수원 , 경기남부 지역의 피부 종양의 고찰

하석준 ( Seog Jun Ha ),김시용 ( Si Yong Kim ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.2

Background: This is the first report of study deals with skin tumors in the Suwon and South Kyungiido area during the past 11 years(1983-1993). Objective : We evaluated incidence of tumors, age and sex distribution, and tumor sites. Methods : We reviewed 1506 cases of skin tumors January 1983 to December 1993, at St. Vincent hospital. Results : l. In the 1506 cases of skin tumors, 1280 cases(85.0%) were benign tumors, and 226 cases(15. 0% ) were malignant tumors. 2. Among the 1280 cases of benign tumors, the most common tumor was epidermal cyst, which followed by lipoma, cavernous hemangioma, pilomatricoma, angiolipoma, neurofibroma and sebor rheic keratosis. 3. Among the 226 cases of malignant tumors, 78 cases of basal cell carcinoma, 59 cases of squamous cell carcinoma, 15 cases of malignant melanoma, 11 cases of actinic keratosis and 10 cases of metastatic carcinoma were found. 4. Among the 10 cases of outaneous metastatic cancer, primary sites were lung(3 cases), kidney(3 cases), breast, urinary bladder, stomach and large intestine. Conclusion : The 1506 cases of skin tumors, which were confirmed histologically at the St. Vincent hospital from January 1983 to December 1993, were reviewed. (Kor J Dermatol 1996;34(2): 199-205)

Tegafur 경구 투여후 발생한 선단 홍반 및 색소침착

하석준 ( Seog Jun Ha ),함상희 ( Sang Hee ham ),박영민 ( Young Min Park ),조상현 ( Sang Hyun Cho ),조백기 ( Baik Kee Cho ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.2

Tegafur is a fluoropyrimidine structurally similar to 5-fluorouracil, used in the treatment of advanced gastrointestinal neoplasms. Mucocutaneous side reactions induced by this agent are rare and include photosensitivity of lichenoid and eczematous types, acral erythema, hyperpigmentation and palmoplantar keratoderma. However, to our knowledge, there has been no report of concurrent development of eruptions of two types in a patient. We describe a female patient with breast cancer, presented with combined features of acral erythema and hyperpigmentation due to oral tegafur. (Korean J Dermatol 1998;36(2) . 363-366)

원발성 폐암과 동반된 Reiter 증후군

하석준 ( Seog Jun Ha ),권윤희 ( Yoon Hee Kwon ),김태윤 ( Tae Yoon Kim ),김정원 ( Chung Won Kim ) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.3

Reiters syndrome is an unusual disease characterized a triad of nongonococcal urethritis, conjunctivitis, and arthritis in association with the mircoutaneous lesions of keratoderma blenorrhagica and balarintis circinata. We present herein a case of Reiters syndome combined yiti lung cancer. A 39-year-old man has experienced naigrating polyarthralgia and high fever ilitermittently for about 20 years, Hyperkeratotic erythemnous patches and plaques, which dyeliped about 1 year ago, have aggravated and expanded to the whole body. Histopathologic sections from the plaque on the right forc ari showed characteristic findings including thickened parakeratotic horny layer and spongiform micropustules of Kogoji He was associated with HLA-B27. On the chest X-ray, a thumbtip size mass was incidently found. Chest CT and bone scan findings supported lung cancer and multiele metastases. (Kor J Dermatol 1995;33(3): 580-584)

약제에 의한 선상 IgA 수포성 피부병 1 례

함상희,하석준,박영민,조상현,김진우,조백기 ( Sang Hee Ham,Seog Jun Ha,Young Min Park,Sang Hyun Cho,Jin Wou Kim,Baik Kee Cho ) 대한천식알레르기학회 1998 천식 및 알레르기 Vol.18 No.3

Linear IgA bullous dermatosis (LABD) is an autoimmune subepidermal blistering disease characterized on direct immunofluorescence of perilesional skin by the linear deposition of IgA at the basement membrane zone. The pathogenesis of LABD is not known, but rar ely some cases of LABD have been reported in association with drug exposure. We report a case of drug-induced LABD showing linear deposits of IgA and IgG at the basement membrane zone on direct immunofluorescence of perilesional skin as well as typical clinical and histologic characteristics, although the causative agent could not be specified.

경피적 폐생검후 발생한 피부선병

백종한,하석준,이준영,김진우 ( Jong Han Paik,Seog Jun Ha,Jun Young Lee,Jin Wou Kim ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.6

Scrofuloderrna results from a direct extension of an underlying tuberculous focus such as the lymph nodes, bone or joint to he overlying skin, and is often associated with pulmonary tuberculosis. A 59-year-old male pai ient presented with an asymptomatic, flesh colored, 0.8 * 1.0 cm sized, solitary nodule on the left, middle back area. He had a CT-guided percutaneous lung biopsy 3 weeks before, for t,he evalu;ition of a round focal inhomogenous mass in the left lower lung field on radiologic study. An cxcisional biopsy specimen from the skin lesion showed granulomatous infiltration, composed of pithelioid cells, mononuclear cells and Langhans giant cells in the deep dermis and the suhcutaru-ous fat, layer. Caseation necrosis within the tubercles was marked and numerous acid-fast bacilli were identified on AFB staining. Here we report an unusual case of scrofuloderma occurring after a percutaneous lung biopsy. (Korean J Dermatol 1997;35(6): 1250-1253)

과립세포 기저세포암 1 예

명재욱(Jae Wook Myung),하석준(Seog Jun Ha),박철종(Chul Jong Park),강석진(Seok Jin Kang),김시용(Si Yong Kim) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.9

Granular cell basal cell carcinoma is a rare histopathologic variant of basal cell carcinoma in which some or all of the neoplastic cells show cytologic features of granular cells. These distinctive cells contain abundant eosinophilic cytoplasm housing numerous fine and coarse refractile granules. The 62-year-old man presented with a 5-year history of asymptomatic, solitary 1 ㎝-diameter, hemispherical, brown to black, smooth-surfaced, hard nodule on the left chest. The histopathological features showed a tumor with the general configuration of a solid basal cell carcinoma, in which there were masses of granular cells with eosinophilic and granular cytoplasm. The tumor was positive for cytokeratin and negative for lysozyme and PAS. Surgical excision was performed. (Korean J Dermatol 2002;40(9):1128~1131)

소아의 안면부에 발생한 외상성 지방 괴사

함상희 ( Sang Hee Ham ),하석준 ( Seog Jun Ha ),박영민 ( Young Min Park ),조상현 ( Sang Hyun Cho ),조백기 ( Baik Kee Cho ),김경미 ( Kyoung Mee Kim ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.3

Traumatic fat necrosis is a localized reaction of panniculus resulting from blunt trauma occurring predominantly on large pendulous breasts in elderly females and on the face in children. The facial lesions in children need no treatment and therapeutic excision is not indicated because a reasonable cosmetic result comes from spontaneous healing in a year or more. The clinicians unfamiliar with this problem may have confusion in diagnosis and management. Herein we report a case of a three-year-old girl who presented with a 3 cm sized erythematous and bullous plaque on her right cheek. The diagnosis of traumatic fat necrosis was made following clinical and pathological findings. (Korean J Dermatol 1998;36(3): 551-553)

한국인의 원형탈모중과 남성형탈모중의 횡단절편 조직 소견

이현정(Hyun Jeong Lee),하석준(Seog Jun Ha),이주한(Joo Han Lee),김정철(Jung Chul Kim),김형옥(Hyung Ok Kim),김진우(Jin Wou Kim) 대한피부과학회 2001 대한피부과학회지 Vol.39 No.5

N/A Background: The advantages of horizontal, over vertical, sectioning of scalp biopsies allow morphometric analysis of follicular structures. Objective: In this study, we performed the morphometric analysis of alopecia areata and androgenetic alopecia in Koreans using the horizontal sectioning method. Methods: Paird, 4-mm punch biopises were taken from the margin of alopecic patch from 21 alopecia areata patients or the frontal lesion of 13 androgenetic alopcia patients, and from clinically normal occipital scalp of all subjects. Results: The general histopathological features were consistent with the known descriptions, but the data on exact follicular counts showed striking differences compared with those from Caucasians. 1. In alopecia areata, numbers of vellus hairs (3.2 < 2.9) and follicular stellae (1.6±1.6) was increased significantly (p<0.05) compared with counts from normal occipital scalp (vellus hairs 1.1±1.3; follicular stellae 0.5±0.8). Anagen/telogen percent ratio was decreased in lesions (64.2%:35.8%) compared with normal occipital scalp (94.0%:5.7%). 2. In androgenetic alopecia, numbers of vellus hairs (4.1±3.7) and follicular stellae (4.4±3.4) was increased significantly (p<0.05) in the lesion compared with the normal occipital scalp (vellus hairs 1.1±1.3; follicular stellae 1.0±1.2). Mild decrease of anagen/telogen percent ratio was observed in lesions (86.5%:13.5%) compared with normal occipital scalp (93.5%:6.5%). Conclusion: Our results suggest that horizontal sectioning of scalp biopsies is a useful diagnostic method but differences in follicular counts should be considered in interpreting the morphometric data in Koreans.

상염색체 우성 유전양식을 보인 선단각화 유탄력섬유증 2예

함상희 ( Sang Hee Ham ),하석준 ( Seog Jun Ha ),박영민 ( Young Min Park ),조상현 ( Sang Hyun Cho ),조백기 ( Baik Kee Cho ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.5

Acrokeratoelastoidosis of Costa is a rare palmoplantar keratoderma with autosomal dominant inheritance. It is clinically charaeterized by small, firm, yellowish, shiny, translucent papules occumng over the dorsal hands, the knuckles, and the lateral margine of the palms and soles. Histologically, the characteristic features are hyperkeratosis, aeanthosis, and most strikingly, fragmentation of coarse elastic fibers within the dermis. The lesions usually begin in early childhood and progress slowly. We herein report two familial cases of acrokeratoelastoidosis of Costa showing typical clinic1 and histopathological features. (Korean J Dermatol 1998;36(5) 946-949)

원형탈모증의 철 결핍 관련성 및 자가면역항체 양성률 , 갑상선 기능 이상 빈도에 관한 연구

이현정(Hyun Jeong Lee),김진우(Jin Wou Kim),이주한(Joo Han Lee),하석준(Seog Jun Ha) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.1

N/A Background:Iron deficiency is known as an aetiological factor in diffuse alopecia and androgen-dependent alopecia, especially in females. In alopecia areata, a few studies have been performed to evaluate the role of iron deficiency, but the results were not conclusive. Alopecia areata is suspected to be an autoimmune disease and increased frequencies of thyroid disease, vitiligo, and autoantibodies have been demonstrated. Objective:The purpose of this study is to assess the role of iron deficiency in alopecia areata and to study the frequency of abnormal thyroid function tests and autoantibodies in Korean patients with alopecia areata. Method:A total of 40 (32 premenopausal and 8 postmenopausal) female and 33 male patients with patchy alopecia areata were included. Hematologic tests, thyroid function tests and autoantibody tests were performed. Result:About 65% of premenopausal female patients with alopecia areata had low level of serum ferritin below 20 ng/ml. This percentage was increased to 87% with low limit of 40 ng/ml, and to 100% with low limit of 70 ng/ml in premenopausal women, but all postmenopausal patients showed normal ferritin level. About one-fifth of premenopausal female patients had low serum iron level and one-tenth had low hemoglobin level. Serum ferritin level was significantly lower in premenopausal women (21.5±12.4 ng/ml) than in postmenopausal women (71.1±47.1 ng/ml) (p<0.05). Hematologic test abnormalities were very infrequent in male patients with alopecia areata. Thyroid function tests were normal in most of the patients. Frequency of antinuclear antibody was 30% in female patients with alopecia areata, which was higher than 9% in male patients. Frequencies of antimicrosomal and antithyroglobulin antibodies were rather low and they were similar in female and male patients. Conclusion:Our results suggest possible role of ferritin deficiency in premenopausal female patients with alopecia areata. Abnormalities in thyroid function tests or autoantibodies were not a major problem in alopecia areata patients. (Korean J Dermatol 2002;40(1):8~13)