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나운성,Moon Hyoungjoon,송대섭 한국미생물학회 2021 The journal of microbiology Vol.59 No.3
SARS-CoV-2 was originated from zoonotic coronaviruses and confirmed as a novel beta-coronavirus, which causes serious respiratory illness such as pneumonia and lung failure, COVID-19. In this review, we describe the genetic characteristics of SARS-CoV-2, including types of mutation, and molecular epidemiology, highlighting its key difference from animal coronaviruses. We further summarized the current knowledge on clinical, genetic, and pathological features of several animal coronaviruses and compared them with SARSCoV- 2, as well as recent evidences of interspecies transmission and recombination of animal coronaviruses to provide a better understanding of SARS-CoV-2 infection in One Health perspectives. We also discuss the potential wildlife hosts and zoonotic origin of this emerging virus in detail, that may help mitigate the spread and damages caused by the disease.
Animal models for dengue vaccine development and testing
나운성,염민주,최일규,육희준,송대섭 대한백신학회 2017 Clinical and Experimental Vaccine Research Vol.6 No.2
Dengue fever is a tropical endemic disease; however, because of climate change, it may become a problem in South Korea in the near future. Research on vaccines for dengue fever and outbreak preparedness are currently insufficient. In addition, because there are no appropriate animal models, controversial results from vaccine efficacy assessments and clinical trials have been reported. Therefore, to study the mechanism of dengue fever and test the immunogenicity of vaccines, an appropriate animal model is urgently needed. In addition to mouse models, more suitable models using animals that can be humanized will need to be constructed. In this report, we look at the current status of model animal construction and discuss which models require further development.
Influenza virus vaccine for neglected hosts: horses and dogs
나운성,염민주,육희준,문형준,강보규,송대섭 대한백신학회 2016 Clinical and Experimental Vaccine Research Vol.5 No.2
This study provides information regarding vaccine research and the epidemiology of influenza virus in neglected hosts (horses and dogs). Equine influenza virus (EIV) causes a highly contagious disease in horses and other equids, and outbreaks have occurred worldwide. EIV has resulted in costly damage to the horse industry and has the ability of cross the host species barrier from horses to dogs. Canine influenza is a virus of equine or avian origin and infects companion animals that live in close contact with humans; this results in possible exposure to the seasonal epizootic influenza virus. There have been case reports of genetic reassortment between human and canine influenza viruses, which results in high virulence and the ability of transmission to ferrets. This emphasizes the need for vaccine research on neglected hosts to update knowledge on current strains and to advance technology for controlling influenza outbreaks for public health.
김건엽,나운성,이선일,정현철,김필주,이종은,서영호,이종식,최은정,서상욱 한국토양비료학회 2016 한국토양비료학회지 Vol.49 No.6
Greenhouse-gas emission factors are widely used to estimate emissions arising from a defined unit of a specific activity. Such estimates are used both for international reporting to the United Nations Framework Convention on Climate Change (UNFCCC) and for myriad national and sub-national reporting purposes (for example, European Union Emissions Trading Scheme; EU ETS). As with the other so-called 'Kyoto protocol GHGs', the Intergovernmental Panel on Climate Change (IPCC) provides a methodology for national and sub-national estimation of N2O emissions, based on the sector from which the emissions arise. The objective of this study was to develop a integrated emission factor to estimate the direct N2O emission from an agricultural field cultivated with the red pepper, soy bean, spring cabbage, autumn cabbage and potato in 2010∼2012. Emission factor of N2O calculated using accumulated N2O emission, N fertilization rate, and background N2O emission over three year experiment was 0.00596±0.001337 kg N2O-N (N kg)-1. More extensive studies need to be conducted to develop N2O emission factors for other upland crops in the various regions of Korea because N2O emission is influenced by many factors including climate characteristics, soil properties, and agricultural practices.