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상엽(桑葉)이 비만 유발 생쥐의 인슐린 저항성 및 지방세포 염증에 미치는 영향
마영훈,김효재,한양희,Ma, Young-hoon,Kim, Hyo-jae,Han, Yang-hee 대한한방내과학회 2016 大韓韓方內科學會誌 Vol.37 No.4
Objective: This study was undertaken to investigate the effects of Mori folium on insulin resistance and adipose tissue inflammation in an experimental mouse model of obesity.Methods: Obesity was induced in C57BL/6 mice by feeding them a high-fat diet. The mice were divided into four groups (n=6): a normal diet, high-fat diet, high-fat diet with 40 mg of Mori folium, and high-fat diet with 800 mg of Mori folium groups. After 13 wk, the body weights, fasting blood glucose and fasting serum insulin levels, insulin resistance (homeostatic model assessment) levels, oral glucose tolerance test levels, epididymal fat and liver weights, and gene expression of tumor necrosis factor-α, interleukin-6, and interferon-γ were measured. In addition, adipose tissue macrophages were analyzed by fluorescence-activated cell sorting.Results: Mori folium significantly reduced blood glucose levels, oral glucose tolerance levels, and liver weights. It also reduced adipose tissue macrophage numbers and tumor necrosis factor receptor-α gene expression.Conclusions: These results show that Mori folium has insulin resistance reduction and anti-inflammatory effects in an experimental mouse model of obesity.
황백(黃柏)이 비만 유발 mouse의 대사기능에 미치는 영향
마영훈,김효재,한양희,김한옥,오재선,Ma, Young-hoon,Kim, Hyo-jae,Han, Yang-hee,Kim, Han-ok,Oh, Jae-seon 대한한방내과학회 2015 大韓韓方內科學會誌 Vol.36 No.4
Objectives: This study was undertaken to investigate how Cortex Phellodendri affects metabolic functional change in an experimental rat model of obesity.Methods: An obesity model was induced in a C57BL/6 mouse with a high-fat diet. Mice were divided into three groups (n=6) of normal diet, high-fat diet (=control), and high-fat diet with Cortex Phellodendri. After 12 weeks, we measured the three mice groups’ body weight, FBG, FBI, HOMA-IR, OGTT, the weight of epididymal fat and liver, the percentage of ATM, and the gene expression of TNF-α, IL-10, and CD68.Results: Cortex Phellodendri significantly reduced blood glucose and oral glucose tolerance levels. It also reduced ATM numbers and TNF-α and CD68 gene expression and increased IL-10 gene expression.Conclusions: This study suggests that Cortex Phellodendri normalized the blood glucose and reduced the expression of inflammatory markers. However, with respect to other indicators of metabolic function in obesity, there were no significant results.
대황(大黃)이 고지방식이로 비만이 유발된 C57BL/6 mouse의 지방조직 염증 및 인슐린 저항성에 미치는 영향
최승범,마영훈,한양희,정수정,조홍석,Choi, Seung-Bum,Ma, Young-Hoon,Han, Yang-Hee,Jung, Soo-Jung,Cho, Hong-Seok 대한한방내과학회 2014 大韓韓方內科學會誌 Vol.35 No.2
Objectives : The purpose of this study was to investigate how Rhei Radix et Rhizoma affects on insulin resistance and adipose tissue inflammatory response in high fat diet induced obese C57BL/6 mice. Methods : Obesity was induced in C57BL/6 mice by high fat diet for 12 weeks. Models were divided into 3 groups (n=6) of normal diet, high fat diet (HFD), and high fat diet with Rhei Radix et Rhizoma and investigated for 12 weeks. We measured body weight, FBS and oral glucose tolerance test (OGTT), serum insulin, homeostatic model assessment-insulin resistance (HOMA-IR), weight of liver and epididymal fat pad. Inflammatory markers such as adipose tissue macrophage (ATM), tumor necrosis factor-${\alpha}$ and interlukin-10 and CD68 of epididymal adipocyte were determined to evaluate the effect of Rhei Radix et Rhizoma on adipose tissue inflammation. Results : Compared with the HFD group, we observed loss of body weight and epididymal fat pad weight, improvement of glucose level and HOMA-IR, reduction of ATM and gene expression of TNF-${\alpha}$, CD68 in the high fat diet with Rhei Radix et Rhizoma group. Conclusions : This study suggests that Rhei Radix et Rhizoma has effects on insulin resistance and adipose tissue inflammatory response in high fat diet induced obese mice.
목향(木香)이 고지방 식이에 의한 비만으로 유발된 인슐린 저항성 mouse의 염증 및 인슐린 저항성에 미치는 영향
오재선,마영훈,최승범,김종호,김경국,전상윤,Oh, Jae-Seon,Ma, Young-Hun,Choi, Seung-Bum,Kim, Jong-Ho,Kim, Kyung-Kook,Jeon, Sang-Yun 대한한방내과학회 2014 大韓韓方內科學會誌 Vol.35 No.4
Objectives: Obesity is an important cause of insulin resistance that leads to obese type 2 diabetes. Recently it has been found that obesity is associated with adipose tissue accumulation which causes systemic inflammation. In this study, we investigated effects of Inula helenium on the inflammation in high fat diet-induced insulin resistance mouse. Methods: Insulin resistance was induced in C57BL/6 male mice (19~21 g) on a 60% fat diet. Mice were divided into 3 groups (n=6) of normal, control and Inula helenium. After 12 weeks, body weight, FBS, oral glucose tolerance test (OGTT), serum level of insulin, epididymal fat pad, liver weight and the gene expression of tumor necrosis factor (TNF)-${\alpha}$, interleukin (IL)-6, interleukin (IL)-10 and cluster of differentiation (CD) 68 were measured. Also, adipose tissue macrophage was analyzed by fluorescence activated cell sorting. Results: Inula helenium significantly reduces oral glucose tolerance levels, insulin serum level and adipose tissue macrophage. Also Inula helenium increased IL-10 gene expression and decreased CD68 gene expression. Conclusions: These results show that Inula helenium has anti-insulin resistance and anti-inflammatory effects on a high fat diet-induced insulin resistance mouse model.
후박(厚朴)이 ob/ob 마우스의 대사성 염증과 인슐린 저항성에 미치는 영향 및 관련기전에 대한 연구
김효재,김은지,마영훈,한양희,Kim, Hyo-jae,Kim, Eun-ji,Ma, Young-hoon,Han, Yang-hee 대한한방내과학회 2018 大韓韓方內科學會誌 Vol.39 No.4
Objective: This study was undertaken to investigate how magnolia bark extract affects ob/ob mouse in terms of metabolic inflammation and insulin resistance. Methods: Leptin-deficient ob/ob mice were divided into 2 groups (n=5): a normal saline treatment (=control) and magnolia bark treatment. Wild type mice were the lean group (n=5). After 5 weeks, we measured fasting blood sugar (FBS) and conducted oral glucose tolerance tests (OGTTs) in each group. After 6 weeks, we measured body weight, epididymal fat pad weight, liver weight, serum glucose, serum insulin, and gene expression of tumor necrosis factor-${\alpha}$, interferon-${\gamma}$, and interleukin-6. We characterized the phenotype of adipose tissue macrophages (ATMs) and analyzed fractions of the phenotype in each group by flow cytometry. Results: In the magnolia bark group, fasting blood sugar, oral glucose tolerance levels, and insulin resistance (HOMA-IR) were significantly decreased. The population and proportion of ATMs among leukocytes in adipose tissue were significantly decreased in the magnolia bark group. The population and proportion of M1 type ATMs among ATMs were significantly decreased in the magnolia bark group. Gene expression of tumor necrosis factor-${\alpha}$ was significantly decreased in the magnolia bark group. Conclusions: These results support a positive effect of magnolia bark on metabolic diseases such as insulin resistance and metabolic inflammation in leptin-deficient ob/ob mice.
국내 한의학계의 항혈전 효과에 대한 실험 연구 고찰 -2001년 이후 한방부인과학회지에 발표된 논문을 중심으로-
정수정 ( Soo Jung Jung ),마영훈 ( Young Hun Ma ),최승범 ( Seung Bum Choi ),박경미 ( Kyung Mi Park ) 대한한방부인과학회 2014 大韓韓方婦人科學會誌 Vol.27 No.1
The purpose of this study is to compare with the result of experimentalstudy about antithrombotic effect by reviewing recent oriental medicine journalsthat have been published since 2001` in Korea. Methods: Articles on antithrombotic effect that have been published from2001` to 2013` in oriental medicine journals registered National Research Foundationof Korea were searched. After that, 12 articles using same ``thrombosis conditionmodel`` were selected and reviewed. Results: The results were as follows. 1. If there is no limit drug concentrations, platelet aggregation induced byadenosine diphosphate (ADP) in hyulbuchukeo-tanggamibang (HBCT) was the largestaggregation inhibitory effect and platelet aggregation induced by epinephrine inSaegeum-san (SGS), Jogan-tanggagambang (JGTG), hyulbuchukeo-tanggamibang (HBCT)had a large inhibitory effect on aggregation. 2. At the lowest concentration, Mokdan-san (MDS) of the inhibition of plateletaggregation induced by ADP and Hyunhosaik-san (HHS) of the inhibition of plateletaggregation induced by epinephrine were effective. 3. Pulmonary embolism induced by collagen and epinephrine in Neungasojeok-tang(NSJT) has the highest antithrombotic effect. 4. Pathological conditions of extravasated blood by dextran, Jogan-tanggagambang(JGTG) has the highest inhibitory effect on decrease in platelet numbers. Comparedto the rest of the experimental drug, Saegeum-san (SGS), Heanggyonghonghwa-tang(HGTHHT), Wusl-san (WSS), Mokdan-san (MDS) showed significant inhibitory effecton the prothrombin time (PT) increases. Honghwadanggui-san (HDS), Saegeum-san(SGS) showed significant inhibitory effect on increase in activated partial thromboplastintime (APTT) and Jogan-tanggagambang (JGTG), Heanggyonghonghwa-tang(HGTHHT) showed significant inhibitory effect on decrease in fibrinogen. Conclusions: This result will provide useful information for the prescriptionsof antithrombotic medicine in the field of Oriental medicine. We will have tocarry out further studies that will compare each herb used in the diseases causedby extravasated blood.
한의학적 치료로 호전된 불면과 우울을 동반한 섬유근통 증후군 환자 치험 1례
김의수,신민구,김태련,오재선,마영훈,이영수,Kim, Eui-su,Shin, Min-koo,Kim, Tae-ryun,Oh, Jae-seon,Ma, Young-hun,Le, Young-su 대한한방내과학회 2015 大韓韓方內科學會誌 Vol.36 No.3
Objectives The study aimed to evaluate the therapeutic effect of Hyungtonghaeul-tang along with Korean medicine treatment for fibromyalgia syndrome. Methods A patient with fibromyalgia syndrome was treated with Hyungtonghaeul-tang as well as Korean medical treatment including acupuncture, electro-acupuncture, bee venom therapy, chuna, aromatherapy, and physical therapy. The counts of tenderness points, widespread pain index (WPI), symptom severity scale score (SS scale score), digital infrared thermal imaging (DITI), Ryodoraku diagnosis, visual analogue scale (VAS), fibromyalgia impact questionnaire (FIQ), and beck depression inventory (BDI) were measured. Results After treatment, the counts of tenderness point, WPI, SS scale score, VAS, FIQ, and BDI were decreased. The DITI and the Ryodoraku pattern recovered normally. Conclusions Hyungtonghaeul-tang along with Korean medicine treatment can be used in the treatment of fibromyalgia syndrome.
말초성 안면신경마비에 대한 황련해독탕약침과 자하거약침의 효능 후향적 비교 연구
이정훈 ( Jung Hun Lee ),양태준 ( Tae Jun Yang ),김선욱 ( Seon Wook Kim ),정주용 ( Joo Yong Jeong ),마영훈 ( Young Hun Ma ),오재선 ( Jae Seon Oh ),최정욱 ( Jeong Wook Choi ),이은지 ( Eun Ji Lee ),위통순 ( Tung Shuen Wei ) 경락경혈학회 2015 Korean Journal of Acupuncture Vol.32 No.4
Objectives: The purpose of this study is to compare the effects of Hwangryunhaedok-tang pharmacopuncture therapy with Hominis Placenta pharmacopncture therapy in hospitalized patients with peripheral facial paralysis. Methods : We investigated 34 cases of patients with peripheral facial paralysis who were admitted into the Dept. of Acupuncture & Moxibustion of Dongshin University Suncheon Oriental Hospital from February 1, 2014 to June 31, 2015. Subjects were divided into two groups, Hwangryunhaedok-tang pharmacopuncture group(HR group), and Hominis Placenta Pharmacopuncture group(JH group). HR group was treated by Hwangryunhaedok-tang pharmacopuncture five times a week and JH group was treated by Hominis Placenta Pharmacopuncture five times a week. And both groups were treated by acupuncture, electroacupuncture, herbal medicine therapy, western drug therapy equally. To investigate the effectiveness of treatment, we used House-Brackmann Grading System, Yanagihara’s unweighted grading system and Sunnybrook facial grading scale at before admission and after admission. Results : Each scores by 3 evaluation methods improved both in two groups. However, there were no significant differences in improvement between two groups. Conclusions : These results suggest that the Hwangryunhaedok-tang pharmacopuncture therapy is as effective as Hominis Placenta pharmacopuncture therapy to improve symptoms of peripheral facial paralysis.
정수정 ( Soo Jung Jung ),박경미 ( Kyung Mi Park ),송유림 ( Yu Rim Song ),조성희 ( Seong Hee Cho ),양승정 ( Seung Jeong Yang ),마영훈 ( Young Hun Ma ) 대한한방부인과학회 2015 大韓韓方婦人科學會誌 Vol.28 No.2
Objectives: This study aims to report the effect of Korean medicine treatments on a sequela of operation of hallux valgus. Methods: The patient was treated with Dangkisoosan-gami, Acupuncture treatment including Herbal-Acupuncture and physical therapy. We evaluated treatment effects by circumference of foot and ankle, Edema index score by Body Composition Analyzer, Ankle-Brachial Index (ABI) and Visual Analogue Scale (VAS). Results: After 25 days of treatment, the symptoms such as lower extremity edema, foot pain and ankle pain were improved. Conclusions: In this case, Korean medicine treatments for a sequela of operation of hallux valgus was effective. But further studies are required to confirm the effect of these methods.