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합성한 펩티드 저해물에 의한 엔케파린 아미노펩티다제의 저해
문병조,차종원 ( Byung Jo Moon,Jong Won Cha ) 생화학분자생물학회 1992 BMB Reports Vol.25 No.2
In an effort to increase effective action of enkephalins, several peptide inhibitors of enkephalin aminopeptidase which contain a zinc binding site at N-terminus and side chains of enkephalin were synthesized. Enkephalin aminopeptidase was purified from rat brain by (NH₄)₂SO₄ fractionation, DEAE-cellulose chromatography, gel-filtration and rechromatography on DEAE-cellulose. The enzyme hydrolyzes L-Tyr-β-naphthylamide with K_m value of 5.91 × 10^(-5) M. The peptide inhibitors are shown to be very strong competitive inhibitors of enkephalin aminopeptidase (K_i=10^(-7)M).
문병조,김준규 ( Byung Jo Moon,Joon Kyoo Kim ) 생화학분자생물학회 1991 BMB Reports Vol.24 No.1
A rapid method for the synthesis of oligodeoxyribonucleotides by the phosphotriester approach in solution is described. This method is suitable for the preparation of relatively large quantities of pure compounds in relatively short time.
Plasma Etch Damage가 (100) SOI에 미치는 영향의 C-V 특성 분석
조영득,김지홍,조대형,문병무,조원주,정홍배,구상모,Jo, Yeong-Deuk,Kim, Ji-Hong,Cho, Dae-Hyung,Moon, Byung-Moo,Cho, Won-Ju,Chung, Hong-Bay,Koo, Sang-Mo 한국전기전자재료학회 2008 전기전자재료학회논문지 Vol.21 No.8
Metal-oxide-semiconductor (MOS) capacitors were fabricated to investigate the plasma damage caused by reactive ion etching (RIE) on (100) oriented silicon-on-insulator (SOI) substrates. The thickness of the top-gate oxide, SOI, and buried oxide layers were 10 nm, 50 nm, and 100 nm, respectively. The MOS/SOI capacitors with an etch-damaged SOI layer were characterized by capacitance-voltage (C-V) measurements and compared to the sacrificial oxidation treated samples and the reference samples without etching. The measured C-V curves were compared to the numerical results from corresponding 2-dimensional (2-D) structures by using a Silvaco Atlas simulator.
문병조,차종원,권오신,Moon Byung Jo,Cha, Jong Won,Kwon Oh Shin 대한화학회 1991 대한화학회지 Vol.35 No.1
Enkephalin의 작용을 연장하기 위한 연구이 하나로서 수개의 enkephalin aminopeptidase의 저해물을 합성하였다. 이 펩티드성 저해물은 zinc 결합자리로서 3-amino-2-hydroxy amino acid와 기질양상의 곁사슬을 가진다. 펩티드들은 용액 중에서 DCC/HOBt를 축합시약으로 사용하여 C-말단으로부터 사슬 연장법으로 합성하였다. 합성한 펩티드 저해물들은 모두 enkephalin aminopeptidase에 대하여 강한 저해 작용을 나타내었다. In an effort to increase effective action of enkephalins, several peptide inhibitors of enkephalin aminopeptidase have been synthesized. The peptides contain 3-amino-2-hydroxy amino acid as a zinc binding site and side chains of substrate pattern. The peptides were synthesized in solution by chain elongation from C-terminal end using DCC/HOBt as coupling reagent. The peptides are shown to have very strong inhibitory activity against enkephalin aminopeptidase.
Rapid Synthesis of Self-Complementary Oligodeoxynucleotides
문병조,김준규,Moon, Byung-Jo,Kim, Joon-Kyoo Korean Society for Biochemistry and Molecular Biol 1991 한국생화학회지 Vol.24 No.1
용액 중에서 포스포트리에스테르 방법에 의한 올라고디옥시리보뉴크레오티드의 신속한 합성법을 개발하였다. 이 방법은 비교적 과량의 순수한 올리고뉴크레오티드를 비교적 짧은 시간에 신속히 합성하는데 적합하다. A rapid method for the synthesis of oligodeoxyribonucleotides by the phosphotriester approach in solution is described. This method is suitable for the preparation of relatively large quantities of pure compounds in relatively short time.