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택사(Alismatis Rhizoma) 추출물의 반복 경구투여 독성 연구
노항식,석지현,정자영,이종권,김태성,최혜경,하헌용,Roh, Hang-Sik,Seok, Ji-Hyun,Jeong, Ja-Young,Lee, Jong-Kwon,Kim, Tae-Sung,Choi, Hye-Kyung,Ha, Hun-Yong 대한한방안이비인후피부과학회 2014 한방안이비인후피부과학회지 Vol.27 No.1
Objectives : This study was carried out to evaluate the repeated dose oral toxicity of Alismatis Rhizoma in Sprague-Dawley(SD) rats. Methods : Male and female rats were administered orally with Alismatis Rhizoma water extract of 500 mg/kg(low dosage group), 1,000 mg/kg(middle dosage group) and 2,000 mg/kg(high dosage group). We daily observed number of deaths, clinical signs and gross findings for 14 days(twice a day). After 14 days, we measured body and organs weight. Also we analyzed hematological changes. Results : No dead SD rats and no clinical signs were found during the experiment period. Also other specific changes were not found between control and treated groups in hematology and serum biochemistry. In addition no significant changes of gross body and individual organs weight. Conclusions : These results suggest that water soluble extract of Alismatis Rhizoma has not repeated dose oral toxicity and oral LD50 value was over 2,000 mg/kg in SD rats. As a result, we can determine Alismatis Rhizoma is a relatively safe substance.
원지(Root of Polygala teunifolia Willd)추출물의 급성 경구투여 독성 연구
노항식 ( Hang Sik Roh ),정자영 ( Ja Young Jeong ),석지현 ( Ji Hyun Seok ),하헌용 ( Hun Yong Ha ) 대한한방부인과학회 2013 大韓韓方婦人科學會誌 Vol.26 No.4
In this study, it was carried out to evaluate the acute oral toxicity of Root of Polygala teunifolia Willd. in Sprague-Dawley (SD) rats. Methods: Male and female rats were administered orally with Root of Polygala teunifolia Willd. water extract of 1,000 mg/kg (low dosage group), 2,000 mg/kg (middle dosage group) and 4,000 mg/kg (high dosage group). We daily observed number of deaths, clinical signs and gross findings for 7 days. After 7 days, we measured body and organs weight. Also we analyzed hematological changes. Results: No dead SD rats and no clinical signs were found during the experiment period. Also other specific changes were not found between control and treated groups in hematology and serum biochemistry. But we found out histopathological changes in liver fat tissues of female. In addition, there were no significant changes of gross body and individual organs weight. Conclusions: These results suggest that water soluble extract of Root of Polygala teunifolia Willd. has not acute oral toxicity and oral LD50 value was over 4,000 mg/kg in SD rats.
백선피(Dictamnus dasycarpus Turcz) 추출물의 급성 경구투여 독성 연구
석지현,노항식,정자영,하헌용,Seok, Ji-Hyun,Roh, Hang-Sik,Jeong, Ja-Young,Ha, Hun-Yong 대한한방안이비인후피부과학회 2014 한방안이비인후피부과학회지 Vol.27 No.1
Objectives : This study was carried out to evaluate the acute oral toxicity of Dictamnus dasycarpus Turcz in Sprague-Dawley(SD) rats. Methods : Male and female rats were administered orally with Dictamnus dasycarpus Turcz water extract of 1,000 mg/kg(low dosage group), 2,000 mg/kg(middle dosage group) and 4,000 mg/kg(high dosage group). We daily observed number of deaths, clinical signs and gross findings for 7 days. After 7 days, we measured body and organs weight. Also we analyzed hematological changes. Results : No dead SD rats and no clinical signs were found during the experiment period. Also other specific changes were not found between control and treated groups in hematology. But we found out subtle changes in body weight and individual organ weight of the female group. In addition specific changes were observed in serum biochemical value of female group. Conclusions : These results suggest that water soluble extract of Dictamnus dasycarpus Turcz has not acute oral toxicity and oral $LD_{50}$ value was over 4,000 mg/kg in SD rats. Also Dictamnus dasycarpus Turcz is expected to be sensitive with respect to the female.
택사(Alismatis Rhizoma) 추출물의 급성 경구투여 독성 연구
석지현,노항식,정자영,하헌용,Seok, Ji-Hyun,Roh, Hang-Sik,Jeong, Ja-Young,Ha, Hun-Yong 대한한방안이비인후피부과학회 2013 한방안이비인후피부과학회지 Vol.26 No.4
Objectives : This study was carried out to evaluate the acute oral toxicity of Alismatis Rhizoma in Sprague-Dawley(SD) rats. Methods : male and female rats were administered orally with Alismatis Rhizoma water extract of 1,000 mg/kg (low dosage group), 2,000 mg/kg(middle dosage group) and 4,000 mg/kg(high dosage group). We daily observed number of deaths, clinical signs and gross findings for 7 days. After 7 days, we measured body and organs weight. Also we analyzed hematological changes. Results : No dead SD rats and no clinical signs were found during the experiment period. Also other specific changes were not found between control and treated groups in hematology and serum biochemistry. In addition no significant changes of gross body and individual organs weight. Conclusions : These results suggest that water soluble extract of Alismatis Rhizoma has not acute oral toxicity and oral $LD_{50}$ value was over 4,000 mg/kg in SD rats.