첩모 (睫毛) 의 Demodex에 관한 연구

변대규(Dae Gyoo Byun),김형옥(Hyung Ok Kim),조백기(Baik Kee Cho),이원구(Won Koo Lee) 대한피부과학회 1983 大韓皮膚科學會誌 Vol.21 No.1

Demodex is easily found from eyelashes and suggested as the one of the causes of some eye diseases. This study was to investigate the occurence rate, and classification of Demodex from eyelashes, and its relationship with blepharitis. The data of this study were compiled from 27 blepharitis patients and 173 patients without blepharitis (control group) who had visited St. Paul's Hospital from October 1981 to December 1981. Three eyelashes from each eyelid-total 12 lashes from a patient-were extracted under the slit lamp, located on a slide glass and fixed with polyvinyl lactophenol mounting medium. (countinued..)

제10회 대한알레르기학회 학술대회 연제 및 순서 : 일반연제 ; 수부습진에서의 첩포시험

변대규 ( Dae Gyoo Byun ),김형옥,김정원 ( Chung Won Kim ),허원,( Shi Ryong Choi ) 대한천식 및 알레르기학회 ( 구 대한알레르기학회 ) 1983 천식 및 알레르기 Vol.3 No.2

설문지를 통한 한국인 아토피피부염 임상병력의 진단적 중요성에 관한 연구

이동원,변대규,김진우 ( Dong Won Lee,Dae Gyoo Byun,Jin Wou Kim ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.3

Backgroud: Recent studies have shown an incomplete agreement with the previously proposed diagnostic criteria of Hanifin and Rajka for atopic dermatitis(AD). This could be due to ethnic differences in the clinical manifestations of AD. To make a diagnosis of AD with confidence, one has to depend on the history and clinical picture according to race. Objectives : The purpose of the present study was to find out the importance of individual symptoms and histories for the diagnosis of Korean AD by questionnaire. Methods : The frequency of 25 questionnaire items was studied in 130 patients with typical AD (48 childhood, 82 adolescence/adult) compared to that in 198 control subjects (89 childhood, 109 adolescence/adult). Results : Nine items(itchy with bodily heat, itchy when sweating, cholinergic urticaria, miliaria, irritation with fabrics, food reaction, pollen allergy, itch with stress) were shown to be of much diagnostic significance(p<0.001) in childhood AD,otherwise thirteen items(itchy with bodily heat, itchy when sweating, cholinergic urticaria, sense of fever, excessive sweating, miliaria, irritation with cosmetics, irritation with fabrics, irritation prone hands, itchy with woolen clothes, pollen allergy, itch with stress, dermographism) were in adolescent and adult, AD. ConClusion : We found some diagnostic significance of clinical histories in Korean AD patients by questionnaire. We propose that this accessible questionnaire would be an efficient and powerful method with which to obtain new and valid information on AD. (Kor J Dermatol 1997;35(3): 443-445)

골미란을 초래한 사구종양

박수근,변대규,조백기,허원,노문제,이강우 ( Soo Keun Park,Dae Gyoo Byun,Baik Kee Cho,Won Houh,Moon Jae Cho,Kang Woo Lee ) 대한피부과학회 1990 대한피부과학회지 Vol.28 No.4

Dirty Neck of Atopics

이동원(Dong Won Lee),변대규(Dae Gyoo Byun),차미경(Mi Kyung Cha),김진우(Jin Won Kim) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.1

We report a case of Dirty Neck in a 27-year-old male suffering from severe atopic dermatitis. 'Dirty Neck', a reticulate pigmentation of the anterior and anterolateral aspects of the neck, is a specific finding in some subjects with atopic dermatitis. Two groups have been indentified. One is found in older patients with severe atopic dermatitis whose pigmentary lesions develop after puberty and show little seasonal variation. The other is found in younger patients with mild eczema who have a increase in pigment during the summer. Our patient showed a dark brown colored, linear, reticulate pigmentation of the neck, especially anterolateral aspeet regarded as the former group. More comprehensive and detailed clinical study is needed to evaluate the importanee of this entity in regard to as a minor clinical feature of Korean atopic dermatitis. (Kor J Dermatol 1994; 32(1): 198-201)

한국 아토피피부염 유병률 역학 조사에 관한 고찰

이현정 ( Hyun Jeong Lee ),변대규 ( Dae Gyoo Byun ),김진우 ( Jin Wou Kim ) 대한피부과학회 1996 大韓皮膚科學會誌 Vol.34 No.6

Background: Atopic dermatit,is is reported to have increased recently, but the epidemiologic studies of atopic dermatitis have not been systematically performed in Korea. Qbjective : The purpose of this study is to review the previous epidemiologic studies of the prevalence of atopic dermatitis in Korea and to discuss important factors in performing the systematic epidemiologic studies of atopic dermatitis. Methods : We reviewed the Korean literature reported since the 1960s, which included 7 field surveys of atopic dermatitis and, 10 prevalence studies of common dermatologic diseases in outpatients. The literature was compared and analyzed in the view of diagnostic criteria, time/period of the studies, method of the surveys, sampling of subjects, the frequency of atopic dermatitis with age and sex distribution, seasonal variation and the secular trend. Results. 1. No definite diagnostic criteria was presented in some studies, and in the others, Hanifin and Rajkas diagnostic criteria or its modification was used. 2. The studies were performed during a season of a year or through spring, summer; and autumn. 3. A variety of methods were employed such as the review of the medical records, the ques- tionnaire, and a doctors physioal examination/interview. 4. Subjects in most of the studies were children under 15 years of age, and the survey area was limited to a certain city or district. 5. The frequency of atopic d: rmatitis ranged fro~rn 2.4% to 15.4% in field surveys and frorn 2.3% to 23.5% in outpatient studies. The secular trends could not be inferred directly though there is a possibility of an increasing tendency. Conclusion : This review may give help to understand the present state and progression of Korean epidemiologic studies of atopic dermatitis and to plan future studies. The epidemiologic studies of atopic dermatitis should be systematically carried out with the consideration of the general factors required in the epidemiologic study and proper understanding of the specific features of atopic dermatitis. (Kor J Dermatol 1996;34(6): 898-907)

표고버섯 피부염(Shiitake Dermatitis)의 임상 및 병리조직학적 고찰

하지현 ( Ji Hyun Ha ),변대규 ( Dae Gyoo Byun ),김석민 ( Seog Min Kim ),유철호 ( Chul Ho Yoo ),박철종 ( Chul Jong Park ) 대한피부과학회 2003 대한피부과학회지 Vol.41 No.4

N/A Background : Shiitake dermatitis has been reported mostly from Japan and characterized by distinctive pattern of itchy skin eruption after the ingestion of raw shiitake mushrooms. Objective : The purpose of this study is to investigate clinical, laboratory and histopathologic profiles about shiitake dermatitis occurring in Korea. Methods : From 1997 to 2001, we had observed 58 patients with shiitake dermatitis and investigated clinical, laboratory and histopathologic aspects. Result : Most patients with shiitake dermatitis presented with a very strong itching sensation, which was accompanied with linearly grouped or disseminated small erythematous papules. 53patients(91%) had noticed their skin eruption within 3 days after eating shiitake mushrooms. The involved sites were trunk, extremities, neck and face in decreasing order of frequency. Laboratory and histopathologic findings were nonspecific. In 33 patients(57%), the eruption occurred after eating boiled or panbroiled shiitake mushrooms. Conclusion : In this study, clinical, laboratory and histopathologic findings of shiitake dermatitis were almost consistent with the previous reports. But, contrary to the previous reports in Japan, many cases with shiitake dermatitis occurred on eating sufficiently boiled or cooked shiitake mushrooms. This may imply another eiologic factor different from thermolabile toxin. (Korean J Dermatol 2003;41(4) : 440∼444)

한국인 아토피 피부염 환자에서의 보조 피부 증상 ( Minor Clinical Features ) 에 대한 고찰 ( II ) : 청장년기 아토피 피부염에서의 보조 피부 증상의 빈도

박영민(Young Min Park),변대규(Dae Gyoo Byun),김진우(Jin Wou Kim) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.6

Background : Three age-depedent clinical phases(infantile, childhood and adult phase) of atopic dermatitis(AD) were recognized. We think that for t he diagnosis of AD there seems to be some differences in minor clinical features of diagnosic significance according to each phase, yet only a few studies about them. Objectives : The purprrse of the present study was to evalute the diagnostic significance of total 39 minor clinical features of AD in Korean adolescenc and adult popluation, all but only skin were proposed by our previous study for Korean childr n Methods : The frequeney of 39 minor clinical features wistudied in 82 patients with typical AD compared to that in 109 control subjects. The age all studied individuals ranged from 13 to 42 years. Furthermore, some characteristic micro features of AD in them were compared with those from our previous study for Korean children. Results : Twenty-seven minor features including xerosis, peifolhcular accentuation, frontal lichenification, anterior neck folds, eyelid eczema, Dennie-Mogan folds, auricular fissure/eczema, pityriasis alba, ventiral wrist eczema, infragluteal eczcm, sandpaper-like skin lesions on elbow/knee/lateral malleblus, white dermographism, scalaling, Hertoghes sign, orbital darkening, cheilitis, facial erythema/pallor, hyperlinear paln, ichthyosiform skin lesions, nipple eczema, nummular eczema, pompholyx, itchy hyperker totic lesions of dorsal hands, knuckle dermatitis of hands, hangnail, non-specific hand/foot dermatitis, chronic dermatophytosis were shown to be of much diagnostic signiic, nce(P<0.001). Conclusion : We think tiat 13 minor features such as Hert piges sign, cheilitis, facial erythe- mapallor, hyperlinear ichthyosiform skin lesions, ripile eczema, nummular eczema, pompholyx, itchy hyperkpratotic lesions of dorsal hands, kzukle dermatitis of hands, hangnail, non-specific hand/foot dermatitis, chronic dermato h tosis are specific for Korean adolescence and adult population with AD. Taken together, to propose that these 13 minor features be added to a gardeline for the large scale field sirvy on the incidence and prevalence of AD in the Korea adolescence and adult population. (Kor J Dermatol 1994; 32(6): 1046-1053)

경기도 부천시 국민학교 1학년 아동들의 아토피 피부염의 유병율과 동반된 보조 피부증상의 빈도

이상진(Sang Chin Lee),변대규(Dae Gyoo Byun),김진우(Won Chul Lee),이원철(Jin Wou Kim) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.1

Bsckground : The incidence of atopic dermatitis(AD) varie widely by different ages and it has been well-founded that the epidemiology of AD has been studied on admission of the first grade schoolchildren. AD is a common skin.disease of childhood and tends to increase significantly during recent decacles, but informations regarding the eact prevalence of AD, based on the large-scale general population study, are unavailable in Korea. Objective : The purpose of this study is to elucidate the prevalence of AD and to evaluate the diagnostic significance of some well-known clinical features associated with AD in the first grade school children in one of Korean citie Puchon, Kyunggi-do. Methods : Four thousands and eighteen first grde school children(boys; 2072, girls; 1946) participated in this study. Two dermatologists determined presence of skin lesions by through skin examination. Diagnosis of AD was made only who typical flexural and/or extensor and/or infraauricular fissure/eczema exist. The frequny as well as their diagnostic significance of ten minor features of AD(xerosis, ichthyosifor skin lesion, hyperlinear palm, keratosis pilaris, non-specific hand/foot dermatitis, cheilitis, ple eczema, perifollicular accentuation, pityriasis alba, Dennie-Morgan infraorbital fold) thught suitable items for field survey by authors, were also evaluated. Results : The total prevalence of AD in the first grade school children of Puchon city was 3.78%. The prevalence in boys was 3.37% and that in girls was 4.1%. Associated minor features in individuals diagnosed as having AD were, in order of frqiency, pityriasis alba(59.8%), perifollicular accentuation(57.8%), keratosis pilaris(56.5%), hyprlinear palms(55.2%), xerosis (43.3%), Dennie-Morgan infraorbital fold(26.3%), etc. All bu the ichthyosiform skin lesions and nipple eczema were significantly more frequent in indivulu, 1s diagnosed as having AD(P<0.01). Conclusion : A relatively low prevalence shown in this stud right be due to arather strict diagnostic criteria. Some belpful and diagnoktically significan tumor clinical features of AD, suitable for field survey suggested. Further studies are need for accurate estimation of the prevalence of AD in Korea including different regional and population. (Kor J Dermatol 1995; 33(1): 1-7)

일과성 세포 해리 피부병

이상배,조백기,허원,변대규 ( Sang Bae Lee,Baik Kee Cho,Won Houh,Dae Gyoo Byun ) 대한피부과학회 1988 대한피부과학회지 Vol.26 No.2

We report herein a case of transient acantholytic dermatosis. The patient was a 24-year-old pregnant woman in the last trimester, who had pruritic, discrete, erythematous or brownish papules on the lateral aspect of the neck. Histopathologic findings of the skin lesion showed changes resembling Darier's disease showing well circumseribed, small foci of acantholysis with acantholytic and dyskeratotic cells over the suprahasal clefts. The patient showed good response to isotretinoin(Roaccutane) therapy, 20mg/day, for 30 days.