65세 이상 외래환자의 NSAIDs 처방현황과 개선방안

류재은,서예원,전수정,이은숙,이병구 한국병원약사회 2006 병원약사회지 Vol.23 No.2

Non-steroidal anti-inflammatory drugs (NSAIDs) are clinically useful in the treatment of inflammatory diseases such as arthritis, pain, headache, and neuromuscular disorder. A retrospective study was conducted for the status of NSAIDs prescription in geriatric (>65 years) outpatients who had visited Seoul National University Bundang Hospital using the Electronic Medical Record (EMR) during the period between the 1st of January and the 30th of June, 2005. The primary objective of the study was to analyze the practice of NSAIDs prescription in geriatric patients and the clinical outcome. In the geriatric patients, the prescription frequency of NSAIDs ranged from 6 to 41%, depending on the clinics [i.e., 41% on Joint Disease and Reconstruction Center (JRC), 21% on Neuroscience Center (CNSC) and 6% on Rehabilitation Medicine (RH)].Amongst the NSAIDs used, aceclofenac was most widely prescribed, followed by celecoxib and meloxicam. The average duration of NSAIDs prescription was 42 days (± 47). Based on the records, duplication of NSAIDs prescription was found to be highly prevalent in the patient group; While 51 cases were found to have duplicated NSAIDs prescription on the day prescription, total of 139 duplicated NSAIDs prescription was found during the course of the therapy. For the clinics that prescribed NSAIDs frequently, the duplication was also prevalent [i.e., 63 cases (33%) was on JRC; 53 cases (28%) on CNSC]. The 45% of the patient group was given the NSAIDs concurrently with the remedies of gastrointestinal irritation [i.e., 39% for aceclofenac, 30% for celecoxib, 22% for meloxicam]; It is noteworthy that the remedies for gastric irritation were prescribed even for COX-2 selective NSAIDs which do not cause gastric irritation. Among the geriatric patients with NSAIDs (i.e., 1,581 patients), a significant number of patients developed gastritis [i.e.,approximately 26(1.6%)] or had elevated level of serum creatinine (Scr; i.e., 31%). In particular, at least 16.6% of the patients had the creatinine clearance below 50 mL/min, suggesting the patients may be categorized as renally insufficient, probably need to adjust dose. Taken together with apparently unnecessary prescription and potential health probelem by the medication, the geriatric patients may be prone to additional adverse drug reaction, which, in turn, may lead to the deterioration of the quality of life. Therefore, these analysis indicated that appropriate counseling of pharmacist is necessary for elderly patients who are prescribed with NSAIDs.

산업환경변화에 따른 쌀 베이커리 산업의 활성화 방안

류재은 (사)한국조리학회 2020 한국조리학회지 Vol.26 No.5

This study was conducted to grasp the current status of the rice bakery industry environment and to prepare a long-term measure to increase the demand for rice bakery by establishing appropriate consumption trends and consumer needs. In addition, this study aims to provide a good example for the sixth industrialization through the political, social, and environmental background of the country. This study aims to suggest the direction of efforts for high-quality and diversification strategies aimed at the needs of smart consumers, and emphasizes the importance of revitalizing the local economy, exporting, and domestic competitiveness through the 6th industrialization. This study intends to provide the implications by analyzing the previous research and online data in order to induce domestic activation and internationalization of the rice bakery industry. Based on the data of the Korea Agro-Fisheries & Food Distribution Corporation, the trends in bread intake per capita over the past five years were examined using the statistics agency data. This study will contribute to resolving and developing social problems by realizing win-win cooperation, shared growth, and corporate social responsibility (CSR).

샤워도 빵에서 분리한 유산균의 항미생물 효과

류재은 한국키틴키토산학회 2019 한국키틴키토산학회지 Vol.24 No.4

This study aimed to evaluate the antimicrobial activity of potential probiotic strains isolated from sourdough bread. The antimicrobial effects of Lactobacillus acidophilus ADH, Bifidobacterium longum B6, Bifidobacterium animalis, Lactobacillus rhamnosus GG, Bifidobacterium bifidum A, Bifidobacterium sanofi BL1, Lactobacillus paracasei ATCC 25598, and the isolated strains (SDB1, SDB2, and SDB3) against indicator bacteria, Salmonella Typhimurium ATCC 19585, Staphylococcus aureus ATCC 13301, Aspergillus niger ATCC 22343 were determined using agar well diffusion assay and time-kill assay. The highest antimicrobial activities against S. Typhimurium were observed for SDB2(45%), B. animalis BB-12(65%), and L. rhamnosusGG(56%). In addition, L. rhamnosus GG(71%) and SDB3(57%) effectively inhibited the growth of S. aureus. The numbers of A. niger were reduced by more than 25% when incubated with L. paracasei and SDB3. This study suggested that the isolated potential probiotic strains can be used to ferment sourdough bread and possibly extend the shelf life.

분당서울대학교병원 노인의료센터 소개

류재은 韓國病院藥師會 2009 병원약사회지 Vol.26 No.1

노인포괄평가 시행 전후의 약물 복용 현황 및 처방 변화

류재은,서예원,이병구,김광일,이은숙 한국병원약사회 2008 병원약사회지 Vol.25 No.2

One of the primary mission for Seoul National University Bundang Hospital is the management Geriatric Center(GC). Therefore, geriatrician, pharmacist, nurse, dietician and social worker was consolidated to provide a better care to geriatric patients in the GC. The role of pharmacist in the team is to identify medicines that are inappropriate, unnecessary and potentially therapeutically problematic(e.g., drug-drug interaction, drug-disease interaction, inappropriate dosage and therapeutic duplication) in geriatric patients. In a previous study, we reported the successful implementation of the Comprehensive Geriatric Assessment(CGA) protocol in the hospital; In particular, we found the assessment score was quite useful in improving the medication assessment. The objective of the current study was to determine further the usefulness of the CGA in the extension of the role of pharmacist in the alteration of prescription. One hundred and fifty geriatric patients, who visited the GC in Seoul National University Bundang Hospital during the period of the 1st of January to the 31st of August of 2006, were involved in this study. Prescription status of the patients indicated that there was a significant incidence of polypharmacy [i.e., more than 4 medications; 114 patients(76%)] and therapeutic duplication [i.e., 28 patients(18.7%)]. In addition, a significant number [i.e., 98(65.3%)] of patients had a reduced renal function(i.e., creatinine clearance below 50 mL/min), suggesting a dose adjustment should have been necessary for the patients, while 48 patients(32%) had inappropriate medication. As for the medication-related characteristics based on ATC codes, the patients were prescribed with drugs for cardiovascular system(82.7%), alimentary tract and metabolism(66%). Particularly, the ratio of patients with inappropriate medication was 1.9-folds higher for patients visiting more than two hospitals, 1.8-folds higher for patients visiting more than two clinics. With the implementation of the CGA, the average number of medicine per patient decreased from 6.9(±4.4) to 3.7(±3.1). In addition, the ratio of polypharmacy(76%->48%) and patients prescribed inappropriate medication(32%->1.3%) were declined. The pharmacist documented 224 recommendations, of which 129(57.6%) were accepted by the physician. The physicians tend to accept the recommendation by the pharmacist for the problems associated with drug-drug interaction(83.3%), inappropriate medication(75.4%) and drug duplication(69.2%). Taken together, these observations indicate that the implementation of CGA is indeed useful in reducing incidences that are related to the pharmacotherapy and the extension of the role of pharmacist for the prescription process. Therefore, the medication assessment of pharmacist may be crucial in the realization of a safer and more appropriate pharmacotherapy.

Co-Ni 합금위에서 수직방향으로 정렬된 탄소나노튜브의 성장

류재은,이철진,이태재,손경희,신동혁,Ryu, Jae-Eun,Lee, Cheol-Jin,Lee, Tae-Jae,Son, Gyeong-Hui,Sin, Dong-Hyeok 대한전기학회 2000 전기학회논문지C Vol.54 No.12

We have grown vertically aligned carbon nanotubes in a large area of Co-Ni codeposited Si substrates by the thermal CVD usign $C_2H_2$ gas. Since the discovery of carbon nanotubes, growth of carbon nanotubes has been achieved by several methods such as laser vaporization, arc discharge, and pyrolysis. In particular, growth of vertically aligned nanotubes is important to flat panel display applications. Recently, vertically aligned carbon nanotubes have been grown on glass by PECVD. Aligned carbon nanotubes can be also grown on mesoporous silica and Fe patterned porous silicon using CVD. In this paper, we demonstrate that carbon nanotubes can be vertically aligned on catalyzed Si substrate when the domain density of catalytic particles reaches a certain value. We suggest that steric hindrance between nanotubes at an initial stage of the growth forces nanotubes to align vertically and each nonotubes are grown in bundle.

논현동 의화빌딩

류재은(Lew, Jai-eun) 현대건축사 2007 월간 CONCEPT Vol.- No.102

열화학기상증착법에 의한 고순도 탄소나노튜브의 성장

柳在銀(Jae-Eun Yoo),朴正訓(Jung-Hoon Park),金大運(Dae-Won Kim),李鐵眞(Cheol-Jin Lee),孫權熙(Hee-Kwon Son),申東赫(Dong-Hyuk Sin),文仁琪(In-Gi Moon) 대한전기학회 2000 전기학회논문지C Vol.49 No.12

韓ㆍ日 兩國의 家計消費支出行態 比較分析

梁世貞,劉哉銀 한국소비자원 1992 消費者問題硏究 Vol.- No.10

국내 초콜릿 산업 동향

최근표,채동진,류재은,Choi, Kun Pyo,Chae, Dong Jin,Ryoo, Jae Eun 한국식품영양과학회 2014 식품산업과 영양 Vol.19 No.2