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조철호(Chul-Ho Cho),고용준(Yong-Joon Ko),안유민(Yoomin Ahn),이성환(Sung-Hwan Lee),조남규(Nahmgyoo Cho),맹준호(Joon-Ho Maeng),이병철(Byung-Chul Lee),황승용(Seung-Yong Hwang) 대한기계학회 2005 대한기계학회 춘추학술대회 Vol.2005 No.5
Immunoassay is a method for clinical diagnoses and biochemical studies with antibody-antigen reaction. However, immunoassay takes a lot of time and expensive reagents. In this research, we report a microbiochip which can detect the electric signal from biochemical reaction with high sensitivity and low sample volume using micro bead. Gold electrode was fabricated on glass substrate using conventional MEMS technology for detecting the electric signal.
주화성에 의한 활동성 정자 분리용 마이크로 바이오칩에 관한 연구
고용준(Yongjun Ko),맹준호(Joon-Ho Maeng),안유민(Yoomin Ahn),황승용(Seung Yong Hwang) 대한기계학회 2008 大韓機械學會論文集A Vol.32 No.12
This paper presents a new microchip which can separate motile sperm by chemotaxis. The microchip was developed to create longitudinal concentration gradient in the microchannel due to diffusion. Linearly good concentration gradient of chemoattractant was generated without any fluid control devices. In sperm separation experiment with the developed microchip, mouse sperm was used as sample and acetylcholine was selected as chemoattractant. Human tubal fluid (HTF), buffer solution, was introduced into the microchannel of the microchip and attractants diluted in ratio of 1, 1/2, 1/4, 1/8, 1/16, 1/32 and 1/64 including control (DI water) were dropped in each outlet by 2 ㎕ volume with micropippet. After 5min, 1 ㎕ sperm solution was dropped into inlet of the chip. After 10 min, when sperms reached to the outlet by chemotaxis, we counted sperms in each outlet by using microscopy. Consequently, we could separate progressive motile sperm with the new microchip. In the experiment, the most sperms were isolated at the outlet dropped with 1/16 diluted solution. The optimal concentration gradient to induce chemotaxis was about 0.625 ㎎/㎖/㎜.
독거노인의 도구적 일상생활수행능력이자기방임에 미치는 영향에 대한 사회적 지지의 조절효과
정희성(Jeong, Hee-Seong),맹준호(Maeng, Joon-Ho) 한국통합사례관리학회 2020 한국케어매니지먼트연구 Vol.0 No.34
본 연구의 목적은 독거노인의 도구적 일상생활수행능력이 자기방임에 미치는 영향을 실증적으로 분석하고 사회적 지지가 가지는 조절효과를 검증하여 노년기의 자기방임을 완화하기 위한 실천적 함의를 도출하는데 있다. 이를 위해 대전광역시 노인돌봄기본서비스를 이용하는 만 65세 이상 독거노인을 모집단으로 하여 설문조사를 실시하였고, 수집된 406명의 자료 중, 366명의 자료를 활용하여 분석하였다. 자료 분석은 인구학적 특성과 주요 변인에 대한 집단비교를 위해 t-test, ANOVA를 실시하였고, 위계적 회귀분석을 통해 도구적 일상생활수행능력과 자기방임 간의 관계에서 사회적 지지의 조절효과를 검증하였다. 연구 결과, 주관적 건강상태가 좋지 않을수록, 도구적 일상생활수행능력, 정서적 지지, 물질적 지지의 수준이 낮을수록 자기방임 정도가 높은 것으로 나타났다. 또한, 도구적 일상생활수행능력과 자기방임의 관계에서는 사회적 지지 중, 정서적 지지만이 조절효과가 있는 것으로 나타났다. 본 연구 결과를 바탕으로 독거노인의 신체적 건강상태 유지 및 증진과 일상생활 기능상의 어려움을 안고 있는 노인에 대한 정서적 지지의 강화 등 자기방임 완화를 위한 실천적 함의를 제시하였다. The purpose of this study is to analyze the effects of IADL on self-neglect in elders who live alone positively and verify the moderating effects of social support and then draw practical implications to reduce self-neglect in old age. To address the goal, this study selected elderly people living alone who were older than 65 and using Basic Care Service in Daejeon for the elderly as target to conduct a survey, and out of data collected from 406 subjects, those from 366 were utilized for analysis. For data analysis, demographic characteristics were analyzed, and for inter-group comparison about major variables, the t-test and ANOVA were done. Through hierarchical regression analysis, the regulating effects of social support were verified in correlation between IADL and self-neglect. According to the study results, as their subjective health condition is worse and the levels of their IADL, emotional support, and material support are lower, the degree of self-neglect becomes higher. Also, in correlation between IADL and self-neglect, among the variables of social support, only emotional support indicates moderating effects. Based on the results, this researcher suggests practical implications to reduce self-neglect, for instance, to maintain and improve physical health conditions in elderly people living alone or to increase emotional support for the elderly having difficulty in IADL.
곡선 나노슬릿내에 놓여진 나노입자의 동전기적 수송 특성
차병준(Byoung-Jun Cha),맹준호(Joon-Ho Maeng),정재원(Jae-Won Chung),이상엽(Sang-Youp Lee) 대한기계학회 2013 대한기계학회 춘추학술대회 Vol.2013 No.12
We have analytically solved trajectories of electrokinetically driven nanoparticles in a curved nanoslit. When electric potential was applied at both ends of curved nanoslit, electric field gradients were formed both in radial and in tangential directions. Nanoparticles in such electric field are exposed both to electrophoretic and to dielectrophoretic forces at the same time. Nanoparticles exerted dielectrophoretic force are supposed to move either inward or outward in radial direction depending on Clausis-Mossotti factor related with the properties of nanoparticles and environment. In our study, nanoparticles were assumed to have the physical properties either of bovine serum albumin (BSA) or fibrinogen while 1X TBE buffer was assumed as the environment where nanoparticles are suspended. Our preliminary results showed that the trajectories of nanoparticles in curved nanoslit directly depend both on radius of curvature of nanoslit and on the magnitude of applied field strength. Based on our analytical results, we were able to separate bovine serum albumin and fibrinogen adjusting both electric field strength and the radius of curvature.
뱀장어 배양 간세포에서의 Cytochrome P4501A (CYP1A) 유전자 발현에 대한 중금속들의 억제효과
권혁추 ( Hyuk Chu Kwon ),맹준호 ( Joon Ho Maeng ),최성희 ( Seong Hee Choi ) 한국어병학회 2010 한국어병학회지 Vol.23 No.2
Effects of heavy metal ions on the gene expression of cytochrome P4501A (CYP1A) were examined in cultured eel hepatocytes. When the expression of CYP1A mRNA was measured by RT-PCR after incubation of eel hepatocytes with benzo[α]pyrene (B[α]P) at concentrations of 10-8∼10-5 M, the CYP1A expression increased with B[α]P treatment in a dose dependent manner, showing significant increase at concentrations more than 10-7 M. When the eel hepatocyte was treated with cadmium (10-6 and 10-5 M), the expression of CYP1A was inhibited and especially at higher concentration (10-5 M). The inhibition of CYP1A expression by cadmium was also observed in cells treated with B[α]P. In another study, effects of heavy metal ions on the expression of CYP1A were examined in cultured hepatocytes isolated from eel which was treated previously with B[α]P in vivo. Hepatocytes isolated from the liver of eel taken at 48 hours after injection of B[α]P (10 mg/kg) were cultured for 2 days with cadmium, copper, lead or zinc (10-6 and 10-5 M). The expression of CYP1A was found to be suppressed by the metal ions compared with the control in which CYP1A was induced with previous treatment of B[α]P in vivo. The present results may provide an important basic information for studying the effects of heavy metal ions on CYP1A expression in other species of fish and studying toxicological mechanisms of heavy metal ions in aquatic livings.