한국인 피부색의 연령, 성별 및 계절에 따른 차이와 특성

이현정(Hyun Jeong Lee),노기영(Kee Young Roh),김동재(Dong Jae Kim),박종갑(Jong Gap Park),하석준(Seog Jun Ha),김진우(Jin Wou Kim) 대한피부과학회 2000 대한피부과학회지 Vol.38 No.12

Background:Human skin color shows variations throughout life and many extrinsic and intrinsic factors influence melanogenesis. The characteristics of skin pigmentation have been studied largely in white Caucasians. However, pigmentary changes due to various regulatory factors may be different in Orientals. Objective:We observed the variations in skin color due to aging, seasonal changes and gender differences in Koreans with skin type IV or V. Methods:Skin pigmentation was measured at five body sites (buttock, glabella, V-neck area, inner arm, and dorsal forearm) using skin reflectance spectroscope in 109 subjects in winter and summer. Results:Constitutive pigmentation of the buttock was at the highest level in the first decade of life. It then decreased during the next two decades. This decreased level was maintained after the third decade. The pattern of pigmentation changes of other four sites with aging was similar to that of the buttock. Gender differences were significant except in the first decade. Seasonal change of pigmentation level was observed in dorsal forearm. Interestingly, our study did demonstrate some differences from the observations in Caucasians. We found that facultative pigmentation in Koreans was not increased with aging, so the sun exposure index was not reliable as a measure of cumulative lifetime UV exposure. Conclusion:These differences between races could imply that genetically determined basal skin color has important effects on characterizing later responsiveness to UV lights and sex hormones. Understanding these differences in skin pigmentation would be helpful in treating pigmentary diseases and skin cancers, and in studying the regulatory mechanisms of melanogenesis. (Korean J Dermatol 2000;38(12):1615~1623)

아토피성 수족부 피부염의 임상적 특징

이현정(Hyun Jeong Lee),노기영(Kee Young Roh),김동재(Dong Jae Kim),하혜정(Hye Jeong Ha),하석준(Seog Jun Ha),박영민(Young Min Park),변대규(Dae Gyoo Byun),김진우(Jin Wou Kim) 대한피부과학회 2000 대한피부과학회지 Vol.38 No.10

Background:Hand-foot (H-F) dermatitis is common in atopic dermatitis patients, but its clinical characteristics have not been studied well. Objective:We performed this study to examine the clinical characteristics of H-F dermatitis of AD and to assess its etiologic associations. Methods:Clinical manifestations of H-F dermatitis were examined in 134 patients with H-F dermatitis of AD between May 1997 and July 1998 at our AD clinic. Results:Both hand and foot were involved in 63(47.0%) patients, and either hand or foot involvement was observed in 20(14.9%) and 51(38.1%) patients, respectively. It usually began in childhood with an early onset of AD. Pruritus was the most frequent symptom, and erythema, scales, lichenification, hyperkeratosis, fissures, and keratolysis exfoliativa were also common. Palmar or plantar involvement showed an equal frequency with the dorsal lesions. The great toe was affected more often than the other toes. Two thirds presented with manifestations of ichthyosis triad (ichthyosis vulgaris, hyperlinear palm and keratosis pilaris) and sandpaper-like skin lesions on the elbow, knee, and lateral malleolus. Palmar or plantar hyperhidrosis was reported in 21% and 27% respectively. The ichthyosis-associated group showed a significantly higher incidence of sandpaper-like skin lesions, fissures, and scales, mainly involving the dorsa of hands and feet. The hyperhidrosis- associated group showed an association with glassy lesions, localized to palmar or plantar areas. Conclusion:Clinical characteristics of AD-associated H-F dermatitis were demonstrated. The disease was suggested to be associated with the nonimmunologic etiologies of AD and clinical subgroups could be identified on the basis of nonimmunologic backgrounds. (Korean J Dermatol 2000;38(10):1341~1347)

조갑하 각화극세포종

이경호 ( Kyung Ho Lee ),노기영 ( Kee Young Roh ),이현정 ( Hyun Jeong Lee ),김진우 ( Jin Wou Kim ) 대한피부과학회 2003 대한피부과학회지 Vol.41 No.5

Subungual keratoacanthoma is a rare, benign tumor occurring mainly on the thumb of middle-aged Caucasians. It presents as a painful keratotic papule or nodule accompanied by consequential partial onycholysis and bacterial infections. Unlike keratoacanthoma of other sites, subungual keratoacanthoma is not spontaneously resolved and surgical interventions have been recommended for treatment. It also needs to be differentiated from other subungual lesions, especially squamous cell carcinoma. We describe a case of subungual keratoacanthoma, which was completely resolved with extraction of the nail followed by oral methotrexate(MTX) medication. (Korean J Dermatol 2003;41(5) : 617~620)

한국인 청장년기 아토피피부염 환자의 임상적 특징에 관한 연구

권지애 ( Ji Ae Kwon ),노기영 ( Kee Young Roh ),고보경 ( Bo Kyung Koh ),김진우 ( Jin Wou Kim ) 대한피부과학회 2004 대한피부과학회지 Vol.42 No.8

흔적 수막류 1 예

이준영,박현정,이창남,조백기,노기영 대한피부과학회 2001 大韓皮膚科學會誌 Vol.39 No.11

Rudimentary meningocele, also known as a `variant of primary cutaneous meningioma` or `acoelic meningeal hamartoma`, is an unusual developmental anomaly in which meningothelial elements are found in the skin. A 8-month-old girl has a well-circumscribed, alopecic, atrophic patch on the midline of the occipital area since birth. Histologically, pseudovascular spaces lined with flattened or cuboidal cells were seen in the papillary and upper reticular dermis without collagen bodies. These flattened or cuboidal cells were positive for vimentin, but negative for EMA, immunohisto-chemically. Radiographic finding of the scalp revealed no underlying bony defect.

피지선 분화와 모낭 상피종 분화를 보인 모모세포종 ( Trichoblastoma ) 1 예

최성우,송계용,노기영 대한피부과학회 2001 大韓皮膚科學會誌 Vol.39 No.2

We report a 40-year-old woman with trichoblastoma on vertex scalp showing trichoepithelioma-like feature in upper part and focal sebaceous differentiation. The co-presence of trichoblastoma and trichoepithelioma-like feature in a same tumor represented that the inclusive term trichoblastoma is better for trichogenic tumors composed of follicular germinative cells, and sebaceous differentiation meant the common embryonic origin of folliculo-sebaceous-apocrine unit.

집단 흑자를 동반한 거대 Becker 모반

김진우,하석준,박종갑,이현정,노기영 대한피부과학회 2001 大韓皮膚科學會誌 Vol.39 No.4

We report a case of a 27-year-old male showing Becker's nevus on his trunk and lower extremities. It represented symmetrically bilateral and extensive(about 50% of body surface) involvement. In addition to the usual clinical findings of Becker's nevus, grouped small darker spots were noted on the lesion of the buttock featuring agminated lentigine. Histologic findings of the brownish pigmented lesion consisted of mild acanthosis, hyperkeratosis, elongation of rete ridges, increase of basal layer pigmentation, and numerous terminal hair follicles. A dark macule in agminated lesions on the buttock showed more dense basal layer pigmentation and more regular elongation and fusion of rete ridges consistent with the histologic findings of lentigo simplex. This report describes a rare case of a giant Becker's nevus involving 50% of body surface in a bilateral and symmetrical distribution with associated agminated lentigine.

모낭성 피지선 아포크린 분화를 보인 연골양 한관종 1예

강석진,김형옥,고재경,양정은,노기영 대한피부과학회 2000 大韓皮膚科學會誌 Vol.38 No.12

Chondroid syringoma is referred as mixed tumor because it has epithelial structure and mesenchymal elements. Mixed tumors could be divided into two distinct types, eccrine and apocrine. Mixed tumor with follicular, sebaceous and apocrine differentiation is considered as an expression of the common embryologic origin of elements of the folliculosebaceous-apocrine unit. A 32-year old man presented with an asymptomatic firm erythematous nodule on the left cheek. Histologically, it showed typical features of chondroid syringoma with tubules exhibiting branching and cystic dilatation in the myxoid and chondroid stroma. Our case is unique in that the tumor arose from follicular infundibulum with follicular, sebacesous and apocrine differentiation.