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한국인 B형 간염 바이러스 관련 간질환에서 HBV C 및 S 유전자 영역 돌연변이의 면역학적 중요성
정정명 ( Jung Myung Chung ),조환진 ( Hwan Jin Cho ),이연재 ( Yeon Jae Lee ),장윤식 ( Yeun Sik Jang ),박은택 ( Eun Taek Park ),최봉기 ( Bong Ki Choi ),모혜경 ( Hye Kyoung Mo ),박영홍 ( Yeong Hong Park ) 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
<목적> 본 연구의 목적은 HBV DNA의 C와 S 유전자 영역에서 돌연변이의 빈도를 관찰하고 면역 상태와 C와 S 유전자 영역의 돌연변이 사이에 상관관계를 알아보고자 한다. <방법> HBV 관련 간질환 소아와 성인 34명으로부터 추출한 혈청이나 생검 간조직으로부터 DNA을 추출하였다. 추출한 DNA로부터 HBV의 C와 S 유전자 영역을 증폭하고 클로닝하여 염기서열을 분석하였다. <결과> 34례의 adr type의 분석 결과 32례(94.1%)에서 co
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각종 만성 간질환들에서 B형간염 바이러스의 잠재성 감염에 대한 관찰
정정명,강석우,윤철,채두근,김성목,설상훈,조환진,조경임,박영홍,모혜경 인제대학교 백병원 2001 仁濟醫學 Vol.22 No.2
Objectives: Occult Hepatitis B virus infection is defined as HBV DNA positivity without HBsAg by serologic test. It has been thought to be caused by the escape mutant which do not express HBsAg or prouduce S protein with altered antigenicity. But the precise mechanism and pathophysiology of this phenomenon is still unclear despite of numerous previous reports. We investigated occult hepatitis B infection and their clinical characteristics in the patients with various chronic liver diseases. Methods and Materials: Thirty eight patients with chronic liver diseases with positive HBsAb or negative HBsAg were included. After confirmation of HBV DNA, we performed entire base pair sequence analysis on the C region of HBV genome. Results: 1. HBV DNA was detected 29 cases among 38 patients(76.3%) they had 12 chronic toxic hepatitis(41.4%), 7 liver cirrhosis(24.1%), 7 cases of simultaneous hepatocellular carcinoma with liver cirrhosis(24.1%), 1 chronic C hepatitis(3.4%), 1 alcoholic liver disease(3.4%), and 1 uncertified cause(3.4%). 2. The mutation at core promoter region were found in 24 patients(83.1%), of which 15 showed simultaneous mutations in both nucleotide 1762 and 1764, and 1 patients in 1764 single mutation. 3. Twenty four of 29 patients(83.1%) have mutations at precore region, of which the nucleotide 1896(codon 28) was the most frequent site(9 patients- 37.5%). 4. The mutations were found at whole length of core gene, but were the most frequent at epitope regions. For cytotoxic T cell epitope region, the mutation in codon 27 and 31 were from 9(31.0%) and 19(65.5%) patients, respectively. For CD4 epitope region, the mutations in codon 49, 60 and 76 were from 12(41.4%), 9(31.0%) and 16 patients(55.2%), respectively. And for B cell epitope region, those in codon 130 and 143 were from 19(65.5%) and 15 patients(52.0%), respectively. 5. S gene mutations were observed in only 3 patients, 2 liver cirrhosis and 1 hepatocellular carcinoma patients. Point mutation was frequently observed in codon 51, 67, 68, 91 of pre-S1, codon 38, 39, 40, 46 of pre-S2, and codon 3, 27, 82, 92 of S gene. In the case of hepatocellular carcinoma, the 120bp deletion from pre-S1 to pre-S2 was observed. Conclusion: From the above results, we may conclude that the occult hepatitis B virus infection is highly prevalent in epidemic area of HBV infection, and may be related with severe liver diseases. Escape mutant may be an important mechanism of this phenomenon.
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