베체트병 관절염의 임상적 특성

남태수 ( Tae Su Nam ),김성일 ( Sung Il Kim ) 대한류마티스학회 2003 대한류마티스학회지 Vol.10 No.2

Objective: To investigate the clinical, laboratory and radiologic characteristics of arthritis presented as initial manifestation in patients with Behcet`s disease. Methods: We retrospectively reviewed medical protocols, laboratory and radiologic findings in 33 patients with Behcet`s disease. Evaluation was made out at diagnosis and included age, sex, duration and onset pattern of arthritis, involved joint, and laboratory findings included erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), anti-nuclear antibody (ANA), rheumatoid factor (RF), and HLA type. Results: In 33 patients (7 males and 26 females), mean age was 34.4±9.4 years, and duration of arthritis was 34.1±37.9 months. The frequency of involved joint was as follows; 58% in knee, 33% in proximal interphalangeal joints, 27% in wrist, and 24% in ankle. The pattern of involvement was oligoarticular in 18 patients (55%), polyarticular in 9 patients (27%), and monoarticular in 6 patients (18%). Monoarticular pattern was more frequent in younger patients (≤35 year-old) than older patients. ESR and CRP were elevated in 17 (53%) and 8 patients (24%), respectively. Radiologic examination of the involved joint was normal in 93% of patients. Conclusion: In patients with Behcet`s disease diagnosed by arthritis as initial manifestation, the most commonly involved joint was knee and the most common pattern of involvement was oligoarticular.

후천성 면역 결핍증 환자 ( AIDS ) 의 혈액면역학적 특성과 기회감염에 대한 임상적 고찰

남태수(Tae Su Nam),서경수(Keung Su Seo),이경인(Kyong In Lee),김윤성(Yun Seong Kim),홍진희(Jin Hee Hong),김광하(Gwang Ha Kim),정준훈(Joon Hoon Jeong),주형준(Hyung Jun Chu),박승근(Seung Keun Park),성낙현(Nak Hean Seoung),정주섭(Ju Sup 대한내과학회 1997 대한내과학회지 Vol.52 No.1

N/A The number of persons with HIV infection in Korea have increased steadily, total number of HIV infection in Korea were 478 on August, 1995. To investigate the clinicoimmunologic manifestation of AIDS in Korea, we reviewed complete blood counts (CBC), CD4 counts, serum β2-microglobulin level, opportunistic infections and cause of death for 19 AIDS patients who had been admitted or visited at Pusan national university hospital during the period of January, 1990 to August, 1995. 1) The predominant mode of HIV transmission was heterosexual contact(18), other modes of transmission were homosexual contact(1). Clues of diagnosis of HIV infection were routine occupational health examination(14), and opportunistic infection symptoms such as fever, coughing(4). 2) Mean CD4 cell counts(/mm3) were 53±72 totally, 22±27 for 8 dead patients at mean 2 month before, 91±87 for 7 living patients. There were not significant difference(p>0.05). 3) Serum β2-microglobulin(MG;ug/ml) was measured at 12 patients, mean serum β2-MG level was4.8±7.3 totally, 7.1±10.3 for 6 dead patients at mean 1.3 month before, 2.5±0.4 for 6 living patients. There were not significant(p>0.05). 4) At CBC examination, WBC(/mm3) was 5,932±2,899 totally, 5,452±3,436 for 10 dead patients, 6,500 ±2,221 for 9 living patients(p>0.05). Hb(g/dl) was 11,4±2.8 totally, 9.4±1.8 for dead patients, 13.6±1.8 for living patients(p<0.05). Lymphocyte count(/mm) was 1,255±800 totally, 731±424 for dead patients, 1,838716 for living patients(p<0.05). ESR(mm/h) was 72±47 totally, 97±33 for dead patients, 47±47 for living patients(p<0.05). 5) Opportunistic infections had developed at 14 patients, candidiasis 7, pneumocystis carinii pneumonia 5, tuberculosis 3, cytomegalovirus infection 2, herpes zoster 3, toxoplasmosis 1, cryptococcal infection 2, bacterial pneumonia 5, and herpes simplex l. Malignant lymphoma had developed in 1 patient. 6) Mean survival interval from diagnosis of HIV infection to death was 32.8±19.1 months, and the most common cause of death was pneumocystis carinii pneumonia, and other causes of death were meningitis, bacterial pneumonia and AIDS-wasting syndrome. Based on these results, We concluded that CD4 counts, serum β2-microglobulin level, Hb, total lymphocyte count and ESR in AIDS patients are specific laboratory markers of progression and prognosis of AIDS, the most common opportunistic infection was candidiasis, and the most common cause of death in AIDS patients was pneumocystis carinii pneumonia.

망막 중심 동맥 폐쇄를 동반한 결절성 다발성 동맥염

김상수 ( Sang Soo Kim ),이주호 ( Joo Ho Lee ),남태수 ( Tae Su Nam ),김성일 ( Sung Il Kim ) 대한류마티스학회 2002 대한류마티스학회지 Vol.9 No.3

Polyarteritis nodosa is a necrotizing vasculitis affecting medium and small-sized arteries throughout the body. Eye involvement is present in about 10% to 20% of patients, including chemosis, iritis, episcleritis, corneal ulcers, keratitiis, choroiditis, retinal detachment, extraocular muscle palsies, and hypertensive retinopathy. Rarely there have been reports of optic neuropathies and occasional central retinal artery occlusions. We experienced a patient with central retinal artery occlusion who had been diagnosed polyarteritis nodosa with mononeuritis multiplex.

균상식육종 1례

성낙현,남태수,고우석,정영태,조군제,권경술,이재홍 大韓血液學會 1995 大韓血液學會誌 Vol.30 No.1

후천성 면역 결핍증환자의 구개에 발생한 악성 림프종 1 예

정영태,이재복,고우석,성낙현,남태수,하태정,황성윤,조군제 대한내과학회 1995 대한내과학회지 Vol.49 No.1

Non-Hodgkin's lymphoma is associated with HIV infection and about 60 times more common in AIDS patients than in the general population. Characteristics of AIDS-related NHL are similar to those observed in immunosuppressed transplanted recipients Most are of intermediate or high-grade B-cell origin. Most patients have advanced disease at presentation and a poor prognosis. A 39 years old man was admitted to our hospital, complaining with pain and swelling on left palatal area, weight loss, and intermittent fever. He has been diagnosed HIV Ab positive 3 years ago. Biopsy of left palatal mass showed diffuse large cell type NHL. So we showed this case of AIDS-related NHL with a literature review.

카포시 육종, 주폐포자층 폐렴 등을 동반한 특발성 CD4+ T 림프구감소증 1 예

김준홍,김병진,정영태,고원욱,김사웅,조군제,정주섭,남태수,서경수,성낙현,김부웅 대한내과학회 1996 대한내과학회지 Vol.51 No.4

The recently recognized immunodeficiency syndrome of idiopathic CD4+ T-lymphocytopenia was defined by the Centers for Disease Control and Prevention (CDC) to include depressed numbers of circulating CD4+ T-lymphocytes ($lt;300 cells/㎣ or $lt;20% of total T cells) on more than one occasion, no laboratory evidence of infection with human immunodeficiency virus type 1(HIV-1) or type 2 (HIV-2), and the absence of any defined immunodeficiency or therapy associated with depressed levels of CD4+ T cells. We had experienced one case of Idiopathic CD4+ T-lymphocytopenia without HIV infection, combined with Kaposi's sarcoma and Pneumocystis carinii pneumonia. She had visited to emergency room due to moderate dyspnea and fever for about three months. On physical examination, multiple purple colored mass lesions were detected on lower back, both upper and lower extremities and right tonsillar area. Skin biopsy on mass of right lower extremity revealed Kaposi's sarcoma. On HRCT of the chest, patch bilateral, symmetric reticulonodular infiltration were founded. So, we performed sputum cytology repeatedly, we identified pneumocystis carinii cysts. Idiopathic CD4+ T-lymphocytopenia is rare and represents various clinical and immunologic states. It is perhaps more important to work harder to track the epidemiologic feature of this syndrome closely, to define the associated immune deficits carefully, and to search broadly for the cause. Further epidemiologic, immunologic, and virologic studies will aid in the characterization of this newly recognized condition.