No. 3 craniofacial cleft including bifid uvula, partial cleft lip, and coloboma of the lower medial eyelid was found. She did not have amblyopia or strabismus. A MEDLINE search of the literature revealed only one reported case of symblepharon associated with a craniofacial cleft.

포장 조건에 따른 저장 중 커피의 향미 특성의 변화와 보존 기간

문준웅(Jun-Woong Moon),조재선(Jae-Sun Cho) 한국식품과학회 1999 한국식품과학회지 Vol.31 No.2

당뇨황반부종에서 시간과 스펙트럼 도메인 빛간섭단층촬영으로 측정한 황반두께의 반복성과 일치도

오세범,문준웅,김형찬,Se Beum Oh,MD,Jun Woong Moon,MD,Hyung Chan Kim,MD,PhD 대한안과학회 2010 대한안과학회지 Vol.51 No.3

Purpose: To evaluate the repeatability of macular thickness measurements using time domain (TD) OCT and spectral domain (SD) OCT in diabetic macular edema. Methods: In 42 eyes of 42 patients with diabetic macular edema, three consecutive macular measurements were performed with TD OCT and SD OCT, and measurements for macular thickness and total macular volume obtained by the two OCTs were compared. The within-subject standard deviation (Sw), coefficient of variation (CVw), and intraclass correlation coefficient (ICC) were calculated to assess repeatability, with agreement between measurements assessed with Bland Altman plots. The correlations were also evaluated via the Pearson’s correlation coefficient. Results: The Sw of TD OCT and SD OCT for foveal thickness, total macular volume were 29.67 μm/16.44 μm, 1.26 mm3/0.23 mm3, respectively, and were significantly lower in SD OCT. The ranges of the respective CVw and ICC values were 1.10-2.78%, 0.78~0.96 for TD OCT, and 0.29~0.94%, 0.92~0.99 for SD OCT. The SD OCT showed better repeatability for macular thickness measurements (all p≤0.001). The 95% limits of agreement for foveal and total macular volume were 88.9 μm, 2.4 mm3, respectively. The Pearson’s correlation coefficients of macular thickness and total macular volume between the two OCT methods were statistically significant (p=0.88-0.99). Conclusions: Although both OCTs proved reliable for macular thickness measurements in diabetic macular edema, SD OCT shows better repeatability than TD OCT. Although macular thickness measurements obtained from the two OCTs cannot be used interchangeably, there were statistically significant correlations between measurements obtained using the two OCTs. J Korean Ophthalmol Soc 2010;51(3):372-378

정상안의 유리체황반경계면 평가에 대한 시간영역과 스펙트럼영역 빛간섭단층촬영의 효용성 비교

유자영,김형찬,문준웅,Ja Young You,Hyung Chan Kim,Jun Woong Moon 대한안과학회 2013 대한안과학회지 Vol.54 No.1

Purpose: To compare the efficacy of time domain (TD) and spectral domain (SD) optical coherence tomography (OCT) in determining vitreomacular interface (VMI). Methods: VMIs were evaluated with TD and SD OCT images crossing the fovea horizontally in 69 eyes (mean age 52.7 ± 15.4 years) and were classified as follows: (1) no vitreomacular separation (VMS), (2) incomplete VMS, and (3) unknown. Results: In TD OCT, no VMS was observed in 2 eyes (2.9%), incomplete VMS in 2 eyes (2.9%), and unknown in 65 eyes (94.2%). In SD OCT, no VMS was observed in 31 eyes (45.0%), incomplete VMS in 13 eyes (18.8%), and unknown in 25 eyes (36.2%). In 31 eyes with no VMS on SD OCT, 29 eyes (93.5%) presented unknown on TD OCT (p<0.0001). In 13 eyes with incomplete VMS on SD OCT, 2 eyes (15.4%) showed incomplete VMS and 11 eyes (84.6%) showed unknown on TD OCT (p<0.0001). TD OCT was also non-informative in all 25 eyes with unknown on SD OCT. Conclusions: SD OCT allows better visualization of VMI than TD OCT, especially in patients with no VMS.

나이관련 황반변성의 맥락막신생혈관에서 베바시주맙 유리체강내 주입술 효과와 예후인자

오세범,조원빈,문준웅,김형찬,Se Beum Oh,Won Bin Cho,Jun Woong Moon,Hyung Chan Kim 대한안과학회 2009 대한안과학회지 Vol.50 No.2

Purpose: To investigate the effects and prognostic factors related to intravitreal injection of bevacizumab on patients with subfoveal choroidal neovascularization secondary to age-related macular degeneration. Methods: The medical records of patients who received 3 consecutive intravitreal injections of bevacizumab (1.25 mg/0.05 ml, 6 weeks interval) for subfoveal choroidal neovascularization secondary to age-related macular degeneration and followed up for more than 12 months were reviewed (a total of 31 eyes; male, 20; mean age, 72.3±7.5 years). Baseline best corrected visual acuity, foveal thickness, and total macular volume were compared with those after 1, 4, and 12 months. The therapeutic effects were investigated with regard to factors such as age, sex, initial visual acuity, lesion size, subtypes of choroidal neovascularization, pigment epithelial detachment, submacular hemorrhage, and previous history of photodynamic therapy. Results: Initial visual acuity (logMAR), foveal thickness, and total macular volume were 0.74±0.49, 320±88 μm and 9.50±2.99 mm3, respectively. Visual acuity improved to 0.68±0.61 (p=0.012), and foveal thickness and total macular volume decreased to 218±69 μm and 6.32±0.71 mm3 (p<0.001), respectively, at 12 months. Visual improvement was achieved less often in patients who were 75 years or older and who had lesions 3 disc areas or greater and relatively good initial vision at 12 months. Conclusions: Intravitreal bevacizumab injection has beneficial effects for patients with subfoveal choroidal neovascularization secondary to age-related macular degeneration with regard to function and anatomy. However, it should be noted that visual improvement may be limited in older patients with larger lesions and good initial vision.