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복수의 감별에 있어 혈청과 복수내 CEA 및 CA19-9의 가치에 관한 연구
김선민 ( Kim Seon Min ),박경식 ( Park Gyeong Sig ),마상인 ( Ma Sang In ),김휘정 ( Kim Hwi Jeong ),유승박 ( Yu Seung Bag ),조준환 ( Jo Jun Hwan ),이재동 ( Lee Jae Dong ),이중건 ( Lee Jung Geon ) 대한내과학회 1992 대한내과학회지 Vol.42 No.4
1989년 4월 1990년 12월까지 본원 내과에서 입원하였던 복수 환자 81예를 대상을 그 원인 악성 질환에 의한 것인지 양성 질환에 의한 것인지를 감별하기 위해 혈청 및 복수내의 CEA, CA19-9의 농도를 측정 비교하여 그 임상적 의의에 대해 다음과 같은 결과를 얻었다. 1) 악성 질환에서의 CEA의 혈청내 평균치는 양성질환보다 의의있는 상승을 보였으며(p<0.05), 복수내 평균치 또한 유의한 상승을 보였다(p<0.01)> 2) CA19-9의 혈청과 복수에서의 평균치는 악성 복수군에서 현저한 상승을 보였으나 통계적 유의성은 없었다.(p>0.05). 3) 복수의 감별진다에 있어 CEA의 복수내의 민감도는 84%였으며 혈청에서는 71%이였으며 CA19-9는 복수내의 민감도가 68% 혈청에서는 60%로 CEA보다는 전체적으로 민감도가 낮았다. 4) 혈청과 복수에서 CEA 병합 검사시 민감도는 86%로 상승하였으며 CA19-9병합 검사시 민감도 또한 73%로 상승 하였으며 모두 병합 검사시 민감도는 92%로 의의있는 상승을 보였다. 5) 혈청내 CEA 복수내 CEA 혈청내 CA19-9 및 복수내 CA19-9 검사간에는 유의한 상관관계가 있었다(p<0.005, p<0.001). 이상과 같이 혈청과 복수에서의 CEA와 CA19-9 농도 측정은 복수의 원인이 악성 질환에 의한 것인지를 아는데 도움이 될 것으로 사료된다. Ascites may be caused by various benign and malignant disease, but it is sometimes difficult to determine whether it is caused by benign disease or malignant diseases. In order to determine whether CEA, CA 19-9 in ascitic fluid and serum assist in the diagnosis of malignant disease that causing ascites, we studied 38 cases of malignant ascites and 43 cases of benign ascites patients who were admitted to Seoul Adventist Hospital from April 1989 to December 1990. The results were obtained as follows: 1) The mean value of CEA in serum and ascitic fluid of the malignant ascites group were significantly higher than that of the benign ascites group in serum (p<0.05), in ascites (p<0.01). 2) The mean value of CA 19-9 in serum and ascitic fluid of the malignant ascites group was signficantly higher than that of the benign ascites group was significantly higher than that of the benign ascites group, there was no significance in statistical aspects(p>0.05). 3) The sensitivity of CEA was 81% in ascites, 78% in serum, the sensitivity of CA 19-9 was 63% in ascites, 65% in serum. 4) The sensitivity of CEA was increased to 87% in serum and ascites combinations, the sensitivity of CA 19-9 was also increased to 81% in serum and ascites combinations. The sensitivity was significantly elevated to 92% in case of all tumor marker combinations. 5) There was a significant correlations between serum CEA and ascites CEA, serum CA 19-9 and ascites CA 19-9. (p<0.01, in all cases) It was concluded that the measurement of serum and ascites CEA, CA 19-9 levels is useful lin differention between ascites caused by benign and malignant diseases. Combinantions of each tumor markers in serum and ascites were more accurate than single test.
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김경진(Kyung Jin Kim),이재동(Jae Dong Lee),석윤철(Yoon Chul Suk),문창훈(Chang Hoon Moon),김선민(Sun Min Kim),마상인(Sang In Ma),박경식(Kyung Sik Park),이중건(Choong Kun Lee) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.4
N/A Clinical studies were carried out on 581 cases who had taken gastrofiberscopic examination because of upper gastrointestinal syptms from July, 1989 to April, 1990 in Seoul Adventist Hospital. The result about esophageal hiatal hernia were as follows; 1) Of total 581 cases, 310 were male, and 271 were female. Of total 581 cases, 73 were averweight group, 207 were drinkmg group, and 18~8 emoki~ng group. 2) Of total 58I cases, 48 were esophageal hiatal hernia group. The incidence of hernia was 8.2%. Of 48 hernia casea, 38 were male, and 10 were female. Of 48 hernia cases, 30 were over aged 40, and 18 were under 40. 3) In overweight group, 19 were hernia cases (26%), and non-overweight group, 29 were hernia cases (5.7%) 4) In drinking group, 30 were hernia caees (14.5%), and non-dringking group, 18 were hernia cases (4.8%). 5) In smoking group, 27 were hernia cases (14.4%) and in non-smoking group, 21 were hernia cases (5.3%) 6) In conclusion, in overweight, drinking, and smoking group, the incidence of esophageal hiatal hernia were significantly higher than non-overweight, non-drinking, and non-smoking group, respectively.
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김선민,이재동,권용만,박경식,마상인,이중건 대한소화기내시경학회 1990 Clinical Endoscopy Vol.11 No.1
Menetriers disease is a rare disease, characterized by a marked hypertrophy of the mucosa of the fundus and corpus of the stomach and gastrointestinal loss af protein often causing transient edema. The 16-Year-old female patient was admitted to the Seoul Adventist Hospital and she complained epigastric pain & discomfort for 20 days. Under the UGI & endoscoyy, pathologic examination was done. The diagnosis was estabilished. She wes treated medically.
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복수내 Cholesterol , CEA 및 CA19 - 9의 진단적 가치에 관한 연구
박경식,이재동,김선민,문창현,마상인,이중건 대한소화기학회 1991 대한소화기학회지 Vol.23 No.1
In order to evalute the diagnostic value of ascitic fluid cholesterol, CEA and CA 19-9 analysis in differentiation between malignant from cirrhotic ascites, the. authors studied 37 cases of malignant ascites patients and 42 cases of cirrhotic ascites patients and analyzed the levels of the cholesterol, CEA and CA 19-9 of those cases from April, 1989 to October, 1990 in Seoul Adventist Hospital. The results were as follows; 1) The median and mean values of cholesterol and CEA were significantly higher in malignant ascites compared to cirrhotic ascites(p$lt;0.01). 2) There was no significant difference in CA 19-9 levels betsveen cirrhotic ascites and malignant ascites. 3) The discrimination value for cholesterol was 45 ㎎/㎗. We defined the upper limit of normal value for CEA and CA 19-9 as 5 ng/㎖ and 37 U/㎖, respectively. 4) The diagnostic efficiency was 89% for cholesterol, 90% for CEA and 81%. for CA 19-9. 5) There was a significant positive correlation between cholesterol and CA 19-9 (r=0.41, p$lt;0.01), CEA and CA 19-9 (r=0.67, p$lt;0.01), respectively. It was concluded that the measurement of ascitic fluid cholesterol and CEA levels is useful in differential diagnosis between malignant from cirrhotic ascites.
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