호밀 (Secale cereale)의 수확시기차이가 종자수량, 종자발아 및 유묘생장에 미치는 영향

류한욱,강광희 한국작물학회 1986 한국작물학회 학술발표대회 논문집 Vol.1986 No.-

Kluver-Bucy증후군으로 나타난재발성 단순 헤르페스 뇌염

류한욱,구본대 대한신경과학회 2008 대한신경과학회지 Vol.26 No.4

Relapse of herpes simplex virus (HSV) encephalitis rarely occurs after acyclovir treatment. We experienced a case of relapsing HSV encephalitis in the contralateral temporal lobe, resulting in Kluver-Bucy syndrome, after a full dose acyclovir treatment. Sudden behavioral and emotional changes after HSV encephalitis treatment suggest relapsing HSV encephalitis as well as temporal lobe epilepsy.

공황장애 환자에서 파록세틴 약물 치료가 바이오피드백 측정 변수들에 미치는 영향

류한욱,구문선,유범희 대한정신약물학회 2004 대한정신약물학회지 Vol.15 No.4

Objective There have been much effort to find reliable indicators predicting treatment response in panic disorder. This study aimed to find the effect of pharmacotherapy on biofeedback measurement variables in panic disorder patients. Method We recruited 38 panic disorder patients(M;25, F;13) in the Samsung Medical Center, who were diagnosed by the ADIS-IV(Anxiety Disorder Interview Schedule-IV), and 33 normal control subjects (M;21 F;12 ). Panic patients were treated with paroxetine for 3 months. All subjects were assessed on forearm and frontal electromyography(EMG), electrodermal response(EDR), and skin temperature in baseline, stress, recovery phases using the Procomp & Biograph biofeedback instrument. Psychological measures such as Hamilton anxiety rating scale(HAM-A), Hamilton depression rating scale(HAM-D), Beck depression inventory( BDI), Spielberger state-trait anxiety inventory(STAI-S, STAI-T), and Anxiety sensitivity index(ASI) were also assessed. All measurements were performed at the beginning of the study and after 3 months of paroxetine treatment. Result Panic patients had significantly higher scores on psychological measures such as HAM-A, HAM-D, BDI, STAI-S, STAI-T, and ASI(all p values<0.001) before treatment. After 3months of treatment, panic patients showed significant improvement on baseline EDR(z=-2.824, p=0.005), stress EDR(z=-2.691, p=0.007), and recovery EDR (z=-3.416, p=0.001). They also showed significant improvement on HAM-A, HAM-D, BDI, STAI-S, STAI-T, and ASI(all p values <0.001) after treatment. Conclusion Electrodermal response, one of the biofeedback measurement variables, was suggested to be the possible indicator predicting treatment response in panic disorder.

폐쇄수면무호흡증후군 환자에서 복합수면무호흡의 유병률 및 예측인자

류한욱,이상암,이은미,이가현,김보미 대한수면연구학회 2013 Journal of sleep medicine Vol.10 No.2

Purpose : Some patients with OSA syndrome experience development of central sleep apnea(CSA) during CPAP application(complex sleep apnea; compSA). We reviewed the prevalence and polysomnographic characteristics of compSA in patients with a primary diagnosis of OSA syndrome. Method : Total 198 patients with OSA syndrome who performed CPAP titration at the Asan Medical Center were studied retrospectively from year 2006 to 2009. CompSA was defined as presenting central sleep apnea ≥5/hr, during CPAP titration to eliminate upper airway obstruction. Demographic profiles and PSG variables were compared between compSA and Non-compSA. Results: The prevalence of compSA was 17 of 198(8.6%) with male predominance(n=17). Among compSA, 11 patients showed persistent central sleep apnea(CSA) during entire titration and 6 patients showed newly developed CSA above certain pressure level(mean 7.2cmH2O). At near optimized CPAP levels, obstructive sleep apnea index(OAI) was not significantly different between two groups(compSA; 0.52±0.74/hr vs Non- compSA; 0.32±0.80/hr) but the level of AHI(apnea hypopnea index), MAI(mixed apnea index), CAI(central apnea index) and HI(hypopnea index) were greater in compSA than Non-compSA.(compSA; AHI;15.23±9.85/hr, MAI;0.97±1.83/hr, CAI;8.22 ±7.96/hr, HI;5.52±4.98/hr vs Non-compSA; AHI;2.20±2.25/hr, MAI;0.08± 0.27/hr, CAI;0.48±0.89/hr, HI;5.52±4.98/hr) At baseline PSG, the value of CAI and MAI was higher in compSA(CAI;3.78±3.92/hr vs 1.03±1.97/hr, MAI;6.71±7.50 vs 4.33±9.59) but there were no differences in AHI, OAI, HI and demographic profiles between two groups. Conclusion: In this study, early recognition of compSA in baseline PSG was CAI and MAI which revealed higher scores than Non-compSA.

Seizure Frequencies and Number of Anti-epileptic Drugs as Risk Factors for Sudden Unexpected Death in Epilepsy

류한욱,홍진표,한수현,최은주,송지현,이상암,강중구 대한의학회 2015 Journal of Korean medical science Vol.30 No.6

The purpose of this study was to investigate the association between clinical variables and sudden unexpected death in epilepsy (SUDEP) and identify risk factors for SUDEP. SUDEP is one of the most frequent causes of death in patients with epilepsy. Previous studies have reported possible risk factors associated with SUDEP, but there need to be elucidated yet. The cases were 26 patients with SUDEP and three control patients were included for each case, matched for age, sex, and date of initial clinical visit. All demographic and clinical characteristics, including age, sex, disease duration, classification of epilepsy, age at seizure onset, kind and number of antiepileptic drugs, were compared between cases and controls. Seizure frequency was higher in SUDEP cases than in controls (P = 0.035). Univariate analysis using conditional logistic regression showed that higher seizure frequency (odds ratio [OR] = 3.1, P = 0.021) and the number of antiepileptic drugs (AEDs) (OR = 2.0, P = 0.009) were significantly associated with SUDEP. Only the number of AEDs remained significant in multivariate analysis (OR = 1.8, P = 0.026). Frequent seizures and multi-drug therapy were associated with SUDEP. This may suggest that the severity of epilepsy is associated with SUDEP, regardless of the type of AED used.

호밀 수확시기가 종실의 수량과 발아 및 유묘생장에 미치는 영향

柳漢煜,姜光熙 韓國作物學會 1988 한국작물학회지 Vol.33 No.2

우리나라에서 호밀을 채종 목적으로 재배할 때 여름 장마로 인한 호밀 성숙후기 이후에 발생하는 종자 품질저하를 최소화할 수 있는 조기수확한계기를 구명하고자 팔당 호밀(재래종)을 공시하여 출수후 25일부터 55일까지 5일 간격으로 수확기를 달리하고 종실발육 수량 및 종자활력에 관한 시험조사를 1984년 및 1986년에 영남대학교 실험농장에서 실시하였던 바 그 결과를 요약하면 다음과 같다. 1. 수확기별 천립중변화는 출수후 50일까지는 수확 지연에 따라 직선적으로 증가하나 그 이후는 연차에 따라 일정하지 않았다. 종실수분함량은 수확이 늦었을 때 반대로 감소하였다. 2. 종실의 길이는 출수후 30일까지 빠르게 그리고 그 이후는 완만하게 신장되었고, 두께와 폭은 출수후 50일까지 완만하게 발육되었다. 3. 수확기가 늦어짐에 따라 수량이 높아지는 영향은 뚜렷하나 출확기 40일과 45일 수확에서 차이가 크다. 4. 20℃ 항온에서 종자발아율은 출수후 25일 수확구를 제외하면 종자성숙에 따라 발아율의 차이가 없으나, 10℃ , 30℃ 에서는 출수후 35일 이전 수확에서 발아율이 낮았다. 실온에서 pot 에 파종한 경우 발아율은 20℃ 항온에서와 유사하였다. 5. pot에서 초장은 종자성숙이 진전될수록 긴 경향이나 출수후 45일 이후 수확 종자간에는 차이가 없고 유묘의 건물중은 출수후 50일까지 종자성숙기간이 길수록 높았다. 6. 항온에서 종실의 성숙일수와 발아율간의 상관은 저온(10℃ ) 및 발아초기(치상후 4일)에서만 정의 상관이 있었다. pot 에서는 종실의 성숙일수와 초장, 건물중 그리고 천립중간에는 유의한 정의 상관을 보였다. 7. 포장에서 월동후 유식물수 비율은 57~67%로 출수후 30일~50일에 수확한 종실간의 차이가 없으나 생육초기의 초장은 출수후 35일 이전 수확한 종실의 경우는 작았다. 출수기는 출수후 40일 수확한 종실은 출수기가 늦지 않으며 간장은 종자 성숙정도 차이가 인정되지 않았다. 8. 채종목적인 호밀 재배에서 우기를 회피하여 종자 수량감소 최소화할 수 있는 수확기는 출수후 45 일 (개화후 38일)경 이라고 본다. To know the optimum harvest time for seed yield and seed quality a local variety of rye 'Paldang-homil'was harvested at seven different harvest times from 25 to 55 day after heading (DAH) at five-day intervals in 1984 ani 1986. Seed development, seed germination and seedling growth were observed. The l000-grain weight increased as harvest time delayed until 50 DAH in both years. Although grain yield tended to increase with delay of harvest time, the yield differences between succeding harvest time was highest between 40 DAH and 45 DAH. Germination rate of seeds harvested before 30 DAH were lower than those after 35 DAH at 20 C, but at 10 and 30 C before 35 DAH were lower after 40 DAH. Plant height and dry weight of seedlings increased with delay of harvest time up to 45 DAH in pot. Heading stages were similar among the seeds harvested 40-55 DAH. Culm length was not different among the harvest times. The optimum harvest time for seed production of rye seems to be 45 DAH (38 days after flowering).

혼합호흡형태를 가진 폐쇄수면무호흡 환자에서 수면무호흡의 특성

류한욱,이상암,이은미,이가현,김보미,김천식 대한수면연구학회 2013 Journal of sleep medicine Vol.10 No.2

Background: Varieties of mixed breathing patterns such as mixed or central sleep apnea in patients with obstructive sleep apnea (OSA) may observed during PSG. Our object is to compare the general feature and sleep apnea characteristics between OSA with and without mixed breathing pattern. Method: Total 244 patients who were diagnosed as OSA [apena-hypopnea index (AHI) ≥5/hr] were studied retrospectively. Mixed breathing pattern was defined as mixed apnea index plus central apnea index (MCAI) with ≥5/hr (Mix-OSA). Non-mix-OSA was defined with MCAI with <5/hr. Central sleep apnea syndrome was excluded. We investigated differences of the distribution and shifting of apnea index across sleep stage, position and sleep time between Mix-OSA and Non-mix-OSA group. Results: The prevalence of Mix-OSA was 42 of 244 OSA patients (17.2%). There were no significant differences in demographics except higher AHI in Mix-OSA group. Mix-OSA showed a significant increment of MCAI and hypopnea index during NREM sleep while Non-mix-OSA showed increased obstructive apnea index (OAI) in REM sleep period. In both groups, supine body position was related to high OAI. There were no meaningful differences in sleep apnea according to the timing of sleep in both groups. Conclusion: OSA patients with mixed breathing pattern had more severe OSA than Non-mix-OSA. There were some significant differences in sleep apnea characteristics between OSA with and without mixed breathing pattern. However, their clinical significance still remains unclear.

반복적인 유사 일과성 허혈발작을 보인국소거미막하출혈

정병민,류한욱,강미경,강진주,서만욱,오선영,신병수 대한신경과학회 2018 대한신경과학회지 Vol.36 No.4

Focal subarachnoid hemorrhage occasionally presents as transient focal neurologic episodes mimicking transient ischemic attack (TIA). Unless properly diagnosed, it may aggravate cerebral hemorrhage by administering antithrombotic agents. Therefore, clinicians need to be aware that such focal subarachnoid hemorrhage sometimes cannot be detected on noncontrast computed tomography and blood-sensitive magnetic resonance imaging can detect even a small amount of hemorrhage. We describe an 85-year-old woman with focal subarachnoid hemorrhage and possible cerebral amyloid angiopathy who presented transient left arm weakness recurrently, which mimicked TIA.

급성 습성각기병을 동반한 베르니케뇌병증

정병민,류한욱,오선영,서만욱,신병수 대한신경과학회 2017 대한신경과학회지 Vol.35 No.4

Wernicke encephalopathy is usually accompanied with peripheral neuropathy, known as dry beriberi. In contrast, wet beriberi presenting as cardiovascular symptoms rarely occurs. The acute type of wet beriberi can be fatal, if untreated quickly. It is reported that the cerebellar vermis has a role of the coordination and control of cardiovascular and autonomic reflex activities. We report a 58-year-old man showing acute wet beriberi in Wernicke encephalopathy with cerebellar vermis lesion.

흉선종을 가진 환자에서 부분운동간대발작으로 발현한 신생물딸림 변연계외부 뇌염

이유진,류한욱,진주예,김효재,이상암 대한신경과학회 2015 대한신경과학회지 Vol.33 No.3

Paraneoplastic encephalitis presenting with partial clonic seizure is rare. We report a 57-year-old man with clonic seizure in his left arm. He had past medical history of recurrent thymoma and thymomectomy. Magnetic resonance imaging showed multiple brain lesions, but none of them were congruent with the partial seizure. His symptoms and brain lesions resolved after steroid therapy. This is the first reported case extralimbic encephalitis presenting as partial seizure with invasive thymoma in Korea.